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<meta name="DC.Title" content="Performance Assessment for Brain MR Imaging Registration Methods" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5122" />
<meta name="DC.Date" content="2017-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Clinical brain MR imaging registration algorithms are often made available by commercial vendors without figures of merit. The purpose of this study was to suggest a rational performance comparison methodology for these products.

MATERIALS AND METHODS: Twenty patients were imaged on clinical 3T scanners by using 4 sequences: T2-weighted, FLAIR, susceptibility-weighted angiography, and T1 postcontrast. Fiducial landmark sites ( n = 1175) were specified throughout these image volumes to define identical anatomic locations across sequences. Multiple registration algorithms were applied by using the T2 sequence as a fixed reference. Euclidean error was calculated before and after each registration and compared with a criterion standard landmark registration. The Euclidean effectiveness ratio is the fraction of Euclidean error remaining after registration, and the statistical effectiveness ratio is similar, but accounts for dispersion and noise.

RESULTS: Before registration, error values for FLAIR, susceptibility-weighted angiography, and T1 postcontrast were 2.07 ± 0.55 mm, 2.63 ± 0.62 mm, and 3.65 ± 2.00 mm, respectively. Postregistration, the best error values for FLAIR, susceptibility-weighted angiography, and T1 postcontrast were 1.55 ± 0.46 mm, 1.34 ± 0.23 mm, and 1.06 ± 0.16 mm, with Euclidean effectiveness ratio values of 0.493, 0.181, and 0.096 and statistical effectiveness ratio values of 0.573, 0.352, and 0.929 for rigid mutual information, affine mutual information, and a commercial GE registration, respectively.

CONCLUSIONS: We demonstrate a method for comparing the performance of registration algorithms and suggest the Euclidean error, Euclidean effectiveness ratio, and statistical effectiveness ratio as performance metrics for clinical registration algorithms. These figures of merit allow registration algorithms to be rationally compared.

ANTs
:   advanced normalization tools
AOI
:   algorithm of interest
CC
:   cross-correlation
EER
:   Euclidean effectiveness ratio
LM
:   landmarks
MI
:   mutual information
SER
:   statistical effectiveness ratio
SWAN
:   susceptibility-weighted angiography
T1C
:   T1 postcontrast
TRE
:   target-to-registration error" />
<meta name="DC.Contributor" content="J.S. Lin" />
<meta name="DC.Contributor" content="D.T. Fuentes" />
<meta name="DC.Contributor" content="A. Chandler" />
<meta name="DC.Contributor" content="S.S. Prabhu" />
<meta name="DC.Contributor" content="J.S. Weinberg" />
<meta name="DC.Contributor" content="V. Baladandayuthapani" />
<meta name="DC.Contributor" content="J.D. Hazle" />
<meta name="DC.Contributor" content="D. Schellingerhout" />
<meta name="article:published_time" content="2017-05-01" />
<meta name="article:section" content="ADULT BRAIN" />
<meta name="citation_title" content="Performance Assessment for Brain MR Imaging Registration Methods" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Clinical brain MR imaging registration algorithms are often made available by commercial vendors without figures of merit. The purpose of this study was to suggest a rational performance comparison methodology for these products.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Twenty patients were imaged on clinical 3T scanners by using 4 sequences: T2-weighted, FLAIR, susceptibility-weighted angiography, and T1 postcontrast. Fiducial landmark sites (&lt;i&gt;n&lt;/i&gt; = 1175) were specified throughout these image volumes to define identical anatomic locations across sequences. Multiple registration algorithms were applied by using the T2 sequence as a fixed reference. Euclidean error was calculated before and after each registration and compared with a criterion standard landmark registration. The Euclidean effectiveness ratio is the fraction of Euclidean error remaining after registration, and the statistical effectiveness ratio is similar, but accounts for dispersion and noise.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Before registration, error values for FLAIR, susceptibility-weighted angiography, and T1 postcontrast were 2.07 ± 0.55 mm, 2.63 ± 0.62 mm, and 3.65 ± 2.00 mm, respectively. Postregistration, the best error values for FLAIR, susceptibility-weighted angiography, and T1 postcontrast were 1.55 ± 0.46 mm, 1.34 ± 0.23 mm, and 1.06 ± 0.16 mm, with Euclidean effectiveness ratio values of 0.493, 0.181, and 0.096 and statistical effectiveness ratio values of 0.573, 0.352, and 0.929 for rigid mutual information, affine mutual information, and a commercial GE registration, respectively.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;We demonstrate a method for comparing the performance of registration algorithms and suggest the Euclidean error, Euclidean effectiveness ratio, and statistical effectiveness ratio as performance metrics for clinical registration algorithms. These figures of merit allow registration algorithms to be rationally compared.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=Front Neuroinform;citation_author=M. McCormick;citation_author=X. Liu;citation_author=J. Jomier;citation_title=ITK: enabling reproducible research and open science;citation_pages=13;citation_volume=8;citation_year=2014;citation_pmid=24600387;citation_doi=10.3389/fninf.2014.00013" />
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<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=PA. Yushkevich;citation_author=J. Piven;citation_author=HC. Hazlett;citation_title=User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability;citation_pages=1116-28;citation_volume=31;citation_year=2006;citation_pmid=16545965;citation_doi=10.1016/j.neuroimage.2006.01.015" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Clinical brain MR imaging registration algorithms are often made available by commercial vendors without figures of merit. The purpose of this study was to suggest a rational performance comparison methodology for these products.

