American Journal of Neuroradiology: 40 (3)

March 01, 2019; Volume 40,Issue 3

Perspectives

Perspectives

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Perspectives
Bejoy Thomas

American Journal of Neuroradiology March 2019, 40 (3) 387; DOI: https://doi.org/10.3174/ajnr.P0055

Review Article

Pediatrics

Open Access
Understanding Subdural Collections in Pediatric Abusive Head Trauma
D. Wittschieber, B. Karger, H. Pfeiffer and M.L. Hahnemann

American Journal of Neuroradiology March 2019, 40 (3) 388-395; DOI: https://doi.org/10.3174/ajnr.A5855

Practice Perspectives

EDITOR'S CHOICE

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Imaging of Patients with Suspected Large-Vessel Occlusion at Primary Stroke Centers: Available Modalities and a Suggested Approach
M.A. Almekhlafi, W.G. Kunz, B.K. Menon, R.A. McTaggart, M.V. Jayaraman, B.W. Baxter, D. Heck, D. Frei, C.P. Derdeyn, T. Takagi, A.H. Aamodt, I.M.R. Fragata, M.D. Hill, A.M. Demchuk and M. Goyal

American Journal of Neuroradiology March 2019, 40 (3) 396-400; DOI: https://doi.org/10.3174/ajnr.A5971

Endovascular thrombectomy has proven efficacy for a wide range of patients with large-vessel occlusion stroke and in selected cases up to 24 hours from onset. While primary stroke centers have increased the proportion of patients withstroke receiving thrombolytic therapy, delays can be encountereduntil patients with LVO are identified and transferred from the primary stroke center to acomprehensive stroke center. Therefore, any extra steps need to be carefullyweighed. The use of CTA (especially multiphase) at the primary stroke center levelhas many advantages in expediting the transfer of appropriate patients to a comprehensive center.

General Contents

EDITOR'S CHOICEAdult Brain

Open Access
3T MRI Whole-Brain Microscopy Discrimination of Subcortical Anatomy, Part 1: Brain Stem
M.J. Hoch, M.T. Bruno, A. Faustin, N. Cruz, L. Crandall, T. Wisniewski, O. Devinsky and T.M. Shepherd

American Journal of Neuroradiology March 2019, 40 (3) 401-407; DOI: https://doi.org/10.3174/ajnr.A5956

The authors applied an optimized TSE T2 sequence to washed postmortem brain samples to reveal exquisite and reproducible brain stem anatomic MR imaging contrast comparable with histologic atlases. Direct TSE MR imaging sequence discrimination of brain stem anatomy can help validate other MR imaging contrasts, such as diffusion tractography, or serve as a structural template for extracting quantitative MR imaging data in future postmortem investigations.
Adult Brain

Open Access
Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain
J. Ivanidze, M. Mackay, A. Hoang, J.M. Chi, K. Cheng, C. Aranow, B. Volpe, B. Diamond and P.C. Sanelli

American Journal of Neuroradiology March 2019, 40 (3) 408-411; DOI: https://doi.org/10.3174/ajnr.A5962
FELLOWS' JOURNAL CLUBAdult Brain

Open Access
Disorder in Pixel-Level Edge Directions on T1WI Is Associated with the Degree of Radiation Necrosis in Primary and Metastatic Brain Tumors: Preliminary Findings
P. Prasanna, L. Rogers, T.C. Lam, M. Cohen, A. Siddalingappa, L. Wolansky, M. Pinho, A. Gupta, K.J. Hatanpaa, A. Madabhushi and P. Tiwari

American Journal of Neuroradiology March 2019, 40 (3) 412-417; DOI: https://doi.org/10.3174/ajnr.A5958

