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    Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients | American Journal of Neuroradiology  
    

















    





























    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticlePatient Safety

  
      

  
      
Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients
  
    	
C.S. Edeklev, M. Halvorsen, G. Løvland, S.A.S. Vatnehol, Ø. Gjertsen, B. Nedregaard, R. Sletteberg, G. Ringstad and P.K. Eide

  
    	
American Journal of Neuroradiology August 2019,  40 (8) 1257-1264; DOI: https://doi.org/10.3174/ajnr.A6136 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
REFERENCES
  1. 1.↵
    1. 

    2. Iliff  JJ, 
    3. Wang  M, 
    4. Liao  Y, et al
    . A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 2012;4:147ra111 doi:10.1126/scitranslmed.3003748 pmid:22896675
    Abstract/FREE Full Text
  2. 2.↵
    1. 

    2. Rasmussen  MK, 
    3. Mestre  H, 
    4. Nedergaard  M
    . The glymphatic pathway in neurological disorders. Lancet Neurol 2018;17:1016–24 doi:10.1016/S1474-4422(18)30318-1 pmid:30353860
    CrossRefPubMed
  3. 3.↵
    1. 

    2. Iliff  JJ, 
    3. Lee  H, 
    4. Yu  M, et al
    . Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 2013;123:1299–309 doi:10.1172/JCI67677 pmid:23434588
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. 

    2. Yang  L, 
    3. Kress  BT, 
    4. Weber  HJ, et al
    . Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J Transl Med 2013;11:107 doi:10.1186/1479-5876-11-107 pmid:23635358
    CrossRefPubMed
  5. 5.↵
    1. 

    2. Ringstad  G, 
    3. Valnes  LM, 
    4. Dale  AM, et al
    . Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight 2018;3 doi:10.1172/jci.insight.121537 pmid:29997300
    CrossRefPubMed
  6. 6.↵
    1. 

    2. Ringstad  G, 
    3. Vatnehol  SA, 
    4. Eide  PK
    . Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain 2017;140:2691–705 doi:10.1093/brain/awx191 pmid:28969373
    CrossRefPubMed
  7. 7.↵
    1. 

    2. Eide  PK, 
    3. Ringstad  G
    . Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: a glymphatic magnetic resonance imaging study. J Cereb Blood Flow Metab 2018 
Feb 
27:271678X18760974. [Epub ahead of print] doi:10.1177/0271678X18760974 pmid:29485341
    CrossRefPubMed
  8. 8.↵
    1. 

    2. Louveau  A, 
    3. Smirnov  I, 
    4. Keyes  TJ, et al
    . Structural and functional features of central nervous system lymphatic vessels. Nature 2015;523:337–41 doi:10.1038/nature14432 pmid:26030524
    CrossRefPubMed
  9. 9.↵
    1. 

    2. Aspelund  A, 
    3. Antila  S, 
    4. Proulx  ST, et al
    . A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 2015;212:991–99 doi:10.1084/jem.20142290 pmid:26077718
    Abstract/FREE Full Text
  10. 10.↵
    1. 

    2. Eide  PK, 
    3. Vatnehol  SA, 
    4. Emblem  KE, et al
    . Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes. Sci Rep 2018;8:7194 doi:10.1038/s41598-018-25666-4 pmid:29740121
    CrossRefPubMed
  11. 11.↵
    1. 

    2. Kanda  T, 
    3. Ishii  K, 
    4. Kawaguchi  H, et al
    . High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 2014;270:834–41 doi:10.1148/radiol.13131669 pmid:24475844
    CrossRefPubMed
  12. 12.↵
    1. 

    2. Gulani  V, 
    3. Calamante  F, 
    4. Shellock  FG, et al
    ; International Society for Magnetic Resonance in Medicine. Gadolinium deposition in the brain: summary of evidence and recommendations. Lancet Neurol 2017;16:564–70 doi:10.1016/S1474-4422(17)30158-8 pmid:28653648
    CrossRefPubMed
  13. 13.↵
    1. 

    2. Radbruch  A, 
    3. Haase  R, 
    4. Kieslich  PJ, et al
    . No signal intensity increase in the dentate nucleus on unenhanced T1-weighted MR images after more than 20 serial injections of macrocyclic gadolinium-based contrast agents. Radiology 2017;282:699–707 doi:10.1148/radiol.2016162241 pmid:27925871
    CrossRefPubMed
  14. 14.↵
    1. 

    2. Berger  F, 
    3. Kubik-Huch  RA, 
    4. Niemann  T, et al
    . Gadolinium distribution in cerebrospinal fluid after administration of a gadolinium-based MR contrast agent in humans. Radiology 2018;288:703–09 doi:10.1148/radiol.2018171829 pmid:29737953
    CrossRefPubMed
  15. 15.↵
    1. 

    2. Nehra  AK, 
    3. McDonald  RJ, 
    4. Bluhm  AM, et al
    . Accumulation of gadolinium in human cerebrospinal fluid after gadobutrol-enhanced MR imaging: a prospective observational cohort study. Radiology 2018;288:416–23 doi:10.1148/radiol.2018171105 pmid:29737947
    CrossRefPubMed
  16. 16.↵
    1. 

    2. Jost  G, 
    3. Frenzel  T, 
    4. Lohrke  J, et al
    . Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue. Eur Radiol 2017;27:2877–85 doi:10.1007/s00330-016-4654-2 pmid:27832312
    CrossRefPubMed
  17. 17.↵
    1. 

    2. Eide  PK, 
    3. Pripp  AH, 
    4. Ringstad  GA
    . Magnetic resonance imaging biomarkers indicate a central venous hypertension syndrome in patients with symptomatic pineal cysts. J Neurol Sci 2016;363:207–16 doi:10.1016/j.jns.2016.02.038 pmid:27000252
    CrossRefPubMed
  18. 18.↵
    1. 

    2. Pradilla  G, 
    3. Jallo  G
    . Arachnoid cysts: case series and review of the literature. Neurosurg Focus 2007;22:E7 pmid:17608350
    PubMed
  19. 19.↵
    1. 

    2. Akbar  JJ, 
    3. Luetmer  PH, 
    4. Schwartz  KM, et al
    . The role of MR myelography with intrathecal gadolinium in localization of spinal CSF leaks in patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2012;33:535–40 doi:10.3174/ajnr.A2815 pmid:22173753
    Abstract/FREE Full Text
  20. 20.↵
    1. 

    2. Selcuk  H, 
    3. Albayram  S, 
    4. Ozer  H, et al
    . Intrathecal gadolinium-enhanced MR cisternography in the evaluation of CSF leakage. AJNR Am J Neuroradiol 2010;31:71–75 doi:10.3174/ajnr.A1788 pmid:19762462
    Abstract/FREE Full Text
  21. 21.↵
    1. 

    2. Tali  ET, 
    3. Ercan  N, 
    4. Kaymaz  M, et al
    . Intrathecal gadolinium (gadopentetate dimeglumine)-enhanced MR cisternography used to determine potential communication between the cerebrospinal fluid pathways and intracranial arachnoid cysts. Neuroradiology 2004;46:744–54 doi:10.1007/s00234-004-1240-0 pmid:15289956
    CrossRefPubMed
  22. 22.↵
    1. 

    2. Algin  O, 
    3. Hakyemez  B, 
    4. Ocakoğlu  G, et al
    . MR cisternography: is it useful in the diagnosis of normal-pressure hydrocephalus and the selection of “good shunt responders”? Diagn Interv Radiol 2011;17:105–11 doi:10.4261/1305-3825.DIR.3133-09.1 pmid:20683818
    CrossRefPubMed
  23. 23.↵
    1. 

    2. Nacar Dogan  S, 
    3. Kizilkilic  O, 
    4. Kocak  B, et al
    . Intrathecal gadolinium-enhanced MR cisternography in patients with otorhinorrhea: 10-year experience of a tertiary referral center. Neuroradiology 2018;60:471–77 doi:10.1007/s00234-018-2014-4 pmid:29572604
    CrossRefPubMed
  24. 24.↵
    1. 

    2. Aydin  K, 
    3. Guven  K, 
    4. Sencer  S, et al
    . MRI cisternography with gadolinium-containing contrast medium: its role, advantages and limitations in the investigation of rhinorrhoea. Neuroradiology 2004;46:75–80 doi:10.1007/s00234-003-1004-2 pmid:14615855
    CrossRefPubMed
  25. 25.↵
    1. 

    2. Aydin  K, 
    3. Terzibasioglu  E, 
    4. Sencer  S, et al
    . Localization of cerebrospinal fluid leaks by gadolinium-enhanced magnetic resonance cisternography: a 5-year single-center experience. Neurosurgery 2008;62:584–89; discussion 584–89 doi:10.1227/01.neu.0000317306.39203.24 pmid:18425007
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. 

