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<meta name="DC.Title" content="Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4628" />
<meta name="DC.Date" content="2016-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: In recent years, several high-resolution vessel wall MR imaging techniques have emerged for the characterization of intracranial atherosclerotic vessel wall lesions in vivo. However, a thorough validation of MR imaging results of intracranial plaques with histopathology is still lacking. The aim of this study was to characterize atherosclerotic plaque components in a quantitative manner by obtaining the MR signal characteristics ( T1 , T2 , T2 *, and proton density) at 7T in ex vivo circle of Willis specimens and using histopathology for validation.

MATERIALS AND METHODS: A multiparametric ultra-high-resolution quantitative MR imaging protocol was performed at 7T to identify the MR signal characteristics of different intracranial atherosclerotic plaque components, and using histopathology for validation. In total, 38 advanced plaques were matched between MR imaging and histology, and ROI analysis was performed on the identified tissue components.

RESULTS: Mean T1 , T2 , and T2 * relaxation times and proton density values were significantly different between different tissue components. The quantitative T1 map showed the most differences among individual tissue components of intracranial plaques with significant differences in T1 values between lipid accumulation ( T1 = 838 ± 167 ms), fibrous tissue ( T1 = 583 ± 161 ms), fibrous cap ( T1 = 481 ± 98 ms), calcifications ( T1 = 314 ± 39 ms), and the intracranial arterial vessel wall ( T1 = 436 ± 122 ms).

CONCLUSIONS: Different tissue components of advanced intracranial plaques have distinguishable imaging characteristics with ultra-high-resolution quantitative MR imaging at 7T. Based on this study, the most promising method for distinguishing intracranial plaque components is T1-weighted imaging.

CoW
:   circle of Willis
DESPOT1
:   driven equilibrium single pulse observation of T1 
DESPOT2
:   driven equilibrium single pulse observation of T2 
PD
:   proton density" />
<meta name="DC.Contributor" content="A.A. Harteveld" />
<meta name="DC.Contributor" content="N.P. Denswil" />
<meta name="DC.Contributor" content="J.C.W. Siero" />
<meta name="DC.Contributor" content="J.J.M. Zwanenburg" />
<meta name="DC.Contributor" content="A. Vink" />
<meta name="DC.Contributor" content="B. Pouran" />
<meta name="DC.Contributor" content="W.G.M. Spliet" />
<meta name="DC.Contributor" content="D.W.J. Klomp" />
<meta name="DC.Contributor" content="P.R. Luijten" />
<meta name="DC.Contributor" content="M.J. Daemen" />
<meta name="DC.Contributor" content="J. Hendrikse" />
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<meta name="article:published_time" content="2016-05-01" />
<meta name="article:section" content="ADULT BRAIN" />
<meta name="citation_title" content="Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;In recent years, several high-resolution vessel wall MR imaging techniques have emerged for the characterization of intracranial atherosclerotic vessel wall lesions in vivo. However, a thorough validation of MR imaging results of intracranial plaques with histopathology is still lacking. The aim of this study was to characterize atherosclerotic plaque components in a quantitative manner by obtaining the MR signal characteristics (&lt;i&gt;T1&lt;/i&gt;, &lt;i&gt;T2&lt;/i&gt;, &lt;i&gt;T2&lt;/i&gt;*, and proton density) at 7T in ex vivo circle of Willis specimens and using histopathology for validation.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;A multiparametric ultra-high-resolution quantitative MR imaging protocol was performed at 7T to identify the MR signal characteristics of different intracranial atherosclerotic plaque components, and using histopathology for validation. In total, 38 advanced plaques were matched between MR imaging and histology, and ROI analysis was performed on the identified tissue components.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Mean &lt;i&gt;T1&lt;/i&gt;, &lt;i&gt;T2&lt;/i&gt;, and &lt;i&gt;T2&lt;/i&gt;* relaxation times and proton density values were significantly different between different tissue components. The quantitative &lt;i&gt;T1&lt;/i&gt; map showed the most differences among individual tissue components of intracranial plaques with significant differences in &lt;i&gt;T1&lt;/i&gt; values between lipid accumulation (&lt;i&gt;T1&lt;/i&gt; = 838 ± 167 ms), fibrous tissue (&lt;i&gt;T1&lt;/i&gt; = 583 ± 161 ms), fibrous cap (&lt;i&gt;T1&lt;/i&gt; = 481 ± 98 ms), calcifications (&lt;i&gt;T1&lt;/i&gt; = 314 ± 39 ms), and the intracranial arterial vessel wall (&lt;i&gt;T1&lt;/i&gt; = 436 ± 122 ms).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Different tissue components of advanced intracranial plaques have distinguishable imaging characteristics with ultra-high-resolution quantitative MR imaging at 7T. Based on this study, the most promising method for distinguishing intracranial plaque components is T1-weighted imaging.&lt;/p&gt;" />
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<meta name="citation_author" content="A.A. Harteveld" />
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<meta name="twitter:title" content="Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/37/5.cover-source.jpg" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: In recent years, several high-resolution vessel wall MR imaging techniques have emerged for the characterization of intracranial atherosclerotic vessel wall lesions in vivo. However, a thorough validation of MR imaging results of intracranial plaques with histopathology is still lacking. The aim of this study was to characterize atherosclerotic plaque components in a quantitative manner by obtaining the MR signal characteristics ( T1 , T2 , T2 *, and proton density) at 7T in ex vivo circle of Willis specimens and using histopathology for validation.

