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<meta name="DC.Title" content="European Multicenter Study for the Evaluation of a Dual-Layer Flow-Diverting Stent for Treatment of Wide-Neck Intracranial Aneurysms: The European Flow-Redirection Intraluminal Device Study" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5592" />
<meta name="DC.Date" content="2018-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2018 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Endoluminal reconstruction with flow-diverting stents represents a widely accepted technique for the treatment of complex intracranial aneurysms. This European registry study analyzed the initial experience of 15 neurovascular centers with the Flow-Redirection Intraluminal Device (FRED) system.

MATERIALS AND METHODS: Consecutive patients with intracranial aneurysms treated with the FRED between February 2012 and March 2015 were retrospectively reviewed. Complications and adverse events, transient and permanent morbidity, mortality, and occlusion rates were evaluated.

RESULTS: During the defined study period, 579 aneurysms in 531 patients (median age, 54 years; range, 13–86 years) were treated with the FRED. Seven percent of patients were treated in the acute phase (≤3 days) of aneurysm rupture. The median aneurysm size was 7.6 mm (range, 1–36.6 mm), and the median neck size 4.5 mm (range, 1–30 mm). Angiographic follow-up of &gt;3 months was available for 516 (89.1%) aneurysms. There was progressive occlusion witnessed with time, with complete occlusion in 18 (20%) aneurysms followed for up to 90 ± 14 days, 141 (82.5%) for 180 ± 20 days, 116 (91.3%) for 1 year ± 24 days, and 122 (95.3%) aneurysms followed for &gt;1 year. Transient and permanent morbidity occurred in 3.2% and 0.8% of procedures, respectively. The overall mortality rate was 1.5%.

CONCLUSIONS: This retrospective study in real-world patients demonstrated the safety and efficacy of the FRED for the treatment of intracranial aneurysms. In most cases, treatment with a single FRED resulted in complete angiographic occlusion at 1 year.

