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<meta name="DC.Title" content="The Effects of Acetazolamide on the Evaluation of Cerebral Hemodynamics and Functional Connectivity Using Blood Oxygen Level–Dependent MR Imaging in Patients with Chronic Steno-Occlusive Disease of the Anterior Circulation" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4973" />
<meta name="DC.Date" content="2017-01-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Measuring cerebrovascular reactivity with the use of vasodilatory stimuli, such as acetazolamide, is useful for chronic cerebrovascular steno-occlusive disease. The purpose of this study was to evaluate the effects of acetazolamide on the assessment of hemodynamic impairment and functional connectivity by using noninvasive resting-state blood oxygen level–dependent MR imaging.

MATERIALS AND METHODS: A 20-minute resting-state blood oxygen level–dependent MR imaging scan was acquired with infusion of acetazolamide starting at 5 minutes after scan initiation. A recently developed temporal-shift analysis technique was applied on blood oxygen level–dependent MR imaging data before and after acetazolamide infusion to identify regions with hemodynamic impairment, and the results were compared by using contrast agent–based DSC perfusion imaging as the reference standard. Functional connectivity was compared with and without correction on the signal by using information from temporal-shift analysis, before and after acetazolamide infusion.

RESULTS: Visually, temporal-shift analysis of blood oxygen level–dependent MR imaging data identified regions with compromised hemodynamics as defined by DSC, though performance deteriorated in patients with bilateral disease. The Dice similarity coefficient between temporal-shift and DSC maps was higher before (0.487 ± 0.150 by using the superior sagittal sinus signal as a reference for temporal-shift analysis) compared with after acetazolamide administration (0.384 ± 0.107) ( P = .006, repeated-measures ANOVA). Functional connectivity analysis with temporal-shift correction identified brain network nodes that were otherwise missed. The accuracy of functional connectivity assessment decreased after acetazolamide administration ( P = .015 for default mode network, repeated-measures ANOVA).

CONCLUSIONS: Temporal-shift analysis of blood oxygen level–dependent MR imaging can identify brain regions with hemodynamic compromise in relation to DSC among patients with chronic cerebrovascular disease. The use of acetazolamide reduces the accuracy of temporal-shift analysis and network connectivity evaluation.

