1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)


  
    
























































































    What Causes Deep Gray Matter Atrophy in Multiple Sclerosis? | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

	  

		
		

			

			  

  
      
  
  

    

  
  
      
Article CommentaryCommentary

  
      

  
      
What Causes Deep Gray Matter Atrophy in Multiple Sclerosis?
  
    	
M.M. Schoonheim and J.J.G. Geurts

  
    	
American Journal of Neuroradiology January 2019,  40 (1) 107-108; DOI: https://doi.org/10.3174/ajnr.A5942 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵
    1. 

    2. Eshaghi  A, 
    3. Marinescu  RV, 
    4. Young  AL, et al
    . Progression of regional grey matter atrophy in multiple sclerosis. Brain 2018;141:1665–77 doi:10.1093/brain/awy088 pmid:29741648
    CrossRefPubMed
  2. 2.↵
    1. 

    2. Eshaghi  A, 
    3. Prados  F, 
    4. Brownlee  WJ, et al
    . Deep gray matter volume loss drives disability worsening in multiple sclerosis. Ann Neurol 2018;83:210–22 doi:10.1002/ana.25145 pmid:29331092
    CrossRefPubMed
  3. 3.↵
    1. 

    2. Eijlers  AJ, 
    3. Van Geest  Q, 
    4. Dekker  I, et al
    . Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study. Brain 2018;141:2605–18 doi:10.1093/brain/awy202 pmid:30169585
    CrossRefPubMed
  4. 4.↵
    1. 

    2. Zivadinov  R, 
    3. Havrdová  E, 
    4. Bergsland  N, et al
    . Thalamic atrophy is associated with development of clinically definite multiple sclerosis. Radiology 2013;268:831–41 doi:10.1148/radiol.13122424 pmid:23613615
    CrossRefPubMed
  5. 5.↵
    1. 

    2. Azevedo  CJ, 
    3. Cen  SY, 
    4. Khadka  S, et al
    . Thalamic atrophy in multiple sclerosis: a magnetic resonance imaging marker of neurodegeneration throughout disease. Ann Neurol 2018;83:223–34 doi:10.1002/ana.25150 pmid:29328531
    CrossRefPubMed
  6. 6.↵
    1. 

    2. Minagar  A, 
    3. Barnett  MH, 
    4. Benedict  RH, et al
    . The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects. Neurology 2013;80:210–19 doi:10.1212/WNL.0b013e31827b910b pmid:23296131
    Abstract/FREE Full Text
  7. 7.↵
    1. 

    2. Schoonheim  MM, 
    3. Meijer  KA, 
    4. Geurts  JJ
    . Network collapse and cognitive impairment in multiple sclerosis. Front Neurol 2015;6:82 doi:10.3389/fneur.2015.00082 pmid:25926813
    CrossRefPubMed
  8. 8.↵
    1. 

    2. Kipp  M, 
    3. Wagenknecht  N, 
    4. Beyer  C, et al
    . Thalamus pathology in multiple sclerosis: from biology to clinical application. Cell Mol Life Sci 2015;72:1127–47 doi:10.1007/s00018-014-1787-9 pmid:25417212
    CrossRefPubMed
  9. 9.↵
    1. 

    2. Pontillo  G, 
    3. Cocozza  S, 
    4. Lanzillo  R, et al
    . Determinants of deep gray matter atrophy in multiple sclerosis: a multimodal MRI study. AJNR Am J Neuroradiol 2019;40:99–106 doi:10.3174/ajnr.A5915
    Abstract/FREE Full Text
  10. 10.↵
    1. 

    2. Larochelle  C, 
    3. Uphaus  T, 
    4. Prat  A, et al
    . Secondary progression in multiple sclerosis: neuronal exhaustion or distinct pathology? Trends Neurosci 2016;39:325–39 doi:10.1016/j.tins.2016.02.001 pmid:26987259
    CrossRefPubMed
  11. 11.↵
    1. 

    2. Gaetano  L, 
    3. Häring  DA, 
    4. Radue  EW, et al
    . Fingolimod effect on gray matter, thalamus, and white matter in patients with multiple sclerosis. Neurology 2018;90:e1324–32 doi:10.1212/WNL.0000000000005292 pmid:29540589
    Abstract/FREE Full Text
  12. 12.↵
    1. 