MATERIALS AND METHODS: A multiparametric ultra-high-resolution quantitative MR imaging protocol was performed at 7T to identify the MR signal characteristics of different intracranial atherosclerotic plaque components, and using histopathology for validation. In total, 38 advanced plaques were matched between MR imaging and histology, and ROI analysis was performed on the identified tissue components.

RESULTS: Mean T1 , T2 , and T2 * relaxation times and proton density values were significantly different between different tissue components. The quantitative T1 map showed the most differences among individual tissue components of intracranial plaques with significant differences in T1 values between lipid accumulation ( T1 = 838 ± 167 ms), fibrous tissue ( T1 = 583 ± 161 ms), fibrous cap ( T1 = 481 ± 98 ms), calcifications ( T1 = 314 ± 39 ms), and the intracranial arterial vessel wall ( T1 = 436 ± 122 ms).

CONCLUSIONS: Different tissue components of advanced intracranial plaques have distinguishable imaging characteristics with ultra-high-resolution quantitative MR imaging at 7T. Based on this study, the most promising method for distinguishing intracranial plaque components is T1-weighted imaging.

CoW
:   circle of Willis
DESPOT1
:   driven equilibrium single pulse observation of T1 
DESPOT2
:   driven equilibrium single pulse observation of T2 
PD
:   proton density" />
<meta name="og-title" property="og:title" content="Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/37/5/802" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: In recent years, several high-resolution vessel wall MR imaging techniques have emerged for the characterization of intracranial atherosclerotic vessel wall lesions in vivo. However, a thorough validation of MR imaging results of intracranial plaques with histopathology is still lacking. The aim of this study was to characterize atherosclerotic plaque components in a quantitative manner by obtaining the MR signal characteristics ( T1 , T2 , T2 *, and proton density) at 7T in ex vivo circle of Willis specimens and using histopathology for validation.

MATERIALS AND METHODS: A multiparametric ultra-high-resolution quantitative MR imaging protocol was performed at 7T to identify the MR signal characteristics of different intracranial atherosclerotic plaque components, and using histopathology for validation. In total, 38 advanced plaques were matched between MR imaging and histology, and ROI analysis was performed on the identified tissue components.

RESULTS: Mean T1 , T2 , and T2 * relaxation times and proton density values were significantly different between different tissue components. The quantitative T1 map showed the most differences among individual tissue components of intracranial plaques with significant differences in T1 values between lipid accumulation ( T1 = 838 ± 167 ms), fibrous tissue ( T1 = 583 ± 161 ms), fibrous cap ( T1 = 481 ± 98 ms), calcifications ( T1 = 314 ± 39 ms), and the intracranial arterial vessel wall ( T1 = 436 ± 122 ms).

