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<meta name="DC.Description" content="SUMMARY: The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus–related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(−) oropharyngeal squamous cell carcinoma. Nodal staging has dramatically changed so that there are different tables for human papillomavirus/p16(+) oropharyngeal squamous cell carcinoma, Epstein-Barr virus–related nasopharyngeal carcinoma, and all other head and neck squamous cell carcinomas. Extranodal extension of tumor is a new clinical feature for this third staging group. In the oral cavity, the pathologically determined depth of tumor invasion is a new staging criterion, while extrinsic tongue muscle invasion is no longer part of staging. This review serves to educate radiologists on the eighth edition changes and their rationale.

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DOI
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EBV
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ENE
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HN
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NPC
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&lt;p&gt;The updated eighth edition of the &lt;i&gt;Cancer Staging Manual&lt;/i&gt; of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus–related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(−) oropharyngeal squamous cell carcinoma. Nodal staging has dramatically changed so that there are different tables for human papillomavirus/p16(+) oropharyngeal squamous cell carcinoma, Epstein-Barr virus–related nasopharyngeal carcinoma, and all other head and neck squamous cell carcinomas. Extranodal extension of tumor is a new clinical feature for this third staging group. In the oral cavity, the pathologically determined depth of tumor invasion is a new staging criterion, while extrinsic tongue muscle invasion is no longer part of staging. This review serves to educate radiologists on the eighth edition changes and their rationale.&lt;/p&gt;" />
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<meta name="twitter:description" content="SUMMARY: The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus–related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(−) oropharyngeal squamous cell carcinoma. Nodal staging has dramatically changed so that there are different tables for human papillomavirus/p16(+) oropharyngeal squamous cell carcinoma, Epstein-Barr virus–related nasopharyngeal carcinoma, and all other head and neck squamous cell carcinomas. Extranodal extension of tumor is a new clinical feature for this third staging group. In the oral cavity, the pathologically determined depth of tumor invasion is a new staging criterion, while extrinsic tongue muscle invasion is no longer part of staging. This review serves to educate radiologists on the eighth edition changes and their rationale.

AJCC
:   American Joint Committee on Cancer
cN
:   clinical nodal staging
DOI
:   depth of invasion
EBV
:   Epstein-Barr virus
ENE
:   extranodal extension
HN
:   head and neck
HPV
:   human papillomavirus
NPC
:   nasopharyngeal carcinoma
OPSCC
:   oropharyngeal squamous cell carcinoma
pN
:   pathologic nodal staging
SCC
:   squamous cell carcinoma
TNM
:   tumor, node, metastasis
UICC
:   Union for International Cancer Control" />
<meta name="og-title" property="og:title" content="Setting the Stage for 2018: How the Changes in the American Joint Committee on Cancer/Union for International Cancer Control Cancer Staging Manual Eighth Edition Impact Radiologists" />
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<meta name="og-description" property="og:description" content="SUMMARY: The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus–related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(−) oropharyngeal squamous cell carcinoma. Nodal staging has dramatically changed so that there are different tables for human papillomavirus/p16(+) oropharyngeal squamous cell carcinoma, Epstein-Barr virus–related nasopharyngeal carcinoma, and all other head and neck squamous cell carcinomas. Extranodal extension of tumor is a new clinical feature for this third staging group. In the oral cavity, the pathologically determined depth of tumor invasion is a new staging criterion, while extrinsic tongue muscle invasion is no longer part of staging. This review serves to educate radiologists on the eighth edition changes and their rationale.