    2. Ziemssen  T, 
    3. Derfuss  T, 
    4. de Stefano  N, et al
    . Optimizing treatment success in multiple sclerosis. J Neurol 2016;263:1053–65 doi:10.1007/s00415-015-7986-y pmid:26705122
    CrossRefPubMed
  13. 13.↵
    1. 

    2. Schoonheim  MM, 
    3. Meijer  KA, 
    4. Geurts  JJ
    . Network collapse and cognitive impairment in multiple sclerosis. Front Neurol 2015;6:82 doi:10.3389/fneur.2015.00082 pmid:25926813
    CrossRefPubMed
  14. 14.↵
    1. 

    2. Wagenknecht  N, 
    3. Becker  B, 
    4. Scheld  M, et al
    . Thalamus degeneration and inflammation in two distinct multiple sclerosis animal models. J Mol Neurosci 2016;60:102–14 doi:10.1007/s12031-016-0790-z pmid:27491786
    CrossRefPubMed
  15. 15.↵
    1. 

    2. van de Pavert  SH, 
    3. Muhlert  N, 
    4. Sethi  V, et al
    . DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime? J Neurol Neurosurg Psychiatry 2016;87:461–67 doi:10.1136/jnnp-2014-310142 pmid:25926483
    Abstract/FREE Full Text
  16. 16.↵
    1. 

    2. Cifelli  A, 
    3. Arridge  M, 
    4. Jezzard  P, et al
    . Thalamic neurodegeneration in multiple sclerosis. Ann Neurol 2002;52:650–53 doi:10.1002/ana.10326 pmid:12402265
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. 

    2. Vercellino  M, 
    3. Masera  S, 
    4. Lorenzatti  M, et al
    . Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter. J Neuropathol Exp Neurol 2009;68:489–502 doi:10.1097/NEN.0b013e3181a19a5a pmid:19525897
    CrossRefPubMed
  18. 18.↵
    1. 

    2. Rissanen  E, 
    3. Tuisku  J, 
    4. Vahlberg  T, et al
    . Microglial activation, white matter tract damage, and disability in MS. Neurol Neuroimmunol Neuroinflamm 2018;5:e443 doi:10.1212/NXI.0000000000000443 pmid:29520366
    Abstract/FREE Full Text
  19. 19.↵
    1. 

    2. Herranz  E, 
    3. Gianni  C, 
    4. Louapre  C, et al
    . Neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol 2016;80:776–90 doi:10.1002/ana.24791 pmid:27686563
    CrossRefPubMed
  20. 20.↵
    1. 

    2. Schweser  F, 
    3. Raffaini Duarte Martins  AL, 
    4. Hagemeier  J, et al
    . Mapping of thalamic magnetic susceptibility in multiple sclerosis indicates decreasing iron with disease duration: a proposed mechanistic relationship between inflammation and oligodendrocyte vitality. Neuroimage 2018;167:438–52 doi:10.1016/j.neuroimage.2017.10.063 pmid:29097315
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

     Back to top  


  
  



			

		

		
		

			

			  

  
        
In this issue

    
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



  


  
  



  
      
  
  

    

	  
  

		

          

            

  
      
  
  

     Print  


  
  



  
      
  
  

     Download PDF  


  
  



  
      
  
  

    
 Email Article
  


  
  



  
      
  
  

    
 Citation Tools
  


  
  



          

        

        
        

          

            



  
      
  
  

    

  

    

  
      
  
  

    

  
  
  
  
      
What Causes Deep Gray Matter Atrophy in Multiple Sclerosis?
  
    	
M.M. Schoonheim, J.J.G. Geurts

  
    	
American Journal of Neuroradiology Jan 2019, 40 (1) 107-108; DOI: 10.3174/ajnr.A5942 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  


  
  



  



  


  
  



  
      
  
  

    
  


  
  



          

        

	
 	
	
	


  


  
  



  
      
  
  

    
              Purchase  


  
  



  
        
Jump to section

    
  
  

    
  


  
  



  
      
  
  

    
  


  
  



			

		

	
	
 	
	
	


    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement