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<meta name="DC.Title" content="Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4807" />
<meta name="DC.Date" content="2016-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2016 by American Journal of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural characteristics associated with postoperative acute ischemic stroke following Pipeline Embolization Device (PED) treatment.

MATERIALS AND METHODS: We identified patients in the IntrePED registry with post-PED-treatment acute ischemic stroke. The rate of postoperative acute ischemic stroke was determined by demographics, comorbidities, aneurysm characteristics, and procedure characteristics (including anticoagulation use, platelet testing, number of devices used, sheaths, and so forth). Categoric variables were compared with χ2 testing, and continuous variables were compared with the Student t test. Odds ratios and 95% confidence intervals were obtained by using univariate logistic regression. Multivariate logistic regression analysis was used to determine which factors were independently associated with postoperative stroke.

RESULTS: Of 793 patients with 906 aneurysms, 36 (4.5%) patients had acute ischemic stroke. Twenty-six (72.2%) strokes occurred within 30 days of treatment (median, 3.5 days; range, 0–397 days). Ten patients died, and the remaining 26 had major neurologic morbidity. Variables associated with higher odds of acute ischemic stroke on univariate analysis included male sex, hypertension, treatment of MCA aneurysms, treatment of fusiform aneurysms, treatment of giant aneurysms, and use of multiple PEDs. However, on multivariate analysis, the only one of these variables independently associated with stroke was treatment of fusiform aneurysms (OR, 2.74; 95% CI, 1.11–6.75; P = .03). Fusiform aneurysms that were associated with stroke were significantly larger than those not associated with stroke (mean, 24.5 ± 12.5 mm versus 13.6 ± 6.8 mm; P &lt; .001).

CONCLUSIONS: Ischemic stroke following PED treatment is an uncommon-but-devastating complication. Fusiform aneurysms were the only variable independently associated with postoperative stroke.

PED
:   Pipeline Embolization Device
IntrePED
:   International Retrospective Study of Pipeline Embolization Device" />
<meta name="DC.Contributor" content="W. Brinjikji" />
<meta name="DC.Contributor" content="G. Lanzino" />
<meta name="DC.Contributor" content="H.J. Cloft" />
<meta name="DC.Contributor" content="A.H. Siddiqui" />
<meta name="DC.Contributor" content="E. Boccardi" />
<meta name="DC.Contributor" content="S. Cekirge" />
<meta name="DC.Contributor" content="D. Fiorella" />
<meta name="DC.Contributor" content="R. Hanel" />
<meta name="DC.Contributor" content="P. Jabbour" />
<meta name="DC.Contributor" content="E. Levy" />
<meta name="DC.Contributor" content="D. Lopes" />
<meta name="DC.Contributor" content="P. Lylyk" />
<meta name="DC.Contributor" content="I. Szikora" />
<meta name="DC.Contributor" content="D.F. Kallmes" />
<meta name="article:published_time" content="2016-09-01" />
<meta name="article:section" content="INTERVENTIONAL" />
<meta name="citation_title" content="Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural characteristics associated with postoperative acute ischemic stroke following Pipeline Embolization Device (PED) treatment.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;We identified patients in the IntrePED registry with post-PED-treatment acute ischemic stroke. The rate of postoperative acute ischemic stroke was determined by demographics, comorbidities, aneurysm characteristics, and procedure characteristics (including anticoagulation use, platelet testing, number of devices used, sheaths, and so forth). Categoric variables were compared with χ&lt;sup&gt;2&lt;/sup&gt; testing, and continuous variables were compared with the Student &lt;i&gt;t&lt;/i&gt; test. Odds ratios and 95% confidence intervals were obtained by using univariate logistic regression. Multivariate logistic regression analysis was used to determine which factors were independently associated with postoperative stroke.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Of 793 patients with 906 aneurysms, 36 (4.5%) patients had acute ischemic stroke. Twenty-six (72.2%) strokes occurred within 30 days of treatment (median, 3.5 days; range, 0–397 days). Ten patients died, and the remaining 26 had major neurologic morbidity. Variables associated with higher odds of acute ischemic stroke on univariate analysis included male sex, hypertension, treatment of MCA aneurysms, treatment of fusiform aneurysms, treatment of giant aneurysms, and use of multiple PEDs. However, on multivariate analysis, the only one of these variables independently associated with stroke was treatment of fusiform aneurysms (OR, 2.74; 95% CI, 1.11–6.75; &lt;i&gt;P&lt;/i&gt; = .03). Fusiform aneurysms that were associated with stroke were significantly larger than those not associated with stroke (mean, 24.5 ± 12.5 mm versus 13.6 ± 6.8 mm; &lt;i&gt;P&lt;/i&gt; &amp;lt; .001).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Ischemic stroke following PED treatment is an uncommon-but-devastating complication. Fusiform aneurysms were the only variable independently associated with postoperative stroke.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=J Neurointerv Surg;citation_author=K. van der Marel;citation_author=MJ. Gounis;citation_author=JP. Weaver;citation_title=Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT;citation_year=2015;citation_pmid=26220411;citation_doi=10.1136/neurintsurg-2015-011843" />
<meta name="twitter:title" content="Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural characteristics associated with postoperative acute ischemic stroke following Pipeline Embolization Device (PED) treatment.