AJCC
:   American Joint Committee on Cancer
cN
:   clinical nodal staging
DOI
:   depth of invasion
EBV
:   Epstein-Barr virus
ENE
:   extranodal extension
HN
:   head and neck
HPV
:   human papillomavirus
NPC
:   nasopharyngeal carcinoma
OPSCC
:   oropharyngeal squamous cell carcinoma
pN
:   pathologic nodal staging
SCC
:   squamous cell carcinoma
TNM
:   tumor, node, metastasis
UICC
:   Union for International Cancer Control" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node57348--5" data-node-nid="57348" id="top-node-57348--61045392637" data-pisa="ajnr;38/12/2231" data-pisa-master="ajnr;ajnr.A5409" data-apath="/ajnr/38/12/2231.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Head &amp; Neck</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Setting the Stage for 2018: How the Changes in the American Joint Committee on Cancer/Union for International Cancer Control <em>Cancer Staging Manual</em> Eighth Edition Impact Radiologists</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">C.M. Glastonbury</span>, <span class="highwire-citation-author" data-delta="1">S.K. Mukherji</span>, <span class="highwire-citation-author" data-delta="2">B. O'Sullivan</span> and <span class="highwire-citation-author" data-delta="3">W.M. Lydiatt</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">December 2017,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">38 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2231-2237; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5409 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-57348--61045392637" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">C.M. Glastonbury </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology and Biomedical Imaging (C.M.G.), University of California, San Francisco, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.M.%2BGlastonbury%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Glastonbury%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.M.%2BGlastonbury%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-9611-1287" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.M. Glastonbury</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">S.K. Mukherji </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Radiology (S.K.M.), Michigan State University, East Lansing, Michigan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.K.%2BMukherji%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Mukherji%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.K.%2BMukherji%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-6472-0248" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.K. Mukherji</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">B. O'Sullivan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiation Oncology (B.O.), Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.%2BO%27Sullivan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=O%27Sullivan%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AB.%2BO%2527Sullivan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-8887-843X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for B. O'Sullivan</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">W.M. Lydiatt </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Surgery, Head and Neck Oncology (W.M.L.), Estabrook Cancer Center, Nebraska Methodist Hospital, Omaha, Nebraska</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Creighton University (W.M.L.), Omaha, Nebraska</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Naval Medical Center (W.M.L.), Portsmouth, Virginia.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.M.%2BLydiatt%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lydiatt%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.M.%2BLydiatt%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-2394-2725" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W.M. Lydiatt</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-book" id="cit-38.12.2231.1"><div class="cit-metadata"><ol class="cit-ed-list"><li><span class="cit-ed"><span class="cit-name-surname">Amin</span>  <span class="cit-name-given-names">MB</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Edge</span>  <span class="cit-name-given-names">SB</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Greene</span>  <span class="cit-name-given-names">FL</span></span>, <span class="cit-etal">et al.</span></li></ol><cite>, eds. <span class="cit-source">AJCC Cancer Staging Manual</span>. <span class="cit-edition">8th ed</span>. <span class="cit-publ-loc">New York</span>: <span class="cit-publ-name">Springer-Verlag</span>; <span class="cit-pub-date">2017</span></cite></div><div class="cit-extra"></div></div></li><li><span class="ref-label">2.</span><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2. in text" id="ref-2">↵</a><div class="cit ref-cit ref-book" id="cit-38.12.2231.2"><div class="cit-metadata"><ol class="cit-ed-list"><li><span class="cit-ed"><span class="cit-name-surname">Brierley</span>  <span class="cit-name-given-names">JD</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Gospodarowicz</span>  <span class="cit-name-given-names">MK</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Wittekind</span>  <span class="cit-name-given-names">C</span></span></li></ol><cite>, eds, <span class="cit-source">TNM Classification of Malignant Tumours</span>. <span class="cit-publ-loc">Hoboken</span>: <span class="cit-publ-name">Wiley Blackwell</span>; <span class="cit-pub-date">2017</span></cite></div><div class="cit-extra"></div></div></li><li><span class="ref-label">3.</span><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3. in text" id="ref-3">↵</a><div class="cit ref-cit ref-book" id="cit-38.12.2231.3"><div class="cit-metadata"><ol class="cit-ed-list"><li><span class="cit-ed"><span class="cit-name-surname">Edge</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Byrd</span>  <span class="cit-name-given-names">DR</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Compton</span>  <span class="cit-name-given-names">CC</span></span>, <span class="cit-etal">et al.