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<meta name="DC.Title" content="Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a BCOR Internal Tandem Duplication" />
<meta name="DC.Identifier" content="10.3174/ajnr.A7367" />
<meta name="DC.Date" content="2022-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2022 by American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: A new brain tumor entity occurring in early childhood characterized by a somatic BCL6 corepressor gene internal tandem duplication was recently described. The aim of this study was to describe the radiologic pattern of these tumors and correlate this pattern with histopathologic findings.

MATERIALS AND METHODS: This retrospective, noninterventional study included 10 children diagnosed with a CNS tumor, either by ribonucleic acid–sequencing analysis or deoxyribonucleic acid methylation analysis. Clinical, radiologic, and histopathologic data were collected. A neuropathologist reviewed 9 tumor samples. Preoperative images were analyzed in consensus by 7 pediatric radiologists.

RESULTS: All tumors were relatively large (range, 4.7–9.2 cm) intra-axial peripheral masses with well-defined borders and no peritumoral edema. All tumors showed mild and heterogeneous enhancement and marked restriction on DWI of the solid portions. Perfusion imaging showed a relatively lower CBF in the tumor than in the adjacent normal parenchyma. Nine of 10 tumors showed areas of necrosis, with the presence of hemorrhage in 8/10 and calcifications in 4/7. Large intratumoral macroscopic veins were observed in 9/10 patients. No intracranial or spinal leptomeningeal dissemination was noted at diagnosis.

CONCLUSIONS: CNS tumors with a BCL6 corepressor gene internal tandem duplication present as large intra-axial peripheral masses with well-defined borders, no edema, restricted diffusion, weak contrast enhancement, frequent central necrosis, hemorrhage and calcifications, intratumoral veins, and no leptomeningeal dissemination at the time of diagnosis. Knowledge of these imaging characteristics may aid in histologic, genomic, and molecular profiling of brain tumors in young children.

ITD
:   internal tandem duplication" />
<meta name="DC.Contributor" content="L. Cardoen" />
<meta name="DC.Contributor" content="A. Tauziède-Espariat" />
<meta name="DC.Contributor" content="V. Dangouloff-Ros" />
<meta name="DC.Contributor" content="S. Moalla" />
<meta name="DC.Contributor" content="N. Nicolas" />
<meta name="DC.Contributor" content="C.-J. Roux" />
<meta name="DC.Contributor" content="Y. Bouchoucha" />
<meta name="DC.Contributor" content="F. Bourdeaut" />
<meta name="DC.Contributor" content="K. Beccaria" />
<meta name="DC.Contributor" content="S. Bolle" />
<meta name="DC.Contributor" content="G. Pierron" />
<meta name="DC.Contributor" content="C. Dufour" />
<meta name="DC.Contributor" content="F. Doz" />
<meta name="DC.Contributor" content="N. Boddaert" />
<meta name="DC.Contributor" content="H.J. Brisse" />
<meta name="article:published_time" content="2022-01-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a BCOR Internal Tandem Duplication" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;A new brain tumor entity occurring in early childhood characterized by a somatic &lt;i&gt;BCL6&lt;/i&gt; corepressor gene internal tandem duplication was recently described. The aim of this study was to describe the radiologic pattern of these tumors and correlate this pattern with histopathologic findings.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;This retrospective, noninterventional study included 10 children diagnosed with a CNS tumor, either by ribonucleic acid–sequencing analysis or deoxyribonucleic acid methylation analysis. Clinical, radiologic, and histopathologic data were collected. A neuropathologist reviewed 9 tumor samples. Preoperative images were analyzed in consensus by 7 pediatric radiologists.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;All tumors were relatively large (range, 4.7–9.2 cm) intra-axial peripheral masses with well-defined borders and no peritumoral edema. All tumors showed mild and heterogeneous enhancement and marked restriction on DWI of the solid portions. Perfusion imaging showed a relatively lower CBF in the tumor than in the adjacent normal parenchyma. Nine of 10 tumors showed areas of necrosis, with the presence of hemorrhage in 8/10 and calcifications in 4/7. Large intratumoral macroscopic veins were observed in 9/10 patients. No intracranial or spinal leptomeningeal dissemination was noted at diagnosis.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;CNS tumors with a &lt;i&gt;BCL6&lt;/i&gt; corepressor gene internal tandem duplication present as large intra-axial peripheral masses with well-defined borders, no edema, restricted diffusion, weak contrast enhancement, frequent central necrosis, hemorrhage and calcifications, intratumoral veins, and no leptomeningeal dissemination at the time of diagnosis. Knowledge of these imaging characteristics may aid in histologic, genomic, and molecular profiling of brain tumors in young children.&lt;/p&gt;" />
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<meta name="twitter:title" content="Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a BCOR Internal Tandem Duplication" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: A new brain tumor entity occurring in early childhood characterized by a somatic BCL6 corepressor gene internal tandem duplication was recently described. The aim of this study was to describe the radiologic pattern of these tumors and correlate this pattern with histopathologic findings.