MATERIALS AND METHODS: We identified patients in the IntrePED registry with post-PED-treatment acute ischemic stroke. The rate of postoperative acute ischemic stroke was determined by demographics, comorbidities, aneurysm characteristics, and procedure characteristics (including anticoagulation use, platelet testing, number of devices used, sheaths, and so forth). Categoric variables were compared with χ2 testing, and continuous variables were compared with the Student t test. Odds ratios and 95% confidence intervals were obtained by using univariate logistic regression. Multivariate logistic regression analysis was used to determine which factors were independently associated with postoperative stroke.

RESULTS: Of 793 patients with 906 aneurysms, 36 (4.5%) patients had acute ischemic stroke. Twenty-six (72.2%) strokes occurred within 30 days of treatment (median, 3.5 days; range, 0–397 days). Ten patients died, and the remaining 26 had major neurologic morbidity. Variables associated with higher odds of acute ischemic stroke on univariate analysis included male sex, hypertension, treatment of MCA aneurysms, treatment of fusiform aneurysms, treatment of giant aneurysms, and use of multiple PEDs. However, on multivariate analysis, the only one of these variables independently associated with stroke was treatment of fusiform aneurysms (OR, 2.74; 95% CI, 1.11–6.75; P = .03). Fusiform aneurysms that were associated with stroke were significantly larger than those not associated with stroke (mean, 24.5 ± 12.5 mm versus 13.6 ± 6.8 mm; P &lt; .001).

CONCLUSIONS: Ischemic stroke following PED treatment is an uncommon-but-devastating complication. Fusiform aneurysms were the only variable independently associated with postoperative stroke.

PED
:   Pipeline Embolization Device
IntrePED
:   International Retrospective Study of Pipeline Embolization Device" />
<meta name="og-title" property="og:title" content="Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/37/9/1673" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural characteristics associated with postoperative acute ischemic stroke following Pipeline Embolization Device (PED) treatment.

MATERIALS AND METHODS: We identified patients in the IntrePED registry with post-PED-treatment acute ischemic stroke. The rate of postoperative acute ischemic stroke was determined by demographics, comorbidities, aneurysm characteristics, and procedure characteristics (including anticoagulation use, platelet testing, number of devices used, sheaths, and so forth). Categoric variables were compared with χ2 testing, and continuous variables were compared with the Student t test. Odds ratios and 95% confidence intervals were obtained by using univariate logistic regression. Multivariate logistic regression analysis was used to determine which factors were independently associated with postoperative stroke.

RESULTS: Of 793 patients with 906 aneurysms, 36 (4.5%) patients had acute ischemic stroke. Twenty-six (72.2%) strokes occurred within 30 days of treatment (median, 3.5 days; range, 0–397 days). Ten patients died, and the remaining 26 had major neurologic morbidity. Variables associated with higher odds of acute ischemic stroke on univariate analysis included male sex, hypertension, treatment of MCA aneurysms, treatment of fusiform aneurysms, treatment of giant aneurysms, and use of multiple PEDs. However, on multivariate analysis, the only one of these variables independently associated with stroke was treatment of fusiform aneurysms (OR, 2.74; 95% CI, 1.11–6.75; P = .03). Fusiform aneurysms that were associated with stroke were significantly larger than those not associated with stroke (mean, 24.5 ± 12.5 mm versus 13.6 ± 6.8 mm; P &lt; .001).

CONCLUSIONS: Ischemic stroke following PED treatment is an uncommon-but-devastating complication. Fusiform aneurysms were the only variable independently associated with postoperative stroke.