ASPIRe
:   Aneurysm Study of Pipeline in an Observational Registry
EuFRED
:   European Flow-Redirection Intraluminal Device Study
FRED
:   Flow-Redirection Intraluminal Device
PUFS
:   Pipeline for Uncoilable or Failed Aneurysms Study" />
<meta name="DC.Contributor" content="M. Killer-Oberpfalzer" />
<meta name="DC.Contributor" content="N. Kocer" />
<meta name="DC.Contributor" content="C.J. Griessenauer" />
<meta name="DC.Contributor" content="H. Janssen" />
<meta name="DC.Contributor" content="T. Engelhorn" />
<meta name="DC.Contributor" content="M. Holtmannspötter" />
<meta name="DC.Contributor" content="J.H. Buhk" />
<meta name="DC.Contributor" content="T. Finkenzeller" />
<meta name="DC.Contributor" content="G. Fesl" />
<meta name="DC.Contributor" content="J. Trenkler" />
<meta name="DC.Contributor" content="W. Reith" />
<meta name="DC.Contributor" content="A. Berlis" />
<meta name="DC.Contributor" content="K. Hausegger" />
<meta name="DC.Contributor" content="M. Augustin" />
<meta name="DC.Contributor" content="C. Islak" />
<meta name="DC.Contributor" content="B. Minnich" />
<meta name="DC.Contributor" content="M. Möhlenbruch" />
<meta name="article:published_time" content="2018-05-01" />
<meta name="article:section" content="Interventional" />
<meta name="citation_title" content="European Multicenter Study for the Evaluation of a Dual-Layer Flow-Diverting Stent for Treatment of Wide-Neck Intracranial Aneurysms: The European Flow-Redirection Intraluminal Device Study" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Endoluminal reconstruction with flow-diverting stents represents a widely accepted technique for the treatment of complex intracranial aneurysms. This European registry study analyzed the initial experience of 15 neurovascular centers with the Flow-Redirection Intraluminal Device (FRED) system.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Consecutive patients with intracranial aneurysms treated with the FRED between February 2012 and March 2015 were retrospectively reviewed. Complications and adverse events, transient and permanent morbidity, mortality, and occlusion rates were evaluated.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;During the defined study period, 579 aneurysms in 531 patients (median age, 54 years; range, 13–86 years) were treated with the FRED. Seven percent of patients were treated in the acute phase (≤3 days) of aneurysm rupture. The median aneurysm size was 7.6 mm (range, 1–36.6 mm), and the median neck size 4.5 mm (range, 1–30 mm). Angiographic follow-up of &amp;gt;3 months was available for 516 (89.1%) aneurysms. There was progressive occlusion witnessed with time, with complete occlusion in 18 (20%) aneurysms followed for up to 90 ± 14 days, 141 (82.5%) for 180 ± 20 days, 116 (91.3%) for 1 year ± 24 days, and 122 (95.3%) aneurysms followed for &amp;gt;1 year. Transient and permanent morbidity occurred in 3.2% and 0.8% of procedures, respectively. The overall mortality rate was 1.5%.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;This retrospective study in real-world patients demonstrated the safety and efficacy of the FRED for the treatment of intracranial aneurysms. In most cases, treatment with a single FRED resulted in complete angiographic occlusion at 1 year.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2018/05/01" />
<meta name="citation_mjid" content="ajnr;39/5/841" />
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<meta name="citation_issn" content="0195-6108" />
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<meta name="citation_firstpage" content="841" />
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<meta name="citation_author" content="M. Killer-Oberpfalzer" />
<meta name="citation_author_institution" content="aFrom the Research Institute of Neurointervention/Department of Neurology (M.K.-O., C.J.G.), Paracelsus Medical University, Salzburg, Austria" />
<meta name="citation_author_orcid" content="https://orcid.org/0000-0001-5572-7694" />
<meta name="citation_author" content="N. Kocer" />
<meta name="citation_author_institution" content="bDepartment of Neuroradiology (N.K., C.I.), Cerrahpasa Medical School, Istanbul University, Turkey" />
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<meta name="citation_author" content="C.J. Griessenauer" />
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<meta name="citation_reference" content="citation_journal_title=Radiology;citation_author=T. Becske;citation_author=DF. Kallmes;citation_author=I. Saatci;citation_title=Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial;citation_volume=267;citation_year=2013;citation_pmid=23418004;citation_doi=10.1148/radiol.13120099" />
<meta name="citation_reference" content="citation_journal_title=Neurosurg Focus;citation_author=F. Briganti;citation_author=G. Leone;citation_author=L. Cirillo;citation_title=Postprocedural, midterm, and long-term results of cerebral aneurysms treated with flow-diverter devices: 7-year experience at a single center;citation_pages=E3;citation_volume=42;citation_year=2017;citation_pmid=28565988;citation_doi=10.3171/2017.3.FOCUS1732" />
<meta name="citation_reference" content="Pivotal Study of the FRED Stent System in the Treatment of Intracranial Aneurysms. ClinicalTrials.gov. https://www.clinicaltrials.gov/ct2/show/NCT01801007?term=FRED&amp;cond=Aneurysm&amp;rank=1. Accessed December 18, 2017" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=H. Luecking;citation_author=T. Engelhorn;citation_author=S. Lang;citation_title=FRED flow diverter: a study on safety and efficacy in a consecutive group of 50 patients;citation_volume=38;citation_year=2017;citation_pmid=28104636;citation_doi=10.3174/ajnr.A5052" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=MA. Möhlenbruch;citation_author=C. Herweh;citation_author=L. Jestaedt;citation_title=The FRED flow-diverter stent for intracranial aneurysms: clinical study to assess safety and efficacy;citation_volume=36;citation_year=2015;citation_pmid=25721079;citation_doi=10.3174/ajnr.A4251" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=F. Drescher;citation_author=W. Weber;citation_author=A. Berlis;citation_title=Treatment of intra- and extracranial aneurysms using the Flow-Redirection Endoluminal Device: multicenter experience and follow-up results;citation_volume=38;citation_year=2017;citation_pmid=27811135;citation_doi=10.3174/ajnr.A4964" />