    2. Reiche  W, 
    3. Komenda  Y, 
    4. Schick  B, et al
    . MR cisternography after intrathecal Gd-DTPA application. Eur Radiol 2002;12:2943–49 pmid:12439574
    PubMed
  27. 27.↵
    1. 

    2. Skalpe  IO, 
    3. Tang  GJ
    . Magnetic resonance imaging contrast media in the subarachnoid space: a comparison between gadodiamide injection and gadopentetate dimeglumine in an experimental study in pigs. Invest Radiol 1997;32:140–48 doi:10.1097/00004424-199703000-00002 pmid:9055126
    CrossRefPubMed
  28. 28.↵
    1. 

    2. Jinkins  JR, 
    3. Rudwan  M, 
    4. Krumina  G, et al
    . Intrathecal gadolinium-enhanced MR cisternography in the evaluation of clinically suspected cerebrospinal fluid rhinorrhea in humans: early experience. Radiology 2002;222:555–59 doi:10.1148/radiol.2222010249 pmid:11818627
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. 

    2. Tali  ET, 
    3. Ercan  N, 
    4. Krumina  G, et al
    . Intrathecal gadolinium (gadopentetate dimeglumine) enhanced magnetic resonance myelography and cisternography: results of a multicenter study. Invest Radiol 2002;37:152–59 doi:10.1097/00004424-200203000-00008 pmid:11882795
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. 

    2. Ray  DE, 
    3. Cavanagh  JB, 
    4. Nolan  CC, et al
    . Neurotoxic effects of gadopentetate dimeglumine: behavioral disturbance and morphology after intracerebroventricular injection in rats. AJNR Am J Neuroradiol 1996;17:365–73 pmid:8938312
    Abstract
  31. 31.↵
    1. 

    2. Li  L, 
    3. Gao  FQ, 
    4. Zhang  B, et al
    . Overdosage of intrathecal gadolinium and neurological response. Clin Radiol 2008;63:1063–68 doi:10.1016/j.crad.2008.02.004 pmid:18718238
    CrossRefPubMed
  32. 32.↵
    1. 

    2. Park  KW, 
    3. Im  SB, 
    4. Kim  BT, et al
    . Neurotoxic manifestations of an overdose intrathecal injection of gadopentetate dimeglumine. J Korean Med Sci 2010;25:505–08 doi:10.3346/jkms.2010.25.3.505 pmid:20191058
    CrossRefPubMed
  33. 33.↵
    1. 

    2. Arlt  S, 
    3. Cepek  L, 
    4. Rustenbeck  HH, et al
    . Gadolinium encephalopathy due to accidental intrathecal administration of gadopentetate dimeglumine. J Neurol 2007;254:810–12 doi:10.1007/s00415-006-0439-x pmid:17401744
    CrossRefPubMed
  34. 34.↵
    1. 

    2. Reeves  C, 
    3. Galang  E, 
    4. Padalia  R, et al
    . Intrathecal injection of gadobutrol: a tale of caution. J Pain Palliat Care Pharmacother 2017;31:139–43 doi:10.1080/15360288.2017.1313353 pmid:28489466
    CrossRefPubMed
  35. 35.↵
    1. 

    2. Palmers  Y, 
    3. Kuhn  FP, 
    4. Petersen  D, et al
    . Comparison in myelography between iodixanol 270 and 320 mgI/ml and iotrolan 300 mgI/ml: a multicentre, randomised, parallel-group, double-blind, phase III trial. Eur Radiol 2002;12:686–91 doi:10.1007/s003300100881 pmid:11870488
    CrossRefPubMed
  36. 36.↵
    1. 

    2. Watts  R, 
    3. Steinklein  JM, 
    4. Waldman  L, et al
    . Measuring glymphatic flow in man using quantitative contrast-enhanced MRI. AJNR Am J Neuroradiol 2019;40:648–51 doi:10.3174/ajnr.A5931 pmid:30679221
    Abstract/FREE Full Text
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients
  
    	
C.S. Edeklev, M. Halvorsen, G. Løvland, S.A.S. Vatnehol, Ø. Gjertsen, B. Nedregaard, R. Sletteberg, G. Ringstad, P.K. Eide

  
    	
American Journal of Neuroradiology Aug 2019, 40 (8) 1257-1264; DOI: 10.3174/ajnr.A6136 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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