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<meta name="DC.Title" content="Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5821" />
<meta name="DC.Date" content="2018-11-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Previous studies indicated that ischemic lesion volume might be a useful surrogate marker for functional outcome in ischemic stroke but should be considered in the context of lesion location. In contrast to previous studies using the ROI approach, which has several drawbacks, the present study aimed to measure the impact of ischemic lesion location on functional outcome using a more precise voxelwise approach.

MATERIALS AND METHODS: Datasets of patients with acute ischemic strokes from the Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) were used. Primary outcome was functional outcome as assessed by the modified Rankin Scale 3 months after stroke. Ischemic lesion volume was determined on CT scans 3–9 days after stroke. Voxel-based lesion-symptom mapping techniques, including covariates that are known to be associated with functional outcome, were used to determine the impact of ischemic lesion location for outcome.

RESULTS: Of the 500 patients in the MR CLEAN trial, 216 were included for analysis. The mean age was 63 years. Lesion-symptom mapping with inclusion of covariates revealed that especially left-hemispheric lesions in the deep periventricular white matter and adjacent internal capsule showed a great influence on functional outcome.

CONCLUSIONS: Our study confirms that infarct location has an important impact on functional outcome of patients with stroke and should be considered in prediction models. After we adjusted for covariates, the left-hemispheric corticosubcortical fiber tracts seemed to be of higher functional importance compared with cortical lesions.

FU-NCCT
:   follow-up noncontrast CT
ILV
:   ischemic lesion volume
VLSM
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<meta name="DC.Contributor" content="M. Ernst" />
<meta name="DC.Contributor" content="A.M.M. Boers" />
<meta name="DC.Contributor" content="N.D. Forkert" />
<meta name="DC.Contributor" content="O.A. Berkhemer" />
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<meta name="DC.Contributor" content="D.W.J. Dippel" />
<meta name="DC.Contributor" content="A. van der Lugt" />
<meta name="DC.Contributor" content="R.J. van Oostenbrugge" />
<meta name="DC.Contributor" content="W.H. van Zwam" />
<meta name="DC.Contributor" content="E. Vettorazzi" />
<meta name="DC.Contributor" content="J. Fiehler" />
<meta name="DC.Contributor" content="H.A. Marquering" />
<meta name="DC.Contributor" content="C.B.L.M. Majoie" />
<meta name="DC.Contributor" content="S. Gellissen" />
<meta name="article:published_time" content="2018-11-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Previous studies indicated that ischemic lesion volume might be a useful surrogate marker for functional outcome in ischemic stroke but should be considered in the context of lesion location. In contrast to previous studies using the ROI approach, which has several drawbacks, the present study aimed to measure the impact of ischemic lesion location on functional outcome using a more precise voxelwise approach.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Datasets of patients with acute ischemic strokes from the Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) were used. Primary outcome was functional outcome as assessed by the modified Rankin Scale 3 months after stroke. Ischemic lesion volume was determined on CT scans 3–9 days after stroke. Voxel-based lesion-symptom mapping techniques, including covariates that are known to be associated with functional outcome, were used to determine the impact of ischemic lesion location for outcome.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Of the 500 patients in the MR CLEAN trial, 216 were included for analysis. The mean age was 63 years. Lesion-symptom mapping with inclusion of covariates revealed that especially left-hemispheric lesions in the deep periventricular white matter and adjacent internal capsule showed a great influence on functional outcome.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Our study confirms that infarct location has an important impact on functional outcome of patients with stroke and should be considered in prediction models. After we adjusted for covariates, the left-hemispheric corticosubcortical fiber tracts seemed to be of higher functional importance compared with cortical lesions.&lt;/p&gt;" />
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<meta name="citation_author" content="A.M.M. Boers" />
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<meta name="twitter:title" content="Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/39/11.cover-source.jpg" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Previous studies indicated that ischemic lesion volume might be a useful surrogate marker for functional outcome in ischemic stroke but should be considered in the context of lesion location. In contrast to previous studies using the ROI approach, which has several drawbacks, the present study aimed to measure the impact of ischemic lesion location on functional outcome using a more precise voxelwise approach.

MATERIALS AND METHODS: Datasets of patients with acute ischemic strokes from the Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) were used. Primary outcome was functional outcome as assessed by the modified Rankin Scale 3 months after stroke. Ischemic lesion volume was determined on CT scans 3–9 days after stroke. Voxel-based lesion-symptom mapping techniques, including covariates that are known to be associated with functional outcome, were used to determine the impact of ischemic lesion location for outcome.

RESULTS: Of the 500 patients in the MR CLEAN trial, 216 were included for analysis. The mean age was 63 years. Lesion-symptom mapping with inclusion of covariates revealed that especially left-hemispheric lesions in the deep periventricular white matter and adjacent internal capsule showed a great influence on functional outcome.

