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    High Prevalence of Spinal Cord Cavernous Malformations in the Familial Cerebral Cavernous Malformations Type 1 Cohort | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticleSpine

  
      
Open Access

  
      
High Prevalence of Spinal Cord Cavernous Malformations in the Familial Cerebral Cavernous Malformations Type 1 Cohort
  
    	
M.C. Mabray, J. Starcevich, J. Hallstrom, M. Robinson, M. Bartlett, J. Nelson, A. Zafar, H. Kim, L. Morrison and B.L. Hart

  
    	
American Journal of Neuroradiology June 2020,  41 (6) 1126-1130; DOI: https://doi.org/10.3174/ajnr.A6584 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵
    1. Zafar  A, 
    2. Quadri  SA, 
    3. Farooqui  M, et al
    . Familial cerebral cavernous malformations. Stroke 2019;50:1294–301 doi:10.1161/STROKEAHA.118.022314 pmid:30909834
    CrossRefPubMed
  2. 2.↵
    1. Akers  A, 
    2. Al-Shahi Salman  R, 
    3. Awad  IA, et al
    . Synopsis of guidelines for the clinical management of cerebral cavernous malformations: Consensus recommendations based on systematic literature review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel. Neurosurgery 2017;80:665–80 doi:10.1093/neuros/nyx091 pmid:28387823
    CrossRefPubMed
  3. 3.↵
    1. Zabramski  JM, 
    2. Wascher  TM, 
    3. Spetzler  RF, et al
    . The natural history of familial cavernous malformations: results of an ongoing study. J Neurosurg 1994;80:422–32 doi:10.3171/jns.1994.80.3.0422 pmid:8113854
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Adam  MP, 
    2. Ardinger  HH, 
    3. Pagon  RA
    1. Morrison  L, 
    2. Akers  A, et al
    . Cerebral Cavernous Malformation, Familial. In: Adam  MP, Ardinger  HH, Pagon  RA, eds. GeneReviews®. University of Washington, Seattle. 1993.
  5. 5.↵
    1. Al-Shahi Salman  R, 
    2. Berg  MJ, 
    3. Morrison  L, et al
    . Hemorrhage from cavernous malformations of the brain: definition and reporting standards. Angioma Alliance Scientific Advisory Board. Stroke 2008;39:3222–30 doi:10.1161/STROKEAHA.108.515544 pmid:18974380
    Abstract/FREE Full Text
  6. 6.↵
    1. Flemming  KD, 
    2. Graff-Radford  J, 
    3. Aakre  J, et al
    . Population-based prevalence of cerebral cavernous malformations in older adults: Mayo Clinic Study of Aging. JAMA Neurol 2017;74:801–05 doi:10.1001/jamaneurol.2017.0439 pmid:28492932
    CrossRefPubMed
  7. 7.↵
    1. Choquet  H, 
    2. Pawlikowska  L, 
    3. Lawton  MT, et al
    . Genetics of cerebral cavernous malformations: current status and future prospects. J Neurosurg Sci 2015;59:211–20 pmid:25900426
    PubMed
  8. 8.↵
    1. Plummer  NW, 
    2. Zawistowski  JS, 
    3. Marchuk  DA
    . Genetics of cerebral cavernous malformations. Curr Neurol Neurosci Rep 2005;5:391–96 doi:10.1007/s11910-005-0063-7 pmid:16131422
    CrossRefPubMed
  9. 9.↵
    1. Gunel  M, 
    2. Awad  IA, 
    3. Finberg  K, et al
    . A founder mutation as a cause of cerebral cavernous malformation in hispanic Americans. N Engl J Med 1996;334:946–51 doi:10.1056/NEJM199604113341503 pmid:8596595
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Babu  R, 
    2. Owens  TR, 
    3. Karikari  IO, et al
    . Spinal cavernous and capillary hemangiomas in adults. Spine 2013;38:E423–30 doi:10.1097/BRS.0b013e318287fef7 pmid:23354109
    CrossRefPubMed
  11. 11.↵
    1. Badhiwala  JH, 
    2. Farrokhyar  F, 
    3. Alhazzani  W, et al
    . Surgical outcomes and natural history of intramedullary spinal cord cavernous malformations: a single-center series and meta-analysis of individual patient data: Clinic article. J Neurosurg Spine 2014;21:662–76 doi:10.3171/2014.6.SPINE13949 pmid:25062285
    CrossRefPubMed
  12. 12.↵
    1. Canavero  S, 
    2. Pagni  CA, 
    3. Duca  S, et al
    . Spinal intramedullary cavernous angiomas: a literature meta-analysis. Surg Neurol 1994;41:381–88 doi:10.1016/0090-3019(94)90031-0 pmid:8009412
    CrossRefPubMed
  13. 13.↵
