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      <h1 class="highwire-cite-title" id="page-title">Cooling Catheters for Selective Brain Hypothermia</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">T.K. Mattingly</span>, <span class="highwire-citation-author" data-delta="1">D.M. Pelz</span> and <span class="highwire-citation-author" data-delta="2">S.P. Lownie</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2016,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">E45; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4749 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-14500--6445566883" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">T.K. Mattingly </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Neurosurgical Associates
Richmond, Virginia</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.K.%2BMattingly%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Mattingly%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AT.K.%2BMattingly%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-2949-5521" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for T.K. Mattingly</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">D.M. Pelz </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>London Health Sciences Centre
London, Ontario, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.M.%2BPelz%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Pelz%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.M.%2BPelz%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-7669-7313" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D.M. Pelz</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">S.P. Lownie </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>London Health Sciences Centre
London, Ontario, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.P.%2BLownie%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lownie%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.P.%2BLownie%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-4959-6725" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.P. Lownie</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article fulltext-view "><span class="highwire-journal-article-marker-start"></span><p id="p-1">We read with interest “Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance” by Cattaneo et al.<sup><a id="xref-ref-1-1" class="xref-bibr" href="#ref-1">1</a></sup> The authors achieved mild brain hypothermia by using a novel indwelling cooling catheter. We appreciate the authors' acknowledgment of our work in selective brain cooling.<sup><a id="xref-ref-2-1" class="xref-bibr" href="#ref-2">2</a></sup> However they may have misunderstood the TwinFlo catheter evaluated in our study (ThermopeutiX, San Diego, California). The TwinFlo inner coaxial balloon catheter is 9.5F, with an inner diameter of 2.0 mm (0.080 inches). This is well within the lumen size needed to perform simultaneous mechanical stent-retriever thrombectomy during selective brain cooling.</p><p id="p-2">Reduction in brain metabolic demand is related to the depth of hypothermia.<sup><a id="xref-ref-3-1" class="xref-bibr" href="#ref-3">3</a></sup> Brain cooling using the authors' device was only mild (−4.2°C to −4.5°C) and took &gt;2 hours to achieve. On the other hand, endovascular cold blood perfusion seems better able to achieve the very low temperatures (25°C–26°C) necessary to avert ischemic stroke and can do so very rapidly (&lt;30°C in a median of 15 minutes). We demonstrated a substantial reduction in stroke volume in our large-animal model, despite starting cooling well into the reperfusion phase and after 3 hours of focal ischemia.</p><div class="section fn-group" id="fn-group-1"><h2>Footnotes</h2><ul><li class="fn-financial-disclosure" id="fn-1"><p id="p-3">Disclosures: Thomas K. Mattingly—<em>RELATED</em>: <em>Grant</em>: Heart and Stroke Foundation,* ThermopeutiX,* <em>Comments</em>: HSF GIA 7273; ThermopeutiX provided the TwinFlo catheters and assisted in data collection on catheter performance. Stephen P. Lownie—<em>Travel/Accommodations/Meeting Expenses Unrelated to Activities Listed</em>: Vice-President, Canadian Neurosurgery Society. *Money paid to the institution.</p></li></ul></div><div class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-37.5.E45.1" data-doi="10.3174/ajnr.A4625"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Cattaneo</span>  <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schumacher</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Maurer</span>  <span class="cit-name-given-names">C</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Endovascular cooling catheter for selective brain hypothermia: an animal feasibility study of cooling performance</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2015</span> 
<span class="cit-month">Dec</span> 
<span class="cit-day">24</span>. <span class="cit-comment">[Epub ahead of print]</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3174/ajnr.A4625</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26705319</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo4OiIzNy81Lzg4NSI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zNy81L0U0NS5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">2.</span><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2. in text" id="ref-2">↵</a><div class="cit ref-cit ref-journal" id="cit-37.5.E45.2" data-doi="10.1136/neurintsurg-2014-011562"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Mattingly</span>  <span class="cit-name-given-names">TK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Denning</span>  <span class="cit-name-given-names">LM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Siroen</span>  <span class="cit-name-given-names">KL</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Catheter based selective hypothermia reduces stroke volume during focal cerebral ischemia in swine</span>. <abbr class="cit-jnl-abbrev">J Neurointerv Surg</abbr> <span class="cit-pub-date">2015</span> 
<span class="cit-month">Feb</span> 
<span class="cit-day">12</span>. <span class="cit-comment">[Epub ahead of print]</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/neurintsurg-2014-011562</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25676148</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1136/neurintsurg-2014-011562&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25676148&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F5%2FE45.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">3.</span><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3. in text" id="ref-3">↵</a><div class="cit ref-cit ref-journal" id="cit-37.5.E45.3" data-doi="10.3171/jns.1955.12.3.0226"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Lougheed</span>  <span class="cit-name-given-names">WM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kahn</span>  <span class="cit-name-given-names">DS</span></span></li></ol><cite>. <span class="cit-article-title">Circumvention of anoxia during arrest of cerebral circulation for intracranial surgery</span>. <abbr class="cit-jnl-abbrev">J Neurosurg</abbr> <span class="cit-pub-date">1955</span>;<span class="cit-vol">12</span>:<span class="cit-fpage">226</span>–<span class="cit-lpage">39</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3171/jns.1955.12.3.0226</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>14381930</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3171/jns.1955.12.3.0226&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=14381930&amp;link_type=MED&amp;atom=%2Fajnr%2F37%2F5%2FE45.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li></ol></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2016 by American Journal of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div>  </div>

  
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