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<meta name="DC.Title" content="Edge Contrast of the FLAIR Hyperintense Region Predicts Survival in Patients with High-Grade Gliomas following Treatment with Bevacizumab" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5620" />
<meta name="DC.Date" content="2018-06-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Treatment with bevacizumab is standard of care for recurrent high-grade gliomas; however, monitoring response to treatment following bevacizumab remains a challenge. The purpose of this study was to determine whether quantifying the sharpness of the fluid-attenuated inversion recovery hyperintense border using a measure derived from texture analysis—edge contrast—improves the evaluation of response to bevacizumab in patients with high-grade gliomas.

MATERIALS AND METHODS: MRIs were evaluated in 33 patients with high-grade gliomas before and after the initiation of bevacizumab. Volumes of interest within the FLAIR hyperintense region were segmented. Edge contrast magnitude for each VOI was extracted using gradients of the 3D FLAIR images. Cox proportional hazards models were generated to determine the relationship between edge contrast and progression-free survival/overall survival using age and the extent of surgical resection as covariates.

RESULTS: After bevacizumab, lower edge contrast of the FLAIR hyperintense region was associated with poorer progression-free survival ( P = .009) and overall survival ( P = .022) among patients with high-grade gliomas. Kaplan-Meier curves revealed that edge contrast cutoff significantly stratified patients for both progression-free survival (log-rank χ2 = 8.3, P = .003) and overall survival (log-rank χ2 = 5.5, P = .019).

CONCLUSIONS: Texture analysis using edge contrast of the FLAIR hyperintense region may be an important predictive indicator in patients with high-grade gliomas following treatment with bevacizumab. Specifically, low FLAIR edge contrast may partially reflect areas of early tumor infiltration. This study adds to a growing body of literature proposing that quantifying features may be important for determining outcomes in patients with high-grade gliomas.

EC
:   edge contrast
GBM
:   glioblastoma
GTR
:   gross total resection
HGG
:   high-grade glioma
MSRS
:   Maximally Selected Rank Statistics
OS
:   overall survival
PFS
:   progression-free survival
RANO
:   Response Assessment in Neuro-Oncology
STR
:   subtotal resection
VOL
:   volume" />
<meta name="DC.Contributor" content="N. Bahrami" />
<meta name="DC.Contributor" content="D. Piccioni" />
<meta name="DC.Contributor" content="R. Karunamuni" />
<meta name="DC.Contributor" content="Y.-H. Chang" />
<meta name="DC.Contributor" content="N. White" />
<meta name="DC.Contributor" content="R. Delfanti" />
<meta name="DC.Contributor" content="T.M. Seibert" />
<meta name="DC.Contributor" content="J.A. Hattangadi-Gluth" />
<meta name="DC.Contributor" content="A. Dale" />
<meta name="DC.Contributor" content="N. Farid" />
<meta name="DC.Contributor" content="C.R. McDonald" />
<meta name="article:published_time" content="2018-06-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Edge Contrast of the FLAIR Hyperintense Region Predicts Survival in Patients with High-Grade Gliomas following Treatment with Bevacizumab" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Treatment with bevacizumab is standard of care for recurrent high-grade gliomas; however, monitoring response to treatment following bevacizumab remains a challenge. The purpose of this study was to determine whether quantifying the sharpness of the fluid-attenuated inversion recovery hyperintense border using a measure derived from texture analysis—edge contrast—improves the evaluation of response to bevacizumab in patients with high-grade gliomas.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;MRIs were evaluated in 33 patients with high-grade gliomas before and after the initiation of bevacizumab. Volumes of interest within the FLAIR hyperintense region were segmented. Edge contrast magnitude for each VOI was extracted using gradients of the 3D FLAIR images. Cox proportional hazards models were generated to determine the relationship between edge contrast and progression-free survival/overall survival using age and the extent of surgical resection as covariates.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;After bevacizumab, lower edge contrast of the FLAIR hyperintense region was associated with poorer progression-free survival (&lt;i&gt;P&lt;/i&gt; = .009) and overall survival (&lt;i&gt;P&lt;/i&gt; = .022) among patients with high-grade gliomas. Kaplan-Meier curves revealed that edge contrast cutoff significantly stratified patients for both progression-free survival (log-rank χ&lt;sup&gt;2&lt;/sup&gt; = 8.3, &lt;i&gt;P&lt;/i&gt; = .003) and overall survival (log-rank χ&lt;sup&gt;2&lt;/sup&gt; = 5.5, &lt;i&gt;P&lt;/i&gt; = .019).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Texture analysis using edge contrast of the FLAIR hyperintense region may be an important predictive indicator in patients with high-grade gliomas following treatment with bevacizumab. Specifically, low FLAIR edge contrast may partially reflect areas of early tumor infiltration. This study adds to a growing body of literature proposing that quantifying features may be important for determining outcomes in patients with high-grade gliomas.&lt;/p&gt;" />
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<meta name="twitter:title" content="Edge Contrast of the FLAIR Hyperintense Region Predicts Survival in Patients with High-Grade Gliomas following Treatment with Bevacizumab" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Treatment with bevacizumab is standard of care for recurrent high-grade gliomas; however, monitoring response to treatment following bevacizumab remains a challenge. The purpose of this study was to determine whether quantifying the sharpness of the fluid-attenuated inversion recovery hyperintense border using a measure derived from texture analysis—edge contrast—improves the evaluation of response to bevacizumab in patients with high-grade gliomas.

