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<meta name="DC.Title" content="Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses" />
<meta name="DC.Identifier" content="10.3174/ajnr.A6869" />
<meta name="DC.Date" content="2021-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2021 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Little is known about microstructural development of cerebellar white matter in vivo. This study aimed to investigate developmental changes of the cerebellar peduncles in second- and third-trimester healthy fetuses using motion-corrected DTI and tractography.

MATERIALS AND METHODS: 3T data of 81 healthy fetuses were reviewed. Structural imaging consisted of multiplanar T2-single-shot sequences; DTI consisted of a series of 12-direction diffusion. A robust motion-tracked section-to-volume registration algorithm reconstructed images. ROI-based deterministic tractography was performed using anatomic landmarks described in postnatal tractography. Asymmetry was evaluated qualitatively with a perceived difference of &gt;25% between sides. Linear regression evaluated gestational age as a predictor of tract volume, ADC, and fractional anisotropy.

RESULTS: Twenty-four cases were excluded due to low-quality reconstructions. Fifty-eight fetuses with a median gestational age of 30.6 weeks (interquartile range, 7 weeks) were analyzed. The superior cerebellar peduncle was identified in 39 subjects (69%), and it was symmetric in 15 (38%). The middle cerebellar peduncle was identified in all subjects and appeared symmetric; in 13 subjects (22%), two distinct subcomponents were identified. The inferior cerebellar peduncle was not found in any subject. There was a significant increase in volume for the superior cerebellar peduncle and middle cerebellar peduncle (both, P  &lt; .05), an increase in fractional anisotropy (both, P  &lt; .001), and a decrease in ADC (both, P  &lt; .001) with gestational age. The middle cerebellar peduncle had higher volume ( P  &lt; .001) and fractional anisotropy ( P  = .002) and lower ADC ( P  &lt; .001) than the superior cerebellar peduncle after controlling for gestational age.

CONCLUSIONS: A robust motion-tracked section-to-volume registration algorithm enabled deterministic tractography of the superior cerebellar peduncle and middle cerebellar peduncle in vivo and allowed characterization of developmental changes.

FA
:   fractional anisotropy
GA
:   gestational age
ICP
:   inferior cerebellar peduncle
MCP
:   middle cerebellar peduncle
MCPcog
:   cognitive pathway of middle cerebellar peduncle
MCPmot
:   motor pathway of middle cerebellar peduncle
MT-SVR
:   motion-tracked slice-to-volume registration
SCP
:   superior cerebellar peduncle" />
<meta name="DC.Contributor" content="F. Machado-Rivas" />
<meta name="DC.Contributor" content="O. Afacan" />
<meta name="DC.Contributor" content="S. Khan" />
<meta name="DC.Contributor" content="B. Marami" />
<meta name="DC.Contributor" content="C.K. Rollins" />
<meta name="DC.Contributor" content="C. Ortinau" />
<meta name="DC.Contributor" content="C. Velasco-Annis" />
<meta name="DC.Contributor" content="S.K. Warfield" />
<meta name="DC.Contributor" content="A. Gholipour" />
<meta name="DC.Contributor" content="C. Jaimes" />
<meta name="article:published_time" content="2021-01-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Little is known about microstructural development of cerebellar white matter in vivo. This study aimed to investigate developmental changes of the cerebellar peduncles in second- and third-trimester healthy fetuses using motion-corrected DTI and tractography.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;3T data of 81 healthy fetuses were reviewed. Structural imaging consisted of multiplanar T2-single-shot sequences; DTI consisted of a series of 12-direction diffusion. A robust motion-tracked section-to-volume registration algorithm reconstructed images. ROI-based deterministic tractography was performed using anatomic landmarks described in postnatal tractography. Asymmetry was evaluated qualitatively with a perceived difference of &amp;gt;25% between sides. Linear regression evaluated gestational age as a predictor of tract volume, ADC, and fractional anisotropy.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Twenty-four cases were excluded due to low-quality reconstructions. Fifty-eight fetuses with a median gestational age of 30.6 weeks (interquartile range, 7 weeks) were analyzed. The superior cerebellar peduncle was identified in 39 subjects (69%), and it was symmetric in 15 (38%). The middle cerebellar peduncle was identified in all subjects and appeared symmetric; in 13 subjects (22%), two distinct subcomponents were identified. The inferior cerebellar peduncle was not found in any subject. There was a significant increase in volume for the superior cerebellar peduncle and middle cerebellar peduncle (both, &lt;i&gt;P &lt;/i&gt;&amp;lt; .05), an increase in fractional anisotropy (both, &lt;i&gt;P &lt;/i&gt;&amp;lt; .001), and a decrease in ADC (both, &lt;i&gt;P &lt;/i&gt;&amp;lt; .001) with gestational age. The middle cerebellar peduncle had higher volume (&lt;i&gt;P &lt;/i&gt;&amp;lt; .001) and fractional anisotropy (&lt;i&gt;P &lt;/i&gt;= .002) and lower ADC (&lt;i&gt;P &lt;/i&gt;&amp;lt; .001) than the superior cerebellar peduncle after controlling for gestational age.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;A robust motion-tracked section-to-volume registration algorithm enabled deterministic tractography of the superior cerebellar peduncle and middle cerebellar peduncle in vivo and allowed characterization of developmental changes.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_author" content="F. Machado-Rivas" />
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<meta name="twitter:title" content="Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Little is known about microstructural development of cerebellar white matter in vivo. This study aimed to investigate developmental changes of the cerebellar peduncles in second- and third-trimester healthy fetuses using motion-corrected DTI and tractography.