</span></li></ol><cite>, eds. <span class="cit-source">AJCC Cancer Staging Manual</span>. <span class="cit-edition">7th ed</span>. <span class="cit-publ-loc">New York</span>: <span class="cit-publ-name">Springer-Verlag</span>; <span class="cit-pub-date">2010</span></cite></div><div class="cit-extra"></div></div></li><li><span class="ref-label">4.</span><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4. in text" id="ref-4">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.4" data-doi="10.1056/NEJMoa0912217"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Ang</span>  <span class="cit-name-given-names">KK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Harris</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wheeler</span>  <span class="cit-name-given-names">R</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Human papillomavirus and survival of patients with oropharyngeal cancer</span>. <abbr class="cit-jnl-abbrev">N Engl J Med</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">363</span>:<span class="cit-fpage">24</span>–<span class="cit-lpage">35</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1056/NEJMoa0912217</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20530316</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1056/NEJMoa0912217&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20530316&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000279343000005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">5.</span><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5. in text" id="ref-5">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.5" data-doi="10.1016/S1470-2045(15)00560-4"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">O'Sullivan</span>  <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Huang</span>  <span class="cit-name-given-names">SH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Su</span>  <span class="cit-name-given-names">J</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal Cancer Network for Staging (ICON-S): a multicentre cohort study</span>. <abbr class="cit-jnl-abbrev">Lancet Oncol</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">17</span>:<span class="cit-fpage">440</span>–<span class="cit-lpage">51</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S1470-2045(15)00560-4</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26936027</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S1470-2045(15)00560-4&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26936027&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">6.</span><a class="rev-xref-ref" href="#xref-ref-6-1" title="View reference 6. in text" id="ref-6">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.6" data-doi="10.1200/JCO.2014.58.6412"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Huang</span>  <span class="cit-name-given-names">SH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Xu</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Waldron</span>  <span class="cit-name-given-names">J</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas</span>. <abbr class="cit-jnl-abbrev">J Clin Oncol</abbr> <span class="cit-pub-date">2015</span>;<span class="cit-vol">33</span>:<span class="cit-fpage">836</span>–<span class="cit-lpage">45</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1200/JCO.2014.58.6412</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25667292</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamNvIjtzOjU6InJlc2lkIjtzOjg6IjMzLzgvODM2IjtzOjQ6ImF0b20iO3M6MjE6Ii9ham5yLzM4LzEyLzIyMzEuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">7.</span><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7. in text" id="ref-7">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.7" data-doi="10.1016/j.oraloncology.2016.09.004"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Haughey</span>  <span class="cit-name-given-names">BH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sinha</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kallogjeri</span>  <span class="cit-name-given-names">D</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx</span>. <abbr class="cit-jnl-abbrev">Oral Oncol</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">62</span>:<span class="cit-fpage">11</span>–<span class="cit-lpage">19</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.oraloncology.2016.09.004</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27865363</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.oraloncology.2016.09.004&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=27865363&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">8.</span><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8. in text" id="ref-8">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.8" data-doi="10.1002/hed.24190"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Wreesmann</span>  <span class="cit-name-given-names">VB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Katabi</span>  <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Palmer</span>  <span class="cit-name-given-names">FL</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma</span>. <abbr class="cit-jnl-abbrev">Head Neck</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">38</span>(<span class="cit-supplement">suppl 1</span>):<span class="cit-fpage">E1192</span>–<span class="cit-lpage">99</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hed.24190</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26514096</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/hed.24190&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26514096&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">9.