<meta name="citation_reference" content="citation_journal_title=Interventional Neuroradiology;citation_journal_abbrev=Interv Neuroradiol;citation_author=CJ. O'Kelly;citation_author=T. Krings;citation_author=D. Fiorella;citation_title=A Novel Grading Scale for the Angiographic Assessment of Intracranial Aneurysms Treated Using Flow Diverting Stents;citation_pages=133-137;citation_volume=16;citation_year=2010;citation_issue=2;citation_pmid=20642887;citation_doi=10.1177/159101991001600204" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=CJ. Griessenauer;citation_author=R. Gupta;citation_author=S. Shi;citation_title=Collar sign in incompletely occluded aneurysms after Pipeline embolization: evaluation with angiography and optical coherence tomography;citation_volume=38;citation_year=2017;citation_pmid=28056454;citation_doi=10.3174/ajnr.A5010" />
<meta name="citation_reference" content="citation_journal_title=J Neurointerv Surg;citation_author=KM. Fargen;citation_author=HE. Soriano-Baron;citation_author=JT. Rushing;citation_title=A survey of intracranial aneurysm treatment practices among United States physicians;citation_volume=10;citation_year=2018;citation_pmid=28184003;citation_doi=10.1136/neurintsurg-2016-012808" />
<meta name="citation_reference" content="citation_journal_title=J Neurointerv Surg;citation_author=G. Dabus;citation_author=JA. Grossberg;citation_author=CM. Cawley;citation_title=Treatment of complex anterior cerebral artery aneurysms with Pipeline flow diversion: mid-term results;citation_volume=9;citation_year=2017;citation_pmid=27382125;citation_doi=10.1136/neurintsurg-2016-012519" />
<meta name="citation_reference" content="citation_journal_title=Clin Neuroradiol;citation_author=P. Bhogal;citation_author=R. Martinez;citation_author=O. Gansladt;citation_title=Management of unruptured saccular aneurysms of the M1 segment with flow diversion: a single centre experience;citation_year=2016;citation_pmid=27942770;citation_doi=10.1007/s00062-016-0553-9" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_author=DK. Lopes;citation_author=DK. Jang;citation_author=S. Cekirge;citation_title=Morbidity and mortality in patients with posterior circulation aneurysms treated with the Pipeline embolization device: a subgroup analysis of the international retrospective study of the Pipeline embolization device;citation_year=2017;citation_pmid=28945879;citation_doi=10.1093/neuros/nyx467" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=W. Brinjikji;citation_author=HJ. Cloft;citation_author=DF. Kallmes;citation_title=Difficult aneurysms for endovascular treatment: overwide or undertall?;citation_volume=30;citation_year=2009;citation_pmid=19461057;citation_doi=10.3174/ajnr.A1633" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_author=N. Chalouhi;citation_author=B. Daou;citation_author=G. Barros;citation_title=Matched comparison of flow diversion and coiling in small, noncomplex intracranial aneurysms;citation_pages=92-97;citation_volume=81;citation_year=2017;citation_pmid=28402491;citation_doi=10.1093/neuros/nyw070" />
<meta name="citation_reference" content="citation_journal_title=Neurocrit Care;citation_author=BP. Walcott;citation_author=MJ. Koch;citation_author=CJ. Stapleton;citation_title=Blood flow diversion as a primary treatment method for ruptured brain aneurysms: concerns, controversy, and future directions;citation_pages=465-73;citation_volume=26;citation_year=2017;citation_pmid=27844465;citation_doi=10.1007/s12028-016-0318-y" />
<meta name="citation_reference" content="citation_journal_title=J Neurosurg;citation_author=T. Becske;citation_author=MB. Potts;citation_author=M. Shapiro;citation_title=Pipeline for uncoilable or failed aneurysms: 3-year follow-up results;citation_pages=81-88;citation_volume=127;citation_year=2017;citation_pmid=27739944;citation_doi=10.3171/2015.6.JNS15311" />
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<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=N. Adeeb;citation_author=JM. Moore;citation_author=M. Wirtz;citation_title=Predictors of incomplete occlusion following Pipeline embolization of intracranial aneurysms: is it less effective in older patients?;citation_volume=38;citation_year=2017;citation_pmid=28912285;citation_doi=10.3174/ajnr.A5375" />
<meta name="citation_reference" content="citation_journal_title=Interv Neurol;citation_author=DF. Kallmes;citation_author=W. Brinjikji;citation_author=E. Boccardi;citation_title=Aneurysm Study of Pipeline in an Observational Registry (ASPIRe);citation_pages=89-99;citation_volume=5;citation_year=2016;citation_pmid=27610126;citation_doi=10.1159/000446503" />
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<meta name="twitter:title" content="European Multicenter Study for the Evaluation of a Dual-Layer Flow-Diverting Stent for Treatment of Wide-Neck Intracranial Aneurysms: The European Flow-Redirection Intraluminal Device Study" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Endoluminal reconstruction with flow-diverting stents represents a widely accepted technique for the treatment of complex intracranial aneurysms. This European registry study analyzed the initial experience of 15 neurovascular centers with the Flow-Redirection Intraluminal Device (FRED) system.