    1. Choi  GH, 
    2. Kim  KN, 
    3. Lee  S, et al
    . The clinical features and surgical outcomes of patients with intramedullary spinal cord cavernous malformations. Acta Neurochir (Wien) 2011;153:1677–84 doi:10.1007/s00701-011-1016-3 pmid:21720938
    CrossRefPubMed
  14. 14.↵
    1. Gross  BA, 
    2. Du  R, 
    3. Popp  AJ, et al
    . Intramedullary spinal cord cavernous malformations. Neurosurg Focus 2010;29:E14 doi:10.3171/2010.6.FOCUS10144 pmid:20809755
    CrossRefPubMed
  15. 15.↵
    1. Goyal  A, 
    2. Rinaldo  L, 
    3. Alkhataybeh  R, et al
    . Clinical presentation, natural history and outcomes of intramedullary spinal cord cavernous malformations. J Neurol Neurosurg Psychiatry 2019;90:695–703 doi:10.1136/jnnp-2018-319553 pmid:30760644
    Abstract/FREE Full Text
  16. 16.↵
    1. Nagoshi  N, 
    2. Tsuji  O, 
    3. Nakashima  D, et al
    . Clinical outcomes and prognostic factors for cavernous hemangiomas of the spinal cord: a retrospective cohort study. J Neurosurg Spine 2019;31:271–78 doi:10.3171/2019.1.SPINE18854
    CrossRef
  17. 17.↵
    1. Ren  J, 
    2. Hong  T, 
    3. He  C, et al
    . Surgical approaches and long-term outcomes of intramedullary spinal cord cavernous malformations: a single-center consecutive series of 219 patients. J Neurosurg Spine 2019;31:123–32 doi:10.3171/2018.12.SPINE181263
    CrossRef
  18. 18.↵
    1. Ren  J, 
    2. Hong  T, 
    3. Zeng  G, et al
    . Characteristics and long-term outcome of 20 children with intramedullary spinal cord cavernous malformations. Neurosurgery 2019;nyz381 doi:10.1093/neuros/nyz381
    CrossRef
  19. 19.↵
    1. Ren  J, 
    2. Hong  T, 
    3. He  C, et al
    . Coexistence of intracranial and spinal cord cavernous malformations predict aggressive clinical presentation. Front Neurol 2019;10:618 doi:10.3389/fneur.2019.00618 pmid:31249549
    CrossRefPubMed
  20. 20.↵
    1. Toldo  I, 
    2. Drigo  P, 
    3. Mammi  I, et al
    . Vertebral and spinal cavernous angiomas associated with familial cerebral cavernous malformation. Surg Neurol 2009;71:167–71 doi:10.1016/j.surneu.2007.07.067 pmid:18207546
    CrossRefPubMed
  21. 21.↵
    1. de Vos  I, 
    2. Vreeburg  M, 
    3. Koek  GH, et al
    . Review of familial cerebral cavernous malformations and report of seven additional families. Am J Med Genet A 2017;173:338–51 doi:10.1002/ajmg.a.38028 pmid:27792856
    CrossRefPubMed
  22. 22.↵
    1. Tandberg  SR, 
    2. Bocklage  T, 
    3. Bartlett  MR, et al
    . Vertebral intraosseous vascular malformations in a familial cerebral cavernous malformation population: prevalence, histologic features, and associations with CNS disease. AJR Am J Roentgenol 2020;214:428–36 doi:10.2214/AJR.19.21492 pmid:31825263
    CrossRefPubMed
  23. 23.↵
    1. de Souza  JM, 
    2. Domingues  RC, 
    3. Cruz  LCH, et al
    . Susceptibility-weighted imaging for the evaluation of patients with familial cerebral cavernous malformations: a comparison with T2-weighted fast spin-echo and gradient-echo sequences. AJNR Am J Neuroradiol 2008;29:154–58 doi:10.3174/ajnr.A0748 pmid:17947370
    Abstract/FREE Full Text
  24. 24.↵
    1. Sparacia  G, 
    2. Speciale  C, 
    3. Banco  A, et al
    . Accuracy of SWI sequences compared to T2*-weighted gradient echo sequences in the detection of cerebral cavernous malformations in the familial form. Neuroradiol J 2016;29:326–35 doi:10.1177/1971400916665376
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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High Prevalence of Spinal Cord Cavernous Malformations in the Familial Cerebral Cavernous Malformations Type 1 Cohort
  
    	
M.C. Mabray, J. Starcevich, J. Hallstrom, M. Robinson, M. Bartlett, J. Nelson, A. Zafar, H. Kim, L. Morrison, B.L. Hart

  
    	
 American Journal of Neuroradiology Jun 2020, 41 (6) 1126-1130; DOI: 10.3174/ajnr.A6584 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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