MATERIALS AND METHODS: MRIs were evaluated in 33 patients with high-grade gliomas before and after the initiation of bevacizumab. Volumes of interest within the FLAIR hyperintense region were segmented. Edge contrast magnitude for each VOI was extracted using gradients of the 3D FLAIR images. Cox proportional hazards models were generated to determine the relationship between edge contrast and progression-free survival/overall survival using age and the extent of surgical resection as covariates.

RESULTS: After bevacizumab, lower edge contrast of the FLAIR hyperintense region was associated with poorer progression-free survival ( P = .009) and overall survival ( P = .022) among patients with high-grade gliomas. Kaplan-Meier curves revealed that edge contrast cutoff significantly stratified patients for both progression-free survival (log-rank χ2 = 8.3, P = .003) and overall survival (log-rank χ2 = 5.5, P = .019).

CONCLUSIONS: Texture analysis using edge contrast of the FLAIR hyperintense region may be an important predictive indicator in patients with high-grade gliomas following treatment with bevacizumab. Specifically, low FLAIR edge contrast may partially reflect areas of early tumor infiltration. This study adds to a growing body of literature proposing that quantifying features may be important for determining outcomes in patients with high-grade gliomas.

EC
:   edge contrast
GBM
:   glioblastoma
GTR
:   gross total resection
HGG
:   high-grade glioma
MSRS
:   Maximally Selected Rank Statistics
OS
:   overall survival
PFS
:   progression-free survival
RANO
:   Response Assessment in Neuro-Oncology
STR
:   subtotal resection
VOL
:   volume" />
<meta name="og-title" property="og:title" content="Edge Contrast of the FLAIR Hyperintense Region Predicts Survival in Patients with High-Grade Gliomas following Treatment with Bevacizumab" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/39/6/1017" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Treatment with bevacizumab is standard of care for recurrent high-grade gliomas; however, monitoring response to treatment following bevacizumab remains a challenge. The purpose of this study was to determine whether quantifying the sharpness of the fluid-attenuated inversion recovery hyperintense border using a measure derived from texture analysis—edge contrast—improves the evaluation of response to bevacizumab in patients with high-grade gliomas.

MATERIALS AND METHODS: MRIs were evaluated in 33 patients with high-grade gliomas before and after the initiation of bevacizumab. Volumes of interest within the FLAIR hyperintense region were segmented. Edge contrast magnitude for each VOI was extracted using gradients of the 3D FLAIR images. Cox proportional hazards models were generated to determine the relationship between edge contrast and progression-free survival/overall survival using age and the extent of surgical resection as covariates.

RESULTS: After bevacizumab, lower edge contrast of the FLAIR hyperintense region was associated with poorer progression-free survival ( P = .009) and overall survival ( P = .022) among patients with high-grade gliomas. Kaplan-Meier curves revealed that edge contrast cutoff significantly stratified patients for both progression-free survival (log-rank χ2 = 8.3, P = .003) and overall survival (log-rank χ2 = 5.5, P = .019).

CONCLUSIONS: Texture analysis using edge contrast of the FLAIR hyperintense region may be an important predictive indicator in patients with high-grade gliomas following treatment with bevacizumab. Specifically, low FLAIR edge contrast may partially reflect areas of early tumor infiltration. This study adds to a growing body of literature proposing that quantifying features may be important for determining outcomes in patients with high-grade gliomas.

