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<meta name="DC.Title" content="Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5871" />
<meta name="DC.Date" content="2018-12-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Traditional cardiovascular risk factors have been associated with white matter disease. Because hypertension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease.

MATERIALS AND METHODS: This was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adjusting for age, sex, and race and maximal linear regression models adjusting for cardiovascular risk factors were performed for regions meeting the Bonferroni threshold in the initial analysis.

RESULTS: Included were 116 subjects (mean age, 49 ± 11 years; 57% men) with a moderate load of cardiovascular risk factors. Subjects with hypertension had significantly lower regional fractional anisotropy in the right cingulum and left stria terminalis in the minimal and maximal regression models. Additionally, there was lower regional fractional anisotropy in the left fornix in the maximal model and right sagittal stratum in the minimal model. Systolic blood pressure values were significantly associated with regional fractional anisotropy in the left superior longitudinal fasciculus in the maximal model. There were no significant differences among regional fractional anisotropy values for other cardiovascular risk factors.

CONCLUSIONS: In middle-aged apparently healthy individuals with susceptibility to vascular disease, among all known cardiovascular risk factors, hypertension was associated with microstructural WM disruption.

BMI
:   body mass index
BP
:   blood pressure
CSVD
:   cerebral small vessel disease
FA
:   fractional anisotropy
LDL
:   low-density lipoprotein
rFA
:   regional fractional anisotropy" />
<meta name="DC.Contributor" content="Y. Hannawi" />
<meta name="DC.Contributor" content="L.R. Yanek" />
<meta name="DC.Contributor" content="B.G. Kral" />
<meta name="DC.Contributor" content="D. Vaidya" />
<meta name="DC.Contributor" content="L.C. Becker" />
<meta name="DC.Contributor" content="D.M. Becker" />
<meta name="DC.Contributor" content="P.A. Nyquist" />
<meta name="article:published_time" content="2018-12-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Traditional cardiovascular risk factors have been associated with white matter disease. Because hypertension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;This was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adjusting for age, sex, and race and maximal linear regression models adjusting for cardiovascular risk factors were performed for regions meeting the Bonferroni threshold in the initial analysis.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Included were 116 subjects (mean age, 49 ± 11 years; 57% men) with a moderate load of cardiovascular risk factors. Subjects with hypertension had significantly lower regional fractional anisotropy in the right cingulum and left stria terminalis in the minimal and maximal regression models. Additionally, there was lower regional fractional anisotropy in the left fornix in the maximal model and right sagittal stratum in the minimal model. Systolic blood pressure values were significantly associated with regional fractional anisotropy in the left superior longitudinal fasciculus in the maximal model. There were no significant differences among regional fractional anisotropy values for other cardiovascular risk factors.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;In middle-aged apparently healthy individuals with susceptibility to vascular disease, among all known cardiovascular risk factors, hypertension was associated with microstructural WM disruption.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=PLoS One;citation_author=BM. Bettcher;citation_author=CM. Walsh;citation_author=C. Watson;citation_title=Body mass and white matter integrity: the influence of vascular and inflammatory markers;citation_pages=e77741;citation_volume=8;citation_year=2013;citation_pmid=24147070;citation_doi=10.1371/journal.pone.0077741" />
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<meta name="citation_reference" content="citation_journal_title=Int J Hypertens;citation_author=PL. Yau;citation_author=R. Hempel;citation_author=A. Tirsi;citation_title=Cerebral white matter and retinal arterial health in hypertension and type 2 diabetes mellitus;citation_pages=329602;citation_volume=2013;citation_year=2013;citation_pmid=23984047;citation_doi=10.1155/2013/329602" />
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<meta name="citation_reference" content="citation_journal_title=Metab Brain Dis;citation_author=L. van Bloemendaal;citation_author=RG. Ijzerman;citation_author=JS. Ten Kulve;citation_title=Alterations in white matter volume and integrity in obesity and type 2 diabetes;citation_pages=621-29;citation_volume=31;citation_year=2016;citation_pmid=26815786;citation_doi=10.1007/s11011-016-9792-3" />
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<meta name="citation_reference" content="citation_journal_title=Neuroradiology;citation_author=X. Tan;citation_author=P. Fang;citation_author=J. An;citation_title=Micro-structural white matter abnormalities in type 2 diabetic patients: a DTI study using TBSS analysis;citation_pages=1209-16;citation_volume=58;citation_year=2016;citation_pmid=27783100;citation_doi=10.1007/s00234-016-1752-4" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=Y. Xiong;citation_author=Y. Sui;citation_author=Z. Xu;citation_title=A diffusion tensor imaging study on white matter abnormalities in patients with type 2 diabetes using tract-based spatial statistics;citation_volume=37;citation_year=2016;citation_pmid=26988810;citation_doi=10.3174/ajnr.A4740" />
<meta name="citation_reference" content="citation_journal_title=RadioGraphics;citation_journal_abbrev=RadioGraphics;citation_author=AG. Thomas;citation_author=P. Koumellis;citation_author=RA. Dineen;citation_title=The Fornix in Health and Disease: An Imaging Review;citation_pages=1107-1121;citation_volume=31;citation_year=2011;citation_issue=4;citation_pmid=21768242;citation_doi=10.1148/rg.314105729" />
<meta name="citation_reference" content="citation_journal_title=Neurosci Biobehav Rev;citation_author=EJ. Bubb;citation_author=C. Metzler-Baddeley;citation_author=JP. Aggleton;citation_title=The cingulum bundle: anatomy, function, and dysfunction;citation_pages=104-27;citation_volume=92;citation_year=2018;citation_pmid=29753752;citation_doi=10.1016/j.neubiorev.2018.05.008" />
<meta name="citation_reference" content="citation_journal_title=Brain Res;citation_author=KM. Madhavan;citation_author=T. McQueeny;citation_author=SR. Howe;citation_title=Superior longitudinal fasciculus and language functioning in healthy aging;citation_pages=11-22;citation_volume=1562;citation_year=2014;citation_pmid=24680744;citation_doi=10.1016/j.brainres.2014.03.012" />
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<meta name="citation_reference" content="citation_journal_title=Current Hypertens Rep;citation_author=KA. Walker;citation_author=MC. Power;citation_author=RF. Gottesman;citation_title=Defining the relationship between hypertension, cognitive decline, and dementia: a review;citation_pages=24;citation_volume=19;citation_year=2017;citation_pmid=28299725;citation_doi=10.1007/s11906-017-0724-3" />
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<meta name="twitter:title" content="Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Traditional cardiovascular risk factors have been associated with white matter disease. Because hypertension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease.

MATERIALS AND METHODS: This was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adjusting for age, sex, and race and maximal linear regression models adjusting for cardiovascular risk factors were performed for regions meeting the Bonferroni threshold in the initial analysis.

RESULTS: Included were 116 subjects (mean age, 49 ± 11 years; 57% men) with a moderate load of cardiovascular risk factors. Subjects with hypertension had significantly lower regional fractional anisotropy in the right cingulum and left stria terminalis in the minimal and maximal regression models. Additionally, there was lower regional fractional anisotropy in the left fornix in the maximal model and right sagittal stratum in the minimal model. Systolic blood pressure values were significantly associated with regional fractional anisotropy in the left superior longitudinal fasciculus in the maximal model. There were no significant differences among regional fractional anisotropy values for other cardiovascular risk factors.

CONCLUSIONS: In middle-aged apparently healthy individuals with susceptibility to vascular disease, among all known cardiovascular risk factors, hypertension was associated with microstructural WM disruption.

BMI
:   body mass index
BP
:   blood pressure
CSVD
:   cerebral small vessel disease
FA
:   fractional anisotropy
LDL
:   low-density lipoprotein
rFA
:   regional fractional anisotropy" />
<meta name="og-title" property="og:title" content="Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/39/12/2243" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Traditional cardiovascular risk factors have been associated with white matter disease. Because hypertension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease.

MATERIALS AND METHODS: This was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adjusting for age, sex, and race and maximal linear regression models adjusting for cardiovascular risk factors were performed for regions meeting the Bonferroni threshold in the initial analysis.

RESULTS: Included were 116 subjects (mean age, 49 ± 11 years; 57% men) with a moderate load of cardiovascular risk factors. Subjects with hypertension had significantly lower regional fractional anisotropy in the right cingulum and left stria terminalis in the minimal and maximal regression models. Additionally, there was lower regional fractional anisotropy in the left fornix in the maximal model and right sagittal stratum in the minimal model. Systolic blood pressure values were significantly associated with regional fractional anisotropy in the left superior longitudinal fasciculus in the maximal model. There were no significant differences among regional fractional anisotropy values for other cardiovascular risk factors.

CONCLUSIONS: In middle-aged apparently healthy individuals with susceptibility to vascular disease, among all known cardiovascular risk factors, hypertension was associated with microstructural WM disruption.

BMI
:   body mass index
BP
:   blood pressure
CSVD
:   cerebral small vessel disease
FA
:   fractional anisotropy
LDL
:   low-density lipoprotein
rFA
:   regional fractional anisotropy" />
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">December 2018,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2243-2248; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5871 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-64571--6475312575" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Y. 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