CONCLUSIONS: Different tissue components of advanced intracranial plaques have distinguishable imaging characteristics with ultra-high-resolution quantitative MR imaging at 7T. Based on this study, the most promising method for distinguishing intracranial plaque components is T1-weighted imaging.

CoW
:   circle of Willis
DESPOT1
:   driven equilibrium single pulse observation of T1 
DESPOT2
:   driven equilibrium single pulse observation of T2 
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:   proton density" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node14485--5" data-node-nid="14485" id="top-node-14485--61858535414" data-pisa="ajnr;37/5/802" data-pisa-master="ajnr;ajnr.A4628" data-apath="/ajnr/37/5/802.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">ADULT BRAIN</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">A.A. Harteveld</span>, <span class="highwire-citation-author" data-delta="1">N.P. Denswil</span>, <span class="highwire-citation-author" data-delta="2">J.C.W. Siero</span>, <span class="highwire-citation-author" data-delta="3">J.J.M. Zwanenburg</span>, <span class="highwire-citation-author" data-delta="4">A. Vink</span>, <span class="highwire-citation-author" data-delta="5">B. Pouran</span>, <span class="highwire-citation-author" data-delta="6">W.G.M. Spliet</span>, <span class="highwire-citation-author" data-delta="7">D.W.J. Klomp</span>, <span class="highwire-citation-author" data-delta="8">P.R. Luijten</span>, <span class="highwire-citation-author" data-delta="9">M.J. Daemen</span>, <span class="highwire-citation-author" data-delta="10">J. Hendrikse</span> and <span class="highwire-citation-author" data-delta="11">A.G. van der Kolk</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2016,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">802-810; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4628 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-14485--61858535414" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">A.A. Harteveld </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.A.%2BHarteveld%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Harteveld%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.A.%2BHarteveld%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-3379-0710" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.A. Harteveld</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">N.P. Denswil </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Pathology (N.P.D., M.J.D.), Academic Medical Center, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.P.%2BDenswil%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Denswil%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.P.%2BDenswil%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-5420-3909" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N.P. Denswil</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">J.C.W. Siero </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.C.W.%2BSiero%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Siero%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.C.W.%2BSiero%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-5079-2868" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.C.W. Siero</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J.J.M. Zwanenburg </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Image Sciences Institute (J.J.M.Z.), University Medical Center Utrecht, Utrecht, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.J.M.%2BZwanenburg%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zwanenburg%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.J.M.%2BZwanenburg%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-4282-5719" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.J.M. Zwanenburg</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">A. Vink </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Pathology (A.V., W.G.M.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BVink%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vink%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BVink%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-9371-8788" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Vink</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">B. Pouran </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Orthopedics (B.P.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Rheumatology (B.P.)</div><div class='author-affiliation'><span class='nlm-sup'>g</span>Department of Biomedical Engineering (B.P.), Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology, Delft, the Netherlands.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.%2BPouran%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Pouran%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AB.%2BPouran%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-1986-3741" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for B. Pouran</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">W.G.M. Spliet </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Pathology (A.V., W.G.M.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.G.M.%2BSpliet%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Spliet%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.G.M.%2BSpliet%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-4038-3264" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W.G.M. Spliet</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">D.W.J. Klomp </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.W.J.%2BKlomp%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Klomp%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.W.J.%2BKlomp%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-5884-5386" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D.W.J. Klomp</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">P.R. Luijten </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.R.%2BLuijten%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Luijten%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AP.R.%2BLuijten%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-8040-8449" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for P.R. Luijten</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">M.J. Daemen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Pathology (N.P.D., M.J.D.), Academic Medical Center, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.J.%2BDaemen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Daemen%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.J.%2BDaemen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-1076-199X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.J. Daemen</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">J. Hendrikse </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (A.A.H., J.C.W.S., J.J.M.Z., D.W.J.K., P.R.L., J.H., A.G.v.d.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BHendrikse%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hendrikse%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BHendrikse%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-6384-6140" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. 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      <div class="highwire-cite-title">Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">802-810; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4628 </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">802-810; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4628 </span></div>
  
  
  
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