MATERIALS AND METHODS: This retrospective, noninterventional study included 10 children diagnosed with a CNS tumor, either by ribonucleic acid–sequencing analysis or deoxyribonucleic acid methylation analysis. Clinical, radiologic, and histopathologic data were collected. A neuropathologist reviewed 9 tumor samples. Preoperative images were analyzed in consensus by 7 pediatric radiologists.

RESULTS: All tumors were relatively large (range, 4.7–9.2 cm) intra-axial peripheral masses with well-defined borders and no peritumoral edema. All tumors showed mild and heterogeneous enhancement and marked restriction on DWI of the solid portions. Perfusion imaging showed a relatively lower CBF in the tumor than in the adjacent normal parenchyma. Nine of 10 tumors showed areas of necrosis, with the presence of hemorrhage in 8/10 and calcifications in 4/7. Large intratumoral macroscopic veins were observed in 9/10 patients. No intracranial or spinal leptomeningeal dissemination was noted at diagnosis.

CONCLUSIONS: CNS tumors with a BCL6 corepressor gene internal tandem duplication present as large intra-axial peripheral masses with well-defined borders, no edema, restricted diffusion, weak contrast enhancement, frequent central necrosis, hemorrhage and calcifications, intratumoral veins, and no leptomeningeal dissemination at the time of diagnosis. Knowledge of these imaging characteristics may aid in histologic, genomic, and molecular profiling of brain tumors in young children.

ITD
:   internal tandem duplication" />
<meta name="og-title" property="og:title" content="Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a BCOR Internal Tandem Duplication" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/43/1/151" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: A new brain tumor entity occurring in early childhood characterized by a somatic BCL6 corepressor gene internal tandem duplication was recently described. The aim of this study was to describe the radiologic pattern of these tumors and correlate this pattern with histopathologic findings.

MATERIALS AND METHODS: This retrospective, noninterventional study included 10 children diagnosed with a CNS tumor, either by ribonucleic acid–sequencing analysis or deoxyribonucleic acid methylation analysis. Clinical, radiologic, and histopathologic data were collected. A neuropathologist reviewed 9 tumor samples. Preoperative images were analyzed in consensus by 7 pediatric radiologists.

RESULTS: All tumors were relatively large (range, 4.7–9.2 cm) intra-axial peripheral masses with well-defined borders and no peritumoral edema. All tumors showed mild and heterogeneous enhancement and marked restriction on DWI of the solid portions. Perfusion imaging showed a relatively lower CBF in the tumor than in the adjacent normal parenchyma. Nine of 10 tumors showed areas of necrosis, with the presence of hemorrhage in 8/10 and calcifications in 4/7. Large intratumoral macroscopic veins were observed in 9/10 patients. No intracranial or spinal leptomeningeal dissemination was noted at diagnosis.

CONCLUSIONS: CNS tumors with a BCL6 corepressor gene internal tandem duplication present as large intra-axial peripheral masses with well-defined borders, no edema, restricted diffusion, weak contrast enhancement, frequent central necrosis, hemorrhage and calcifications, intratumoral veins, and no leptomeningeal dissemination at the time of diagnosis. Knowledge of these imaging characteristics may aid in histologic, genomic, and molecular profiling of brain tumors in young children.

