How Far Can We Take Vessel Wall MRI for Intracranial Atherosclerosis? The Tissue is Still the Issue | American Journal of Neuroradiology

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    How Far Can We Take Vessel Wall MRI for Intracranial Atherosclerosis? The Tissue is Still the Issue | American Journal of Neuroradiology  
    



















    

































    
  
  




    
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      LetterLETTER
  
      Open Access
  
      How Far Can We Take Vessel Wall MRI for Intracranial Atherosclerosis? The Tissue is Still the Issue  
    	M.D. Alexander, A. de Havenon, M. Mossa-Basha and J.S. McNally
  
    	American Journal of Neuroradiology May 2020,  41 (5) E30-E31; DOI: https://doi.org/10.3174/ajnr.A6501 
  
  
  

M.D. Alexander 
aDepartments of Radiology and Imaging Sciences and Neurosurgery
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A. de Havenon 
bDepartment of NeurologyUniversity of UtahSalt Lake City, Utah
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M. Mossa-Basha 
cDepartment of RadiologyUniversity of WashingtonSeattle, Washington
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J.S. McNally 
dDepartments of Radiology and Imaging SciencesUniversity of UtahSalt Lake City, Utah
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    We read with great interest the recent article by Zwartbol et al¹, and the accompanying commentary by Dr Chan.² While the data from the SMART-MR cohort add to the body of research on intracranial vessel wall MR imaging (vwMRI) studies, we have concerns with the interpretation of the results, specifically that the findings do not support “a different etiology” between intracranial (ICAD) and extracranial (ECAD) atherosclerosis. While vwMRI allows us to visualize disease in the vessel walls themselves, this provides only a snapshot of a dynamic process (atherogenesis) that is years-to-decades in the making. We are far from being able to see underlying processes at a molecular and tissue level that lead to these vwMRI findings.
Since the Virchow era, it has been understood that the distribution of atherosclerosis is not uniform; plaques occur primarily at bifurcations, in curved segments, and in coronary arteries. Intracranial and extracranial arterial systems are derived from different germ cell layers, ectoderm and mesoderm, respectively, and have distinct structural elements and physiologic flow characteristics.³ Accordingly, the risk factors for the development of ECAD and ICAD differ with respect to systemic processes like hyperlipidemia, hyperglycemia, or hypertension. Furthermore, atherosclerosis causes symptoms through different mechanisms and recurrence rates by site. As providers who are often frustrated by suboptimal treatment options for ICAD, we can confirm what has been known for decades, that atherosclerosis responds to treatment differently depending on location. Indeed, Dr Chan cites a seminal manuscript from 1964.⁴ Pathophysiologic mechanisms must be taken into account when considering what is seen on imaging.
The association between ICAD and general vascular risk factors examined in Zwartbol et al¹ has previously been identified. A major limitation of these factors is over-reliance on stenosis. Prior work suggests that high-grade stenosis in ICAD is a feature of late-stage disease, and algorithms relying on stenosis measurement alone can ignore nonstenotic-but-clinically-active disease. A major benefit of vwMRI is the ability to identify plaque features like remodeling pattern, enhancement, fibrous cap thickness, proximity to perforator ostia, intraplaque hemorrhage, or lipid-rich necrotic core volume. Using vwMRI to merely identify the presence of ICAD misses an opportunity to better characterize the disease.
Another limitation of the methodology in Zwartbol et al¹ is identification of ICAD burden regardless of symptomatology. The prevalence of ICAD is rather high, but most lesions prove harmless. The advantage of the granularity of vwMRI is that it could potentially distinguish the multiple ways ICAD can cause ischemic strokes and possibly predict which ICAD plaques are most likely to cause stroke, regardless of level of stenosis. This study also evaluates ICAD and ECAD cross-sectionally, without any clarification of the temporal relationship of disease development in each vascular bed. In addition, there is no indication of ethnicities within the study cohort of 130 patients; certain ethnic populations preferentially develop atherosclerosis in different vascular beds.
This critique is not meant to disparage the work of Zwartbol et al¹ or the fine research conducted by the UCC-SMART study group. However, this must be viewed as an opportunity to refocus on the need for tissue validation of vwMRI for the investigation of ICAD, a feat that will prove difficult and likely rely on animal models. The burden of proof lies in such validation, and the value of vwMRI lies in its potential to identify processes that mediate disease rather than assuming there is a common pathophysiologic driver of atherosclerosis in all vascular beds.
Footnotes
Disclosures: Adam de Havenon—RELATED: Grant: National Institutes of Health–National Institute of Neurological Disorders and Stroke, Comments: supported by the National Institutes of Health–National Institute of Neurological Disorders and Stroke K23NS105924.* Joseph Scott McNally—RELATED: Grant: American Heart Association, National Institutes of Health, Comments: support from the following grants: 1) American Heart Association Scientist Development Grant (Principal Investigator) 17SDG33460420; 2) American Cancer Society, Huntsman Cancer Institute grant (Principal Investigator) 129785IRG1619001IRG; 3) National Institutes of Health (Co-Investigator under D. Dennis Parker, Principal Investigator) 1R01 HL127582-01A1.* *Money paid to the Institution.
Indicates open access to non-subscribers at www.ajnr.org
References
1.↵Zwartbol  MH, 
Geerlings  MI, 
Ghaznawi  R, et al
. Intracranial atherosclerotic burden on 7T MRI is associated with markers of extracranial atherosclerosis: the SMART-MR study. AJNR Am J Neuroradiol 2019;40:2016–22 doi:10.3174/ajnr.A6308] pmid:31806592
CrossRefPubMed
2.↵Chan  LL
. Intracranial and extracranial atherosclerosis: more similar than different? AJNR Am J Neuroradiol 2019;40:2023–24 doi:10.3174/ajnr.A6349] pmid:31780463
FREE Full Text
3.↵Lasjaunias  PL, 
ter Brugge  KG, 
Berenstein  A, et al
. Clinical and Interventional Aspects in Children: With 102 Tables. 2nd ed. Heidelberg: Springer-Verlag; 2006
4.↵Resch  JA, 
Baker  AB
. Etiologic mechanisms in cerebral atherosclerosis: preliminary study of 3,839 cases. Arch Neurol 1964;10:617–28 doi:10.1001/archneur.1964.00460180083008 pmid:14130420
CrossRefPubMed
© 2020 by American Journal of Neuroradiology
  

  
  

  
      
  
  
    
  

  
  

  

  

  
  

  
      
  
  
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      How Far Can We Take Vessel Wall MRI for Intracranial Atherosclerosis? The Tissue is Still the Issue  
    	M.D. Alexander, A. de Havenon, M. Mossa-Basha, J.S. McNally
  
    	 American Journal of Neuroradiology May 2020, 41 (5) E30-E31; DOI: 10.3174/ajnr.A6501 
  
  
  

  
  
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      How Far Can We Take Vessel Wall MRI for Intracranial Atherosclerosis? The Tissue is Still the Issue  
    	M.D. Alexander, A. de Havenon, M. Mossa-Basha, J.S. McNally
  
    	 American Journal of Neuroradiology May 2020, 41 (5) E30-E31; DOI: 10.3174/ajnr.A6501 
  
  
  

  

  
  

  
      
  
  
    
  
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      Regarding “Comparative Evaluation of Lower Gadolinium Doses for MR Imaging of Meningiomas: How Low Can We Go?”  
  
  
  
  

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Print ISSN: 0195-6108 Online ISSN: 1936-959X