MATERIALS AND METHODS: Twenty patients were imaged on clinical 3T scanners by using 4 sequences: T2-weighted, FLAIR, susceptibility-weighted angiography, and T1 postcontrast. Fiducial landmark sites ( n = 1175) were specified throughout these image volumes to define identical anatomic locations across sequences. Multiple registration algorithms were applied by using the T2 sequence as a fixed reference. Euclidean error was calculated before and after each registration and compared with a criterion standard landmark registration. The Euclidean effectiveness ratio is the fraction of Euclidean error remaining after registration, and the statistical effectiveness ratio is similar, but accounts for dispersion and noise.

RESULTS: Before registration, error values for FLAIR, susceptibility-weighted angiography, and T1 postcontrast were 2.07 ± 0.55 mm, 2.63 ± 0.62 mm, and 3.65 ± 2.00 mm, respectively. Postregistration, the best error values for FLAIR, susceptibility-weighted angiography, and T1 postcontrast were 1.55 ± 0.46 mm, 1.34 ± 0.23 mm, and 1.06 ± 0.16 mm, with Euclidean effectiveness ratio values of 0.493, 0.181, and 0.096 and statistical effectiveness ratio values of 0.573, 0.352, and 0.929 for rigid mutual information, affine mutual information, and a commercial GE registration, respectively.

CONCLUSIONS: We demonstrate a method for comparing the performance of registration algorithms and suggest the Euclidean error, Euclidean effectiveness ratio, and statistical effectiveness ratio as performance metrics for clinical registration algorithms. These figures of merit allow registration algorithms to be rationally compared.

ANTs
:   advanced normalization tools
AOI
:   algorithm of interest
CC
:   cross-correlation
EER
:   Euclidean effectiveness ratio
LM
:   landmarks
MI
:   mutual information
SER
:   statistical effectiveness ratio
SWAN
:   susceptibility-weighted angiography
T1C
:   T1 postcontrast
TRE
:   target-to-registration error" />
<meta name="og-title" property="og:title" content="Performance Assessment for Brain MR Imaging Registration Methods" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/38/5/973" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Clinical brain MR imaging registration algorithms are often made available by commercial vendors without figures of merit. The purpose of this study was to suggest a rational performance comparison methodology for these products.

MATERIALS AND METHODS: Twenty patients were imaged on clinical 3T scanners by using 4 sequences: T2-weighted, FLAIR, susceptibility-weighted angiography, and T1 postcontrast. Fiducial landmark sites ( n = 1175) were specified throughout these image volumes to define identical anatomic locations across sequences. Multiple registration algorithms were applied by using the T2 sequence as a fixed reference. Euclidean error was calculated before and after each registration and compared with a criterion standard landmark registration. The Euclidean effectiveness ratio is the fraction of Euclidean error remaining after registration, and the statistical effectiveness ratio is similar, but accounts for dispersion and noise.

