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<meta name="HW.identifier" content="/ajnr/40/12/2052.atom" />
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<meta name="DC.Title" content="Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions" />
<meta name="DC.Identifier" content="10.3174/ajnr.A6297" />
<meta name="DC.Date" content="2019-12-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2019 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Attempts have been made to quantify the microvascular leakiness of glioblastomas and use it as an imaging biomarker to predict the prognosis of the tumor. The purpose of our study was to evaluate whether the extraction fraction value from DSC-MR imaging within nonenhancing FLAIR hyperintense lesions was a better prognostic imaging biomarker than dynamic contrast-enhanced MR imaging parameters for patients with glioblastoma.

MATERIALS AND METHODS: A total of 102 patients with glioblastoma who received a preoperative dynamic contrast-enhanced MR imaging and DSC-MR imaging were included in this retrospective study. Patients were classified into the progression ( n  = 87) or nonprogression ( n  = 15) groups at 24 months after surgery. We extracted the means and 95th percentile values for the contrast leakage information parameters from both modalities within the nonenhancing FLAIR high-signal-intensity lesions.

RESULTS: The extraction fraction 95th percentile value was higher in the progression-free survival group of &gt;24 months than at ≤24 months. The median progression-free survival of the group with an extraction fraction 95th percentile value of &gt;13.32 was 17 months, whereas that of the group of ≤13.32 was 12 months. In addition, it was an independent predictor variable for progression-free survival in the patients regardless of their ages and genetic information.

CONCLUSIONS: The extraction fraction 95th percentile value was the only independent parameter for prognostic prediction in patients with glioblastoma among the contrast leakage information, which has no statistically significant correlations with the DCE-MR imaging parameters.

DCE
:   dynamic contrast-enhanced
EF
:   extraction fraction
K trans
:   volume transfer constant
MGMT 
:   O6-methylguanine methyltransferase 
PFS
:   progression-free survival
Ve
:   volume of extravascular extracellular space
Vp
:   volume of vascular plasma space
IDH 
:   isocitrate dehydrogenase" />
<meta name="DC.Contributor" content="S.H. Kim" />
<meta name="DC.Contributor" content="K.H. Cho" />
<meta name="DC.Contributor" content="S.H. Choi" />
<meta name="DC.Contributor" content="T.M. Kim" />
<meta name="DC.Contributor" content="C.K. Park" />
<meta name="DC.Contributor" content="S.H. Park" />
<meta name="DC.Contributor" content="J.K. Won" />
<meta name="DC.Contributor" content="I.H. Kim" />
<meta name="DC.Contributor" content="S.T. Lee" />
<meta name="article:published_time" content="2019-12-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Attempts have been made to quantify the microvascular leakiness of glioblastomas and use it as an imaging biomarker to predict the prognosis of the tumor. The purpose of our study was to evaluate whether the extraction fraction value from DSC-MR imaging within nonenhancing FLAIR hyperintense lesions was a better prognostic imaging biomarker than dynamic contrast-enhanced MR imaging parameters for patients with glioblastoma.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;A total of 102 patients with glioblastoma who received a preoperative dynamic contrast-enhanced MR imaging and DSC-MR imaging were included in this retrospective study. Patients were classified into the progression (&lt;i&gt;n&lt;/i&gt; = 87) or nonprogression (&lt;i&gt;n&lt;/i&gt; = 15) groups at 24 months after surgery. We extracted the means and 95th percentile values for the contrast leakage information parameters from both modalities within the nonenhancing FLAIR high-signal-intensity lesions.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The extraction fraction 95th percentile value was higher in the progression-free survival group of &amp;gt;24 months than at ≤24 months. The median progression-free survival of the group with an extraction fraction 95th percentile value of &amp;gt;13.32 was 17 months, whereas that of the group of ≤13.32 was 12 months. In addition, it was an independent predictor variable for progression-free survival in the patients regardless of their ages and genetic information.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The extraction fraction 95th percentile value was the only independent parameter for prognostic prediction in patients with glioblastoma among the contrast leakage information, which has no statistically significant correlations with the DCE-MR imaging parameters.&lt;/p&gt;" />
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<meta name="twitter:title" content="Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Attempts have been made to quantify the microvascular leakiness of glioblastomas and use it as an imaging biomarker to predict the prognosis of the tumor. The purpose of our study was to evaluate whether the extraction fraction value from DSC-MR imaging within nonenhancing FLAIR hyperintense lesions was a better prognostic imaging biomarker than dynamic contrast-enhanced MR imaging parameters for patients with glioblastoma.

