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<meta name="DC.Title" content="Value of BRAF V600E in High-Risk Thyroid Nodules with Benign Cytology Results" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5898" />
<meta name="DC.Date" content="2018-12-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Limitations of ultrasound-guided fine-needle aspiration include nondiagnostic, indeterminate cytology and false-negative results. The BRAF V600E mutation is a specific biomarker for papillary thyroid carcinoma. This study aimed to investigate the additional diagnostic role of the BRAF V600E mutation in high-risk thyroid nodules with benign cytology results.

MATERIALS AND METHODS: A total of 787 high-risk nodules in 720 patients underwent ultrasound–fine-needle aspiration. A subsequent BRAF V600E mutation test was performed on thyroid nodules with benign cytology. Final pathology confirmed thyroid nodules with benign cytology that were positive for the BRAF V600E mutation. Ultrasound was performed on thyroid nodules with benign cytology results that were negative for the BRAF V600E mutation. Fine-needle aspiration was repeated on thyroid nodules with enlarged size or changed ultrasound features.

RESULTS: Among the 787 nodules, 292 thyroid nodules had benign cytology results with 256 nodules negative for the BRAF V600E mutation and 36 nodules positive for the BRAF V600E mutation. Thirty-one nodules positive for the BRAF V600E mutation were confirmed malignant, and 5 nodules were confirmed benign by pathology. Fine-needle aspiration was repeated on 11 enlarged thyroid nodules with benign cytology findings that were negative for the BRAF V600E mutation. The results of repeat fine-needle aspiration were 4 benign nodules, 2 follicular neoplasms or suspected follicular neoplasms, 3 suspected malignancies, and 2 malignant nodules. Among the 36 thyroid nodules positive for the BRAF V600E mutation, 25 (69.4%) had ≥2 suspicious ultrasound features and 11 (30.6%) nodules had 1 suspicious ultrasound feature.

CONCLUSIONS: The BRAF V600E mutation test can detect papillary thyroid carcinomas that might be missed by fine-needle aspiration. We recommend that fine-needle aspiration be routinely accompanied by the BRAF V600E mutation test in high-risk thyroid nodules with ≥2 suspicious ultrasound features.

FNA
:   fine-needle aspiration
PCR
:   polymerase chain reaction
PTC
:   papillary thyroid carcinoma
US
:   ultrasound" />
<meta name="DC.Contributor" content="X. Chen" />
<meta name="DC.Contributor" content="Q. Zhou" />
<meta name="DC.Contributor" content="F. Wang" />
<meta name="DC.Contributor" content="F. Zhang" />
<meta name="DC.Contributor" content="H. Du" />
<meta name="DC.Contributor" content="Q. Zhang" />
<meta name="DC.Contributor" content="W. Wu" />
<meta name="DC.Contributor" content="X. Gong" />
<meta name="article:published_time" content="2018-12-01" />
<meta name="article:section" content="Head &amp;amp; Neck" />
<meta name="citation_title" content="Value of BRAF V600E in High-Risk Thyroid Nodules with Benign Cytology Results" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Limitations of ultrasound-guided fine-needle aspiration include nondiagnostic, indeterminate cytology and false-negative results. The &lt;i&gt;BRAF&lt;/i&gt; V600E mutation is a specific biomarker for papillary thyroid carcinoma. This study aimed to investigate the additional diagnostic role of the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation in high-risk thyroid nodules with benign cytology results.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;A total of 787 high-risk nodules in 720 patients underwent ultrasound–fine-needle aspiration. A subsequent &lt;i&gt;BRAF&lt;/i&gt; V600E mutation test was performed on thyroid nodules with benign cytology. Final pathology confirmed thyroid nodules with benign cytology that were positive for the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation. Ultrasound was performed on thyroid nodules with benign cytology results that were negative for the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation. Fine-needle aspiration was repeated on thyroid nodules with enlarged size or changed ultrasound features.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Among the 787 nodules, 292 thyroid nodules had benign cytology results with 256 nodules negative for the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation and 36 nodules positive for the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation. Thirty-one nodules positive for the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation were confirmed malignant, and 5 nodules were confirmed benign by pathology. Fine-needle aspiration was repeated on 11 enlarged thyroid nodules with benign cytology findings that were negative for the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation. The results of repeat fine-needle aspiration were 4 benign nodules, 2 follicular neoplasms or suspected follicular neoplasms, 3 suspected malignancies, and 2 malignant nodules. Among the 36 thyroid nodules positive for the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation, 25 (69.4%) had ≥2 suspicious ultrasound features and 11 (30.6%) nodules had 1 suspicious ultrasound feature.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The &lt;i&gt;BRAF&lt;/i&gt; V600E mutation test can detect papillary thyroid carcinomas that might be missed by fine-needle aspiration. We recommend that fine-needle aspiration be routinely accompanied by the &lt;i&gt;BRAF&lt;/i&gt; V600E mutation test in high-risk thyroid nodules with ≥2 suspicious ultrasound features.&lt;/p&gt;" />
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<meta name="twitter:title" content="Value of BRAF V600E in High-Risk Thyroid Nodules with Benign Cytology Results" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Limitations of ultrasound-guided fine-needle aspiration include nondiagnostic, indeterminate cytology and false-negative results. The BRAF V600E mutation is a specific biomarker for papillary thyroid carcinoma. This study aimed to investigate the additional diagnostic role of the BRAF V600E mutation in high-risk thyroid nodules with benign cytology results.