RESULTS: Before registration, error values for FLAIR, susceptibility-weighted angiography, and T1 postcontrast were 2.07 ± 0.55 mm, 2.63 ± 0.62 mm, and 3.65 ± 2.00 mm, respectively. Postregistration, the best error values for FLAIR, susceptibility-weighted angiography, and T1 postcontrast were 1.55 ± 0.46 mm, 1.34 ± 0.23 mm, and 1.06 ± 0.16 mm, with Euclidean effectiveness ratio values of 0.493, 0.181, and 0.096 and statistical effectiveness ratio values of 0.573, 0.352, and 0.929 for rigid mutual information, affine mutual information, and a commercial GE registration, respectively.

CONCLUSIONS: We demonstrate a method for comparing the performance of registration algorithms and suggest the Euclidean error, Euclidean effectiveness ratio, and statistical effectiveness ratio as performance metrics for clinical registration algorithms. These figures of merit allow registration algorithms to be rationally compared.

ANTs
:   advanced normalization tools
AOI
:   algorithm of interest
CC
:   cross-correlation
EER
:   Euclidean effectiveness ratio
LM
:   landmarks
MI
:   mutual information
SER
:   statistical effectiveness ratio
SWAN
:   susceptibility-weighted angiography
T1C
:   T1 postcontrast
TRE
:   target-to-registration error" />
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<div id="hw-article-author-popups-top-node-54369--6890536401" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J.S. Lin </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Bioengineering (J.S.L.), Rice University, Houston, Texas</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Departments of Imaging Physics (J.S.L., D.T.F., A.C., J.D.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.S.%2BLin%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lin%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.S.%2BLin%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-0146-4232" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.S. Lin</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">D.T. Fuentes </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Departments of Imaging Physics (J.S.L., D.T.F., A.C., J.D.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.T.%2BFuentes%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fuentes%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.T.%2BFuentes%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-2572-6962" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D.T. Fuentes</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A. Chandler </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Departments of Imaging Physics (J.S.L., D.T.F., A.C., J.D.H.)</div><div class='author-affiliation'><span class='nlm-sup'>g</span>Molecular Imaging and Computed Tomography Research (A.C.), GE Healthcare, Milwaukee, Wisconsin.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BChandler%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chandler%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BChandler%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-0322-2410" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Chandler</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">S.S. Prabhu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Neurosurgery (S.S.P., J.S.W.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.S.%2BPrabhu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Prabhu%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.S.%2BPrabhu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-8155-0623" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.S. 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Weinberg </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Neurosurgery (S.S.P., J.S.W.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.S.%2BWeinberg%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Weinberg%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.S.%2BWeinberg%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-5587-6673" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.S. 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Hazle </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Departments of Imaging Physics (J.S.L., D.T.F., A.C., J.D.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.D.%2BHazle%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hazle%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.D.%2BHazle%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-4695-5825" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.D. 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Schellingerhout </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Diagnostic Radiology (D.S.)</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Cancer Systems Imaging (D.S.), University of Texas M.D. Anderson Cancer Center, Houston, Texas</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BSchellingerhout%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Schellingerhout%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BSchellingerhout%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-3659-435X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">REFERENCES</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.1" data-doi="10.1109/42.563664"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Maes</span>  <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Collignon</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Vandermeulen</span>  <span class="cit-name-given-names">D</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Multimodality image registration by maximization of mutual information</span>. <abbr class="cit-jnl-abbrev">IEEE Trans Med Imaging</abbr> <span class="cit-pub-date">1997</span>;<span class="cit-vol">16</span>:<span class="cit-fpage">187</span>–<span class="cit-lpage">98</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1109/42.563664</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9101328</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1109/42.563664&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9101328&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1997WR58700007&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">2.</span><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2. in text" id="ref-2">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.2" data-doi="10.1016/S0031-3203(98)00091-0"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Studholme</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hill</span>  <span class="cit-name-given-names">DL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hawkes</span>  <span class="cit-name-given-names">DJ</span></span></li></ol><cite>. <span class="cit-article-title">An overlap invariant entropy measure of 3D medical image alignment</span>. <abbr class="cit-jnl-abbrev">Pattern Recognition</abbr> <span class="cit-pub-date">1999</span>;<span class="cit-vol">32</span>:<span class="cit-fpage">71</span>–<span class="cit-lpage">86</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S0031-3203(98)00091-0</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S0031-3203(98)00091-0&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=000078298000006&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">3.