The authors sought to investigate whether co-occurrence of local anisotropic gradient orientations (COLLAGE) measurements from posttreatment gadolinium-contrast T1WI could distinguish varying extents of cerebral radiation necrosis and recurrent tumor classes in a lesion across primary and metastatic brain tumors. On 75 gadolinium-contrast T1WI studies obtained from patients with primary and metastatic brain tumors and nasopharyngeal carcinoma, the extent of cerebral radiation necrosis and recurrent tumor in every brain lesion was histopathologically defined by a neuropathologist as the following: 1) “pure” cerebral radiation necrosis; 2) “mixed” pathology with coexistence of cerebral radiation necrosis and recurrent tumors; 3) “predominant” (>80%) cerebral radiation necrosis; 4) predominant (>80%) recurrent tumor; and 5) pure tumor. COLLAGE features were extracted from the expert-annotated ROIs on MR imaging. COLLAGE features exhibited decreased skewness for patients with pure and predominant cerebral radiation necrosis and were statistically significantly different from those in patients with predominant recurrent tumors, which had highly skewed COLLAGE values.
FELLOWS' JOURNAL CLUBAdult Brain

Open Access
Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning
L.S. Hu, H. Yoon, J.M. Eschbacher, L.C. Baxter, A.C. Dueck, A. Nespodzany, K.A. Smith, P. Nakaji, Y. Xu, L. Wang, J.P. Karis, A.J. Hawkins-Daarud, K.W. Singleton, P.R. Jackson, B.J. Anderies, B.R. Bendok, R.S. Zimmerman, C. Quarles, A.B. Porter-Umphrey, M.M. Mrugala, A. Sharma, J.M. Hoxworth, M.G. Sattur, N. Sanai, P.E. Koulemberis, C. Krishna, J.R. Mitchell, T. Wu, N.L. Tran, K.R. Swanson and J. Li

American Journal of Neuroradiology March 2019, 40 (3) 418-425; DOI: https://doi.org/10.3174/ajnr.A5981

The authors evaluated tumor cell density using a transfer learning method that generates individualized patient models, grounded in the wealth of population data, while also detecting and adjusting for interpatient variabilities based on each patient's own histologic data. They collected 82 image-recorded biopsy samples, from 18 patients with primary GBM. With multivariate modeling, transfer learning improved performance (r = 0.88) compared with one-model-fits-all (r = 0.39). They conclude that transfer learning significantly improves predictive modeling performance for quantifying tumor cell density in glioblastoma.
FELLOWS' JOURNAL CLUBAdult Brain

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Neuroimaging-Based Classification Algorithm for Predicting 1p/19q-Codeletion Status in IDH-Mutant Lower Grade Gliomas
P.P. Batchala, T.J.E. Muttikkal, J.H. Donahue, J.T. Patrie, D. Schiff, C.E. Fadul, E.K. Mrachek, M.-B. Lopes, R. Jain and S.H. Patel

American Journal of Neuroradiology March 2019, 40 (3) 426-432; DOI: https://doi.org/10.3174/ajnr.A5957

One hundred two IDH-mutant lower grade gliomas with preoperative MR imaging and known 1p/19q status from The Cancer Genome Atlas composed a training dataset. Two neuroradiologists in consensus analyzed the training dataset for various imaging features: tumor or cyst texture, margins, cortical infiltration, T2-FLAIR mismatch, tumor cyst, T2* susceptibility, hydrocephalus, midline shift, maximum dimension, primary lobe, necrosis, enhancement, edema, and gliomatosis. Statistical analysis of the training data produced a multivariate classification model for codeletion prediction based on a subset of MR imaging features and patient age. Training dataset analysis produced a 2-step classification algorithm with 86.3% codeletion prediction accuracy, based on the following: 1) the presence of the T2-FLAIR mismatch sign, which was 100% predictive of noncodeleted lowergrade gliomas; and 2)a logistic regression model based on texture, patient age, T2* susceptibility, primary lobe, and hydrocephalus. Independent validation ofthe classification algorithm rendered codeletion prediction accuracies of 81.1% and 79.2% in 2 independent readers.
Adult Brain

Open Access
Preoperative MR Imaging to Differentiate Chordoid Meningiomas from Other Meningioma Histologic Subtypes
J.D. Baal, W.C. Chen, D.A. Solomon, J.S. Pai, C.-H. Lucas, J.H. Hara, N.A. Oberheim Bush, M.W. McDermott, D.R. Raleigh and J.E. Villanueva-Meyer

American Journal of Neuroradiology March 2019, 40 (3) 433-439; DOI: https://doi.org/10.3174/ajnr.A5996
Adult Brain

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Improved Detection of Subtle Mesial Temporal Sclerosis: Validation of a Commercially Available Software for Automated Segmentation of Hippocampal Volume
J.M. Mettenburg, B.F. Branstetter, C.A. Wiley, P. Lee and R.M. Richardson

American Journal of Neuroradiology March 2019, 40 (3) 440-445; DOI: https://doi.org/10.3174/ajnr.A5966
Adult Brain

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A Serial 10-Year Follow-Up Study of Atrophied Brain Lesion Volume and Disability Progression in Patients with Relapsing-Remitting MS
R. Zivadinov, D. Horakova, N. Bergsland, J. Hagemeier, D.P. Ramasamy, T. Uher, M. Vaneckova, E. Havrdova and M.G. Dwyer

American Journal of Neuroradiology March 2019, 40 (3) 446-452; DOI: https://doi.org/10.3174/ajnr.A5987
Adult Brain

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Aqueductal CSF Stroke Volume Is Increased in Patients with Idiopathic Normal Pressure Hydrocephalus and Decreases after Shunt Surgery
J. Shanks, K. Markenroth Bloch, K. Laurell, K.G. Cesarini, M. Fahlström, E.-M. Larsson and J. Virhammar

American Journal of Neuroradiology March 2019, 40 (3) 453-459; DOI: https://doi.org/10.3174/ajnr.A5972
Adult Brain

Open Access
Quantitative Susceptibility Mapping to Assess Cerebral Vascular Compliance
C. Birkl, C. Langkammer, P. Sati, C. Enzinger, F. Fazekas and S. Ropele

American Journal of Neuroradiology March 2019, 40 (3) 460-463; DOI: https://doi.org/10.3174/ajnr.A5933
Adult Brain

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Acute and Evolving MRI of High-Altitude Cerebral Edema: Microbleeds, Edema, and Pathophysiology
P.H. Hackett, P.R. Yarnell, D.A. Weiland and K.B. Reynard

American Journal of Neuroradiology March 2019, 40 (3) 464-469; DOI: https://doi.org/10.3174/ajnr.A5897
Adult Brain

Open Access
Alterations in Blood-Brain Barrier Permeability in Patients with Systemic Lupus Erythematosus
J.M. Chi, M. Mackay, A. Hoang, K. Cheng, C. Aranow, J. Ivanidze, B. Volpe, B. Diamond and P.C. Sanelli

American Journal of Neuroradiology March 2019, 40 (3) 470-477; DOI: https://doi.org/10.3174/ajnr.A5990
Adult Brain

Open Access
Longitudinal White Matter Changes following Carbon Monoxide Poisoning: A 9-Month Follow-Up Voxelwise Diffusional Kurtosis Imaging Study
M.-C. Chou, J.-Y. Li and P.-H. Lai

American Journal of Neuroradiology March 2019, 40 (3) 478-482; DOI: https://doi.org/10.3174/ajnr.A5979
Adult Brain

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Focal Hypoperfusion in Acute Ischemic Stroke Perfusion CT: Clinical and Radiologic Predictors and Accuracy for Infarct Prediction
O. Bill, N.M. Inácio, D. Lambrou, M. Wintermark, G. Ntaios, V. Dunet and P. Michel

American Journal of Neuroradiology March 2019, 40 (3) 483-489; DOI: https://doi.org/10.3174/ajnr.A5984
Adult Brain

Open Access
Complementary Roles of Dynamic Contrast-Enhanced MR Imaging and Postcontrast Vessel Wall Imaging in Detecting High-Risk Intracranial Aneurysms
H. Qi, X. Liu, P. Liu, W. Yuan, A. Liu, Y. Jiang, Y. Li, J. Sun and H. Chen

American Journal of Neuroradiology March 2019, 40 (3) 490-496; DOI: https://doi.org/10.3174/ajnr.A5983
Interventional

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Flow-Diversion Treatment of Unruptured Saccular Anterior Communicating Artery Aneurysms: A Systematic Review and Meta-Analysis
F. Cagnazzo, N. Limbucci, S. Nappini, L. Renieri, A. Rosi, A. Laiso, D. Tiziano di Carlo, P. Perrini and S. Mangiafico