MATERIALS AND METHODS: A total of 102 patients with glioblastoma who received a preoperative dynamic contrast-enhanced MR imaging and DSC-MR imaging were included in this retrospective study. Patients were classified into the progression ( n  = 87) or nonprogression ( n  = 15) groups at 24 months after surgery. We extracted the means and 95th percentile values for the contrast leakage information parameters from both modalities within the nonenhancing FLAIR high-signal-intensity lesions.

RESULTS: The extraction fraction 95th percentile value was higher in the progression-free survival group of &gt;24 months than at ≤24 months. The median progression-free survival of the group with an extraction fraction 95th percentile value of &gt;13.32 was 17 months, whereas that of the group of ≤13.32 was 12 months. In addition, it was an independent predictor variable for progression-free survival in the patients regardless of their ages and genetic information.

CONCLUSIONS: The extraction fraction 95th percentile value was the only independent parameter for prognostic prediction in patients with glioblastoma among the contrast leakage information, which has no statistically significant correlations with the DCE-MR imaging parameters.

DCE
:   dynamic contrast-enhanced
EF
:   extraction fraction
K trans
:   volume transfer constant
MGMT 
:   O6-methylguanine methyltransferase 
PFS
:   progression-free survival
Ve
:   volume of extravascular extracellular space
Vp
:   volume of vascular plasma space
IDH 
:   isocitrate dehydrogenase" />
<meta name="og-title" property="og:title" content="Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/40/12/2052" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Attempts have been made to quantify the microvascular leakiness of glioblastomas and use it as an imaging biomarker to predict the prognosis of the tumor. The purpose of our study was to evaluate whether the extraction fraction value from DSC-MR imaging within nonenhancing FLAIR hyperintense lesions was a better prognostic imaging biomarker than dynamic contrast-enhanced MR imaging parameters for patients with glioblastoma.

MATERIALS AND METHODS: A total of 102 patients with glioblastoma who received a preoperative dynamic contrast-enhanced MR imaging and DSC-MR imaging were included in this retrospective study. Patients were classified into the progression ( n  = 87) or nonprogression ( n  = 15) groups at 24 months after surgery. We extracted the means and 95th percentile values for the contrast leakage information parameters from both modalities within the nonenhancing FLAIR high-signal-intensity lesions.

RESULTS: The extraction fraction 95th percentile value was higher in the progression-free survival group of &gt;24 months than at ≤24 months. The median progression-free survival of the group with an extraction fraction 95th percentile value of &gt;13.32 was 17 months, whereas that of the group of ≤13.32 was 12 months. In addition, it was an independent predictor variable for progression-free survival in the patients regardless of their ages and genetic information.

CONCLUSIONS: The extraction fraction 95th percentile value was the only independent parameter for prognostic prediction in patients with glioblastoma among the contrast leakage information, which has no statistically significant correlations with the DCE-MR imaging parameters.

DCE
:   dynamic contrast-enhanced
EF
:   extraction fraction
K trans
:   volume transfer constant
MGMT 
:   O6-methylguanine methyltransferase 
PFS
:   progression-free survival
Ve
:   volume of extravascular extracellular space
Vp
:   volume of vascular plasma space
IDH 
:   isocitrate dehydrogenase" />
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    <title>Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions | American Journal of Neuroradiology</title>  
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node71896--7" data-node-nid="71896" id="top-node-71896--8751105644" data-pisa="ajnr;40/12/2052" data-pisa-master="ajnr;ajnr.A6297" data-apath="/ajnr/40/12/2052.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Adult Brain</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S.H. Kim</span>, <span class="highwire-citation-author" data-delta="1">K.H. Cho</span>, <span class="highwire-citation-author" data-delta="2">S.H. Choi</span>, <span class="highwire-citation-author" data-delta="3">T.M. Kim</span>, <span class="highwire-citation-author" data-delta="4">C.K. Park</span>, <span class="highwire-citation-author" data-delta="5">S.H. Park</span>, <span class="highwire-citation-author" data-delta="6">J.K. Won</span>, <span class="highwire-citation-author" data-delta="7">I.H. Kim</span> and <span class="highwire-citation-author" data-delta="8">S.T. Lee</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">December 2019,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">40 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2052-2058; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A6297 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-71896--8751105644" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S.H. Kim </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (S.H.K., K.H.C., S.H.C.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.H.%2BKim%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kim%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.H.%2BKim%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8582-4751" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.H. Kim</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">K.H. Cho </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (S.H.K., K.H.C., S.H.C.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.H.%2BCho%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cho%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AK.H.%2BCho%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0670-2284" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for K.H. Cho</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">S.H. Choi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (S.H.K., K.H.C., S.H.C.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Center for Nanoparticle Research (S.H.C.), Institute for Basic Science, Seoul, Korea</div><div class='author-affiliation'><span class='nlm-sup'>e</span>School of Chemical and Biological Engineering (S.H.C.), Seoul National University, Seoul, Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.H.%2BChoi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Choi%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.H.%2BChoi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0412-2270" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.H. Choi</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">T.M. Kim </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Departments of Internal Medicine (T.M.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.M.%2BKim%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kim%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AT.M.%2BKim%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6145-4426" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for T.M. Kim</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">C.K. Park </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Department of Neurosurgery (C.K.P.), Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.K.%2BPark%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Park%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.K.%2BPark%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2350-9876" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.K. Park</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">S.H. Park </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Pathology (S.H.P., J.K.W.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.H.%2BPark%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Park%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.H.%2BPark%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-8681-1597" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.H. Park</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">J.K. Won </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Pathology (S.H.P., J.K.W.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.K.%2BWon%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Won%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.K.%2BWon%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1459-8093" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.K. Won</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">I.H. Kim </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Radiation Oncology (I.H.K.), Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.H.%2BKim%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kim%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AI.H.%2BKim%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4755-5201" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for I.H. Kim</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">S.T. Lee </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Neurology (S.T.L.), Seoul National University College of Medicine, Seoul, Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.T.%2BLee%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lee%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.T.%2BLee%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4767-7564" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.T. Lee</a></li></ul></div></div></div>  </div>

