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<meta name="DC.Title" content="Relationship between APOE Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4805" />
<meta name="DC.Date" content="2016-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: The presence of the apolipoprotein E ε 4 allele is the strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that apolipoprotein E ε 4 carriers and noncarriers may already differ in imaging patterns in midlife. We therefore sought to identify the effect of apolipoprotein E genotype on brain atrophy across almost the entire adult age span by using advanced MR imaging–based pattern analysis.

MATERIALS AND METHODS: We analyzed MR imaging scans of 1472 participants from the Study of Health in Pomerania (22–90 years of age). We studied the association among age, apolipoprotein E ε 4 carrier status, and brain atrophy, which was quantified by using 2 MR imaging–based indices: Spatial Pattern of Atrophy for Recognition of Brain Aging (summarizing age-related brain atrophy) and Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease (summarizing Alzheimer disease-like brain atrophy patterns), as well as the gray matter volumes in several Alzheimer disease- and apolipoprotein E –related ROIs (lateral frontal, lateral temporal, medial frontal, and hippocampus).

RESULTS: No significant association was found between apolipoprotein E ε 4 carrier status and the studied ROIs or the MR imaging–based indices in linear regression models adjusted for age, sex, and education, including an interaction term between apolipoprotein E and age.

CONCLUSIONS: Our study indicates that measurable apolipoprotein E –related brain atrophy does not occur in early adulthood and midlife and suggests that such atrophy may only occur more proximal to the onset of clinical symptoms of dementia.

AD
:   Alzheimer disease
APOE 
:   apolipoprotein E 
MCI
:   mild cognitive impairment
SHIP
:   Study of Health in Pomerania
SNP
:   single nucleotide polymorphism
SPARE-AD
:   Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease
SPARE-BA
:   Spatial Pattern of Atrophy for Recognition of Brain Aging" />
<meta name="DC.Contributor" content="M. Habes" />
<meta name="DC.Contributor" content="J.B. Toledo" />
<meta name="DC.Contributor" content="S.M. Resnick" />
<meta name="DC.Contributor" content="J. Doshi" />
<meta name="DC.Contributor" content="S. Van der Auwera" />
<meta name="DC.Contributor" content="G. Erus" />
<meta name="DC.Contributor" content="D. Janowitz" />
<meta name="DC.Contributor" content="K. Hegenscheid" />
<meta name="DC.Contributor" content="G. Homuth" />
<meta name="DC.Contributor" content="H. Völzke" />
<meta name="DC.Contributor" content="W. Hoffmann" />
<meta name="DC.Contributor" content="H.J. Grabe" />
<meta name="DC.Contributor" content="C. Davatzikos" />
<meta name="article:published_time" content="2016-09-01" />
<meta name="article:section" content="ADULT BRAIN" />
<meta name="citation_title" content="Relationship between APOE Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;The presence of the &lt;i&gt;apolipoprotein E&lt;/i&gt; ε&lt;i&gt;4&lt;/i&gt; allele is the strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that &lt;i&gt;apolipoprotein E&lt;/i&gt; ε&lt;i&gt;4&lt;/i&gt; carriers and noncarriers may already differ in imaging patterns in midlife. We therefore sought to identify the effect of &lt;i&gt;apolipoprotein E&lt;/i&gt; genotype on brain atrophy across almost the entire adult age span by using advanced MR imaging–based pattern analysis.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;We analyzed MR imaging scans of 1472 participants from the Study of Health in Pomerania (22–90 years of age). We studied the association among age, &lt;i&gt;apolipoprotein E&lt;/i&gt; ε&lt;i&gt;4&lt;/i&gt; carrier status, and brain atrophy, which was quantified by using 2 MR imaging–based indices: Spatial Pattern of Atrophy for Recognition of Brain Aging (summarizing age-related brain atrophy) and Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease (summarizing Alzheimer disease-like brain atrophy patterns), as well as the gray matter volumes in several Alzheimer disease- and &lt;i&gt;apolipoprotein E&lt;/i&gt;–related ROIs (lateral frontal, lateral temporal, medial frontal, and hippocampus).&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;No significant association was found between &lt;i&gt;apolipoprotein E&lt;/i&gt; ε&lt;i&gt;4&lt;/i&gt; carrier status and the studied ROIs or the MR imaging–based indices in linear regression models adjusted for age, sex, and education, including an interaction term between &lt;i&gt;apolipoprotein E&lt;/i&gt; and age.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Our study indicates that measurable &lt;i&gt;apolipoprotein E&lt;/i&gt;–related brain atrophy does not occur in early adulthood and midlife and suggests that such atrophy may only occur more proximal to the onset of clinical symptoms of dementia.&lt;/p&gt;" />
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<meta name="twitter:title" content="Relationship between APOE Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: The presence of the apolipoprotein E ε 4 allele is the strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that apolipoprotein E ε 4 carriers and noncarriers may already differ in imaging patterns in midlife. We therefore sought to identify the effect of apolipoprotein E genotype on brain atrophy across almost the entire adult age span by using advanced MR imaging–based pattern analysis.

MATERIALS AND METHODS: We analyzed MR imaging scans of 1472 participants from the Study of Health in Pomerania (22–90 years of age). We studied the association among age, apolipoprotein E ε 4 carrier status, and brain atrophy, which was quantified by using 2 MR imaging–based indices: Spatial Pattern of Atrophy for Recognition of Brain Aging (summarizing age-related brain atrophy) and Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease (summarizing Alzheimer disease-like brain atrophy patterns), as well as the gray matter volumes in several Alzheimer disease- and apolipoprotein E –related ROIs (lateral frontal, lateral temporal, medial frontal, and hippocampus).