</span><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3. in text" id="ref-3">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.3" data-doi="10.1016/S1361-8415(01)80004-9"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Wells</span>  <span class="cit-name-given-names">WM</span>  <span class="cit-name-suffix">3rd</span>.</span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Viola</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Atsumi</span>  <span class="cit-name-given-names">H</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Multi-modal volume registration by maximization of mutual information</span>. <abbr class="cit-jnl-abbrev">Med Image Anal</abbr> <span class="cit-pub-date">1996</span>;<span class="cit-vol">1</span>:<span class="cit-fpage">35</span>–<span class="cit-lpage">51</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S1361-8415(01)80004-9</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9873920</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S1361-8415(01)80004-9&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9873920&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">4.</span><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4. in text" id="ref-4">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.4" data-doi="10.1097/00004728-199707000-00007"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">West</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fitzpatrick</span>  <span class="cit-name-given-names">JM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wang</span>  <span class="cit-name-given-names">MY</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Comparison and evaluation of retrospective intermodality brain image registration techniques</span>. <abbr class="cit-jnl-abbrev">J Comput Assist Tomogr</abbr> <span class="cit-pub-date">1997</span>;<span class="cit-vol">21</span>:<span class="cit-fpage">554</span>–<span class="cit-lpage">66</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1097/00004728-199707000-00007</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9216759</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/00004728-199707000-00007&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9216759&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1997XH71300007&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">5.</span><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5. in text" id="ref-5">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.5" data-doi="10.1097/00004728-199801000-00027"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Woods</span>  <span class="cit-name-given-names">RP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Grafton</span>  <span class="cit-name-given-names">ST</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Holmes</span>  <span class="cit-name-given-names">CJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Automated image registration, I: general methods and intrasubject, intramodality validation</span>. <abbr class="cit-jnl-abbrev">J Comput Assist Tomogr</abbr> <span class="cit-pub-date">1998</span>;<span class="cit-vol">22</span>:<span class="cit-fpage">139</span>–<span class="cit-lpage">52</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1097/00004728-199801000-00027</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9448779</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/00004728-199801000-00027&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9448779&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000071451100027&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">6.</span><a class="rev-xref-ref" href="#xref-ref-6-1" title="View reference 6. in text" id="ref-6">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.6" data-doi="10.1016/j.neuroimage.2008.12.037"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Klein</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Andersson</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ardekani</span>  <span class="cit-name-given-names">BA</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">46</span>:<span class="cit-fpage">786</span>–<span class="cit-lpage">802</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2008.12.037</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19195496</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2008.12.037&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19195496&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000265938700025&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">7.</span><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7. in text" id="ref-7">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.7" data-doi="10.1007/s00234-003-1071-4"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Hoelper</span>  <span class="cit-name-given-names">BM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Soldner</span>  <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lachner</span>  <span class="cit-name-given-names">R</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Enhancing accuracy of magnetic resonance image fusion by defining a volume of interest</span>. <abbr class="cit-jnl-abbrev">Neuroradiology</abbr> <span class="cit-pub-date">2003</span>;<span class="cit-vol">45</span>:<span class="cit-fpage">804</span>–<span class="cit-lpage">09</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s00234-003-1071-4</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>12955369</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s00234-003-1071-4&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12955369&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">8.</span><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8. in text" id="ref-8">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.8" data-doi="10.1109/TMI.2002.808358"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Nyúl</span>  <span class="cit-name-given-names">LG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Udupa</span>  <span class="cit-name-given-names">JK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Saha</span>  <span class="cit-name-given-names">PK</span></span></li></ol><cite>. <span class="cit-article-title">Incorporating a measure of local scale in voxel-based 3-D image registration</span>. <abbr class="cit-jnl-abbrev">IEEE Trans Med Imaging</abbr> <span class="cit-pub-date">2003</span>;<span class="cit-vol">22</span>:<span class="cit-fpage">228</span>–<span class="cit-lpage">37</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1109/TMI.2002.808358</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>12715999</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1109/TMI.2002.808358&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12715999&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">9.