1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => FreeToRead
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)


  
    
















































































































































    A Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      



          


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

	  

		
		

			

			  

  
      
  
  

    

  
  
      
Research ArticlePediatrics

  
      

  
      
A Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study
  
    	
C.A.P.F. Alves, U. Löbel, J.S. Martin-Saavedra, S. Toescu, M.H. Tsunemi, S.R. Teixeira, K. Mankad, D. Hargrave, T.S. Jacques, C. da Costa Leite, F.G. Gonçalves, A. Vossough and F. D'Arco

  
    	
American Journal of Neuroradiology May 2021,  42 (5) 961-968; DOI: https://doi.org/10.3174/ajnr.A7057 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵
    1. 

    2. Chhabda  S, 
    3. Carney  O, 
    4. D'Arco  F, et al
    . The 2016 World Health Organization Classification of Tumours of the Central Nervous System: what the paediatric neuroradiologist needs to know. Quant Imaging Med Surg 2016;6:486–89 doi:10.21037/qims.2016.10.01 pmid:27942466
    CrossRefPubMed
  2. 2.↵
    1. 

    2. Louis  DN, 
    3. Perry  A, 
    4. Reifenberger  G, et al
    . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016;131:803–20 doi:10.1007/s00401-016-1545-1 pmid:27157931
    CrossRefPubMed
  3. 3.↵
    1. 

    2. Taylor  MD, 
    3. Northcott  PA, 
    4. Korshunov  A, et al
    . Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 2012;123:465–72 doi:10.1007/s00401-011-0922-z pmid:22134537
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. 

    2. Ramaswamy  V, 
    3. Remke  M, 
    4. Bouffet  E, et al
    . Risk stratification of childhood medulloblastoma in the molecular era: the current consensus. Acta Neuropathol 2016;131:821–31 doi:10.1007/s00401-016-1569-6 pmid:27040285
    CrossRefPubMed
  5. 5.↵
    1. 

    2. Nowak  J, 
    3. Nemes  K, 
    4. Hohm  A, et al
    . Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor. Neuro Oncol 2018;20:1672–79 doi:10.1093/neuonc/noy111 pmid:30010851
    CrossRefPubMed
  6. 6.↵
    1. 

    2. Pajtler  KW, 
    3. Witt  H, 
    4. Sill  M, et al
    . Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell 2015;27:728–43 doi:10.1016/j.ccell.2015.04.002 pmid:25965575
    CrossRefPubMed
  7. 7.↵
    1. 

    2. Patay  Z, 
    3. DeSain  LA, 
    4. Hwang  SN, et al
    . MR imaging characteristics of wingless-type-subgroup pediatric medulloblastoma. AJNR Am J Neuroradiol 2015;36:2386–93 doi:10.3174/ajnr.A4495 pmid:26338912
    Abstract/FREE Full Text
  8. 8.↵
    1. 

    2. Perreault  S, 
    3. Ramaswamy  V, 
    4. Achrol  AS, et al
    . MRI surrogates for molecular subgroups of medulloblastoma. AJNR Am J Neuroradiol 2014;35:1263–69 doi:10.3174/ajnr.A3990 pmid:24831600
    Abstract/FREE Full Text
  9. 9.↵
    1. 

    2. D'Arco  F, 
    3. Culleton  S, 
    4. De Cocker  LJL, et al
    . Current concepts in radiologic assessment of pediatric brain tumors during treatment, Part 1. Pediatr Radiol 2018;48:1833–43 doi:10.1007/s00247-018-4194-9 pmid:29980859
    CrossRefPubMed
  10. 10.↵
    1. 

    2. Tamrazi  B, 
    3. Mankad  K, 
    4. Nelson  M, et al
    . Current concepts and challenges in the radiologic assessment of brain tumors in children, Part 2. Pediatr Radiol 2018;48:1844–60 doi:10.1007/s00247-018-4232-7 pmid:30215111
    CrossRefPubMed
  11. 11.↵
    1. 

    2. D'Arco  F, 
    3. Khan  F, 
    4. Mankad  K, et al
    . Differential diagnosis of posterior fossa tumours in children: new insights. Pediatr Radiol 2018;48:1955–63 doi:10.1007/s00247-018-4224-7 pmid:30120502
    CrossRefPubMed
  12. 12.↵
    1. 

    2. von Elm  E, 
    3. Altman  DG, 
    4. Egger  M, et al
    . STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Epidemiology 2007;18:800–04 doi:10.1097/EDE.0b013e3181577654 pmid:18049194
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. 

    2. McGee  S
    . Simplifying likelihood ratios. J Gen Intern Med 2002;17:646–49 doi:10.1046/j.1525-1497.2002.10750.x pmid:12213147
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. 

    2. Srinivasan  VM, 
    3. Ghali  MG, 
    4. North  RY, et al
    . Modern management of medulloblastoma: molecular classification, outcomes, and the role of surgery. Surg Neurol Int 2016;7:S1135–41 doi:10.4103/2152-7806.196922 pmid:28194300
    CrossRefPubMed
  15. 15.↵
    1. 

    2. Kuzan-Fischer  CM, 
    3. Juraschka  K, 
    4. Taylor  MD
    . Medulloblastoma in the molecular era. J Korean Neurosurg Soc 2018;61:292–301 doi:10.3340/jkns.2018.0028 pmid:29742881
    CrossRefPubMed
  16. 16.↵
    1. 

    2. Raybaud  C, 
    3. Ramaswamy  V, 
    4. Taylor  MD, et al
    . Posterior fossa tumors in children: developmental anatomy and diagnostic imaging. Childs Nerv Syst 2015;31:1661–76 doi:10.1007/s00381-015-2834-z pmid:26351220
    CrossRefPubMed
  17. 17.↵
    1. 