MATERIALS AND METHODS: Consecutive patients with intracranial aneurysms treated with the FRED between February 2012 and March 2015 were retrospectively reviewed. Complications and adverse events, transient and permanent morbidity, mortality, and occlusion rates were evaluated.

RESULTS: During the defined study period, 579 aneurysms in 531 patients (median age, 54 years; range, 13–86 years) were treated with the FRED. Seven percent of patients were treated in the acute phase (≤3 days) of aneurysm rupture. The median aneurysm size was 7.6 mm (range, 1–36.6 mm), and the median neck size 4.5 mm (range, 1–30 mm). Angiographic follow-up of &gt;3 months was available for 516 (89.1%) aneurysms. There was progressive occlusion witnessed with time, with complete occlusion in 18 (20%) aneurysms followed for up to 90 ± 14 days, 141 (82.5%) for 180 ± 20 days, 116 (91.3%) for 1 year ± 24 days, and 122 (95.3%) aneurysms followed for &gt;1 year. Transient and permanent morbidity occurred in 3.2% and 0.8% of procedures, respectively. The overall mortality rate was 1.5%.

CONCLUSIONS: This retrospective study in real-world patients demonstrated the safety and efficacy of the FRED for the treatment of intracranial aneurysms. In most cases, treatment with a single FRED resulted in complete angiographic occlusion at 1 year.

ASPIRe
:   Aneurysm Study of Pipeline in an Observational Registry
EuFRED
:   European Flow-Redirection Intraluminal Device Study
FRED
:   Flow-Redirection Intraluminal Device
PUFS
:   Pipeline for Uncoilable or Failed Aneurysms Study" />
<meta name="og-title" property="og:title" content="European Multicenter Study for the Evaluation of a Dual-Layer Flow-Diverting Stent for Treatment of Wide-Neck Intracranial Aneurysms: The European Flow-Redirection Intraluminal Device Study" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/39/5/841" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Endoluminal reconstruction with flow-diverting stents represents a widely accepted technique for the treatment of complex intracranial aneurysms. This European registry study analyzed the initial experience of 15 neurovascular centers with the Flow-Redirection Intraluminal Device (FRED) system.

MATERIALS AND METHODS: Consecutive patients with intracranial aneurysms treated with the FRED between February 2012 and March 2015 were retrospectively reviewed. Complications and adverse events, transient and permanent morbidity, mortality, and occlusion rates were evaluated.

RESULTS: During the defined study period, 579 aneurysms in 531 patients (median age, 54 years; range, 13–86 years) were treated with the FRED. Seven percent of patients were treated in the acute phase (≤3 days) of aneurysm rupture. The median aneurysm size was 7.6 mm (range, 1–36.6 mm), and the median neck size 4.5 mm (range, 1–30 mm). Angiographic follow-up of &gt;3 months was available for 516 (89.1%) aneurysms. There was progressive occlusion witnessed with time, with complete occlusion in 18 (20%) aneurysms followed for up to 90 ± 14 days, 141 (82.5%) for 180 ± 20 days, 116 (91.3%) for 1 year ± 24 days, and 122 (95.3%) aneurysms followed for &gt;1 year. Transient and permanent morbidity occurred in 3.2% and 0.8% of procedures, respectively. The overall mortality rate was 1.5%.