RESULTS: No significant association was found between apolipoprotein E ε 4 carrier status and the studied ROIs or the MR imaging–based indices in linear regression models adjusted for age, sex, and education, including an interaction term between apolipoprotein E and age.

CONCLUSIONS: Our study indicates that measurable apolipoprotein E –related brain atrophy does not occur in early adulthood and midlife and suggests that such atrophy may only occur more proximal to the onset of clinical symptoms of dementia.

AD
:   Alzheimer disease
APOE 
:   apolipoprotein E 
MCI
:   mild cognitive impairment
SHIP
:   Study of Health in Pomerania
SNP
:   single nucleotide polymorphism
SPARE-AD
:   Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease
SPARE-BA
:   Spatial Pattern of Atrophy for Recognition of Brain Aging" />
<meta name="og-title" property="og:title" content="Relationship between APOE Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/37/9/1636" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: The presence of the apolipoprotein E ε 4 allele is the strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that apolipoprotein E ε 4 carriers and noncarriers may already differ in imaging patterns in midlife. We therefore sought to identify the effect of apolipoprotein E genotype on brain atrophy across almost the entire adult age span by using advanced MR imaging–based pattern analysis.

MATERIALS AND METHODS: We analyzed MR imaging scans of 1472 participants from the Study of Health in Pomerania (22–90 years of age). We studied the association among age, apolipoprotein E ε 4 carrier status, and brain atrophy, which was quantified by using 2 MR imaging–based indices: Spatial Pattern of Atrophy for Recognition of Brain Aging (summarizing age-related brain atrophy) and Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease (summarizing Alzheimer disease-like brain atrophy patterns), as well as the gray matter volumes in several Alzheimer disease- and apolipoprotein E –related ROIs (lateral frontal, lateral temporal, medial frontal, and hippocampus).

RESULTS: No significant association was found between apolipoprotein E ε 4 carrier status and the studied ROIs or the MR imaging–based indices in linear regression models adjusted for age, sex, and education, including an interaction term between apolipoprotein E and age.

CONCLUSIONS: Our study indicates that measurable apolipoprotein E –related brain atrophy does not occur in early adulthood and midlife and suggests that such atrophy may only occur more proximal to the onset of clinical symptoms of dementia.

AD
:   Alzheimer disease
APOE 
:   apolipoprotein E 
MCI
:   mild cognitive impairment
SHIP
:   Study of Health in Pomerania
SNP
:   single nucleotide polymorphism
SPARE-AD
:   Spatial Pattern of Abnormality for Recognition of Early Alzheimer Disease
SPARE-BA
:   Spatial Pattern of Atrophy for Recognition of Brain Aging" />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">ADULT BRAIN</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Relationship between <em>APOE</em> Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">M. Habes</span>, <span class="highwire-citation-author" data-delta="1">J.B. Toledo</span>, <span class="highwire-citation-author" data-delta="2">S.M. Resnick</span>, <span class="highwire-citation-author" data-delta="3">J. Doshi</span>, <span class="highwire-citation-author" data-delta="4">S. Van der Auwera</span>, <span class="highwire-citation-author" data-delta="5">G. Erus</span>, <span class="highwire-citation-author" data-delta="6">D. Janowitz</span>, <span class="highwire-citation-author" data-delta="7">K. Hegenscheid</span>, <span class="highwire-citation-author" data-delta="8">G. Homuth</span>, <span class="highwire-citation-author" data-delta="9">H. Völzke</span>, <span class="highwire-citation-author" data-delta="10">W. Hoffmann</span>, <span class="highwire-citation-author" data-delta="11">H.J. Grabe</span> and <span class="highwire-citation-author" data-delta="12">C. Davatzikos</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2016,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1636-1642; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4805 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-14577--61096025897" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M. Habes </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Institute for Community Medicine (M.H., H.V., W.H.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Psychiatry (M.H., S.V.d.A., D.J., H.J.G.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Center for Biomedical Image Computing and Analytics (M.H., J.D., G.E., C.D.), University of Pennsylvania, Philadelphia, Pennsylvania</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BHabes%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Habes%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BHabes%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-9447-5805" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Habes</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J.B. Toledo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Pathology and Laboratory Medicine (J.B.T.), Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.B.%2BToledo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Toledo%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.B.%2BToledo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-4366-9268" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.B. Toledo</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">S.M. Resnick </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Laboratory of Behavioral Neuroscience (S.M.R), National Institute on Aging, Bethesda, Maryland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.M.%2BResnick%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Resnick%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.M.%2BResnick%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-1115-7145" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.M. Resnick</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-37.9.1636.1" data-doi="10.1126/science.8346443"><div class="cit-metadata"><ol class="cit-auth-list"><li>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 37</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 9 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 2016 </div></div>
      
      
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      <div class="highwire-cite-title">Relationship between <em>APOE</em> Genotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Habes</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.B.</span> <span class="nlm-surname">Toledo</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">S.M.</span> <span class="nlm-surname">Resnick</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Doshi</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Van der Auwera</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Erus</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Janowitz</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Hegenscheid</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Homuth</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Völzke</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Hoffmann</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">H.J.</span> <span class="nlm-surname">Grabe</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Davatzikos</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1636-1642; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4805 </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1636-1642; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4805 </span></div>
  
  
  
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