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<meta name="DC.Description" content="SUMMARY: Our aim was to prospectively evaluate the relationship between low back pain–related disability and quantitative measures from [18F]-sodium fluoride ([18F]-NaF) MR imaging. Six patients with facetogenic low back pain underwent dynamic [18F]-NaF PET/MR imaging. PET metrics were correlated with clinical measures and MR imaging grading of lumbar facet arthropathy. A significant positive correlation was observed between maximum facet joint uptake rate and clinical disability ( P &lt; .05). These data suggest that dynamic [18F]-NaF PET may serve as a useful biomarker for facetogenic disability.

FJ
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max
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&lt;p&gt;Our aim was to prospectively evaluate the relationship between low back pain–related disability and quantitative measures from [&lt;sup&gt;18&lt;/sup&gt;F]-sodium fluoride ([&lt;sup&gt;18&lt;/sup&gt;F]-NaF) MR imaging. Six patients with facetogenic low back pain underwent dynamic [&lt;sup&gt;18&lt;/sup&gt;F]-NaF PET/MR imaging. PET metrics were correlated with clinical measures and MR imaging grading of lumbar facet arthropathy. A significant positive correlation was observed between maximum facet joint uptake rate and clinical disability (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05). These data suggest that dynamic [&lt;sup&gt;18&lt;/sup&gt;F]-NaF PET may serve as a useful biomarker for facetogenic disability.&lt;/p&gt;" />
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<meta name="twitter:title" content="[18F]-Sodium Fluoride PET MR–Based Localization and Quantification of Bone Turnover as a Biomarker for Facet Joint–Induced Disability" />
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<meta name="twitter:description" content="SUMMARY: Our aim was to prospectively evaluate the relationship between low back pain–related disability and quantitative measures from [18F]-sodium fluoride ([18F]-NaF) MR imaging. Six patients with facetogenic low back pain underwent dynamic [18F]-NaF PET/MR imaging. PET metrics were correlated with clinical measures and MR imaging grading of lumbar facet arthropathy. A significant positive correlation was observed between maximum facet joint uptake rate and clinical disability ( P &lt; .05). These data suggest that dynamic [18F]-NaF PET may serve as a useful biomarker for facetogenic disability.

FJ
:   facet joint
IPAQ
:   International Physical Activity Questionnaire
max
:   maximum
min
:   minimum
mL/ccm/min
:   milliliters/cubic centimeter/minute
ODI
:   Oswestry Disability Index
SUV
:   standard uptake value" />
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<meta name="og-description" property="og:description" content="SUMMARY: Our aim was to prospectively evaluate the relationship between low back pain–related disability and quantitative measures from [18F]-sodium fluoride ([18F]-NaF) MR imaging. Six patients with facetogenic low back pain underwent dynamic [18F]-NaF PET/MR imaging. PET metrics were correlated with clinical measures and MR imaging grading of lumbar facet arthropathy. A significant positive correlation was observed between maximum facet joint uptake rate and clinical disability ( P &lt; .05). These data suggest that dynamic [18F]-NaF PET may serve as a useful biomarker for facetogenic disability.

FJ
:   facet joint
IPAQ
:   International Physical Activity Questionnaire
max
:   maximum
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ODI
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SUV
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node56246--5" data-node-nid="56246" id="top-node-56246--671973861" data-pisa="ajnr;38/10/2028" data-pisa-master="ajnr;ajnr.A5348" data-apath="/ajnr/38/10/2028.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Spine</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">[<sup>18</sup>F]-Sodium Fluoride PET MR–Based Localization and Quantification of Bone Turnover as a Biomarker for Facet Joint–Induced Disability</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">N.W. Jenkins</span>, <span class="highwire-citation-author" data-delta="1">J.F. Talbott</span>, <span class="highwire-citation-author" data-delta="2">V. Shah</span>, <span class="highwire-citation-author" data-delta="3">P. Pandit</span>, <span class="highwire-citation-author" data-delta="4">Y. Seo</span>, <span class="highwire-citation-author" data-delta="5">W.P. Dillon</span> and <span class="highwire-citation-author" data-delta="6">S. Majumdar</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 2017,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">38 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2028-2031; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5348 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-56246--671973861" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">N.W. Jenkins </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology and Biomedical Imaging (N.W.J., J.F.T., V.S., P.P., Y.S., W.P.D., S.M.), University of California, San Francisco, San Francisco, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.W.%2BJenkins%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jenkins%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.W.%2BJenkins%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-1613-0072" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N.W. Jenkins</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J.F. Talbott </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology and Biomedical Imaging (N.W.J., J.F.T., V.S., P.P., Y.S., W.P.D., S.M.), University of California, San Francisco, San Francisco, California</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Radiology and Biomedical Imaging (J.F.T.), Zuckerberg San Francisco General Hospital, San Francisco, California.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.F.%2BTalbott%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Talbott%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.F.%2BTalbott%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-3943-5530" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.F. Talbott</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">V. Shah </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology and Biomedical Imaging (N.W.J., J.F.T., V.S., P.P., Y.S., W.P.D., S.M.), University of California, San Francisco, San Francisco, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=V.%2BShah%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Shah%20V&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AV.%2BShah%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-0803-5067" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for V. Shah</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">P. Pandit </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology and Biomedical Imaging (N.W.J., J.F.T., V.S., P.P., Y.S., W.P.D., S.M.), University of California, San Francisco, San Francisco, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BPandit%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Pandit%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AP.%2BPandit%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-3448-714X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for P. Pandit</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Y. Seo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology and Biomedical Imaging (N.W.J., J.F.T., V.S., P.P., Y.S., W.P.D., S.M.), University of California, San Francisco, San Francisco, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.%2BSeo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Seo%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AY.%2BSeo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-5908-6636" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Y. Seo</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">W.P. Dillon </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology and Biomedical Imaging (N.W.J., J.F.T., V.S., P.P., Y.S., W.P.D., S.M.), University of California, San Francisco, San Francisco, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.P.%2BDillon%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dillon%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.P.%2BDillon%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-7222-4615" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W.P. Dillon</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">S. Majumdar </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology and Biomedical Imaging (N.W.J., J.F.T., V.S., P.P., Y.S., W.P.D., S.M.), University of California, San Francisco, San Francisco, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BMajumdar%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Majumdar%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BMajumdar%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-0201-871X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Majumdar</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-38.10.2028.1" data-doi="10.1097/00007632-199501000-00003"><div class="cit-metadata"><ol class="cit-auth-list"><li>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 38</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 10 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Oct 2017 </div></div>
      
      
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      <div class="highwire-cite-title">[<sup>18</sup>F]-Sodium Fluoride PET MR–Based Localization and Quantification of Bone Turnover as a Biomarker for Facet Joint–Induced Disability</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">N.W.</span> <span class="nlm-surname">Jenkins</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.F.</span> <span class="nlm-surname">Talbott</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">V.</span> <span class="nlm-surname">Shah</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Pandit</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Seo</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">W.P.</span> <span class="nlm-surname">Dillon</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Majumdar</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2017, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">38 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2028-2031; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5348 </span></div>
  
  
  
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      <div class="highwire-cite-title">[<sup>18</sup>F]-Sodium Fluoride PET MR–Based Localization and Quantification of Bone Turnover as a Biomarker for Facet Joint–Induced Disability</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">N.W.</span> <span class="nlm-surname">Jenkins</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.F.</span> <span class="nlm-surname">Talbott</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">V.</span> <span class="nlm-surname">Shah</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Pandit</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Seo</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">W.P.</span> <span class="nlm-surname">Dillon</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Majumdar</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2017, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">38 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2028-2031; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5348 </span></div>
  
  
  
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