EC
:   edge contrast
GBM
:   glioblastoma
GTR
:   gross total resection
HGG
:   high-grade glioma
MSRS
:   Maximally Selected Rank Statistics
OS
:   overall survival
PFS
:   progression-free survival
RANO
:   Response Assessment in Neuro-Oncology
STR
:   subtotal resection
VOL
:   volume" />
<meta name="og-type" property="og:type" content="article" />
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">N. Bahrami</span>, <span class="highwire-citation-author" data-delta="1">D. Piccioni</span>, <span class="highwire-citation-author" data-delta="2">R. Karunamuni</span>, <span class="highwire-citation-author" data-delta="3">Y.-H. Chang</span>, <span class="highwire-citation-author" data-delta="4">N. White</span>, <span class="highwire-citation-author" data-delta="5">R. Delfanti</span>, <span class="highwire-citation-author" data-delta="6">T.M. Seibert</span>, <span class="highwire-citation-author" data-delta="7">J.A. Hattangadi-Gluth</span>, <span class="highwire-citation-author" data-delta="8">A. Dale</span>, <span class="highwire-citation-author" data-delta="9">N. Farid</span> and <span class="highwire-citation-author" data-delta="10">C.R. McDonald</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">June 2018,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1017-1024; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5620 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-61286--6816396361" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">N. Bahrami </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Center for Multimodal Imaging and Genetics (N.B., N.W., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Psychiatry (N.B., Y.-H.C., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology (N.B., N.W., R.D., A.D., N.F., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Multimodal Imaging Laboratory (N.B., N.W., A.D., C.R.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BBahrami%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bahrami%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BBahrami%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-7491-3302" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Bahrami</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">D. Piccioni </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Neurosciences (D.P., A.D., N.F.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BPiccioni%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Piccioni%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BPiccioni%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6006-0126" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. Piccioni</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">R. Karunamuni </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Radiation Medicine (R.K., T.M.S., J.A.H.-G.), University of California, San Diego, La Jolla, California.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BKarunamuni%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Karunamuni%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.%2BKarunamuni%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6918-0589" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R. Karunamuni</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Y.-H. Chang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Psychiatry (N.B., Y.-H.C., C.R.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.-H.%2BChang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chang%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AY.-H.%2BChang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0953-0094" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Y.-H. Chang</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">N. White </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Center for Multimodal Imaging and Genetics (N.B., N.W., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology (N.B., N.W., R.D., A.D., N.F., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Multimodal Imaging Laboratory (N.B., N.W., A.D., C.R.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BWhite%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=White%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BWhite%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4564-2237" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. White</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">R. Delfanti </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology (N.B., N.W., R.D., A.D., N.F., C.R.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BDelfanti%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Delfanti%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.%2BDelfanti%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2373-5419" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R. Delfanti</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">T.M. Seibert </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Radiation Medicine (R.K., T.M.S., J.A.H.-G.), University of California, San Diego, La Jolla, California.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.M.%2BSeibert%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Seibert%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AT.M.%2BSeibert%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4089-7399" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for T.M. Seibert</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">J.A. Hattangadi-Gluth </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Radiation Medicine (R.K., T.M.S., J.A.H.-G.), University of California, San Diego, La Jolla, California.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.A.%2BHattangadi-Gluth%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hattangadi-Gluth%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.A.%2BHattangadi-Gluth%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8222-606X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.A. Hattangadi-Gluth</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">A. Dale </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Multimodal Imaging Laboratory (N.B., N.W., A.D., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Neurosciences (D.P., A.D., N.F.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BDale%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dale%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BDale%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6126-2966" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Dale</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">N. Farid </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology (N.B., N.W., R.D., A.D., N.F., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Neurosciences (D.P., A.D., N.F.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BFarid%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Farid%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BFarid%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0876-1934" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. 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McDonald </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Center for Multimodal Imaging and Genetics (N.B., N.W., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Psychiatry (N.B., Y.-H.C., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Radiology (N.B., N.W., R.D., A.D., N.F., C.R.M.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Multimodal Imaging Laboratory (N.B., N.W., A.D., C.R.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.R.%2BMcDonald%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=McDonald%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.R.%2BMcDonald%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0721-5640" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.R. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 39</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jun 2018 </div></div>
      
      
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      <div class="highwire-cite-title">Edge Contrast of the FLAIR Hyperintense Region Predicts Survival in Patients with High-Grade Gliomas following Treatment with Bevacizumab</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Bahrami</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Piccioni</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Karunamuni</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Y.-H.</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">N.</span> <span class="nlm-surname">White</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Delfanti</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">T.M.</span> <span class="nlm-surname">Seibert</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Hattangadi-Gluth</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Dale</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Farid</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">C.R.</span> <span class="nlm-surname">McDonald</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1017-1024; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5620 </span></div>
  
  
  
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      <div class="highwire-cite-title">Edge Contrast of the FLAIR Hyperintense Region Predicts Survival in Patients with High-Grade Gliomas following Treatment with Bevacizumab</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Bahrami</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Piccioni</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Karunamuni</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Y.-H.</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">N.</span> <span class="nlm-surname">White</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Delfanti</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">T.M.</span> <span class="nlm-surname">Seibert</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Hattangadi-Gluth</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Dale</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Farid</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">C.R.</span> <span class="nlm-surname">McDonald</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2018, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1017-1024; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5620 </span></div>
  
  
  
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