ACZ
:   acetazolamide
BOLD
:   blood oxygen level–dependent MR imaging
DMN
:   default mode network
SMN
:   sensorimotor network
SSS
:   superior sagittal sinus
Tmax
:   time-to-maximum of the residue function
TS
:   temporal-shift" />
<meta name="DC.Contributor" content="J. Wu" />
<meta name="DC.Contributor" content="S. Dehkharghani" />
<meta name="DC.Contributor" content="F. Nahab" />
<meta name="DC.Contributor" content="J. Allen" />
<meta name="DC.Contributor" content="D. Qiu" />
<meta name="article:published_time" content="2017-01-01" />
<meta name="article:section" content="FUNCTIONAL" />
<meta name="citation_title" content="The Effects of Acetazolamide on the Evaluation of Cerebral Hemodynamics and Functional Connectivity Using Blood Oxygen Level–Dependent MR Imaging in Patients with Chronic Steno-Occlusive Disease of the Anterior Circulation" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Measuring cerebrovascular reactivity with the use of vasodilatory stimuli, such as acetazolamide, is useful for chronic cerebrovascular steno-occlusive disease. The purpose of this study was to evaluate the effects of acetazolamide on the assessment of hemodynamic impairment and functional connectivity by using noninvasive resting-state blood oxygen level–dependent MR imaging.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;A 20-minute resting-state blood oxygen level–dependent MR imaging scan was acquired with infusion of acetazolamide starting at 5 minutes after scan initiation. A recently developed temporal-shift analysis technique was applied on blood oxygen level–dependent MR imaging data before and after acetazolamide infusion to identify regions with hemodynamic impairment, and the results were compared by using contrast agent–based DSC perfusion imaging as the reference standard. Functional connectivity was compared with and without correction on the signal by using information from temporal-shift analysis, before and after acetazolamide infusion.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Visually, temporal-shift analysis of blood oxygen level–dependent MR imaging data identified regions with compromised hemodynamics as defined by DSC, though performance deteriorated in patients with bilateral disease. The Dice similarity coefficient between temporal-shift and DSC maps was higher before (0.487 ± 0.150 by using the superior sagittal sinus signal as a reference for temporal-shift analysis) compared with after acetazolamide administration (0.384 ± 0.107) (&lt;i&gt;P&lt;/i&gt; = .006, repeated-measures ANOVA). Functional connectivity analysis with temporal-shift correction identified brain network nodes that were otherwise missed. The accuracy of functional connectivity assessment decreased after acetazolamide administration (&lt;i&gt;P&lt;/i&gt; = .015 for default mode network, repeated-measures ANOVA).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Temporal-shift analysis of blood oxygen level–dependent MR imaging can identify brain regions with hemodynamic compromise in relation to DSC among patients with chronic cerebrovascular disease. The use of acetazolamide reduces the accuracy of temporal-shift analysis and network connectivity evaluation.&lt;/p&gt;" />
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<meta name="citation_author" content="S. Dehkharghani" />
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<meta name="citation_reference" content="citation_journal_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_author=Translational Medicine Research Collaboration Multicentre Acute Stroke Imaging Study;citation_title=Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds.;citation_pages=384-401;citation_volume=70;citation_year=2011;citation_issue=3;citation_pmid=21796665;citation_doi=10.1002/ana.22500" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_journal_abbrev=Stroke;citation_author=Council on Cardiovascular Radiology of the American Heart Association;citation_title=Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia: A Scientific Statement for Healthcare Professionals by the Writing Group on Perfusion Imaging, From the Council on Cardiovascular Radiology of the American Heart Association;citation_pages=1084-1104;citation_volume=34;citation_year=2003;citation_issue=4;citation_pmid=12677088;citation_doi=10.1161/01.STR.0000064840.99271.9E" />
<meta name="citation_reference" content="citation_journal_title=International Journal of Stroke;citation_journal_abbrev=Int J Stroke;citation_author=DEFUSE Investigators;citation_title=Angiographic Outcome of Endovascular Stroke Therapy Correlated with MR Findings, Infarct Growth, and Clinical Outcome in the DEFUSE 2 Trial;citation_pages=860-865;citation_volume=9;citation_year=2014;citation_issue=7;citation_pmid=24684804;citation_doi=10.1111/ijs.12271" />
<meta name="citation_reference" content="citation_journal_title=Lancet. Neurology;citation_journal_abbrev=Lancet Neurol;citation_author=DEFUSE 2 study investigators;citation_title=MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study.;citation_pages=860-867;citation_volume=11;citation_year=2012;citation_issue=10;citation_pmid=22954705;citation_doi=10.1016/S1474-4422(12)70203-X" />
<meta name="citation_reference" content="citation_journal_title=N Engl J Med;citation_author=SWIFT PRIME Investigators;citation_title=Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke;citation_pages=2285-95;citation_volume=372;citation_year=2015;citation_pmid=25882376;citation_doi=10.1056/NEJMoa1415061" />
