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<meta name="DC.Title" content="Prognostic Value of the Metabolic and Volumetric Parameters of 11C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5707" />
<meta name="DC.Date" content="2018-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2018 by American Journal of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND: Several studies have demonstrated that 11C-methionine positron-emission tomography provides information on prognosis.

PURPOSE: We performed a systematic review and meta-analysis of the prognostic value of the metabolic and volumetric parameters of 11C-methionine-PET for gliomas.

DATA SOURCES: A systematic search was performed using the following combination of keywords: “methionine,” “PET,” “glioma,” and “prognosis.”

STUDY SELECTION: The inclusion criteria were the use of 11C-methionine-PET as an imaging tool, studies limited to gliomas, studies including metabolic parameters (tumor-to-normal ratio) and/or volumetric parameters (metabolic tumor volume), and studies reporting survival data. The electronic search first identified 181 records, and 14 studies were selected.

DATA ANALYSIS: Event-free survival and overall survival were the outcome measures of interest. The effect of the tumor-to-normal ratio and metabolic tumor volume on survival was determined by the effect size of the hazard ratio. Hazard ratios were extracted directly from each study when provided or determined by analyzing the Kaplan-Meier curves.

DATA SYNTHESIS: The combined hazard ratios of the tumor-to-normal ratio for event-free survival was 1.74 with no significance and that of the tumor-to-normal ratio for overall survival was 2.02 with significance. The combined hazard ratio of the metabolic tumor volume for event-free survival was 2.72 with significance and that of the metabolic tumor volume for overall survival was 3.50 with significance.

LIMITATIONS: The studies selected were all retrospective, and there were only 4 studies involving the metabolic tumor volume.

CONCLUSIONS: The present meta-analysis of 11C-methionine-PET suggests that the tumor-to-normal ratio for overall survival and the metabolic tumor volume for event-free survival and overall survival are significant prognostic factors for patients with gliomas.

EFS
:   event-free survival
HR
:   hazard ratio
MTV
:   metabolic tumor volume
OS
:   overall survival
SUVmax
:   maximum standardized uptake value
SUVmean
:   mean standardized uptake value
TNR
:   tumor-to-normal ratio" />
<meta name="DC.Contributor" content="Y.-i. Kim" />
<meta name="DC.Contributor" content="Y. Kim" />
<meta name="DC.Contributor" content="J.Y. Lee" />
<meta name="DC.Contributor" content="S.J. Jang" />
<meta name="article:published_time" content="2018-09-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Prognostic Value of the Metabolic and Volumetric Parameters of 11C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND:&lt;/h3&gt;
&lt;p&gt;Several studies have demonstrated that &lt;sup&gt;11&lt;/sup&gt;C-methionine positron-emission tomography provides information on prognosis.&lt;/p&gt;&lt;h3&gt;PURPOSE:&lt;/h3&gt;
&lt;p&gt;We performed a systematic review and meta-analysis of the prognostic value of the metabolic and volumetric parameters of &lt;sup&gt;11&lt;/sup&gt;C-methionine-PET for gliomas.&lt;/p&gt;&lt;h3&gt;DATA SOURCES:&lt;/h3&gt;
&lt;p&gt;A systematic search was performed using the following combination of keywords: “methionine,” “PET,” “glioma,” and “prognosis.”&lt;/p&gt;&lt;h3&gt;STUDY SELECTION:&lt;/h3&gt;
&lt;p&gt;The inclusion criteria were the use of &lt;sup&gt;11&lt;/sup&gt;C-methionine-PET as an imaging tool, studies limited to gliomas, studies including metabolic parameters (tumor-to-normal ratio) and/or volumetric parameters (metabolic tumor volume), and studies reporting survival data. The electronic search first identified 181 records, and 14 studies were selected.&lt;/p&gt;&lt;h3&gt;DATA ANALYSIS:&lt;/h3&gt;
&lt;p&gt;Event-free survival and overall survival were the outcome measures of interest. The effect of the tumor-to-normal ratio and metabolic tumor volume on survival was determined by the effect size of the hazard ratio. Hazard ratios were extracted directly from each study when provided or determined by analyzing the Kaplan-Meier curves.&lt;/p&gt;&lt;h3&gt;DATA SYNTHESIS:&lt;/h3&gt;
&lt;p&gt;The combined hazard ratios of the tumor-to-normal ratio for event-free survival was 1.74 with no significance and that of the tumor-to-normal ratio for overall survival was 2.02 with significance. The combined hazard ratio of the metabolic tumor volume for event-free survival was 2.72 with significance and that of the metabolic tumor volume for overall survival was 3.50 with significance.&lt;/p&gt;&lt;h3&gt;LIMITATIONS:&lt;/h3&gt;
&lt;p&gt;The studies selected were all retrospective, and there were only 4 studies involving the metabolic tumor volume.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The present meta-analysis of &lt;sup&gt;11&lt;/sup&gt;C-methionine-PET suggests that the tumor-to-normal ratio for overall survival and the metabolic tumor volume for event-free survival and overall survival are significant prognostic factors for patients with gliomas.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2018/09/01" />
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<meta name="citation_firstpage" content="1629" />
<meta name="citation_lastpage" content="1634" />
<meta name="citation_author" content="Y.-i. Kim" />
<meta name="citation_author_institution" content="aFrom the Department of Nuclear Medicine (Y.-i.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea" />
<meta name="citation_author_institution" content="bDepartment of Nuclear Medicine (Y.-i.K., J.Y.L., S.J.J.), CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea" />
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<meta name="citation_author" content="Y. Kim" />
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<meta name="citation_author" content="J.Y. Lee" />
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<meta name="twitter:title" content="Prognostic Value of the Metabolic and Volumetric Parameters of 11C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis" />
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<meta name="twitter:description" content="BACKGROUND: Several studies have demonstrated that 11C-methionine positron-emission tomography provides information on prognosis.

