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<meta name="twitter:title" content="Fast and Robust Unsupervised Identification of MS Lesion Change Using the Statistical Detection of Changes Algorithm" />
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<meta name="twitter:description" content="SUMMARY: We developed a robust automated algorithm called statistical detection of changes for detecting morphologic changes of multiple sclerosis lesions between 2 T2-weighted FLAIR brain images. Results from 30 patients showed that statistical detection of changes achieved significantly higher sensitivity and specificity (0.964, 95% CI, 0.823–0.994; 0.691, 95% CI, 0.612–0.761) than with the lesion-prediction algorithm (0.614, 95% CI, 0.410–0.784; 0.281, 95% CI, 0.228–0.314), while resulting in a 49% reduction in human review time ( P = .007).

LPA
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SDC
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<meta name="og-description" property="og:description" content="SUMMARY: We developed a robust automated algorithm called statistical detection of changes for detecting morphologic changes of multiple sclerosis lesions between 2 T2-weighted FLAIR brain images. Results from 30 patients showed that statistical detection of changes achieved significantly higher sensitivity and specificity (0.964, 95% CI, 0.823–0.994; 0.691, 95% CI, 0.612–0.761) than with the lesion-prediction algorithm (0.614, 95% CI, 0.410–0.784; 0.281, 95% CI, 0.228–0.314), while resulting in a 49% reduction in human review time ( P = .007).

LPA
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SDC
:   statistical detection of changes" />
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      <h1 class="highwire-cite-title" id="page-title">Fast and Robust Unsupervised Identification of MS Lesion Change Using the Statistical Detection of Changes Algorithm</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">T.D. Nguyen</span>, <span class="highwire-citation-author" data-delta="1">S. Zhang</span>, <span class="highwire-citation-author" data-delta="2">A. Gupta</span>, <span class="highwire-citation-author" data-delta="3">Y. Zhao</span>, <span class="highwire-citation-author" data-delta="4">S.A. Gauthier</span> and <span class="highwire-citation-author" data-delta="5">Y. Wang</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2018,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">830-833; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5594 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-60869--6128136631" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">T.D. Nguyen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (T.D.N., S.Z., A.G., Y.W.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.D.%2BNguyen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nguyen%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AT.D.%2BNguyen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1411-7694" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for T.D. Nguyen</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">S. Zhang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (T.D.N., S.Z., A.G., Y.W.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BZhang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhang%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BZhang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0001-1880" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Zhang</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A. Gupta </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (T.D.N., S.Z., A.G., Y.W.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Feil Family Brain and Mind Research Institute (A.G., S.A.G.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BGupta%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gupta%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BGupta%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2816-0340" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Gupta</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Y. Zhao </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Healthcare Policy and Research (Y.Z.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.%2BZhao%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhao%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AY.%2BZhao%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6283-2302" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Y. 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Gauthier </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Feil Family Brain and Mind Research Institute (A.G., S.A.G.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Neurology (S.A.G.), Weill Cornell Medicine, New York, New York.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.A.%2BGauthier%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gauthier%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.A.%2BGauthier%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4015-1781" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.A. Gauthier</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">Y. Wang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (T.D.N., S.Z., A.G., Y.W.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.%2BWang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wang%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AY.%2BWang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1404-8526" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Y. 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      <div class="highwire-cite-title">Fast and Robust Unsupervised Identification of MS Lesion Change Using the Statistical Detection of Changes Algorithm</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">T.D.</span> <span class="nlm-surname">Nguyen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Gupta</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Zhao</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">S.A.</span> <span class="nlm-surname">Gauthier</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Wang</span></span></span></div>
  
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      <div class="highwire-cite-title">Fast and Robust Unsupervised Identification of MS Lesion Change Using the Statistical Detection of Changes Algorithm</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">T.D.</span> <span class="nlm-surname">Nguyen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Gupta</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Zhao</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">S.A.</span> <span class="nlm-surname">Gauthier</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Wang</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">830-833; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5594 </span></div>
  
  
  
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