</span><a class="rev-xref-ref" href="#xref-ref-9-1" title="View reference 9. in text" id="ref-9">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.9" data-doi="10.1006/nimg.1998.0397"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Grachev</span>  <span class="cit-name-given-names">ID</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Berdichevsky</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rauch</span>  <span class="cit-name-given-names">SL</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A method for assessing the accuracy of intersubject registration of the human brain using anatomic landmarks</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">1999</span>;<span class="cit-vol">9</span>:<span class="cit-fpage">250</span>–<span class="cit-lpage">68</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9927554</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1006/nimg.1998.0397&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9927554&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">10.</span><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10. in text" id="ref-10">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.10" data-doi="10.1118/1.4709600"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Mercier</span>  <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Del Maestro</span>  <span class="cit-name-given-names">RF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Petrecca</span>  <span class="cit-name-given-names">K</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Online database of clinical MR and ultrasound images of brain tumors</span>. <abbr class="cit-jnl-abbrev">Med Phys</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">39</span>:<span class="cit-fpage">3253</span>–<span class="cit-lpage">61</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1118/1.4709600</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22755708</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1118/1.4709600&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22755708&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">11.</span><a class="rev-xref-ref" href="#xref-ref-11-1" title="View reference 11. in text" id="ref-11">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.11" data-doi="10.1016/j.neuroimage.2006.11.060"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Archip</span>  <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Clatz</span>  <span class="cit-name-given-names">O</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Whalen</span>  <span class="cit-name-given-names">S</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2007</span>;<span class="cit-vol">35</span>:<span class="cit-fpage">609</span>–<span class="cit-lpage">24</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2006.11.060</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>17289403</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2006.11.060&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=17289403&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">12.</span><a class="rev-xref-ref" href="#xref-ref-12-1" title="View reference 12. in text" id="ref-12">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.12" data-doi="10.1109/TMI.2006.874963"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Skerl</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Likar</span>  <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Pernus</span>  <span class="cit-name-given-names">F</span></span></li></ol><cite>. <span class="cit-article-title">A protocol for evaluation of similarity measures for rigid registration</span>. <abbr class="cit-jnl-abbrev">IEEE Trans Med Imaging</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">25</span>:<span class="cit-fpage">779</span>–<span class="cit-lpage">91</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1109/TMI.2006.874963</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16768242</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1109/TMI.2006.874963&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16768242&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">13.</span><a class="rev-xref-ref" href="#xref-ref-13-1" title="View reference 13. in text" id="ref-13">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.13" data-doi="10.1016/j.patcog.2011.04.008"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">So</span>  <span class="cit-name-given-names">RW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tang</span>  <span class="cit-name-given-names">TW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chung</span>  <span class="cit-name-given-names">AC</span></span></li></ol><cite>. <span class="cit-article-title">Non-rigid image registration of brain magnetic resonance images using graph-cuts</span>. <abbr class="cit-jnl-abbrev">Pattern Recognition</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">44</span>:<span class="cit-fpage">2450</span>–<span class="cit-lpage">67</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.patcog.2011.04.008</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.patcog.2011.04.008&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a></div></div></li><li><span class="ref-label">14.</span><a class="rev-xref-ref" href="#xref-ref-14-1" title="View reference 14. in text" id="ref-14">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.14" data-doi="10.1016/j.patrec.2008.11.004"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Siddiqui</span>  <span class="cit-name-given-names">AM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Masood</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Saleem</span>  <span class="cit-name-given-names">M</span></span></li></ol><cite>. <span class="cit-article-title">A locally constrained radial basis function for registration and warping of images</span>. <abbr class="cit-jnl-abbrev">Pattern Recognition Letters</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">30</span>:<span class="cit-fpage">377</span>–<span class="cit-lpage">90</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.patrec.2008.11.004</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.patrec.2008.11.004&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a></div></div></li><li><span class="ref-label">15.