CONCLUSIONS: Our study confirms that infarct location has an important impact on functional outcome of patients with stroke and should be considered in prediction models. After we adjusted for covariates, the left-hemispheric corticosubcortical fiber tracts seemed to be of higher functional importance compared with cortical lesions.

FU-NCCT
:   follow-up noncontrast CT
ILV
:   ischemic lesion volume
VLSM
:   voxel-based lesion-symptom mapping" />
<meta name="og-title" property="og:title" content="Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/39/11/1989" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Previous studies indicated that ischemic lesion volume might be a useful surrogate marker for functional outcome in ischemic stroke but should be considered in the context of lesion location. In contrast to previous studies using the ROI approach, which has several drawbacks, the present study aimed to measure the impact of ischemic lesion location on functional outcome using a more precise voxelwise approach.

MATERIALS AND METHODS: Datasets of patients with acute ischemic strokes from the Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) were used. Primary outcome was functional outcome as assessed by the modified Rankin Scale 3 months after stroke. Ischemic lesion volume was determined on CT scans 3–9 days after stroke. Voxel-based lesion-symptom mapping techniques, including covariates that are known to be associated with functional outcome, were used to determine the impact of ischemic lesion location for outcome.

RESULTS: Of the 500 patients in the MR CLEAN trial, 216 were included for analysis. The mean age was 63 years. Lesion-symptom mapping with inclusion of covariates revealed that especially left-hemispheric lesions in the deep periventricular white matter and adjacent internal capsule showed a great influence on functional outcome.

CONCLUSIONS: Our study confirms that infarct location has an important impact on functional outcome of patients with stroke and should be considered in prediction models. After we adjusted for covariates, the left-hemispheric corticosubcortical fiber tracts seemed to be of higher functional importance compared with cortical lesions.