PURPOSE: We performed a systematic review and meta-analysis of the prognostic value of the metabolic and volumetric parameters of 11C-methionine-PET for gliomas.

DATA SOURCES: A systematic search was performed using the following combination of keywords: “methionine,” “PET,” “glioma,” and “prognosis.”

STUDY SELECTION: The inclusion criteria were the use of 11C-methionine-PET as an imaging tool, studies limited to gliomas, studies including metabolic parameters (tumor-to-normal ratio) and/or volumetric parameters (metabolic tumor volume), and studies reporting survival data. The electronic search first identified 181 records, and 14 studies were selected.

DATA ANALYSIS: Event-free survival and overall survival were the outcome measures of interest. The effect of the tumor-to-normal ratio and metabolic tumor volume on survival was determined by the effect size of the hazard ratio. Hazard ratios were extracted directly from each study when provided or determined by analyzing the Kaplan-Meier curves.

DATA SYNTHESIS: The combined hazard ratios of the tumor-to-normal ratio for event-free survival was 1.74 with no significance and that of the tumor-to-normal ratio for overall survival was 2.02 with significance. The combined hazard ratio of the metabolic tumor volume for event-free survival was 2.72 with significance and that of the metabolic tumor volume for overall survival was 3.50 with significance.

LIMITATIONS: The studies selected were all retrospective, and there were only 4 studies involving the metabolic tumor volume.

CONCLUSIONS: The present meta-analysis of 11C-methionine-PET suggests that the tumor-to-normal ratio for overall survival and the metabolic tumor volume for event-free survival and overall survival are significant prognostic factors for patients with gliomas.

EFS
:   event-free survival
HR
:   hazard ratio
MTV
:   metabolic tumor volume
OS
:   overall survival
SUVmax
:   maximum standardized uptake value
SUVmean
:   mean standardized uptake value
TNR
:   tumor-to-normal ratio" />
<meta name="og-title" property="og:title" content="Prognostic Value of the Metabolic and Volumetric Parameters of 11C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND: Several studies have demonstrated that 11C-methionine positron-emission tomography provides information on prognosis.

PURPOSE: We performed a systematic review and meta-analysis of the prognostic value of the metabolic and volumetric parameters of 11C-methionine-PET for gliomas.

DATA SOURCES: A systematic search was performed using the following combination of keywords: “methionine,” “PET,” “glioma,” and “prognosis.”

STUDY SELECTION: The inclusion criteria were the use of 11C-methionine-PET as an imaging tool, studies limited to gliomas, studies including metabolic parameters (tumor-to-normal ratio) and/or volumetric parameters (metabolic tumor volume), and studies reporting survival data. The electronic search first identified 181 records, and 14 studies were selected.

DATA ANALYSIS: Event-free survival and overall survival were the outcome measures of interest. The effect of the tumor-to-normal ratio and metabolic tumor volume on survival was determined by the effect size of the hazard ratio. Hazard ratios were extracted directly from each study when provided or determined by analyzing the Kaplan-Meier curves.

DATA SYNTHESIS: The combined hazard ratios of the tumor-to-normal ratio for event-free survival was 1.74 with no significance and that of the tumor-to-normal ratio for overall survival was 2.02 with significance. The combined hazard ratio of the metabolic tumor volume for event-free survival was 2.72 with significance and that of the metabolic tumor volume for overall survival was 3.50 with significance.

LIMITATIONS: The studies selected were all retrospective, and there were only 4 studies involving the metabolic tumor volume.

CONCLUSIONS: The present meta-analysis of 11C-methionine-PET suggests that the tumor-to-normal ratio for overall survival and the metabolic tumor volume for event-free survival and overall survival are significant prognostic factors for patients with gliomas.

EFS
:   event-free survival
HR
:   hazard ratio
MTV
:   metabolic tumor volume
OS
:   overall survival
SUVmax
:   maximum standardized uptake value
SUVmean
:   mean standardized uptake value
TNR
:   tumor-to-normal ratio" />
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    <title>Prognostic Value of the Metabolic and Volumetric Parameters of 11C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis | American Journal of Neuroradiology</title>  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Y.-i. Kim</span>, <span class="highwire-citation-author" data-delta="1">Y. Kim</span>, <span class="highwire-citation-author" data-delta="2">J.Y. Lee</span> and <span class="highwire-citation-author" data-delta="3">S.J. Jang</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2018,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1629-1634; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5707 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-62608--62131416154" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Y.-i. 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Jang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Nuclear Medicine (Y.-i.K., J.Y.L., S.J.J.), CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.J.%2BJang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jang%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.J.%2BJang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6103-6830" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.J. 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      <div class="highwire-cite-title">Prognostic Value of the Metabolic and Volumetric Parameters of <sup>11</sup>C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis</div>  
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