</span><a class="rev-xref-ref" href="#xref-ref-15-1" title="View reference 15. in text" id="ref-15">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.15" data-doi="10.1016/j.neuroimage.2008.09.037"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Saad</span>  <span class="cit-name-given-names">ZS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Glen</span>  <span class="cit-name-given-names">DR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chen</span>  <span class="cit-name-given-names">G</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A new method for improving functional-to-structural MRI alignment using local Pearson correlation</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">44</span>:<span class="cit-fpage">839</span>–<span class="cit-lpage">48</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2008.09.037</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18976717</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2008.09.037&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18976717&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000262301500024&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">16.</span><a class="rev-xref-ref" href="#xref-ref-16-1" title="View reference 16. in text" id="ref-16">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.16" data-doi="10.3389/fninf.2014.00013"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">McCormick</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Liu</span>  <span class="cit-name-given-names">X</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Jomier</span>  <span class="cit-name-given-names">J</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">ITK: enabling reproducible research and open science</span>. <abbr class="cit-jnl-abbrev">Front Neuroinform</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">8</span>:<span class="cit-fpage">13</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3389/fninf.2014.00013</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24600387</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3389/fninf.2014.00013&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24600387&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">17.</span><a class="rev-xref-ref" href="#xref-ref-17-1" title="View reference 17. in text" id="ref-17">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.17" data-doi="10.1002/hbm.10062"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Smith</span>  <span class="cit-name-given-names">SM</span></span></li></ol><cite>. <span class="cit-article-title">Fast robust automated brain extraction</span>. <abbr class="cit-jnl-abbrev">Hum Brain Mapp</abbr> <span class="cit-pub-date">2002</span>;<span class="cit-vol">17</span>:<span class="cit-fpage">143</span>–<span class="cit-lpage">55</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hbm.10062</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>12391568</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/hbm.10062&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12391568&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000178994100001&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">18.</span><a class="rev-xref-ref" href="#xref-ref-18-1" title="View reference 18. in text" id="ref-18">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.18" data-doi="10.1016/j.neuroimage.2010.07.033"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Fonov</span>  <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Evans</span>  <span class="cit-name-given-names">AC</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Botteron</span>  <span class="cit-name-given-names">K</span></span>, <span class="cit-etal">et al</span></li></ol><cite>; <span class="cit-auth cit-collab">Brain Development Cooperative Group</span>. <span class="cit-article-title">Unbiased average age-appropriate atlases for pediatric studies</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">54</span>:<span class="cit-fpage">313</span>–<span class="cit-lpage">27</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2010.07.033</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20656036</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2010.07.033&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20656036&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000283825000033&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">19.</span><a class="rev-xref-ref" href="#xref-ref-19-1" title="View reference 19. in text" id="ref-19">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.19" data-doi="10.1016/j.neuroimage.2006.01.015"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Yushkevich</span>  <span class="cit-name-given-names">PA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Piven</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hazlett</span>  <span class="cit-name-given-names">HC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">31</span>:<span class="cit-fpage">1116</span>–<span class="cit-lpage">28</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2006.01.015</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16545965</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2006.01.015&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16545965&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000238358500015&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">20.</span><a class="rev-xref-ref" href="#xref-ref-20-1" title="View reference 20. in text" id="ref-20">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.20" data-doi="10.3389/fninf.2014.00044"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Avants</span>  <span class="cit-name-given-names">BB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tustison</span>  <span class="cit-name-given-names">NJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stauffer</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">The Insight ToolKit image registration framework</span>. <abbr class="cit-jnl-abbrev">Front Neuroinform</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">8</span>:<span class="cit-fpage">44</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3389/fninf.2014.00044</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24817849</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3389/fninf.2014.00044&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24817849&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">21.</span><a class="rev-xref-ref" href="#xref-ref-21-1" title="View reference 21. in text" id="ref-21">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.21" data-doi="10.1088/0031-9155/46/3/201"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Hill</span>  <span class="cit-name-given-names">DL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Batchelor</span>  <span class="cit-name-given-names">PG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Holden</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Medical image registration</span>. <abbr class="cit-jnl-abbrev">Phys Med Biol</abbr> <span class="cit-pub-date">2001</span>;<span class="cit-vol">46</span>:<span class="cit-fpage">R1</span>–<span class="cit-lpage">45</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1088/0031-9155/46/3/201</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>11277237</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1088/0031-9155/46/3/201&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=11277237&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000167520400001&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">22.