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<meta name="DC.Description" content="SUMMARY: Previous studies using diffusion tensor imaging to examine white matter in Niemann-Pick disease type C have produced mixed results. However, diffusion tensor imaging does not directly measure myelin and may be affected by other structural changes. We used myelin water imaging to more directly examine demyelination in 2 patients with Niemann-Pick disease type C. The results suggest that this technique may be useful for identifying regional changes in myelination in this condition.

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&lt;p&gt;Previous studies using diffusion tensor imaging to examine white matter in Niemann-Pick disease type C have produced mixed results. However, diffusion tensor imaging does not directly measure myelin and may be affected by other structural changes. We used myelin water imaging to more directly examine demyelination in 2 patients with Niemann-Pick disease type C. The results suggest that this technique may be useful for identifying regional changes in myelination in this condition.&lt;/p&gt;" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node14518--5" data-node-nid="14518" id="top-node-14518--6841241535" data-pisa="ajnr;37/8/1487" data-pisa-master="ajnr;ajnr.A4719" data-apath="/ajnr/37/8/1487.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">ADULT BRAIN</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Reduced Myelin Water in the White Matter Tracts of Patients with Niemann-Pick Disease Type C</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">J. Davies-Thompson</span>, <span class="highwire-citation-author" data-delta="1">I. Vavasour</span>, <span class="highwire-citation-author" data-delta="2">M. Scheel</span>, <span class="highwire-citation-author" data-delta="3">A. Rauscher</span> and <span class="highwire-citation-author" data-delta="4">J.J.S. Barton</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2016,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1487-1489; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4719 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-14518--6841241535" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J. Davies-Thompson </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Crossmodal Perception and Plasticity Laboratory (J.D.-T.), Center of Mind/Brain Sciences, University of Trento, Trento, Italy</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Human Vision and Eye Movement Laboratory (J.D.-T., J.J.S.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BDavies-Thompson%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Davies-Thompson%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BDavies-Thompson%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-9355-4306" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Davies-Thompson</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">I. Vavasour </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Medicine (Neurology), Ophthalmology, and Visual Sciences, Department of Radiology (I.V.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.%2BVavasour%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vavasour%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AI.%2BVavasour%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-9286-0953" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for I. Vavasour</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">M. Scheel </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Radiology (M.S.), Charité University Clinics, Berlin, Germany.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BScheel%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Scheel%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BScheel%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-3505-2914" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Scheel</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">A. Rauscher </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Pediatrics, and UBC MRI Research Centre (A.R.), University of British Columbia, Vancouver, British Columbia, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BRauscher%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rauscher%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BRauscher%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-1961-8252" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Rauscher</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">J.J.S. Barton </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Human Vision and Eye Movement Laboratory (J.D.-T., J.J.S.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.J.S.%2BBarton%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Barton%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.J.S.%2BBarton%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-8264-3795" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.J.S. Barton</a></li></ul></div></div></div>  </div>