  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">vol. 40 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">no. 12 </span><span  class="highwire-cite-metadata-page-string highwire-cite-metadata">2052-2058 </span></div>
  
  
  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">S.H. Kim</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">K.H. Cho</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-3"><span class="name">S.H. Choi</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">d</a><span class="xref-sep">,</span><a id="xref-aff-5-1" class="xref-aff" href="#aff-5">e</a>, </li><li class="contributor" id="contrib-4"><span class="name">T.M. Kim</span><a id="xref-aff-6-1" class="xref-aff" href="#aff-6">f</a>, </li><li class="contributor" id="contrib-5"><span class="name">C.K. Park</span><a id="xref-aff-8-1" class="xref-aff" href="#aff-8">h</a>, </li><li class="contributor" id="contrib-6"><span class="name">S.H. Park</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-7"><span class="name">J.K. Won</span><a id="xref-aff-2-2" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-8"><span class="name">I.H. Kim</span><a id="xref-aff-7-1" class="xref-aff" href="#aff-7">g</a> and </li><li class="last" id="contrib-9"><span class="name">S.T. Lee</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Departments of Radiology (S.H.K., K.H.C., S.H.C.)</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Pathology (S.H.P., J.K.W.)</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Neurology (S.T.L.), Seoul National University College of Medicine, Seoul, Korea</address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>d</sup>Center for Nanoparticle Research (S.H.C.), Institute for Basic Science, Seoul, Korea</address></li><li class="aff"><a id="aff-5" name="aff-5"></a><address><sup>e</sup>School of Chemical and Biological Engineering (S.H.C.), Seoul National University, Seoul, Korea</address></li><li class="aff"><a id="aff-6" name="aff-6"></a><address><sup>f</sup>Departments of Internal Medicine (T.M.K.)</address></li><li class="aff"><a id="aff-7" name="aff-7"></a><address><sup>g</sup>Radiation Oncology (I.H.K.), Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</address></li><li class="aff"><a id="aff-8" name="aff-8"></a><address><sup>h</sup>Department of Neurosurgery (C.K.P.), Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea.</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Seung Hong Choi, MD, PhD, <span class="addr-line">Department of Radiology, Seoul National University College of Medicine, 28, Yongon-dong, Chongno-gu, 110-744, Seoul, Korea</span>; e-mail: <span class="em-link"><span class="em-addr">verocay{at}snuh.org</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/40/12/2052.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Dec 2019, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">40 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2052-2058; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A6297 </span></div>
  
  
  
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      <div class="highwire-cite-title">Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S.H.</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">K.H.</span> <span class="nlm-surname">Cho</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">S.H.</span> <span class="nlm-surname">Choi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">T.M.</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">C.K.</span> <span class="nlm-surname">Park</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">S.H.</span> <span class="nlm-surname">Park</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.K.</span> <span class="nlm-surname">Won</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">I.H.</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">S.T.</span> <span class="nlm-surname">Lee</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Dec 2019, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">40 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2052-2058; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A6297 </span></div>
  
  
  
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