MATERIALS AND METHODS: A total of 787 high-risk nodules in 720 patients underwent ultrasound–fine-needle aspiration. A subsequent BRAF V600E mutation test was performed on thyroid nodules with benign cytology. Final pathology confirmed thyroid nodules with benign cytology that were positive for the BRAF V600E mutation. Ultrasound was performed on thyroid nodules with benign cytology results that were negative for the BRAF V600E mutation. Fine-needle aspiration was repeated on thyroid nodules with enlarged size or changed ultrasound features.

RESULTS: Among the 787 nodules, 292 thyroid nodules had benign cytology results with 256 nodules negative for the BRAF V600E mutation and 36 nodules positive for the BRAF V600E mutation. Thirty-one nodules positive for the BRAF V600E mutation were confirmed malignant, and 5 nodules were confirmed benign by pathology. Fine-needle aspiration was repeated on 11 enlarged thyroid nodules with benign cytology findings that were negative for the BRAF V600E mutation. The results of repeat fine-needle aspiration were 4 benign nodules, 2 follicular neoplasms or suspected follicular neoplasms, 3 suspected malignancies, and 2 malignant nodules. Among the 36 thyroid nodules positive for the BRAF V600E mutation, 25 (69.4%) had ≥2 suspicious ultrasound features and 11 (30.6%) nodules had 1 suspicious ultrasound feature.

CONCLUSIONS: The BRAF V600E mutation test can detect papillary thyroid carcinomas that might be missed by fine-needle aspiration. We recommend that fine-needle aspiration be routinely accompanied by the BRAF V600E mutation test in high-risk thyroid nodules with ≥2 suspicious ultrasound features.

FNA
:   fine-needle aspiration
PCR
:   polymerase chain reaction
PTC
:   papillary thyroid carcinoma
US
:   ultrasound" />
<meta name="og-title" property="og:title" content="Value of BRAF V600E in High-Risk Thyroid Nodules with Benign Cytology Results" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/39/12/2360" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Limitations of ultrasound-guided fine-needle aspiration include nondiagnostic, indeterminate cytology and false-negative results. The BRAF V600E mutation is a specific biomarker for papillary thyroid carcinoma. This study aimed to investigate the additional diagnostic role of the BRAF V600E mutation in high-risk thyroid nodules with benign cytology results.

MATERIALS AND METHODS: A total of 787 high-risk nodules in 720 patients underwent ultrasound–fine-needle aspiration. A subsequent BRAF V600E mutation test was performed on thyroid nodules with benign cytology. Final pathology confirmed thyroid nodules with benign cytology that were positive for the BRAF V600E mutation. Ultrasound was performed on thyroid nodules with benign cytology results that were negative for the BRAF V600E mutation. Fine-needle aspiration was repeated on thyroid nodules with enlarged size or changed ultrasound features.

RESULTS: Among the 787 nodules, 292 thyroid nodules had benign cytology results with 256 nodules negative for the BRAF V600E mutation and 36 nodules positive for the BRAF V600E mutation. Thirty-one nodules positive for the BRAF V600E mutation were confirmed malignant, and 5 nodules were confirmed benign by pathology. Fine-needle aspiration was repeated on 11 enlarged thyroid nodules with benign cytology findings that were negative for the BRAF V600E mutation. The results of repeat fine-needle aspiration were 4 benign nodules, 2 follicular neoplasms or suspected follicular neoplasms, 3 suspected malignancies, and 2 malignant nodules. Among the 36 thyroid nodules positive for the BRAF V600E mutation, 25 (69.4%) had ≥2 suspicious ultrasound features and 11 (30.6%) nodules had 1 suspicious ultrasound feature.

CONCLUSIONS: The BRAF V600E mutation test can detect papillary thyroid carcinomas that might be missed by fine-needle aspiration. We recommend that fine-needle aspiration be routinely accompanied by the BRAF V600E mutation test in high-risk thyroid nodules with ≥2 suspicious ultrasound features.