MATERIALS AND METHODS: 3T data of 81 healthy fetuses were reviewed. Structural imaging consisted of multiplanar T2-single-shot sequences; DTI consisted of a series of 12-direction diffusion. A robust motion-tracked section-to-volume registration algorithm reconstructed images. ROI-based deterministic tractography was performed using anatomic landmarks described in postnatal tractography. Asymmetry was evaluated qualitatively with a perceived difference of &gt;25% between sides. Linear regression evaluated gestational age as a predictor of tract volume, ADC, and fractional anisotropy.

RESULTS: Twenty-four cases were excluded due to low-quality reconstructions. Fifty-eight fetuses with a median gestational age of 30.6 weeks (interquartile range, 7 weeks) were analyzed. The superior cerebellar peduncle was identified in 39 subjects (69%), and it was symmetric in 15 (38%). The middle cerebellar peduncle was identified in all subjects and appeared symmetric; in 13 subjects (22%), two distinct subcomponents were identified. The inferior cerebellar peduncle was not found in any subject. There was a significant increase in volume for the superior cerebellar peduncle and middle cerebellar peduncle (both, P  &lt; .05), an increase in fractional anisotropy (both, P  &lt; .001), and a decrease in ADC (both, P  &lt; .001) with gestational age. The middle cerebellar peduncle had higher volume ( P  &lt; .001) and fractional anisotropy ( P  = .002) and lower ADC ( P  &lt; .001) than the superior cerebellar peduncle after controlling for gestational age.

CONCLUSIONS: A robust motion-tracked section-to-volume registration algorithm enabled deterministic tractography of the superior cerebellar peduncle and middle cerebellar peduncle in vivo and allowed characterization of developmental changes.

FA
:   fractional anisotropy
GA
:   gestational age
ICP
:   inferior cerebellar peduncle
MCP
:   middle cerebellar peduncle
MCPcog
:   cognitive pathway of middle cerebellar peduncle
MCPmot
:   motor pathway of middle cerebellar peduncle
MT-SVR
:   motion-tracked slice-to-volume registration
SCP
:   superior cerebellar peduncle" />
<meta name="og-title" property="og:title" content="Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/42/1/194" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Little is known about microstructural development of cerebellar white matter in vivo. This study aimed to investigate developmental changes of the cerebellar peduncles in second- and third-trimester healthy fetuses using motion-corrected DTI and tractography.

MATERIALS AND METHODS: 3T data of 81 healthy fetuses were reviewed. Structural imaging consisted of multiplanar T2-single-shot sequences; DTI consisted of a series of 12-direction diffusion. A robust motion-tracked section-to-volume registration algorithm reconstructed images. ROI-based deterministic tractography was performed using anatomic landmarks described in postnatal tractography. Asymmetry was evaluated qualitatively with a perceived difference of &gt;25% between sides. Linear regression evaluated gestational age as a predictor of tract volume, ADC, and fractional anisotropy.

RESULTS: Twenty-four cases were excluded due to low-quality reconstructions. Fifty-eight fetuses with a median gestational age of 30.6 weeks (interquartile range, 7 weeks) were analyzed. The superior cerebellar peduncle was identified in 39 subjects (69%), and it was symmetric in 15 (38%). The middle cerebellar peduncle was identified in all subjects and appeared symmetric; in 13 subjects (22%), two distinct subcomponents were identified. The inferior cerebellar peduncle was not found in any subject. There was a significant increase in volume for the superior cerebellar peduncle and middle cerebellar peduncle (both, P  &lt; .05), an increase in fractional anisotropy (both, P  &lt; .001), and a decrease in ADC (both, P  &lt; .001) with gestational age. The middle cerebellar peduncle had higher volume ( P  &lt; .001) and fractional anisotropy ( P  = .002) and lower ADC ( P  &lt; .001) than the superior cerebellar peduncle after controlling for gestational age.

CONCLUSIONS: A robust motion-tracked section-to-volume registration algorithm enabled deterministic tractography of the superior cerebellar peduncle and middle cerebellar peduncle in vivo and allowed characterization of developmental changes.