  
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    <div class="elements-frag-data highwire-markup" id="fig-data"><div id="fig-data-figures" class="group frag-figure"><div class="fig-data-title-jump clearfix"><h3 class="fig-data-group-title">Figures</h3><div class="fig-data-jump-links"></div></div><div class="item-list"><ul class="fig-data-list clearfix" id="fragments-fig"><li class="first"><div class="element-fig-data clearfix figure-caption"><div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="fig-expansion " id="F1"><span class="highwire-journal-article-marker-start"></span><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F1.large.jpg?width=800&amp;height=600&amp;carousel=1" title="Whole-brain myelin water z score maps in the 2 patients. Statistical z score maps show the difference between patients and their respective control subjects, where negative z scores indicate reduced myelin water. For clarity, maps were spatially smoothed with a Gaussian 6-mm filter and are shown on a diluted fractional anisotropy skeleton. Statistical maps (minimum thresholded at z = &#x2212; 1.6 for clarity) are overlaid on the average Montreal Neurological Institute brain. Green arrows highlight areas where the myelin is substantially reduced in the patients compared with their controls. IC-RL indicates retrolenticular portion of internal capsule; PTR, posterior thalamic radiation including the optic radiation; CR-A, anterior corona radiata; SLF, superior longitudinal fasciculus; CC-G, genu of corpus callosum; CC-S, splenium of the corpus callosum." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-463640071" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;&lt;div xmlns=&quot;http://www.w3.org/1999/xhtml&quot;&gt;Whole-brain myelin water &lt;em&gt;z&lt;/em&gt; score maps in the 2 patients. Statistical &lt;em&gt;z&lt;/em&gt; score maps show the difference between patients and their respective control subjects, where negative &lt;em&gt;z&lt;/em&gt; scores indicate reduced myelin water. For clarity, maps were spatially smoothed with a Gaussian 6-mm filter and are shown on a diluted fractional anisotropy skeleton. Statistical maps (minimum thresholded at &lt;em&gt;z&lt;/em&gt; = &#x2212; 1.6 for clarity) are overlaid on the average Montreal Neurological Institute brain. &lt;em&gt;Green arrows&lt;/em&gt; highlight areas where the myelin is substantially reduced in the patients compared with their controls. IC-RL indicates retrolenticular portion of internal capsule; PTR, posterior thalamic radiation including the optic radiation; CR-A, anterior corona radiata; SLF, superior longitudinal fasciculus; CC-G, genu of corpus callosum; CC-S, splenium of the corpus callosum.&lt;/div&gt;&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="Fig 1." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F1.medium.gif" width="440" height="181"/><noscript><img class="highwire-fragment fragment-image" alt="Fig 1." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F1.medium.gif" width="440" height="181"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F1.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Fig 1." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F1.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/46342" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"><span class="fig-label">Fig 1.</span> <p id="p-15">Whole-brain myelin water <em>z</em> score maps in the 2 patients. Statistical <em>z</em> score maps show the difference between patients and their respective control subjects, where negative <em>z</em> scores indicate reduced myelin water. For clarity, maps were spatially smoothed with a Gaussian 6-mm filter and are shown on a diluted fractional anisotropy skeleton. Statistical maps (minimum thresholded at <em>z</em> = − 1.6 for clarity) are overlaid on the average Montreal Neurological Institute brain. <em>Green arrows</em> highlight areas where the myelin is substantially reduced in the patients compared with their controls. IC-RL indicates retrolenticular portion of internal capsule; PTR, posterior thalamic radiation including the optic radiation; CR-A, anterior corona radiata; SLF, superior longitudinal fasciculus; CC-G, genu of corpus callosum; CC-S, splenium of the corpus callosum.</p><div class="sb-div caption-clear"></div></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div></div></li><li class="last"><div class="element-fig-data clearfix figure-caption"><div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="fig-expansion " id="F2"><span class="highwire-journal-article-marker-start"></span><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F2.large.jpg?width=800&amp;height=600&amp;carousel=1" title="Tract analysis for patients (red and blue bars) and their age-matched control subjects (gray bars). CR-a indicates anterior corona radiata, CR-p, posterior corona radiata; CR-s, superior corona radiata; IC-a, anterior limb of internal capsule; IC-p, posterior limb of internal capsule; PTR, posterior thalamic radiation including optic radiation; IC-rl, retrolenticular portion of internal capsule; SFOF, superior fronto-occipital fasciculus; SLF, superior longitudinal fasciculus; Cg, cingulum including the hippocampus; EC, external capsule; Fnx, column and body of fornix; SS, sagittal stratum including inferior longitudinal fasciculus and inferior fronto-occipital fasciculus; Fx/ST, fornix and stria terminalis; CC-g, genu of the corpus callosum; CC-s, splenium of corpus callosum; TAP, tapetum. Asterisks indicate P &lt; .05 as determined by Crawford t-tests.9 Error bars show 1 standard error of the mean." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-463640071" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;&lt;div xmlns=&quot;http://www.w3.org/1999/xhtml&quot;&gt;Tract analysis for patients (&lt;em&gt;red and blue bars&lt;/em&gt;) and their age-matched control subjects (&lt;em&gt;gray bars&lt;/em&gt;). CR-a indicates anterior corona radiata, CR-p, posterior corona radiata; CR-s, superior corona radiata; IC-a, anterior limb of internal capsule; IC-p, posterior limb of internal capsule; PTR, posterior thalamic radiation including optic radiation; IC-rl, retrolenticular portion of internal capsule; SFOF, superior fronto-occipital fasciculus; SLF, superior longitudinal fasciculus; Cg, cingulum including the hippocampus; EC, external capsule; Fnx, column and body of fornix; SS, sagittal stratum including inferior longitudinal fasciculus and inferior fronto-occipital fasciculus; Fx/ST, fornix and stria terminalis; CC-g, genu of the corpus callosum; CC-s, splenium of corpus callosum; TAP, tapetum. &lt;em&gt;Asterisks&lt;/em&gt; indicate &lt;em&gt;P&lt;/em&gt; &lt; .05 as determined by Crawford t-tests.&lt;sup&gt;9&lt;/sup&gt; &lt;em&gt;Error bars&lt;/em&gt; show 1 standard error of the mean.&lt;/div&gt;&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="Fig 2." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F2.medium.gif" width="440" height="192"/><noscript><img class="highwire-fragment fragment-image" alt="Fig 2." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F2.medium.gif" width="440" height="192"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F2.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Fig 2." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/37/8/1487/F2.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/46325" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"><span class="fig-label">Fig 2.</span> <p id="p-17">Tract analysis for patients (<em>red and blue bars</em>) and their age-matched control subjects (<em>gray bars</em>). CR-a indicates anterior corona radiata, CR-p, posterior corona radiata; CR-s, superior corona radiata; IC-a, anterior limb of internal capsule; IC-p, posterior limb of internal capsule; PTR, posterior thalamic radiation including optic radiation; IC-rl, retrolenticular portion of internal capsule; SFOF, superior fronto-occipital fasciculus; SLF, superior longitudinal fasciculus; Cg, cingulum including the hippocampus; EC, external capsule; Fnx, column and body of fornix; SS, sagittal stratum including inferior longitudinal fasciculus and inferior fronto-occipital fasciculus; Fx/ST, fornix and stria terminalis; CC-g, genu of the corpus callosum; CC-s, splenium of corpus callosum; TAP, tapetum. <em>Asterisks</em> indicate <em>P</em> &lt; .05 as determined by Crawford t-tests.<sup><span id="xref-ref-9-2" class="xref-bibr">9</span></sup> <em>Error bars</em> show 1 standard error of the mean.</p><div class="sb-div caption-clear"></div></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div></div></li></ul></div></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 37</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 8 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Aug 2016 </div></div>
      
      
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      <div class="highwire-cite-title">Reduced Myelin Water in the White Matter Tracts of Patients with Niemann-Pick Disease Type C</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Davies-Thompson</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Vavasour</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Scheel</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Rauscher</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">J.J.S.</span> <span class="nlm-surname">Barton</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1487-1489; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4719 </span></div>
  
  
  
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      <div class="highwire-cite-title">Reduced Myelin Water in the White Matter Tracts of Patients with Niemann-Pick Disease Type C</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Davies-Thompson</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Vavasour</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Scheel</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Rauscher</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">J.J.S.</span> <span class="nlm-surname">Barton</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1487-1489; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4719 </span></div>
  
  
  
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