American Journal of Neuroradiology March 2019, 40 (3) 497-502; DOI: https://doi.org/10.3174/ajnr.A5967
EDITOR'S CHOICEInterventional

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Endovascular Treatment of Unruptured MCA Bifurcation Aneurysms Regardless of Aneurysm Morphology: Short- and Long-Term Follow-Up
F. Hagen, C.J. Maurer and A. Berlis

American Journal of Neuroradiology March 2019, 40 (3) 503-509; DOI: https://doi.org/10.3174/ajnr.A5977

Between May 2008 and July 2017, endovascular treatment of 1184 aneurysms in 827 patients was performed in a single institution. Twenty-four percent of these aneurysms were located at the MCA, and 150 unruptured MCA bifurcation aneurysms treated with coiling, stent-assistedcoiling, or endovascular flow diverter (WEB device) were identified for this retrospective data analysis. The procedure-associated good clinical outcome was 89.9%, and the mortality rate was 2.7%. Short-term follow-up good clinical outcome/mortality rates were 91.3%/0.7%. At discharge, 137 patients had an mRS of 0–2 (91.3%) and 13 had an mRS of 3–6 (8.7%). The authors conclude that regardless of the architecture of MCA bifurcation aneurysms, endovascular treatment can be performed with low morbidity/mortality rates.
Interventional

Open Access
Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall
J.R. Cebral, F. Detmer, B.J. Chung, J. Choque-Velasquez, B. Rezai, H. Lehto, R. Tulamo, J. Hernesniemi, M. Niemela, A. Yu, R. Williamson, K. Aziz, S. Sakur, S. Amin-Hanjani, F. Charbel, Y. Tobe, A. Robertson and J. Frösen

American Journal of Neuroradiology March 2019, 40 (3) 510-516; DOI: https://doi.org/10.3174/ajnr.A5970
Interventional

Open Access
Aneurysm Characteristics, Study Population, and Endovascular Techniques for the Treatment of Intracranial Aneurysms in a Large, Prospective, Multicenter Cohort: Results of the Analysis of Recanalization after Endovascular Treatment of Intracranial Aneurysm Study
M. Gawlitza, S. Soize, C. Barbe, A. le Clainche, P. White, L. Spelle and L. Pierot ARETA Study Group

American Journal of Neuroradiology March 2019, 40 (3) 517-523; DOI: https://doi.org/10.3174/ajnr.A5991
Interventional

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Comparison of Pipeline Embolization Device Sizing Based on Conventional 2D Measurements and Virtual Simulation Using the Sim&Size Software: An Agreement Study
J.M. Ospel, G. Gascou, V. Costalat, L. Piergallini, K.A. Blackham and D.W. Zumofen

American Journal of Neuroradiology March 2019, 40 (3) 524-530; DOI: https://doi.org/10.3174/ajnr.A5973
Commentary

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Pipeline Sizing Based on Computer Simulation
T. Becske

American Journal of Neuroradiology March 2019, 40 (3) 531-532; DOI: https://doi.org/10.3174/ajnr.A5998
Interventional

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Predictors and Clinical Impact of Delayed Stent Thrombosis after Thrombectomy for Acute Stroke with Tandem Lesions
R. Pop, I. Zinchenko, V. Quenardelle, D. Mihoc, M. Manisor, J.S. Richter, F. Severac, M. Simu, S. Chibbaro, O. Rouyer, V. Wolff and R. Beaujeux

American Journal of Neuroradiology March 2019, 40 (3) 533-539; DOI: https://doi.org/10.3174/ajnr.A5976
Interventional

Open Access
Validating the Automatic Independent Component Analysis of DSA
J.-S. Hong, Y.-H. Kao, F.-C. Chang and C.-J. Lin

American Journal of Neuroradiology March 2019, 40 (3) 540-542; DOI: https://doi.org/10.3174/ajnr.A5963
Head & Neck