</span><a class="rev-xref-ref" href="#xref-ref-9-1" title="View reference 9. in text" id="ref-9">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.9" data-doi="10.1002/1097-0142(20011215)92:12&lt;3030::AID-CNCR10148&gt;3.0.CO;2-P"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Myers</span>  <span class="cit-name-given-names">JN</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Greenberg</span>  <span class="cit-name-given-names">JS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mo</span>  <span class="cit-name-given-names">V</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Extracapsular spread: a significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue</span>. <abbr class="cit-jnl-abbrev">Cancer</abbr> <span class="cit-pub-date">2001</span>;<span class="cit-vol">92</span>:<span class="cit-fpage">3030</span>–<span class="cit-lpage">36</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>11753980</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/1097-0142(20011215)92:12&lt;3030::AID-CNCR10148&gt;3.0.CO;2-P&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11753980&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000172757600008&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">10.</span><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10. in text" id="ref-10">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.10" data-doi="10.1002/cncr.26671"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Sinha</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lewis</span>  <span class="cit-name-given-names">JS</span>  <span class="cit-name-suffix">Jr</span>.</span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Piccirillo</span>  <span class="cit-name-given-names">JF</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma</span>. <abbr class="cit-jnl-abbrev">Cancer</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">118</span>:<span class="cit-fpage">3519</span>–<span class="cit-lpage">30</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/cncr.26671</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22086669</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/cncr.26671&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22086669&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">11.</span><a class="rev-xref-ref" href="#xref-ref-11-1" title="View reference 11. in text" id="ref-11">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.11" data-doi="10.3322/caac.21389"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Lydiatt</span>  <span class="cit-name-given-names">WM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Patel</span>  <span class="cit-name-given-names">SG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">O'Sullivan</span>  <span class="cit-name-given-names">B</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual</span>. <abbr class="cit-jnl-abbrev">CA Cancer J Clin</abbr> <span class="cit-pub-date">2017</span>;<span class="cit-vol">67</span>:<span class="cit-fpage">122</span>–<span class="cit-lpage">37</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3322/caac.21389</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28128848</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3322/caac.21389&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28128848&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">12.</span><a class="rev-xref-ref" href="#xref-ref-12-1" title="View reference 12. in text" id="ref-12">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.12" data-doi="10.1016/j.ejrad.2004.03.004"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">King</span>  <span class="cit-name-given-names">AD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tse</span>  <span class="cit-name-given-names">GM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yuen</span>  <span class="cit-name-given-names">EH</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Comparison of CT and MR imaging for the detection of extranodal neoplastic spread in metastatic neck nodes</span>. <abbr class="cit-jnl-abbrev">Eur J Radiol</abbr> <span class="cit-pub-date">2004</span>;<span class="cit-vol">52</span>:<span class="cit-fpage">264</span>–<span class="cit-lpage">70</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.ejrad.2004.03.004</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>15544904</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.ejrad.2004.03.004&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=15544904&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">13.</span><a class="rev-xref-ref" href="#xref-ref-13-1" title="View reference 13. in text" id="ref-13">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.13" data-doi="10.1016/j.oraloncology.2013.02.010"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Lodder</span>  <span class="cit-name-given-names">WL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lange</span>  <span class="cit-name-given-names">CA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">van Velthuysen</span>  <span class="cit-name-given-names">ML</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Can extranodal spread in head and neck cancer be detected on MR imaging</span>. <abbr class="cit-jnl-abbrev">Oral Oncol</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">49</span>:<span class="cit-fpage">626</span>–<span class="cit-lpage">33</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.oraloncology.2013.02.010</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23523347</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.oraloncology.2013.02.010&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23523347&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">14.