CONCLUSIONS: This retrospective study in real-world patients demonstrated the safety and efficacy of the FRED for the treatment of intracranial aneurysms. In most cases, treatment with a single FRED resulted in complete angiographic occlusion at 1 year.

ASPIRe
:   Aneurysm Study of Pipeline in an Observational Registry
EuFRED
:   European Flow-Redirection Intraluminal Device Study
FRED
:   Flow-Redirection Intraluminal Device
PUFS
:   Pipeline for Uncoilable or Failed Aneurysms Study" />
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    <title>European Multicenter Study for the Evaluation of a Dual-Layer Flow-Diverting Stent for Treatment of Wide-Neck Intracranial Aneurysms: The European Flow-Redirection Intraluminal Device Study | American Journal of Neuroradiology</title>  
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node60855--5" data-node-nid="60855" id="top-node-60855--6367110689" data-pisa="ajnr;39/5/841" data-pisa-master="ajnr;ajnr.A5592" data-apath="/ajnr/39/5/841.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Interventional</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">European Multicenter Study for the Evaluation of a Dual-Layer Flow-Diverting Stent for Treatment of Wide-Neck Intracranial Aneurysms: The European Flow-Redirection Intraluminal Device Study</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">M. Killer-Oberpfalzer</span>, <span class="highwire-citation-author" data-delta="1">N. Kocer</span>, <span class="highwire-citation-author" data-delta="2">C.J. Griessenauer</span>, <span class="highwire-citation-author" data-delta="3">H. Janssen</span>, <span class="highwire-citation-author" data-delta="4">T. Engelhorn</span>, <span class="highwire-citation-author" data-delta="5">M. Holtmannspötter</span>, <span class="highwire-citation-author" data-delta="6">J.H. Buhk</span>, <span class="highwire-citation-author" data-delta="7">T. Finkenzeller</span>, <span class="highwire-citation-author" data-delta="8">G. Fesl</span>, <span class="highwire-citation-author" data-delta="9">J. Trenkler</span>, <span class="highwire-citation-author" data-delta="10">W. Reith</span>, <span class="highwire-citation-author" data-delta="11">A. Berlis</span>, <span class="highwire-citation-author" data-delta="12">K. Hausegger</span>, <span class="highwire-citation-author" data-delta="13">M. Augustin</span>, <span class="highwire-citation-author" data-delta="14">C. Islak</span>, <span class="highwire-citation-author" data-delta="15">B. Minnich</span> and <span class="highwire-citation-author" data-delta="16">M. Möhlenbruch</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2018,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">841-847; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5592 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-60855--6367110689" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M. Killer-Oberpfalzer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Research Institute of Neurointervention/Department of Neurology (M.K.-O., C.J.G.), Paracelsus Medical University, Salzburg, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BKiller-Oberpfalzer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Killer-Oberpfalzer%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BKiller-Oberpfalzer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5572-7694" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Killer-Oberpfalzer</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">N. Kocer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neuroradiology (N.K., C.I.), Cerrahpasa Medical School, Istanbul University, Turkey</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BKocer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kocer%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BKocer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0884-6492" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Kocer</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">C.J. Griessenauer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Research Institute of Neurointervention/Department of Neurology (M.K.-O., C.J.G.), Paracelsus Medical University, Salzburg, Austria</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurosurgery (C.J.G.), Geisinger Health, Danville, Pennsylvania</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.J.%2BGriessenauer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Griessenauer%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.J.%2BGriessenauer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2952-3812" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.J. Griessenauer</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">H. Janssen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Institute of Radiology and Neuroradiology (H.J., T.F.), Klinikum Nuernberg Sued, Paracelsus Medical University, Nuernberg, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BJanssen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Janssen%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.%2BJanssen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5903-1280" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H. Janssen</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">T. Engelhorn </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Neuroradiology (T.E.), University Hospital, Erlangen, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.%2BEngelhorn%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Engelhorn%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AT.%2BEngelhorn%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-7341-3584" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for T. Engelhorn</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">M. Holtmannspötter </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Diagnostic Radiology (M.H.), Rigshospitalet, Copenhagen, Denmark</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BHoltmannsp%C3%B6tter%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Holtmannsp%C3%B6tter%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BHoltmannsp%25C3%25B6tter%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2536-5244" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Holtmannspötter</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">J.H. Buhk </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Department of Neuroradiology (J.H.B.), University Hospital Hamburg, Eppendorf, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.H.%2BBuhk%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Buhk%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.H.%2BBuhk%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-8003-6446" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.H. Buhk</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">T. Finkenzeller </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Institute of Radiology and Neuroradiology (H.J., T.F.), Klinikum Nuernberg Sued, Paracelsus Medical University, Nuernberg, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.%2BFinkenzeller%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Finkenzeller%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AT.%2BFinkenzeller%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9637-9497" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for T. Finkenzeller</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">G. Fesl </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Department of Neuroradiology (G.F.), Klinikum Grosshadern, University of Munich, Munich, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BFesl%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fesl%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BFesl%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6357-6694" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. Fesl</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">J. Trenkler </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>i</span>Department of Neuroradiology (J.T.), Kepler Universitätsklinikum, Linz, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BTrenkler%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Trenkler%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BTrenkler%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6060-4234" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Trenkler</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">W. Reith </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>j</span>Klinik für Diagnostische und Interventionelle Neuroradiologie (W.R.), Universitätsklinikum des Saarlandes, Homburg/Saar, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.%2BReith%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Reith%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.%2BReith%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8373-4090" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W. Reith</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">A. Berlis </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>k</span>Klinik für Diagnostische Radiologie und Neuroradiologie (A.B.), Klinikum Augsburg, Augsburg, Germany</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BBerlis%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Berlis%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BBerlis%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5321-5118" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Berlis</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">K. Hausegger </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>l</span>Department of Diagnostic and Interventional Radiology (K.H.), Klinikum Klagenfurt, Klagenfurt, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.%2BHausegger%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hausegger%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AK.%2BHausegger%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4108-4071" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for K. Hausegger</a></li></ul></div><div class="author-tooltip-13"><div class="author-tooltip-name">M. Augustin </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>m</span>Department of Radiology (M.A.), University Hospital, Graz, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BAugustin%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Augustin%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BAugustin%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1301-0764" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Augustin</a></li></ul></div><div class="author-tooltip-14"><div class="author-tooltip-name">C. Islak </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neuroradiology (N.K., C.I.), Cerrahpasa Medical School, Istanbul University, Turkey</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BIslak%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Islak%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BIslak%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3626-6244" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. Islak</a></li></ul></div><div class="author-tooltip-15"><div class="author-tooltip-name">B. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 39</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 5 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 May 2018 </div></div>
      