FA
:   fractional anisotropy
GA
:   gestational age
ICP
:   inferior cerebellar peduncle
MCP
:   middle cerebellar peduncle
MCPcog
:   cognitive pathway of middle cerebellar peduncle
MCPmot
:   motor pathway of middle cerebellar peduncle
MT-SVR
:   motion-tracked slice-to-volume registration
SCP
:   superior cerebellar peduncle" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node88083--5" data-node-nid="88083" id="top-node-88083--61172360862" data-pisa="ajnr;42/1/194" data-pisa-master="ajnr;42/1/194" data-apath="/ajnr/42/1/194.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">F. Machado-Rivas</span>, <span class="highwire-citation-author" data-delta="1">O. Afacan</span>, <span class="highwire-citation-author" data-delta="2">S. Khan</span>, <span class="highwire-citation-author" data-delta="3">B. Marami</span>, <span class="highwire-citation-author" data-delta="4">C.K. Rollins</span>, <span class="highwire-citation-author" data-delta="5">C. Ortinau</span>, <span class="highwire-citation-author" data-delta="6">C. Velasco-Annis</span>, <span class="highwire-citation-author" data-delta="7">S.K. Warfield</span>, <span class="highwire-citation-author" data-delta="8">A. Gholipour</span> and <span class="highwire-citation-author" data-delta="9">C. Jaimes</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2021,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">42 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">194-200; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A6869 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-88083--61172360862" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">F. Machado-Rivas </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Computational Radiology Laboratory (F.M.-R., O.A., S.K., B.M., C.V.-A., S.K.W., A.G., C.J.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Harvard Medical School (F.M.-R., O.A., S.K., B.M., C.K.R., S.K.W., A.G., C.J.), Boston, Massachusetts</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BMachado-Rivas%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Machado-Rivas%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BMachado-Rivas%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3095-414X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. Machado-Rivas</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">O. Afacan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Computational Radiology Laboratory (F.M.-R., O.A., S.K., B.M., C.V.-A., S.K.W., A.G., C.J.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Harvard Medical School (F.M.-R., O.A., S.K., B.M., C.K.R., S.K.W., A.G., C.J.), Boston, Massachusetts</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=O.%2BAfacan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Afacan%20O&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AO.%2BAfacan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2112-3205" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for O. Afacan</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">S. Khan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Computational Radiology Laboratory (F.M.-R., O.A., S.K., B.M., C.V.-A., S.K.W., A.G., C.J.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Harvard Medical School (F.M.-R., O.A., S.K., B.M., C.K.R., S.K.W., A.G., C.J.), Boston, Massachusetts</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BKhan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Khan%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BKhan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0754-8912" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Khan</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">B. Marami </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Computational Radiology Laboratory (F.M.-R., O.A., S.K., B.M., C.V.-A., S.K.W., A.G., C.J.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Harvard Medical School (F.M.-R., O.A., S.K., B.M., C.K.R., S.K.W., A.G., C.J.), Boston, Massachusetts</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.%2BMarami%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Marami%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AB.%2BMarami%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2555-2402" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for B. Marami</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">C.K. Rollins </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Radiology, Department of Neurology (C.K.R.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Harvard Medical School (F.M.-R., O.A., S.K., B.M., C.K.R., S.K.W., A.G., C.J.), Boston, Massachusetts</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.K.%2BRollins%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rollins%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.K.%2BRollins%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0500-0056" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.K. Rollins</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">C. Ortinau </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Pediatrics (C.O.), Washington University School of Medicine in St. Louis, St. Louis, Missouri</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BOrtinau%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ortinau%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BOrtinau%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0851-0796" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. Ortinau</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">C. Velasco-Annis </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Computational Radiology Laboratory (F.M.-R., O.A., S.K., B.M., C.V.-A., S.K.W., A.G., C.J.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BVelasco-Annis%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Velasco-Annis%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BVelasco-Annis%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7176-3852" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. 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Warfield </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Computational Radiology Laboratory (F.M.-R., O.A., S.K., B.M., C.V.-A., S.K.W., A.G., C.J.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Harvard Medical School (F.M.-R., O.A., S.K., B.M., C.K.R., S.K.W., A.G., C.J.), Boston, Massachusetts</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.K.%2BWarfield%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Warfield%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.K.%2BWarfield%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7659-3880" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.K. Warfield</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">A. Gholipour </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Computational Radiology Laboratory (F.M.-R., O.A., S.K., B.M., C.V.-A., S.K.W., A.G., C.J.)</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Harvard Medical School (F.M.-R., O.A., S.K., B.M., C.K.R., S.K.W., A.G., C.J.), Boston, Massachusetts</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BGholipour%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gholipour%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BGholipour%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-7699-4564" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Gholipour</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">C. Jaimes </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Computational Radiology Laboratory (F.M.-R., O.A., S.K., B.M., C.V.-A., S.K.W., A.G., C.J.)</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children’s Hospital, Boston, Massachusetts</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Harvard Medical School (F.M.-R., O.A., S.K., B.M., C.K.R., S.K.W., A.G., C.J.), Boston, Massachusetts</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BJaimes%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jaimes%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BJaimes%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7169-4244" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. 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      <div class="highwire-cite-title">Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Machado-Rivas</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">O.</span> <span class="nlm-surname">Afacan</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Khan</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Marami</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">C.K.</span> <span class="nlm-surname">Rollins</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Ortinau</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Velasco-Annis</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">S.K.</span> <span class="nlm-surname">Warfield</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Gholipour</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Jaimes</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2021, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">42 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">194-200; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A6869 </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2021, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">42 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">194-200; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A6869 </span></div>
  
  
  
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