</span><a class="rev-xref-ref" href="#xref-ref-14-1" title="View reference 14. in text" id="ref-14">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.14" data-doi="10.1016/j.ijrobp.2013.10.002"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Prabhu</span>  <span class="cit-name-given-names">RS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Magliocca</span>  <span class="cit-name-given-names">KR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hanasoge</span>  <span class="cit-name-given-names">S</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Accuracy of computed tomography for predicting pathologic nodal extracapsular extension in patients with head-and-neck cancer undergoing initial surgical resection</span>. <abbr class="cit-jnl-abbrev">Int J Radiat Oncol Biol Phys</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">88</span>:<span class="cit-fpage">122</span>–<span class="cit-lpage">29</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.ijrobp.2013.10.002</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24331658</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.ijrobp.2013.10.002&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24331658&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">15.</span><a class="rev-xref-ref" href="#xref-ref-15-1" title="View reference 15. in text" id="ref-15">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.15" data-doi="10.1002/cncr.30198"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Pan</span>  <span class="cit-name-given-names">JJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ng</span>  <span class="cit-name-given-names">WT</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Zong</span>  <span class="cit-name-given-names">JF</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Prognostic nomogram for refining the prognostication of the proposed 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy</span>. <abbr class="cit-jnl-abbrev">Cancer</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">122</span>:<span class="cit-fpage">3307</span>–<span class="cit-lpage">15</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/cncr.30198</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27434142</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/cncr.30198&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=27434142&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">16.</span><a class="rev-xref-ref" href="#xref-ref-16-1" title="View reference 16. in text" id="ref-16">↵</a><div class="cit ref-cit ref-journal" id="cit-38.12.2231.16" data-doi="10.1001/jamaoto.2015.3228"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Motz</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Qualliotine</span>  <span class="cit-name-given-names">JR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rettig</span>  <span class="cit-name-given-names">E</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Changes in unknown primary squamous cell carcinoma of the head and neck at initial presentation in the era of human papillomavirus</span>. <abbr class="cit-jnl-abbrev">JAMA Otolaryngol Head Neck Surg</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">142</span>:<span class="cit-fpage">223</span>–<span class="cit-lpage">28</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1001/jamaoto.2015.3228</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26769661</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1001/jamaoto.2015.3228&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26769661&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F12%2F2231.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">17.</span><a class="rev-xref-ref" href="#xref-ref-17-1" title="View reference 17. in text" id="ref-17">↵</a><div class="cit ref-cit ref-book" id="cit-38.12.2231.17"><div class="cit-metadata"><ol class="duplicate"><li><span class="cit-ed"><span class="cit-name-surname">Amin</span>  <span class="cit-name-given-names">MB</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Edge</span>  <span class="cit-name-given-names">SB</span></span>, </li><li><span class="cit-ed"><span class="cit-name-surname">Greene</span>  <span class="cit-name-given-names">FL</span></span>, <span class="cit-etal">et al.</span></li></ol><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Gress</span>  <span class="cit-name-given-names">DM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Edge</span>  <span class="cit-name-given-names">SB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Greene</span>  <span class="cit-name-given-names">FL</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Principles of cancer staging</span>. In: <span class="cit-ed"><span class="cit-name-surname">Amin</span>  <span class="cit-name-given-names">MB</span></span>, <span class="cit-ed"><span class="cit-name-surname">Edge</span>  <span class="cit-name-given-names">SB</span></span>, <span class="cit-ed"><span class="cit-name-surname">Greene</span>  <span class="cit-name-given-names">FL</span></span>, <span class="cit-etal">et al.</span>, eds. <span class="cit-source">AJCC Cancer Staging Manual</span>. <span class="cit-edition">8th Ed</span>. <span class="cit-publ-loc">New York</span>: <span class="cit-publ-name">Springer-Verlag</span>; <span class="cit-pub-date">2017</span>:<span class="cit-fpage">3</span>–<span class="cit-lpage">30</span></cite></div><div class="cit-extra"></div></div></li></ol></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 38</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 12 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Dec 2017 </div></div>
      
      
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">C.M.</span> <span class="nlm-surname">Glastonbury</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.K.</span> <span class="nlm-surname">Mukherji</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">B.</span> <span class="nlm-surname">O'Sullivan</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">W.M.</span> <span class="nlm-surname">Lydiatt</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Dec 2017, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">38 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2231-2237; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5409 </span></div>
  
  
  
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