PED
:   Pipeline Embolization Device
IntrePED
:   International Retrospective Study of Pipeline Embolization Device" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node14569--5" data-node-nid="14569" id="top-node-14569--61162494696" data-pisa="ajnr;37/9/1673" data-pisa-master="ajnr;ajnr.A4807" data-apath="/ajnr/37/9/1673.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">INTERVENTIONAL</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="ajnr;ajnr.A4807" data-atom-uri="/ajnr/37/9/1673.atom" data-request-view="full"></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">W. Brinjikji</span>, <span class="highwire-citation-author" data-delta="1">G. Lanzino</span>, <span class="highwire-citation-author" data-delta="2">H.J. Cloft</span>, <span class="highwire-citation-author" data-delta="3">A.H. Siddiqui</span>, <span class="highwire-citation-author" data-delta="4">E. Boccardi</span>, <span class="highwire-citation-author" data-delta="5">S. Cekirge</span>, <span class="highwire-citation-author" data-delta="6">D. Fiorella</span>, <span class="highwire-citation-author" data-delta="7">R. Hanel</span>, <span class="highwire-citation-author" data-delta="8">P. Jabbour</span>, <span class="highwire-citation-author" data-delta="9">E. Levy</span>, <span class="highwire-citation-author" data-delta="10">D. Lopes</span>, <span class="highwire-citation-author" data-delta="11">P. Lylyk</span>, <span class="highwire-citation-author" data-delta="12">I. Szikora</span> and <span class="highwire-citation-author" data-delta="13">D.F. Kallmes</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2016,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1673-1678; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4807 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-14569--61162494696" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">W. Brinjikji </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (W.B., G.L., H.J.C., D.F.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.%2BBrinjikji%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Brinjikji%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.%2BBrinjikji%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-5271-5524" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W. Brinjikji</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">G. Lanzino </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (W.B., G.L., H.J.C., D.F.K.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Neurosurgery (G.L., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BLanzino%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lanzino%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BLanzino%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-1479-465X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. Lanzino</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">H.J. Cloft </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (W.B., G.L., H.J.C., D.F.K.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Neurosurgery (G.L., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.J.%2BCloft%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cloft%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.J.%2BCloft%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-2590-3815" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H.J. Cloft</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">A.H. Siddiqui </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurosurgery (A.H.S., D.F., E.L.), State University of New York, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.H.%2BSiddiqui%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Siddiqui%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.H.%2BSiddiqui%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-9519-0059" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.H. Siddiqui</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">E. Boccardi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neuroradiology (E.B.), Ospedale Niguarda-Ca' Granda, Milan, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BBoccardi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Boccardi%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2BBoccardi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-5792-7187" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. Boccardi</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">S. Cekirge </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Radiology (S.C.), Hacettepe University Hospitals, Ankara, Turkey</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BCekirge%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cekirge%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BCekirge%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-4521-2301" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Cekirge</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">D. Fiorella </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurosurgery (A.H.S., D.F., E.L.), State University of New York, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BFiorella%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fiorella%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BFiorella%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-2677-8780" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. Fiorella</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">R. Hanel </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Neurosurgery (R.H.), Baptist Neurological Institute, Jacksonville, Florida</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BHanel%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hanel%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.%2BHanel%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-7195-5806" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R. Hanel</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">P. Jabbour </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Department Neurosurgery (P.J.), Thomas Jefferson University Hospital, Philadelphia, Pennsylvania</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BJabbour%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jabbour%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AP.%2BJabbour%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-8965-2413" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for P. Jabbour</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">E. Levy </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurosurgery (A.H.S., D.F., E.L.), State University of New York, Buffalo, New York</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BLevy%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Levy%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2BLevy%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-6208-3724" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. Levy</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">D. Lopes </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Department of Neurosurgery (D.L.), Rush University Medical Center, Chicago, Illinois</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BLopes%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lopes%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BLopes%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-6280-0113" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. Lopes</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">P. Lylyk </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>i</span>Department of Interventional Neuroradiology (P.L.), Instituto Clínico ENERI, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BLylyk%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lylyk%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AP.%2BLylyk%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-7044-4369" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for P. Lylyk</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">I. Szikora </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>j</span>Department of Neuroradiology (I.S.), National Institute of Neurosciences, Budapest, Hungary.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.%2BSzikora%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Szikora%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AI.%2BSzikora%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-3730-3278" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for I. Szikora</a></li></ul></div><div class="author-tooltip-13"><div class="author-tooltip-name">D.F. Kallmes </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (W.B., G.L., H.J.C., D.F.K.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Neurosurgery (G.L., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.F.%2BKallmes%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kallmes%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.F.%2BKallmes%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-8495-0040" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D.F. 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class="table-center">54.2 ± 15.6/57.0 ± 14.1</td><td align="char" char="(" rowspan="1" colspan="1" id="td-3" class="table-char">0.99 (0.97–1.01)</td><td align="char" char="." rowspan="1" colspan="1" id="td-4" class="table-char">.2516</td></tr><tr id="tr-3"><td align="left" rowspan="1" colspan="1" id="td-5" class="table-left">Sex</td><td rowspan="1" colspan="1" id="td-6"></td><td rowspan="1" colspan="1" id="td-7"></td><td rowspan="1" colspan="1" id="td-8"></td></tr><tr id="tr-4"><td align="left" rowspan="1" colspan="1" id="td-9" class="table-left">    Male</td><td align="char" char="(" rowspan="1" colspan="1" id="td-10" class="table-char">8.1% (13/161)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-11" class="table-char">2.33 (1.15–4.70)</td><td align="char" char="." rowspan="1" colspan="1" id="td-12" class="table-char">.0187</td></tr><tr id="tr-5"><td align="left" rowspan="1" colspan="1" id="td-13" class="table-left">    Female</td><td align="char" char="(" rowspan="1" colspan="1" id="td-14" class="table-char">3.6% (23/632)</td><td align="left" rowspan="1" colspan="1" id="td-15" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-16"></td></tr><tr id="tr-6"><td align="left" rowspan="1" colspan="1" id="td-17" class="table-left">Hypertension</td><td rowspan="1" colspan="1" id="td-18"></td><td rowspan="1" colspan="1" id="td-19"></td><td rowspan="1" colspan="1" id="td-20"></td></tr><tr id="tr-7"><td align="left" rowspan="1" colspan="1" id="td-21" class="table-left">    Yes</td><td align="char" char="(" rowspan="1" colspan="1" id="td-22" class="table-char">9.2% (23/249)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-23" class="table-char">2.60 (1.26–5.33)</td><td align="char" char="." rowspan="1" colspan="1" id="td-24" class="table-char">.0093</td></tr><tr id="tr-8"><td align="left" rowspan="1" colspan="1" id="td-25" class="table-left">    No</td><td align="char" char="(" rowspan="1" colspan="1" id="td-26" class="table-char">3.8% (12/318)</td><td align="left" rowspan="1" colspan="1" id="td-27" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-28"></td></tr><tr id="tr-9"><td align="left" rowspan="1" colspan="1" id="td-29" class="table-left">Controlled hypertension</td><td rowspan="1" colspan="1" id="td-30"></td><td rowspan="1" colspan="1" id="td-31"></td><td rowspan="1" colspan="1" id="td-32"></td></tr><tr id="tr-10"><td align="left" rowspan="1" colspan="1" id="td-33" class="table-left">    Yes</td><td align="char" char="(" rowspan="1" colspan="1" id="td-34" class="table-char">8.7% (18/206)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-35" class="table-char">3.03 (1.54–5.94)</td><td align="char" char="." rowspan="1" colspan="1" id="td-36" class="table-char">.0013</td></tr><tr id="tr-11"><td align="left" rowspan="1" colspan="1" id="td-37" class="table-left">    No</td><td align="char" char="(" rowspan="1" colspan="1" id="td-38" class="table-char">0.0% (0/4)</td><td align="left" rowspan="1" colspan="1" id="td-39" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-40"></td></tr><tr id="tr-12"><td align="left" rowspan="1" colspan="1" id="td-41" class="table-left">Current smoker</td><td rowspan="1" colspan="1" id="td-42"></td><td rowspan="1" colspan="1" id="td-43"></td><td rowspan="1" colspan="1" id="td-44"></td></tr><tr id="tr-13"><td align="left" rowspan="1" colspan="1" id="td-45" class="table-left">    Yes</td><td align="char" char="(" rowspan="1" colspan="1" id="td-46" class="table-char">4.3% (4/94)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-47" class="table-char">0.93 (0.32–2.68)</td><td align="char" char="." rowspan="1" colspan="1" id="td-48" class="table-char">.8878</td></tr><tr id="tr-14"><td align="left" rowspan="1" colspan="1" id="td-49" class="table-left">    No</td><td align="char" char="(" rowspan="1" colspan="1" id="td-50" class="table-char">4.6% (32/699)</td><td align="left" rowspan="1" colspan="1" id="td-51" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-52"></td></tr><tr id="tr-15"><td align="left" rowspan="1" colspan="1" id="td-53" class="table-left">Aneurysm location</td><td rowspan="1" colspan="1" id="td-54"></td><td rowspan="1" colspan="1" id="td-55"></td><td rowspan="1" colspan="1" id="td-56"></td></tr><tr id="tr-16"><td align="left" rowspan="1" colspan="1" id="td-57" class="table-left">    Posterior circulation</td><td align="char" char="(" rowspan="1" colspan="1" id="td-58" class="table-char">6.7% (6/89)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-59" class="table-char">1.62 (0.66–4.02)</td><td align="char" char="." rowspan="1" colspan="1" id="td-60" class="table-char">.2940</td></tr><tr id="tr-17"><td align="left" rowspan="1" colspan="1" id="td-61" class="table-left">    Anterior circulation</td><td align="char" char="(" rowspan="1" colspan="1" id="td-62" class="table-char">4.3% (30/704)</td><td align="left" rowspan="1" colspan="1" id="td-63" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-64"></td></tr><tr id="tr-18"><td align="left" rowspan="1" colspan="1" id="td-65" class="table-left">Aneurysm location by vessel</td><td rowspan="1" colspan="1" id="td-66"></td><td rowspan="1" colspan="1" id="td-67"></td><td rowspan="1" colspan="1" id="td-68"></td></tr><tr id="tr-19"><td align="left" rowspan="1" colspan="1" id="td-69" class="table-left">    Internal carotid artery</td><td align="char" char="(" rowspan="1" colspan="1" id="td-70" class="table-char">3.9% (23/590)</td><td align="left" rowspan="1" colspan="1" id="td-71" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-72"></td></tr><tr id="tr-20"><td align="left" rowspan="1" colspan="1" id="td-73" class="table-left">    Anterior cerebral artery</td><td align="char" char="(" rowspan="1" colspan="1" id="td-74" class="table-char">12.5% (1/8)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-75" class="table-char">4.83 (0.72–32.44)</td><td align="char" char="." rowspan="1" colspan="1" id="td-76" class="table-char">.1052</td></tr><tr id="tr-21"><td align="left" rowspan="1" colspan="1" id="td-77" class="table-left">    Basilar artery</td><td align="char" char="(" rowspan="1" colspan="1" id="td-78" class="table-char">9.3% (4/43)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-79" class="table-char">2.75 (0.94–8.02)</td><td align="char" char="." rowspan="1" colspan="1" id="td-80" class="table-char">.0636</td></tr><tr id="tr-22"><td align="left" rowspan="1" colspan="1" id="td-81" class="table-left">    Middle cerebral artery</td><td align="char" char="(" rowspan="1" colspan="1" id="td-82" class="table-char">12.5% (5/40)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-83" class="table-char">3.74 (1.38–10.16)</td><td align="char" char="." rowspan="1" colspan="1" id="td-84" class="table-char">.0096</td></tr><tr id="tr-23"><td align="left" rowspan="1" colspan="1" id="td-85" class="table-left">    PcomA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-86" class="table-char">1.9% (1/53)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-87" class="table-char">0.69 (0.13–3.74)</td><td align="char" char="." rowspan="1" colspan="1" id="td-88" class="table-char">.6668</td></tr><tr id="tr-24"><td align="left" rowspan="1" colspan="1" id="td-89" class="table-left">    Vertebral artery</td><td align="char" char="(" rowspan="1" colspan="1" id="td-90" class="table-char">6.1% (2/33)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-91" class="table-char">1.92 (0.49–7.55)</td><td align="char" char="." rowspan="1" colspan="1" id="td-92" class="table-char">.3523</td></tr><tr id="tr-25"><td align="left" rowspan="1" colspan="1" id="td-93" class="table-left">    Other</td><td align="char" char="(" rowspan="1" colspan="1" id="td-94" class="table-char">0.0% (0/26)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-95" class="table-char">0.46 (0.03–8.12)</td><td align="char" char="." rowspan="1" colspan="1" id="td-96" class="table-char">.5928</td></tr><tr id="tr-26"><td align="left" rowspan="1" colspan="1" id="td-97" class="table-left">Rupture status</td><td rowspan="1" colspan="1" id="td-98"></td><td rowspan="1" colspan="1" id="td-99"></td><td rowspan="1" colspan="1" id="td-100"></td></tr><tr id="tr-27"><td align="left" rowspan="1" colspan="1" id="td-101" class="table-left">    Ruptured</td><td align="char" char="(" rowspan="1" colspan="1" id="td-102" class="table-char">5.4% (4/74)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-103" class="table-char">1.23 (0.42–3.57)</td><td align="char" char="." rowspan="1" colspan="1" id="td-104" class="table-char">.7074</td></tr><tr id="tr-28"><td align="left" rowspan="1" colspan="1" id="td-105" class="table-left">    Unruptured</td><td align="char" char="(" rowspan="1" colspan="1" id="td-106" class="table-char">4.5% (32/719)</td><td align="left" rowspan="1" colspan="1" id="td-107" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-108"></td></tr><tr id="tr-29"><td align="left" rowspan="1" colspan="1" id="td-109" class="table-left">Aneurysm type</td><td rowspan="1" colspan="1" id="td-110"></td><td rowspan="1" colspan="1" id="td-111"></td><td rowspan="1" colspan="1" id="td-112"></td></tr><tr id="tr-30"><td align="left" rowspan="1" colspan="1" id="td-113" class="table-left">    Saccular</td><td align="char" char="(" rowspan="1" colspan="1" id="td-114" class="table-char">3.2% (19/600)</td><td align="left" rowspan="1" colspan="1" id="td-115" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-116"></td></tr><tr id="tr-31"><td align="left" rowspan="1" colspan="1" id="td-117" class="table-left">    Fusiform</td><td align="char" char="(" rowspan="1" colspan="1" id="td-118" class="table-char">12.7% (13/102)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-119" class="table-char">4.47 (2.13–9.36)</td><td align="char" char="." rowspan="1" colspan="1" id="td-120" class="table-char">.0001</td></tr><tr id="tr-32"><td align="left" rowspan="1" colspan="1" id="td-121" class="table-left">    Dissecting</td><td align="char" char="(" rowspan="1" colspan="1" id="td-122" class="table-char">3.8% (2/53)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-123" class="table-char">1.20 (0.27–5.29)</td><td align="char" char="." rowspan="1" colspan="1" id="td-124" class="table-char">.8105</td></tr><tr id="tr-33"><td align="left" rowspan="1" colspan="1" id="td-125" class="table-left">    Other</td><td align="char" char="(" rowspan="1" colspan="1" id="td-126" class="table-char">5.3% (2/38)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-127" class="table-char">1.70 (0.38–7.58)</td><td align="char" char="." rowspan="1" colspan="1" id="td-128" class="table-char">.4873</td></tr><tr id="tr-34"><td align="left" rowspan="1" colspan="1" id="td-129" class="table-left">Aneurysm size</td><td rowspan="1" colspan="1" id="td-130"></td><td rowspan="1" colspan="1" id="td-131"></td><td rowspan="1" colspan="1" id="td-132"></td></tr><tr id="tr-35"><td align="left" rowspan="1" colspan="1" id="td-133" class="table-left">    &lt;10 mm</td><td align="char" char="(" rowspan="1" colspan="1" id="td-134" class="table-char">2.6% (10/387)</td><td align="left" rowspan="1" colspan="1" id="td-135" class="table-left">Ref</td><td rowspan="1" colspan="1" id="td-136"></td></tr><tr id="tr-36"><td align="left" rowspan="1" colspan="1" id="td-137" class="table-left">    10–24.9 mm</td><td align="char" char="(" rowspan="1" colspan="1" id="td-138" class="table-char">4.7% (16/338)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-139" class="table-char">1.87 (0.84–4.19)</td><td align="char" char="." rowspan="1" colspan="1" id="td-140" class="table-char">.1260</td></tr><tr id="tr-37"><td align="left" rowspan="1" colspan="1" id="td-141" class="table-left">    ≥25 mm</td><td align="char" char="(" rowspan="1" colspan="1" id="td-142" class="table-char">14.3% (9/63)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-143" class="table-char">6.28 (2.44–16.16)</td><td align="char" char="." rowspan="1" colspan="1" id="td-144" class="table-char">.0001</td></tr></tbody></table><div class="table-foot"><ul class="table-footnotes"><li class="fn-abbr" id="fn-1"><p id="p-15"><strong>Note:</strong>—Ref. indicates reference; PcomA, posterior communicating artery.</p></li></ul></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div></div></li><li><div class="element-fig-data clearfix table-caption"><div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="table-expansion " id="T2"><span class="highwire-journal-article-marker-start"></span><div class="table-caption"><ul class="inline table-expansion-links"><li class="view-popup first last"><a href="/highwire/markup/46527/expansion?width=1000&amp;height=500&amp;iframe=true&amp;postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed" class="colorbox colorbox-load table-expand-popup" rel="gallery-fragment-tables-1065397541" data-icon-position="" data-hide-link-title="0">View popup</a></li></ul><span class="table-label">Table 2:</span> <p id="p-19">Multivariate analysis</p><div class="sb-div caption-clear"></div></div><table frame="hsides" id="table-2" alt="Table 2:"><thead valign="bottom" id="thead-2" class="table-vbottom"><tr id="tr-38"><th align="center" rowspan="1" colspan="1" id="th-5" class="table-center">Variable</th><th align="center" rowspan="1" colspan="1" id="th-6" class="table-center">OR (95% CI)</th><th align="center" rowspan="1" colspan="1" id="th-7" class="table-center"><em>P</em> Value</th></tr></thead><tbody valign="top" id="tbody-2" class="table-vtop"><tr id="tr-39"><td align="left" rowspan="1" colspan="1" id="td-145" class="table-left">Male</td><td align="char" char="(" rowspan="1" colspan="1" id="td-146" class="table-char">1.21 (0.51–2.85)</td><td align="char" char="." rowspan="1" colspan="1" id="td-147" class="table-char">.6636</td></tr><tr id="tr-40"><td align="left" rowspan="1" colspan="1" id="td-148" class="table-left">HTN</td><td align="char" char="(" rowspan="1" colspan="1" id="td-149" class="table-char">2.01 (0.99–4.08)</td><td align="char" char="." rowspan="1" colspan="1" id="td-150" class="table-char">.0533</td></tr><tr id="tr-41"><td align="left" rowspan="1" colspan="1" id="td-151" class="table-left">ACA vs ICA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-152" class="table-char">4.47 (0.58–34.44)</td><td align="char" char="." rowspan="1" colspan="1" id="td-153" class="table-char">.1502</td></tr><tr id="tr-42"><td align="left" rowspan="1" colspan="1" id="td-154" class="table-left">BAS vs ICA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-155" class="table-char">1.12 (0.31–4.04)</td><td align="char" char="." rowspan="1" colspan="1" id="td-156" class="table-char">.8584</td></tr><tr id="tr-43"><td align="left" rowspan="1" colspan="1" id="td-157" class="table-left">MCA vs ICA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-158" class="table-char">2.79 (0.91–8.60)</td><td align="char" char="." rowspan="1" colspan="1" id="td-159" class="table-char">.0734</td></tr><tr id="tr-44"><td align="left" rowspan="1" colspan="1" id="td-160" class="table-left">Other artery vs ICA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-161" class="table-char">0.53 (0.03–9.04)</td><td align="char" char="." rowspan="1" colspan="1" id="td-162" class="table-char">.6596</td></tr><tr id="tr-45"><td align="left" rowspan="1" colspan="1" id="td-163" class="table-left">PcomA vs ICA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-164" class="table-char">0.84 (0.15–4.53)</td><td align="char" char="." rowspan="1" colspan="1" id="td-165" class="table-char">.8351</td></tr><tr id="tr-46"><td align="left" rowspan="1" colspan="1" id="td-166" class="table-left">Vertebral artery vs ICA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-167" class="table-char">1.27 (0.27–6.09)</td><td align="char" char="." rowspan="1" colspan="1" id="td-168" class="table-char">.7620</td></tr><tr id="tr-47"><td align="left" rowspan="1" colspan="1" id="td-169" class="table-left">Dissecting vs saccular</td><td align="char" char="(" rowspan="1" colspan="1" id="td-170" class="table-char">0.83 (0.19–3.63)</td><td align="char" char="." rowspan="1" colspan="1" id="td-171" class="table-char">.8089</td></tr><tr id="tr-48"><td align="left" rowspan="1" colspan="1" id="td-172" class="table-left">Fusiform vs saccular</td><td align="char" char="(" rowspan="1" colspan="1" id="td-173" class="table-char">2.74 (1.11–6.75)</td><td align="char" char="." rowspan="1" colspan="1" id="td-174" class="table-char">.0283</td></tr><tr id="tr-49"><td align="left" rowspan="1" colspan="1" id="td-175" class="table-left">Other aneurysm type vs saccular</td><td align="char" char="(" rowspan="1" colspan="1" id="td-176" class="table-char">1.71 (0.44–6.66)</td><td align="char" char="." rowspan="1" colspan="1" id="td-177" class="table-char">.4370</td></tr><tr id="tr-50"><td align="left" rowspan="1" colspan="1" id="td-178" class="table-left">Aneurysm size</td><td align="char" char="(" rowspan="1" colspan="1" id="td-179" class="table-char">1.03 (0.99–1.07)</td><td align="char" char="." rowspan="1" colspan="1" id="td-180" class="table-char">.1370</td></tr><tr id="tr-51"><td align="left" rowspan="1" colspan="1" id="td-181" class="table-left">PED No.</td><td align="char" char="(" rowspan="1" colspan="1" id="td-182" class="table-char">1.17 (0.94–1.45)</td><td align="char" char="." rowspan="1" colspan="1" id="td-183" class="table-char">.1610</td></tr></tbody></table><div class="table-foot"><ul class="table-footnotes"><li class="fn-abbr" id="fn-2"><p id="p-20"><strong>Note:</strong>—HTN indicates hypertension; ACA, anterior cerebral artery; BAS, basilar artery; PcomA, posterior communicating artery.</p></li></ul></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div></div></li><li class="last"><div class="element-fig-data clearfix table-caption"><div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="table-expansion " id="T3"><span class="highwire-journal-article-marker-start"></span><div class="table-caption"><ul class="inline table-expansion-links"><li class="view-popup first last"><a href="/highwire/markup/46470/expansion?width=1000&amp;height=500&amp;iframe=true&amp;postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed" class="colorbox colorbox-load table-expand-popup" rel="gallery-fragment-tables-1065397541" data-icon-position="" data-hide-link-title="0">View popup</a></li></ul><span class="table-label">Table 3:</span> <p id="p-23">Subgroup analysis of fusiform aneurysms</p><div class="sb-div caption-clear"></div></div><table frame="hsides" id="table-3" alt="Table 3:"><thead valign="bottom" id="thead-3" class="table-vbottom"><tr id="tr-52"><th align="center" rowspan="1" colspan="1" id="th-8" class="table-center">Aneurysm Characteristics</th><th align="center" rowspan="1" colspan="1" id="th-9" class="table-center">With Stroke</th><th align="center" rowspan="1" colspan="1" id="th-10" class="table-center">Without Stroke</th><th align="center" rowspan="1" colspan="1" id="th-11" class="table-center"><em>P</em> Value</th></tr></thead><tbody valign="top" id="tbody-3" class="table-vtop"><tr id="tr-53"><td align="left" rowspan="1" colspan="1" id="td-184" class="table-left">Aneurysm size (mm)</td><td rowspan="1" colspan="1" id="td-185"></td><td rowspan="1" colspan="1" id="td-186"></td><td align="char" char="." rowspan="1" colspan="1" id="td-187" class="table-char">&lt;.001</td></tr><tr id="tr-54"><td align="left" rowspan="1" colspan="1" id="td-188" class="table-left">    Mean (No.)</td><td align="char" char="&#xB1;" rowspan="1" colspan="1" id="td-189" class="table-char">24.5 ± 12.5 (12)</td><td align="char" char="&#xB1;" rowspan="1" colspan="1" id="td-190" class="table-char">13.6 ± 6.8 (88)</td><td rowspan="1" colspan="1" id="td-191"></td></tr><tr id="tr-55"><td align="left" rowspan="1" colspan="1" id="td-192" class="table-left">    Median (range)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-193" class="table-char">21.0 (13.0–55.0)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-194" class="table-char">11.8, (1.6–42.0)</td><td rowspan="1" colspan="1" id="td-195"></td></tr><tr id="tr-56"><td align="left" rowspan="1" colspan="1" id="td-196" class="table-left">Aneurysm neck (mm)</td><td rowspan="1" colspan="1" id="td-197"></td><td rowspan="1" colspan="1" id="td-198"></td><td align="char" char="." rowspan="1" colspan="1" id="td-199" class="table-char">.010</td></tr><tr id="tr-57"><td align="left" rowspan="1" colspan="1" id="td-200" class="table-left">    Mean (No.)</td><td align="char" char="&#xB1;" rowspan="1" colspan="1" id="td-201" class="table-char">26.2 ± 19.5 (9)</td><td align="char" char="&#xB1;" rowspan="1" colspan="1" id="td-202" class="table-char">10.2 ± 5.2 (60)</td><td rowspan="1" colspan="1" id="td-203"></td></tr><tr id="tr-58"><td align="left" rowspan="1" colspan="1" id="td-204" class="table-left">    Median (range)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-205" class="table-char">22.0 (8.0–53.0)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-206" class="table-char">9.0 (2.0–27.0)</td><td rowspan="1" colspan="1" id="td-207"></td></tr><tr id="tr-59"><td align="left" rowspan="1" colspan="1" id="td-208" class="table-left">Aneurysm location</td><td rowspan="1" colspan="1" id="td-209"></td><td rowspan="1" colspan="1" id="td-210"></td><td align="char" char="." rowspan="1" colspan="1" id="td-211" class="table-char">.211</td></tr><tr id="tr-60"><td align="left" rowspan="1" colspan="1" id="td-212" class="table-left">    Posterior circulation</td><td align="char" char="(" rowspan="1" colspan="1" id="td-213" class="table-char">38.5% (5/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-214" class="table-char">22.5% (20/89)</td><td rowspan="1" colspan="1" id="td-215"></td></tr><tr id="tr-61"><td align="left" rowspan="1" colspan="1" id="td-216" class="table-left">    Anterior circulation</td><td