FNA
:   fine-needle aspiration
PCR
:   polymerase chain reaction
PTC
:   papillary thyroid carcinoma
US
:   ultrasound" />
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">X. Chen</span>, <span class="highwire-citation-author" data-delta="1">Q. Zhou</span>, <span class="highwire-citation-author" data-delta="2">F. Wang</span>, <span class="highwire-citation-author" data-delta="3">F. Zhang</span>, <span class="highwire-citation-author" data-delta="4">H. Du</span>, <span class="highwire-citation-author" data-delta="5">Q. Zhang</span>, <span class="highwire-citation-author" data-delta="6">W. Wu</span> and <span class="highwire-citation-author" data-delta="7">X. Gong</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">December 2018,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2360-2365; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5898 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-64709--61316309468" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">X. Chen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Endocrinology and Metabolism (X.C., Q. Zhou, W.W., X.G.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=X.%2BChen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chen%20X&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AX.%2BChen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0021-7483" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for X. Chen</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Q. Zhou </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Endocrinology and Metabolism (X.C., Q. Zhou, W.W., X.G.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Q.%2BZhou%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhou%20Q&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AQ.%2BZhou%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5653-160X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Q. Zhou</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">F. Wang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Pathology (F.W., Q. Zhang)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BWang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wang%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BWang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4829-2164" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. Wang</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">F. Zhang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Medicine (F.Z.), School of Renji College, Wenzhou Medical University, Wenzhou, China.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BZhang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhang%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BZhang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4806-1972" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. Zhang</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">H. Du </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Ultrasound (H.D.), The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BDu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Du%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.%2BDu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7000-0845" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H. Du</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">Q. Zhang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Pathology (F.W., Q. Zhang)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Q.%2BZhang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhang%20Q&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AQ.%2BZhang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3337-3842" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Q. Zhang</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">W. Wu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Endocrinology and Metabolism (X.C., Q. Zhou, W.W., X.G.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.%2BWu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wu%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.%2BWu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6502-4893" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W. Wu</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">X. Gong </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Endocrinology and Metabolism (X.C., Q. Zhou, W.W., X.G.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=X.%2BGong%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gong%20X&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AX.%2BGong%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9376-0126" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for X. Gong</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-39.12.2360.1" data-doi="10.1089/thy.2009.1608"><div class="cit-metadata"><ol class="cit-auth-list"><li>
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</li><li><span class="cit-auth"><span class="cit-name-surname">Haugen</span>  <span class="cit-name-given-names">BR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Alexander</span>  <span class="cit-name-given-names">EK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bible</span>  <span class="cit-name-given-names">KC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">2015 American Thyroid Association Management</span>. <abbr class="cit-jnl-abbrev">Thyroid</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">26</span>:<span class="cit-fpage">1</span>–<span class="cit-lpage">133</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1089/thy.2015.0020</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26462967</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1089/thy.2015.0020&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26462967&amp;link_type=MED&amp;atom=%2Fajnr%2F39%2F12%2F2360.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">4.</span><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4. in text" id="ref-4">↵</a><div class="cit ref-cit ref-journal" id="cit-39.12.2360.4" data-doi="10.1245/s10434-011-1605-7"><div class="cit-metadata"><ol class="cit-auth-list"><li>
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</li><li><span class="cit-auth"><span class="cit-name-surname">Huang</span>  <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Zhuge</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Zhang</span>  <span class="cit-name-given-names">WW</span></span></li></ol><cite>. <span class="cit-article-title">Sensitive detection of BRAF V600E mutation by Amplification Refractory Mutation System (ARMS)-PCR</span>. <abbr class="cit-jnl-abbrev">Biomarker Res</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">1</span>:<span class="cit-fpage">3</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1186/2050-7771-1-3</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24252159</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1186/2050-7771-1-3&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24252159&amp;link_type=MED&amp;atom=%2Fajnr%2F39%2F12%2F2360.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">26.</span><a class="rev-xref-ref" href="#xref-ref-26-1" title="View reference 26. in text" id="ref-26">↵</a><div class="cit ref-cit ref-journal" id="cit-39.12.2360.26" data-doi="10.4158/EP13294.CR"><div class="cit-metadata"><ol class="cit-auth-list"><li>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 39</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 12 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Dec 2018 </div></div>
      
      
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      <div class="highwire-cite-title">Value of <em>BRAF</em> V600E in High-Risk Thyroid Nodules with Benign Cytology Results</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">X.</span> <span class="nlm-surname">Chen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Q.</span> <span class="nlm-surname">Zhou</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Du</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Q.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Wu</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">X.</span> <span class="nlm-surname">Gong</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Dec 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2360-2365; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5898 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">X.</span> <span class="nlm-surname">Chen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Q.</span> <span class="nlm-surname">Zhou</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Du</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Q.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Wu</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">X.</span> <span class="nlm-surname">Gong</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Dec 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2360-2365; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5898 </span></div>
  
  
  
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