FU-NCCT
:   follow-up noncontrast CT
ILV
:   ischemic lesion volume
VLSM
:   voxel-based lesion-symptom mapping" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node63891--5" data-node-nid="63891" id="top-node-63891--61131901687" data-pisa="ajnr;39/11/1989" data-pisa-master="ajnr;ajnr.A5821" data-apath="/ajnr/39/11/1989.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Adult Brain</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="ajnr;ajnr.A5821" data-atom-uri="/ajnr/39/11/1989.atom" data-request-view="full"></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">M. Ernst</span>, <span class="highwire-citation-author" data-delta="1">A.M.M. Boers</span>, <span class="highwire-citation-author" data-delta="2">N.D. Forkert</span>, <span class="highwire-citation-author" data-delta="3">O.A. Berkhemer</span>, <span class="highwire-citation-author" data-delta="4">Y.B. Roos</span>, <span class="highwire-citation-author" data-delta="5">D.W.J. Dippel</span>, <span class="highwire-citation-author" data-delta="6">A. van der Lugt</span>, <span class="highwire-citation-author" data-delta="7">R.J. van Oostenbrugge</span>, <span class="highwire-citation-author" data-delta="8">W.H. van Zwam</span>, <span class="highwire-citation-author" data-delta="9">E. Vettorazzi</span>, <span class="highwire-citation-author" data-delta="10">J. Fiehler</span>, <span class="highwire-citation-author" data-delta="11">H.A. Marquering</span>, <span class="highwire-citation-author" data-delta="12">C.B.L.M. Majoie</span> and <span class="highwire-citation-author" data-delta="13">S. Gellissen</span> <span  class="highwire-citation-author last"><span class="nlm-on-behalf-of"><span class="span" data-class="nlm-on-behalf-of">on behalf of the MR CLEAN trial investigators (www.mrclean-trial.org)</span></span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2018,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1989-1994; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5821 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-63891--61131901687" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M. Ernst </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Diagnostic and Interventional Neuroradiology (M.E., J.F., S.G.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BErnst%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ernst%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BErnst%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2870-4109" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Ernst</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A.M.M. Boers </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Radiology and Nuclear Medicine (A.M.M.B., O.A.B., H.A.M., C.B.L.M.M.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Biomedical Engineering and Physics (A.M.M.B., H.A.M.)</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Robotics and Mechatronics (A.M.M.B.), University of Twente, Enschede, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.M.M.%2BBoers%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Boers%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.M.M.%2BBoers%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3950-1561" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.M.M. Boers</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">N.D. Forkert </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Department of Radiology and Hotchkiss Brain Institute (N.D.F.), University of Calgary, Calgary, Alberta, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.D.%2BForkert%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Forkert%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.D.%2BForkert%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2556-3224" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N.D. Forkert</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">O.A. Berkhemer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Radiology and Nuclear Medicine (A.M.M.B., O.A.B., H.A.M., C.B.L.M.M.)</div><div class='author-affiliation'><span class='nlm-sup'>h</span>Departments of Neurology (O.A.B., D.W.J.D.)</div><div class='author-affiliation'><span class='nlm-sup'>l</span>Department of Radiology (O.A.B.), Maastricht University Medical Center, Maastricht, the Netherlands.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=O.A.%2BBerkhemer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Berkhemer%20O&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AO.A.%2BBerkhemer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2212-6128" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for O.A. Berkhemer</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Y.B. Roos </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Neurology (Y.B.R.), Academic Medical Center, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.B.%2BRoos%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Roos%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AY.B.%2BRoos%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9205-5882" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Y.B. Roos</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">D.W.J. Dippel </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Departments of Neurology (O.A.B., D.W.J.D.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.W.J.%2BDippel%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dippel%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.W.J.%2BDippel%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9234-3515" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D.W.J. Dippel</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">A. van der Lugt </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>i</span>Radiology (A.v.d.L.), Erasmus MC University Medical Center, Rotterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2Bvan%2Bder%2BLugt%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20der%20Lugt%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2Bvan%2Bder%2BLugt%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6159-2228" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. van der Lugt</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">R.J. van Oostenbrugge </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>j</span>Department of Neurology (R.J.v.O.), Maastricht University Medical Center and Cardiovascular Research Institute, Maastricht, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.J.%2Bvan%2BOostenbrugge%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20Oostenbrugge%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.J.%2Bvan%2BOostenbrugge%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1032-9099" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R.J. van Oostenbrugge</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">W.H. van Zwam </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>k</span>Department of Radiology and Cardiovascular Research Institute Maastricht (W.H.v.Z.), Maastricht University Medical Center, Maastricht, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.H.%2Bvan%2BZwam%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20Zwam%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.H.%2Bvan%2BZwam%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1631-7056" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W.H. van Zwam</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">E. Vettorazzi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Medical Biometry and Epidemiology (E.V.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BVettorazzi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vettorazzi%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2BVettorazzi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3737-6402" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. Vettorazzi</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">J. Fiehler </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Diagnostic and Interventional Neuroradiology (M.E., J.F., S.G.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BFiehler%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fiehler%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BFiehler%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8533-7478" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Fiehler</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">H.A. Marquering </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Radiology and Nuclear Medicine (A.M.M.B., O.A.B., H.A.M., C.B.L.M.M.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Biomedical Engineering and Physics (A.M.M.B., H.A.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.A.%2BMarquering%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Marquering%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.A.%2BMarquering%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1414-6313" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H.A. Marquering</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">C.B.L.M. Majoie </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Radiology and Nuclear Medicine (A.M.M.B., O.A.B., H.A.M., C.B.L.M.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.B.L.M.%2BMajoie%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Majoie%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.B.L.M.%2BMajoie%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7600-9568" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.B.L.M. Majoie</a></li></ul></div><div class="author-tooltip-13"><div class="author-tooltip-name">S. Gellissen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Diagnostic and Interventional Neuroradiology (M.E., J.F., S.G.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BGellissen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gellissen%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BGellissen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7444-7265" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Gellissen</a></li></ul></div></div></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Ernst</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.M.M.</span> <span class="nlm-surname">Boers</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">N.D.</span> <span class="nlm-surname">Forkert</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">O.A.</span> <span class="nlm-surname">Berkhemer</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Y.B.</span> <span class="nlm-surname">Roos</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">D.W.J.</span> <span class="nlm-surname">Dippel</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">A.</span> <span class="nlm-surname">van der Lugt</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">R.J.</span> <span class="nlm-surname">van Oostenbrugge</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">W.H.</span> <span class="nlm-surname">van Zwam</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Vettorazzi</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Fiehler</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">H.A.</span> <span class="nlm-surname">Marquering</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">C.B.L.M.</span> <span class="nlm-surname">Majoie</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Gellissen</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1989-1994; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5821 </span></div>
  
  
  
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      <div class="highwire-cite-title">Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Ernst</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.M.M.</span> <span class="nlm-surname">Boers</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">N.D.</span> <span class="nlm-surname">Forkert</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">O.A.</span> <span class="nlm-surname">Berkhemer</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Y.B.</span> <span class="nlm-surname">Roos</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">D.W.J.</span> <span class="nlm-surname">Dippel</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">A.</span> <span class="nlm-surname">van der Lugt</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">R.J.</span> <span class="nlm-surname">van Oostenbrugge</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">W.H.</span> <span class="nlm-surname">van Zwam</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Vettorazzi</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Fiehler</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">H.A.</span> <span class="nlm-surname">Marquering</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">C.B.L.M.</span> <span class="nlm-surname">Majoie</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Gellissen</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1989-1994; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5821 </span></div>
  
  
  
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