    2. Poretti  A, 
    3. Meoded  A, 
    4. Huisman  TA
    . Neuroimaging of pediatric posterior fossa tumors including review of the literature. J Magn Reson Imaging 2012;35:32–47 doi:10.1002/jmri.22722 pmid:21989968
    CrossRefPubMed
  18. 18.↵
    1. 

    2. Treisman  DM, 
    3. Li  Y, 
    4. Pierce  BR, et al
    . Sox2+ cells in sonic hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence. Neurooncol Adv 2019;11:vdz027 doi:10.1093/noajnl/vdz027 pmid:31763624
    CrossRefPubMed
  19. 19.↵
    1. 

    2. Wang  J, 
    3. Garancher  A, 
    4. Ramaswamy  V, et al
    . Medulloblastoma: from molecular subgroups to molecular targeted therapies. Annu Rev Neurosci 2018;41:207–32 doi:10.1146/annurev-neuro-070815-013838 pmid:29641939
    CrossRefPubMed
  20. 20.↵
    1. 

    2. Drezner  NL, 
    3. Packer  RJ
    . The impact of molecular analysis on the survival of children with embryonal tumors. Transl Pediatr 2016;51:5–8 doi:10.3978/j.issn.2224-4336.2015.11.01 pmid:26835399
    CrossRefPubMed
  21. 21.↵
    1. 

    2. Ho  B, 
    3. Johann  PD, 
    4. Grabovska  Y, et al
    . Molecular subgrouping of atypical teratoid/rhabdoid tumors (ATRT): a reinvestigation and current consensus. Neuro Oncol 2020;22:613–24 doi:10.1093/neuonc/noz23531889194 pmid:31889194
    CrossRefPubMed
  22. 22.↵
    1. 

    2. Venneti  S
    . Integrating ependymoma molecular subgroups into clinical trials. Neuro Oncol 2019;21:1219–20 doi:10.1093/neuonc/noz132 pmid:31402383
    CrossRefPubMed
  23. 23.↵
    1. 

    2. Meyers  SP, 
    3. Khademian  ZP, 
    4. Biegel  JA, et al
    . Primary intracranial atypical teratoid/rhabdoid tumors of infancy and childhood: MRI features and patient outcomes. AJNR Am J Neuroradiol 2006;27:962–71 pmid:6687525
    Abstract/FREE Full Text
  24. 24.↵
    1. 

    2. Northcott  PA, 
    3. Dubuc  AM, 
    4. Pfister  S, et al
    . Molecular subgroups of medulloblastoma. Expert Rev Neurother 2012;12:871–84 doi:10.1586/ern.12.66 pmid:22853794
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. 

    2. Stock  A, 
    3. Mynarek  M, 
    4. Pietsch  T, et al
    . Imaging characteristics of wingless pathway subgroup medulloblastomas: results from the German HIT/SIOP-Trial cohort. AJNR Am J Neuroradiol 2019;40:1811–17 doi:10.3174/ajnr.A6286 pmid:31649159
    Abstract/FREE Full Text
  26. 26.↵
    1. 

    2. Hanzlik  E, 
    3. Woodrome  SE, 
    4. Abdel-Baki  M, et al
    . A systematic review of neuropsychological outcomes following posterior fossa tumor surgery in children. Childs Nerv Syst 2015;31:1869–75 doi:10.1007/s00381-015-2867-3 pmid:26351236
    CrossRefPubMed
  27. 27.↵
    1. 

    2. Iv  M, 
    3. Zhou  M, 
    4. Shpanskaya  K, et al
    . MR imaging-based radiomic signatures of distinct molecular subgroups of medulloblastoma. AJNR Am J Neuroradiol 2019;40:154–61 doi:10.3174/ajnr.A5899 pmid:30523141
    Abstract/FREE Full Text
  28. 28.↵
    1. 

    2. Sotoudeh  H, 
    3. Shafaat  O, 
    4. Bernstock  JD, et al
    . Artificial intelligence in the management of glioma: era of personalized medicine. Front Oncol 2019;9:768 doi:10.3389/fonc.2019.00768 pmid:31475111
    CrossRefPubMed
  29. 29.↵
    1. 

    2. Tang  TT, 
    3. Zawaski  JA, 
    4. Francis  KN, et al
    . Image-based classification of tumor type and growth rate using machine learning: a preclinical study. Sci Rep 2019;9:12529 doi:10.1038/s41598-019-48738-5 pmid:31467303
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

     Back to top  


  
  



			

		

		
		

			

			  

  
        
In this issue

    
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



  


  
  



  
      
  
  

    

	  
  

		

          

            

  
      
  
  

     Print  


  
  



  
      
  
  

     Download PDF  


  
  



  
      
  
  

    
 Email Article
  


  
  



  
      
  
  

    
 Citation Tools
  


  
  



          

        

        
        

          

            



  
      
  
  

    

  

    

  
      
  
  

    

  
  
  
  
      
A Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study
  
    	
C.A.P.F. Alves, U. Löbel, J.S. Martin-Saavedra, S. Toescu, M.H. Tsunemi, S.R. Teixeira, K. Mankad, D. Hargrave, T.S. Jacques, C. da Costa Leite, F.G. Gonçalves, A. Vossough, F. D'Arco

  
    	
American Journal of Neuroradiology May 2021, 42 (5) 961-968; DOI: 10.3174/ajnr.A7057 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  


  
  



  



  


  
  



  
      
  
  

    
  


  
  



          

        

	
 	
	
	


  


  
  



  
      
  
  

    
              Purchase  


  
  



  
        
Jump to section

    
  
  

    
  


  
  



  
      
  
  

    
  


  
  



			

		

	
	
 	
	
	


    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement