American Journal of Neuroradiology: 37 (5)

Index by author

May 01, 2016; Volume 37,Issue 5

Pal, P.
1. EDITOR'S CHOICEADULT BRAIN
  
  Open Access
  Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging
  S.J. Mills, D. du Plessis, P. Pal, G. Thompson, G. Buonacorrsi, C. Soh, G.J.M. Parker and A. Jackson
  
  American Journal of Neuroradiology May 2016, 37 (5) 811-817; DOI: https://doi.org/10.3174/ajnr.A4623
  
  Twenty-eight patients with newly presenting glioblastoma multiforme underwent preoperative conventional imaging and T1 dynamic contrast-enhanced MRI. Parametric maps of the initial area under the contrast agent concentration curve, contrast transfer coefficient, estimate of volume of the extravascular extracellular space, and estimate of blood plasma volume were generated, and the enhancing fraction was calculated. High values of the estimate of volume of the extravascular extracellular space were associated with a fibrillary histologic pattern and increased mitotic activity. This finding is counterintuitive to the standard concept that more proliferative tumors would be more densely packed with cells and have less extracellular space. As the authors point out, this surprising finding requires more investigation to understand whether this relationship will hold, and what the underlying mechanism might be.
Pannek, K.
1. PEDIATRICS
  
  You have access
  Diffusion Tractography Biomarkers of Pediatric Cerebellar Hypoplasia/Atrophy: Preliminary Results Using Constrained Spherical Deconvolution
  S. Fiori, A. Poretti, K. Pannek, R. Del Punta, R. Pasquariello, M. Tosetti, A. Guzzetta, S. Rose, G. Cioni and R. Battini
  
  American Journal of Neuroradiology May 2016, 37 (5) 917-923; DOI: https://doi.org/10.3174/ajnr.A4607
Paolozza, A.
1. EDITOR'S CHOICEPEDIATRICS
  
  Open Access
  Brain Structural and Vascular Anatomy Is Altered in Offspring of Pre-Eclamptic Pregnancies: A Pilot Study
  M.T. Rätsep, A. Paolozza, A.F. Hickman, B. Maser, V.R. Kay, S. Mohammad, J. Pudwell, G.N. Smith, D. Brien, P.W. Stroman, M.A. Adams, J.N. Reynolds, B.A. Croy and N.D. Forkert
  
  American Journal of Neuroradiology May 2016, 37 (5) 939-945; DOI: https://doi.org/10.3174/ajnr.A4640
  
  The authors assessed the brain structural and vascular anatomy in 7- to 10-year-old offspring of pre-eclamptic pregnancies compared with matched controls (n=10 per group). TOF-MRA and a high-resolution anatomic T1-weighted MPRAGE sequence were acquired for each participant. Offspring of pre-eclamptic pregnancies exhibited enlarged brain regional volumes of the cerebellum, temporal lobe, brain stem, and right and left amygdalae. These offspring displayed reduced cerebral vessel radii in the occipital and parietal lobes. The authors conclude that these structural and vascular anomalies may underlie the cognitive deficits reported in the pre-eclamptic offspring population.
Parazzini, C.
1. FELLOWS' JOURNAL CLUBPEDIATRICS
  
  You have access
  Diagnostic Value of Prenatal MR Imaging in the Detection of Brain Malformations in Fetuses before the 26th Week of Gestational Age
  G. Conte, C. Parazzini, G. Falanga, C. Cesaretti, G. Izzo, M. Rustico and A. Righini
  
  American Journal of Neuroradiology May 2016, 37 (5) 946-951; DOI: https://doi.org/10.3174/ajnr.A4639
  
  The authors retrospectively evaluated 109 fetuses within 25 weeks of gestational age who had undergone both prenatal and postnatal MR imaging of the brain between 2002 and 2014, and using the postnatal MRI as the reference standard, they calculated the sensitivity, specificity, positive predictive value, and negative predictive value of the prenatal MRI in detecting brain malformations. Prenatal MR imaging failed to detect correctly 11 of the 111 malformations. They conclude that diagnostic value of prenatal MRI for brain malformations within 25 weeks of GA is very high, despite limitations of sensitivity in the early detection of disorders of cortical development, such as polymicrogyria and periventricular nodular heterotopias.
Parker, G.J.M.
1. EDITOR'S CHOICEADULT BRAIN
  
  Open Access
  Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging
  S.J. Mills, D. du Plessis, P. Pal, G. Thompson, G. Buonacorrsi, C. Soh, G.J.M. Parker and A. Jackson
  
  American Journal of Neuroradiology May 2016, 37 (5) 811-817; DOI: https://doi.org/10.3174/ajnr.A4623
  
  Twenty-eight patients with newly presenting glioblastoma multiforme underwent preoperative conventional imaging and T1 dynamic contrast-enhanced MRI. Parametric maps of the initial area under the contrast agent concentration curve, contrast transfer coefficient, estimate of volume of the extravascular extracellular space, and estimate of blood plasma volume were generated, and the enhancing fraction was calculated. High values of the estimate of volume of the extravascular extracellular space were associated with a fibrillary histologic pattern and increased mitotic activity. This finding is counterintuitive to the standard concept that more proliferative tumors would be more densely packed with cells and have less extracellular space. As the authors point out, this surprising finding requires more investigation to understand whether this relationship will hold, and what the underlying mechanism might be.
Pasquariello, R.
1. PEDIATRICS
  
  You have access
  Diffusion Tractography Biomarkers of Pediatric Cerebellar Hypoplasia/Atrophy: Preliminary Results Using Constrained Spherical Deconvolution
  S. Fiori, A. Poretti, K. Pannek, R. Del Punta, R. Pasquariello, M. Tosetti, A. Guzzetta, S. Rose, G. Cioni and R. Battini
  
  American Journal of Neuroradiology May 2016, 37 (5) 917-923; DOI: https://doi.org/10.3174/ajnr.A4607
Patankar, T.
1. INTERVENTIONAL
  
  You have access
  WEB in Partially Thrombosed Intracranial Aneurysms: A Word of Caution
  G. Anil, A.J.P. Goddard, S.M. Ross, K. Deniz and T. Patankar
  
  American Journal of Neuroradiology May 2016, 37 (5) 892-896; DOI: https://doi.org/10.3174/ajnr.A4604
Patz, S.
1. FELLOWS' JOURNAL CLUBADULT BRAIN
  
  You have access
  Cough-Associated Changes in CSF Flow in Chiari I Malformation Evaluated by Real-Time MRI
  R.A. Bhadelia, S. Patz, C. Heilman, D. Khatami, E. Kasper, Y. Zhao and N. Madan
  
  American Journal of Neuroradiology May 2016, 37 (5) 825-830; DOI: https://doi.org/10.3174/ajnr.A4629
  
  Eight symptomatic patients with Chiari I malformation and 6 healthy participants were studied by using MR pencil beam imaging with a temporal resolution of 50 ms. Patients and healthy participants were scanned in real-time during resting, coughing, and postcoughing periods. CSF flow waveform amplitude, CSF stroke volume, and CSF flow rate were compared between the patients and the control population. Real-time MR imaging noninvasively showed a transient decrease in CSF flow across the foramen magnum after coughing in symptomatic patients with Chiari I malformation.
Pauranik, A.
1. SPINE
  
  You have access
  Comparison of Sagittal FSE T2, STIR, and T1-Weighted Phase-Sensitive Inversion Recovery in the Detection of Spinal Cord Lesions in MS at 3T
  P. Alcaide-Leon, A. Pauranik, L. Alshafai, S. Rawal, J. Oh, W. Montanera, G. Leung and A. Bharatha
  
  American Journal of Neuroradiology May 2016, 37 (5) 970-975; DOI: https://doi.org/10.3174/ajnr.A4656
Pelz, D.M.
1. You have access
  Cooling Catheters for Selective Brain Hypothermia
  T.K. Mattingly, D.M. Pelz and S.P. Lownie
  
  American Journal of Neuroradiology May 2016, 37 (5) E45; DOI: https://doi.org/10.3174/ajnr.A4749

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American Journal of Neuroradiology

Index by author

Pal, P.

Pannek, K.

Paolozza, A.

Parazzini, C.

Parker, G.J.M.

Pasquariello, R.

Patankar, T.

Patz, S.

Pauranik, A.

Pelz, D.M.

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