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CT Texture Analysis of Cervical Lymph Nodes on Contrast-Enhanced [¹⁸F] FDG-PET/CT Images to Differentiate Nodal Metastases from Reactive Lymphadenopathy in HIV-Positive Patients with Head and Neck Squamous Cell Carcinoma
H. Kuno, N. Garg, M.M. Qureshi, M.N. Chapman, B. Li, S.K. Meibom, M.T. Truong, K. Takumi and O. Sakai

American Journal of Neuroradiology March 2019, 40 (3) 543-550; DOI: https://doi.org/10.3174/ajnr.A5974
Head & Neck

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Etiology-Specific Mineralization Patterns in Patients with Labyrinthitis Ossificans
K. Buch, B. Baylosis, A. Fujita, M.M. Qureshi, K. Takumi, P.C. Weber and O. Sakai

American Journal of Neuroradiology March 2019, 40 (3) 551-557; DOI: https://doi.org/10.3174/ajnr.A5985
Head & Neck

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Diagnostic Utility of Optic Nerve Measurements with MRI in Patients with Optic Nerve Atrophy
B. Zhao, N. Torun, M. Elsayed, A.-D. Cheng, A. Brook, Y.-M. Chang and R.A. Bhadelia

American Journal of Neuroradiology March 2019, 40 (3) 558-561; DOI: https://doi.org/10.3174/ajnr.A5975
Pediatrics

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Infant Midnasal Stenosis: Reliability of Nasal Metrics
M.E. Graham, K.M. Loveridge, S.H. Pollard, K.R. Moore and J.R. Skirko

American Journal of Neuroradiology March 2019, 40 (3) 562-567; DOI: https://doi.org/10.3174/ajnr.A5980
Pediatrics

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Evaluation of the Implementation of the Response Assessment in Neuro-Oncology Criteria in the HERBY Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas
D. Rodriguez, T. Chambers, M. Warmuth-Metz, E. Sanchez Aliaga, D. Warren, R. Calmon, D. Hargrave, J. Garcia, G. Vassal, J. Grill, G. Zahlmann, P.S. Morgan and T. Jaspan

American Journal of Neuroradiology March 2019, 40 (3) 568-575; DOI: https://doi.org/10.3174/ajnr.A5982
Pediatrics

Open Access
Underdevelopment of the Human Hippocampus in Callosal Agenesis: An In Vivo Fetal MRI Study
V. Knezović, G. Kasprian, A. Štajduhar, E. Schwartz, M. Weber, G.M. Gruber, P.C. Brugger, D. Prayer and M. Vukšić

American Journal of Neuroradiology March 2019, 40 (3) 576-581; DOI: https://doi.org/10.3174/ajnr.A5986

35 Years Ago in AJNR

35 Years Ago in AJNR

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Celebrating 35 Years of the AJNR
American Journal of Neuroradiology March 2019, 40 (3) 582; DOI: https://doi.org/10.3174/ajnr.P0080

Online Features

Memorial
- Memorial
  
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  Robert H. Ackerman, MD, MPH (1935–2018)
  M.H. Lev, J.M. Romero, L.H. Schwamm, M.E. Cudkowicz and J.A. Brink
  
  American Journal of Neuroradiology March 2019, 40 (3) E12-E13; DOI: https://doi.org/10.3174/ajnr.A5989
Letters
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  Engorged Medullary Veins in Neurosarcoidosis: A Reflection of Underlying Phlebitis?
  G. Bathla, N. Soni, T. Moritani and A.A. Capizzano
  
  American Journal of Neuroradiology March 2019, 40 (3) E14-E15; DOI: https://doi.org/10.3174/ajnr.A5951
- LETTER
  
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  Reply:
  C. Zamora and M. Castillo
  
  American Journal of Neuroradiology March 2019, 40 (3) E16; DOI: https://doi.org/10.3174/ajnr.A5968
- LETTER
  
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  High-Resolution Vessel Wall MR Imaging as an Alternative to Brain Biopsy
  D.G. Corrêa and L.C. Hygino da Cruz
  
  American Journal of Neuroradiology March 2019, 40 (3) E17-E18; DOI: https://doi.org/10.3174/ajnr.A5950

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American Journal of Neuroradiology

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Perspectives

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35 Years Ago in AJNR

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