align="char" char="(" rowspan="1" colspan="1" id="td-217" class="table-char">61.5% (8/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-218" class="table-char">77.5% (69/89)</td><td rowspan="1" colspan="1" id="td-219"></td></tr><tr id="tr-62"><td align="left" rowspan="1" colspan="1" id="td-220" class="table-left">Aneurysm location by vessel</td><td rowspan="1" colspan="1" id="td-221"></td><td rowspan="1" colspan="1" id="td-222"></td><td align="char" char="." rowspan="1" colspan="1" id="td-223" class="table-char">.677</td></tr><tr id="tr-63"><td align="left" rowspan="1" colspan="1" id="td-224" class="table-left">    ICA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-225" class="table-char">53.8% (7/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-226" class="table-char">59.6% (53/89)</td><td rowspan="1" colspan="1" id="td-227"></td></tr><tr id="tr-64"><td align="left" rowspan="1" colspan="1" id="td-228" class="table-left">    ACA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-229" class="table-char">0.0% (0/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-230" class="table-char">1.1% (1/89)</td><td rowspan="1" colspan="1" id="td-231"></td></tr><tr id="tr-65"><td align="left" rowspan="1" colspan="1" id="td-232" class="table-left">    BA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-233" class="table-char">23.1% (3/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-234" class="table-char">10.1% (9/89)</td><td rowspan="1" colspan="1" id="td-235"></td></tr><tr id="tr-66"><td align="left" rowspan="1" colspan="1" id="td-236" class="table-left">    MCA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-237" class="table-char">7.7% (1/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-238" class="table-char">13.5% (12/89)</td><td rowspan="1" colspan="1" id="td-239"></td></tr><tr id="tr-67"><td align="left" rowspan="1" colspan="1" id="td-240" class="table-left">    PcomA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-241" class="table-char">0.0% (0/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-242" class="table-char">0.0% (0/89)</td><td rowspan="1" colspan="1" id="td-243"></td></tr><tr id="tr-68"><td align="left" rowspan="1" colspan="1" id="td-244" class="table-left">    VA</td><td align="char" char="(" rowspan="1" colspan="1" id="td-245" class="table-char">15.4% (2/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-246" class="table-char">10.1% (9/89)</td><td rowspan="1" colspan="1" id="td-247"></td></tr><tr id="tr-69"><td align="left" rowspan="1" colspan="1" id="td-248" class="table-left">    Other</td><td align="char" char="(" rowspan="1" colspan="1" id="td-249" class="table-char">0.0% (0/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-250" class="table-char">5.6% (5/89)</td><td rowspan="1" colspan="1" id="td-251"></td></tr><tr id="tr-70"><td align="left" rowspan="1" colspan="1" id="td-252" class="table-left">Presented with ruptured aneurysm</td><td align="char" char="(" rowspan="1" colspan="1" id="td-253" class="table-char">0.0% (0/13)</td><td align="char" char="(" rowspan="1" colspan="1" id="td-254" class="table-char">5.6% (5/89)</td><td align="char" char="." rowspan="1" colspan="1" id="td-255" class="table-char">.381</td></tr></tbody></table><div class="table-foot"><ul class="table-footnotes"><li class="fn-abbr" id="fn-3"><p id="p-24"><strong>Note:</strong>—BA indicates basilar artery; VA, vertebral artery; PcomA, posterior communicating artery; ACA, anterior cerebral artery.</p></li></ul></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div></div></li></ul></div></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 37</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 9 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 2016 </div></div>
      
      
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      <div class="highwire-cite-title">Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Brinjikji</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Lanzino</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">H.J.</span> <span class="nlm-surname">Cloft</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">A.H.</span> <span class="nlm-surname">Siddiqui</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Boccardi</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Cekirge</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Fiorella</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Hanel</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Jabbour</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Levy</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Lopes</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Lylyk</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Szikora</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">D.F.</span> <span class="nlm-surname">Kallmes</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1673-1678; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4807 </span></div>
  
  
  
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      <div class="highwire-cite-title">Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Brinjikji</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Lanzino</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">H.J.</span> <span class="nlm-surname">Cloft</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">A.H.</span> <span class="nlm-surname">Siddiqui</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Boccardi</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Cekirge</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Fiorella</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Hanel</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Jabbour</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Levy</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Lopes</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Lylyk</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Szikora</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">D.F.</span> <span class="nlm-surname">Kallmes</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1673-1678; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4807 </span></div>
  
  
  
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