</span><a class="rev-xref-ref" href="#xref-ref-22-1" title="View reference 22. in text" id="ref-22">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.22" data-doi="10.1016/S1361-8415(01)80026-8"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Maintz</span>  <span class="cit-name-given-names">JB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Viergever</span>  <span class="cit-name-given-names">MA</span></span></li></ol><cite>. <span class="cit-article-title">A survey of medical image registration</span>. <abbr class="cit-jnl-abbrev">Med Image Anal</abbr> <span class="cit-pub-date">1998</span>;<span class="cit-vol">2</span>:<span class="cit-fpage">1</span>–<span class="cit-lpage">36</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>10638851</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S1361-8415(01)80026-8&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10638851&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">23.</span><a class="rev-xref-ref" href="#xref-ref-23-1" title="View reference 23. in text" id="ref-23">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.23" data-doi="10.1016/j.neuroimage.2010.09.025"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Avants</span>  <span class="cit-name-given-names">BB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tustison</span>  <span class="cit-name-given-names">NJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Song</span>  <span class="cit-name-given-names">G</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A reproducible evaluation of ANTs similarity metric performance in brain image registration</span>. <abbr class="cit-jnl-abbrev">Neuroimage</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">54</span>:<span class="cit-fpage">2033</span>–<span class="cit-lpage">44</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neuroimage.2010.09.025</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20851191</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.neuroimage.2010.09.025&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20851191&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">24.</span><a class="rev-xref-ref" href="#xref-ref-24-1" title="View reference 24. in text" id="ref-24">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.24" data-doi="10.1016/j.ijrobp.2009.06.031"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Brock</span>  <span class="cit-name-given-names">KK</span></span></li></ol><cite>; <span class="cit-auth cit-collab">Deformable Registration Accuracy Consortium</span>. <span class="cit-article-title">Results of a multi-institution deformable registration accuracy study (MIDRAS)</span>. <abbr class="cit-jnl-abbrev">Int J Radiat Oncol Biol Phys</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">76</span>:<span class="cit-fpage">583</span>–<span class="cit-lpage">96</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.ijrobp.2009.06.031</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19910137</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.ijrobp.2009.06.031&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19910137&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">25.</span><a class="rev-xref-ref" href="#xref-ref-25-1" title="View reference 25. in text" id="ref-25">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.25" data-doi="10.1088/0031-9155/54/7/001"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Castillo</span>  <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Castillo</span>  <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Guerra</span>  <span class="cit-name-given-names">R</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A framework for evaluation of deformable image registration spatial accuracy using large landmark point sets</span>. <abbr class="cit-jnl-abbrev">Phys Med Biol</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">54</span>:<span class="cit-fpage">1849</span>–<span class="cit-lpage">70</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1088/0031-9155/54/7/001</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19265208</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1088/0031-9155/54/7/001&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19265208&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">26.</span><a class="rev-xref-ref" href="#xref-ref-26-1" title="View reference 26. in text" id="ref-26">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.26" data-doi="10.1120/jacmp.v12i1.3306"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Li</span>  <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Xie</span>  <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ning</span>  <span class="cit-name-given-names">H</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Correction of motion-induced misalignment in co-registered PET/CT and MRI (T1/T2/FLAIR) head images for stereotactic radiosurgery</span>. <abbr class="cit-jnl-abbrev">J Appl Clin Med Phys</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">12</span>:<span class="cit-fpage">58</span>–<span class="cit-lpage">67</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1120/jacmp.v12i1.3306</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21330976</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1120/jacmp.v12i1.3306&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21330976&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">27.</span><a class="rev-xref-ref" href="#xref-ref-27-1" title="View reference 27. in text" id="ref-27">↵</a><div class="cit ref-cit ref-journal" id="cit-38.5.973.27" data-doi="10.1097/01.wco.0000194141.56429.3c"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Bechara</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Van Der Linden</span>  <span class="cit-name-given-names">M</span></span></li></ol><cite>. <span class="cit-article-title">Decision-making and impulse control after frontal lobe injuries</span>. <abbr class="cit-jnl-abbrev">Curr Opin Neurol</abbr> <span class="cit-pub-date">2005</span>;<span class="cit-vol">18</span>:<span class="cit-fpage">734</span>–<span class="cit-lpage">39</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1097/01.wco.0000194141.56429.3c</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16280687</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/01.wco.0000194141.56429.3c&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16280687&amp;link_type=MED&amp;atom=%2Fajnr%2F38%2F5%2F973.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000233678800017&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li></ol></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 38</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 5 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 May 2017 </div></div>
      
      
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