<meta name="citation_reference" content="citation_journal_title=N Engl J Med;citation_author=REVASCAT Trial Investigators;citation_title=Thrombectomy within 8 hours after symptom onset in ischemic stroke;citation_pages=2296-306;citation_volume=372;citation_year=2015;citation_pmid=25882510;citation_doi=10.1056/NEJMoa1503780" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=BCV. Campbell;citation_author=S. Christensen;citation_author=CR. Levi;citation_title=Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke;citation_volume=43;citation_year=2012;citation_pmid=22858726;citation_doi=10.1161/STROKEAHA.112.660548" />
<meta name="citation_reference" content="citation_journal_title=International Journal of Stroke;citation_journal_abbrev=Int J Stroke;citation_author=SWIFT PRIME Investigators;citation_title=Author Index;citation_pages=439-458;citation_volume=10;citation_year=2015;citation_issue=2_suppl;citation_pmid=25777831;citation_doi=10.1111/ijs.12480" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance imaging :  JMRI;citation_journal_abbrev=J Magn Reson Imaging;citation_author=L. Østergaard;citation_title=Principles of cerebral perfusion imaging by bolus tracking.;citation_pages=710-717;citation_volume=22;citation_year=2005;citation_issue=6;citation_pmid=16261573;citation_doi=10.1002/jmri.20460" />
<meta name="citation_reference" content="citation_journal_title=Radiology;citation_author=RJ. McDonald;citation_author=JS. McDonald;citation_author=DF. Kallmes;citation_title=Intracranial gadolinium deposition after contrast-enhanced MR imaging;citation_pages=772-82;citation_volume=275;citation_year=2015;citation_pmid=25742194;citation_doi=10.1148/radiol.15150025" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=S. Ovadia-Caro;citation_author=DS. Margulies;citation_author=A. Villringer;citation_title=The value of resting-state functional magnetic resonance imaging in stroke;citation_volume=45;citation_year=2014;citation_pmid=25013022;citation_doi=10.1161/STROKEAHA.114.003689" />
<meta name="citation_reference" content="citation_journal_title=British Journal of Radiology;citation_journal_abbrev=Br. J. Radiol.;citation_author=ET. Petersen;citation_author=I. Zimine;citation_author=YC. Ho;citation_title=Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques;citation_pages=688-701;citation_volume=79;citation_year=2006;citation_issue=944;citation_pmid=16861326;citation_doi=10.1259/bjr/67705974" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=National Institutes of Health Stroke Natural History Investigators;citation_title=Whole-brain arterial spin labeling perfusion MRI in patients with acute stroke;citation_volume=43;citation_year=2012;citation_pmid=22426319;citation_doi=10.1161/STROKEAHA.110.589234" />
<meta name="citation_reference" content="citation_journal_title=Cerebrovascular and brain metabolism reviews;citation_journal_abbrev=Cerebrovasc Brain Metab Rev;citation_author=A. Villringer;citation_author=U. Dirnagl;citation_title=Coupling of brain activity and cerebral blood flow: basis of functional neuroimaging.;citation_pages=240-276;citation_volume=7;citation_year=1995;citation_issue=3;citation_pmid=8519605" />
<meta name="citation_reference" content="citation_journal_title=J Magn Reson Imaging;citation_author=T. Christen;citation_author=H. Jahanian;citation_author=WW. Ni;citation_title=Noncontrast mapping of arterial delay and functional connectivity using resting-state functional MRI: a study in Moyamoya patients;citation_pages=424-30;citation_volume=41;citation_year=2015;citation_pmid=24419985;citation_doi=10.1002/jmri.24558" />
<meta name="citation_reference" content="citation_journal_title=Radiology;citation_author=S. Amemiya;citation_author=A. Kunimatsu;citation_author=N. Saito;citation_title=Cerebral hemodynamic impairment: assessment with resting-state functional MR imaging;citation_pages=548-55;citation_volume=270;citation_year=2014;citation_pmid=24072777;citation_doi=10.1148/radiol.13130982" />
<meta name="citation_reference" content="citation_journal_title=Ann Neurol;citation_author=Y. Lv;citation_author=DS. Margulies;citation_author=R. Cameron Craddock;citation_title=Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging;citation_pages=136-40;citation_volume=73;citation_year=2013;citation_pmid=23378326;citation_doi=10.1002/ana.23763" />
<meta name="citation_reference" content="citation_journal_title=Nature reviews. Neuroscience;citation_journal_abbrev=Nat Rev Neurosci;citation_author=MD. Fox;citation_author=ME. Raichle;citation_title=Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.;citation_pages=700-711;citation_volume=8;citation_year=2007;citation_issue=9;citation_pmid=17704812;citation_doi=10.1038/nrn2201" />
<meta name="citation_reference" content="citation_journal_title=Proc Natl Acad Sci U S A;citation_author=SM. Smith;citation_author=PT. Fox;citation_author=KL. Miller;citation_title=Correspondence of the brain's functional architecture during activation and rest;citation_volume=106;citation_year=2009;citation_pmid=19620724;citation_doi=10.1073/pnas.0905267106" />
<meta name="citation_reference" content="citation_journal_title=European neuropsychopharmacology :  the journal of the European College of Neuropsychopharmacology;citation_journal_abbrev=Eur Neuropsychopharmacol;citation_author=MP. van den Heuvel;citation_author=HE. Hulshoff Pol;citation_title=Exploring the brain network: a review on resting-state fMRI functional connectivity.;citation_pages=519-534;citation_volume=20;citation_year=2010;citation_issue=8;citation_pmid=20471808;citation_doi=10.1016/j.euroneuro.2010.03.008" />
<meta name="citation_reference" content="citation_journal_title=J Cereb Blood Flow Metab;citation_author=TY. Chang;citation_author=KL. Huang;citation_author=MY. Ho;citation_title=Graph theoretical analysis of functional networks and its relationship to cognitive decline in patients with carotid stenosis;citation_volume=36;citation_year=2016;citation_pmid=26661184;citation_doi=10.1177/0271678X15608390" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=HL. Cheng;citation_author=CJ. Lin;citation_author=BW. Soong;citation_title=Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis;citation_volume=43;citation_year=2012;citation_pmid=22935402;citation_doi=10.1161/STROKEAHA.111.645614" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_journal_abbrev=Stroke;citation_author=A. Gupta;citation_author=JL. Chazen;citation_author=M. Hartman;citation_title=Cerebrovascular Reserve and Stroke Risk in Patients With Carotid Stenosis or Occlusion: A Systematic Review and Meta-Analysis;citation_pages=2884-2891;citation_volume=43;citation_year=2012;citation_issue=11;citation_pmid=23091119;citation_doi=10.1161/STROKEAHA.112.663716" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=AS. Vagal;citation_author=JL. Leach;citation_author=M. Fernandez-Ulloa;citation_title=The acetazolamide challenge: techniques and applications in the evaluation of chronic cerebral ischemia;citation_volume=30;citation_year=2009;citation_pmid=19246526;citation_doi=10.3174/ajnr.A1538" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=JC. Siero;citation_author=NS. Hartkamp;citation_author=MJ. Donahue;citation_title=Neuronal activation induced BOLD and CBF responses upon acetazolamide administration in patients with steno-occlusive artery disease;citation_pages=276-85;citation_volume=105;citation_year=2015;citation_pmid=25261002;citation_doi=10.1016/j.neuroimage.2014.09.033" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance imaging :  JMRI;citation_journal_abbrev=J Magn Reson Imaging;citation_author=M. Straka;citation_author=GW. Albers;citation_author=R. Bammer;citation_title=Real-time diffusion-perfusion mismatch analysis in acute stroke.;citation_pages=1024-1037;citation_volume=32;citation_year=2010;citation_issue=5;citation_pmid=21031505;citation_doi=10.1002/jmri.22338" />
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<meta name="citation_reference" content="citation_journal_title=Cereb Cortex;citation_author=WR. Shirer;citation_author=S. Ryali;citation_author=E. Rykhlevskaia;citation_title=Decoding subject-driven cognitive states with whole-brain connectivity patterns;citation_volume=22;citation_year=2012;citation_pmid=21616982;citation_doi=10.1093/cercor/bhr099" />
<meta name="citation_reference" content="citation_journal_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_author=DEFUSE Investigators;citation_title=Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study.;citation_pages=508-517;citation_volume=60;citation_year=2006;citation_issue=5;citation_pmid=17066483;citation_doi=10.1002/ana.20976" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=S. Amemiya;citation_author=H. Takao;citation_author=S. Hanaoka;citation_title=Global and structured waves of rs-fMRI signal identified as putative propagation of spontaneous neural activity;citation_pages=331-40;citation_volume=133;citation_year=2016;citation_pmid=27012499;citation_doi=10.1016/j.neuroimage.2016.03.033" />
<meta name="citation_reference" content="citation_journal_title=Journal of Cerebral Blood Flow and Metabolism;citation_journal_abbrev=J Cereb Blood Flow Metab;citation_author=JU. Blicher;citation_author=CJ. Stagg;citation_author=J. O'Shea;citation_title=Visualization of Altered Neurovascular Coupling in Chronic Stroke Patients using Multimodal Functional MRI;citation_pages=2044-2054;citation_volume=32;citation_year=2012;citation_issue=11;citation_pmid=22828998;citation_doi=10.1038/jcbfm.2012.105" />
<meta name="citation_reference" content="citation_journal_title=Journal of Cerebral Blood Flow and Metabolism;citation_journal_abbrev=J Cereb Blood Flow Metab;citation_author=GG. Brown;citation_author=LT. Eyler Zorrilla;citation_author=B. Georgy;citation_title=BOLD and Perfusion Response to Finger-Thumb Apposition after Acetazolamide Administration: Differential Relationship to Global Perfusion;citation_pages=829-837;citation_volume=23;citation_year=2003;citation_issue=7;citation_pmid=12843786;citation_doi=10.1097/01.WCB.0000071887.63724.B2" />
<meta name="citation_reference" content="citation_journal_title=PLoS One;citation_author=C. Preibisch;citation_author=G JG. Castrillón;citation_author=M. Bührer;citation_title=Evaluation of multiband EPI acquisitions for resting state fMRI;citation_pages=e0136961;citation_volume=10;citation_year=2015;citation_pmid=26375666;citation_doi=10.1371/journal.pone.0136961" />
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<meta name="twitter:title" content="The Effects of Acetazolamide on the Evaluation of Cerebral Hemodynamics and Functional Connectivity Using Blood Oxygen Level–Dependent MR Imaging in Patients with Chronic Steno-Occlusive Disease of the Anterior Circulation" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Measuring cerebrovascular reactivity with the use of vasodilatory stimuli, such as acetazolamide, is useful for chronic cerebrovascular steno-occlusive disease. The purpose of this study was to evaluate the effects of acetazolamide on the assessment of hemodynamic impairment and functional connectivity by using noninvasive resting-state blood oxygen level–dependent MR imaging.

MATERIALS AND METHODS: A 20-minute resting-state blood oxygen level–dependent MR imaging scan was acquired with infusion of acetazolamide starting at 5 minutes after scan initiation. A recently developed temporal-shift analysis technique was applied on blood oxygen level–dependent MR imaging data before and after acetazolamide infusion to identify regions with hemodynamic impairment, and the results were compared by using contrast agent–based DSC perfusion imaging as the reference standard. Functional connectivity was compared with and without correction on the signal by using information from temporal-shift analysis, before and after acetazolamide infusion.

RESULTS: Visually, temporal-shift analysis of blood oxygen level–dependent MR imaging data identified regions with compromised hemodynamics as defined by DSC, though performance deteriorated in patients with bilateral disease. The Dice similarity coefficient between temporal-shift and DSC maps was higher before (0.487 ± 0.150 by using the superior sagittal sinus signal as a reference for temporal-shift analysis) compared with after acetazolamide administration (0.384 ± 0.107) ( P = .006, repeated-measures ANOVA). Functional connectivity analysis with temporal-shift correction identified brain network nodes that were otherwise missed. The accuracy of functional connectivity assessment decreased after acetazolamide administration ( P = .015 for default mode network, repeated-measures ANOVA).

CONCLUSIONS: Temporal-shift analysis of blood oxygen level–dependent MR imaging can identify brain regions with hemodynamic compromise in relation to DSC among patients with chronic cerebrovascular disease. The use of acetazolamide reduces the accuracy of temporal-shift analysis and network connectivity evaluation.

ACZ
:   acetazolamide
BOLD
:   blood oxygen level–dependent MR imaging
DMN
:   default mode network
SMN
:   sensorimotor network
SSS
:   superior sagittal sinus
Tmax
:   time-to-maximum of the residue function
TS
:   temporal-shift" />
<meta name="og-title" property="og:title" content="The Effects of Acetazolamide on the Evaluation of Cerebral Hemodynamics and Functional Connectivity Using Blood Oxygen Level–Dependent MR Imaging in Patients with Chronic Steno-Occlusive Disease of the Anterior Circulation" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/38/1/139" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Measuring cerebrovascular reactivity with the use of vasodilatory stimuli, such as acetazolamide, is useful for chronic cerebrovascular steno-occlusive disease. The purpose of this study was to evaluate the effects of acetazolamide on the assessment of hemodynamic impairment and functional connectivity by using noninvasive resting-state blood oxygen level–dependent MR imaging.