      
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Killer-Oberpfalzer</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Kocer</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">C.J.</span> <span class="nlm-surname">Griessenauer</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Janssen</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Engelhorn</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Holtmannspötter</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Buhk</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Finkenzeller</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Fesl</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Trenkler</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Reith</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Berlis</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Hausegger</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Augustin</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Islak</span></span>, <span class="highwire-citation-author" data-delta="15"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Minnich</span></span>, <span class="highwire-citation-author" data-delta="16"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Möhlenbruch</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">841-847; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5592 </span></div>
  
  
  
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      <div class="highwire-cite-title">European Multicenter Study for the Evaluation of a Dual-Layer Flow-Diverting Stent for Treatment of Wide-Neck Intracranial Aneurysms: The European Flow-Redirection Intraluminal Device Study</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Killer-Oberpfalzer</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Kocer</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">C.J.</span> <span class="nlm-surname">Griessenauer</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Janssen</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Engelhorn</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Holtmannspötter</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Buhk</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Finkenzeller</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Fesl</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Trenkler</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Reith</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Berlis</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Hausegger</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Augustin</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Islak</span></span>, <span class="highwire-citation-author" data-delta="15"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Minnich</span></span>, <span class="highwire-citation-author" data-delta="16"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Möhlenbruch</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">841-847; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5592 </span></div>
  
  
  
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