MATERIALS AND METHODS: A 20-minute resting-state blood oxygen level–dependent MR imaging scan was acquired with infusion of acetazolamide starting at 5 minutes after scan initiation. A recently developed temporal-shift analysis technique was applied on blood oxygen level–dependent MR imaging data before and after acetazolamide infusion to identify regions with hemodynamic impairment, and the results were compared by using contrast agent–based DSC perfusion imaging as the reference standard. Functional connectivity was compared with and without correction on the signal by using information from temporal-shift analysis, before and after acetazolamide infusion.

RESULTS: Visually, temporal-shift analysis of blood oxygen level–dependent MR imaging data identified regions with compromised hemodynamics as defined by DSC, though performance deteriorated in patients with bilateral disease. The Dice similarity coefficient between temporal-shift and DSC maps was higher before (0.487 ± 0.150 by using the superior sagittal sinus signal as a reference for temporal-shift analysis) compared with after acetazolamide administration (0.384 ± 0.107) ( P = .006, repeated-measures ANOVA). Functional connectivity analysis with temporal-shift correction identified brain network nodes that were otherwise missed. The accuracy of functional connectivity assessment decreased after acetazolamide administration ( P = .015 for default mode network, repeated-measures ANOVA).

CONCLUSIONS: Temporal-shift analysis of blood oxygen level–dependent MR imaging can identify brain regions with hemodynamic compromise in relation to DSC among patients with chronic cerebrovascular disease. The use of acetazolamide reduces the accuracy of temporal-shift analysis and network connectivity evaluation.

ACZ
:   acetazolamide
BOLD
:   blood oxygen level–dependent MR imaging
DMN
:   default mode network
SMN
:   sensorimotor network
SSS
:   superior sagittal sinus
Tmax
:   time-to-maximum of the residue function
TS
:   temporal-shift" />
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    <title>The Effects of Acetazolamide on the Evaluation of Cerebral Hemodynamics and Functional Connectivity Using Blood Oxygen Level–Dependent MR Imaging in Patients with Chronic Steno-Occlusive Disease of the Anterior Circulation | American Journal of Neuroradiology</title>  
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      <h1 class="highwire-cite-title" id="page-title">The Effects of Acetazolamide on the Evaluation of Cerebral Hemodynamics and Functional Connectivity Using Blood Oxygen Level–Dependent MR Imaging in Patients with Chronic Steno-Occlusive Disease of the Anterior Circulation</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">J. Wu</span>, <span class="highwire-citation-author" data-delta="1">S. Dehkharghani</span>, <span class="highwire-citation-author" data-delta="2">F. Nahab</span>, <span class="highwire-citation-author" data-delta="3">J. Allen</span> and <span class="highwire-citation-author" data-delta="4">D. Qiu</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2017,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">38 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">139-145; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4973 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-143--6562399439" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J. 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Dehkharghani </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology and Imaging Sciences (J.W., S.D., J.A., D.Q.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BDehkharghani%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dehkharghani%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BDehkharghani%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-3141-1094" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. 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Nahab </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Neurology (F.N.), Emory University School of Medicine, Atlanta, Georgia.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BNahab%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nahab%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BNahab%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-1710-9881" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. 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Allen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology and Imaging Sciences (J.W., S.D., J.A., D.Q.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BAllen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Allen%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BAllen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-5274-1105" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. 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      <div class="highwire-cite-title">The Effects of Acetazolamide on the Evaluation of Cerebral Hemodynamics and Functional Connectivity Using Blood Oxygen Level–Dependent MR Imaging in Patients with Chronic Steno-Occlusive Disease of the Anterior Circulation</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Wu</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Dehkharghani</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Nahab</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Allen</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Qiu</span></span></span></div>
  
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      <div class="highwire-cite-title">The Effects of Acetazolamide on the Evaluation of Cerebral Hemodynamics and Functional Connectivity Using Blood Oxygen Level–Dependent MR Imaging in Patients with Chronic Steno-Occlusive Disease of the Anterior Circulation</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Wu</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Dehkharghani</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Nahab</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Allen</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Qiu</span></span></span></div>
  
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