ITD
:   internal tandem duplication" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node94823--7" data-node-nid="94823" id="top-node-94823--8700335428" data-pisa="ajnr;43/1/151" data-pisa-master="ajnr;ajnr.A7367" data-apath="/ajnr/43/1/151.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="ajnr;ajnr.A7367" data-atom-uri="/ajnr/43/1/151.atom" data-request-view="full"></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a <em>BCOR</em> Internal Tandem Duplication</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">L. Cardoen</span>, <span class="highwire-citation-author" data-delta="1">A. Tauziède-Espariat</span>, <span class="highwire-citation-author" data-delta="2">V. Dangouloff-Ros</span>, <span class="highwire-citation-author" data-delta="3">S. Moalla</span>, <span class="highwire-citation-author" data-delta="4">N. Nicolas</span>, <span class="highwire-citation-author" data-delta="5">C.-J. Roux</span>, <span class="highwire-citation-author" data-delta="6">Y. Bouchoucha</span>, <span class="highwire-citation-author" data-delta="7">F. Bourdeaut</span>, <span class="highwire-citation-author" data-delta="8">K. Beccaria</span>, <span class="highwire-citation-author" data-delta="9">S. Bolle</span>, <span class="highwire-citation-author" data-delta="10">G. Pierron</span>, <span class="highwire-citation-author" data-delta="11">C. Dufour</span>, <span class="highwire-citation-author" data-delta="12">F. Doz</span>, <span class="highwire-citation-author" data-delta="13">N. Boddaert</span> and <span class="highwire-citation-author" data-delta="14">H.J. Brisse</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2022,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">43 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">151-156; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7367 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-94823--8700335428" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">L. Cardoen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging Department (L.C., N.N., H.J.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.%2BCardoen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cardoen%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AL.%2BCardoen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-7842-8638" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for L. Cardoen</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A. Tauziède-Espariat </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neuropathology (A.T.-E.), Centre Hospitalier Sainte Anne, Paris, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BTauzi%C3%A8de-Espariat%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tauzi%C3%A8de-Espariat%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BTauzi%25C3%25A8de-Espariat%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9795-5828" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Tauziède-Espariat</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">V. Dangouloff-Ros </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Pediatric Radiology Department (V.D.-R., C.-J.R., N.B.), Assistance Publique–Hôpitaux de Paris, Hôpital Universitaire Necker-Enfants Malades, Paris, France</div><div class='author-affiliation'><span class='nlm-sup'>g</span>Institut Imagine (V.D.-R., N.B.), Université de Paris, Unité Médicale de Recherche (UMR) 1163, Paris, France</div><div class='author-affiliation'><span class='nlm-sup'>k</span>Université de Paris (V.D.-R., K.B., F.D., N.B.), Institut National de la Santé et de la Recherche Médicale, ERL UA10, Paris, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=V.%2BDangouloff-Ros%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dangouloff-Ros%20V&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AV.%2BDangouloff-Ros%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1260-5886" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for V. Dangouloff-Ros</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">S. Moalla </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Departments of Radiology (S.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BMoalla%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Moalla%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BMoalla%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9769-734X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Moalla</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">N. Nicolas </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging Department (L.C., N.N., H.J.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BNicolas%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nicolas%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BNicolas%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6946-9235" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Nicolas</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">C.-J. Roux </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Pediatric Radiology Department (V.D.-R., C.-J.R., N.B.), Assistance Publique–Hôpitaux de Paris, Hôpital Universitaire Necker-Enfants Malades, Paris, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.-J.%2BRoux%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Roux%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.-J.%2BRoux%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9008-548X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.-J. Roux</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">Y. Bouchoucha </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>SIREDO Oncology Center Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer (Y.B., F.B., F.D.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.%2BBouchoucha%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bouchoucha%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AY.%2BBouchoucha%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9965-6573" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Y. Bouchoucha</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">F. Bourdeaut </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>SIREDO Oncology Center Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer (Y.B., F.B., F.D.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BBourdeaut%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bourdeaut%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BBourdeaut%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9489-6781" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. Bourdeaut</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">K. Beccaria </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Neurosurgery (K.B.)</div><div class='author-affiliation'><span class='nlm-sup'>k</span>Université de Paris (V.D.-R., K.B., F.D., N.B.), Institut National de la Santé et de la Recherche Médicale, ERL UA10, Paris, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.%2BBeccaria%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Beccaria%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AK.%2BBeccaria%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3405-1944" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for K. Beccaria</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">S. Bolle </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>i</span>Radiation Oncology (S.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BBolle%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bolle%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BBolle%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1311-9214" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Bolle</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">G. Pierron </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Biopathology and Genetics (G.P.), Institut Curie, Paris, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BPierron%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Pierron%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BPierron%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2536-7680" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. Pierron</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">C. Dufour </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>j</span>Paediatric and Adolescent Oncology (C.D.), Gustave Roussy, Villejuif, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BDufour%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dufour%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BDufour%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5993-8077" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. Dufour</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">F. Doz </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>SIREDO Oncology Center Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer (Y.B., F.B., F.D.)</div><div class='author-affiliation'><span class='nlm-sup'>k</span>Université de Paris (V.D.-R., K.B., F.D., N.B.), Institut National de la Santé et de la Recherche Médicale, ERL UA10, Paris, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BDoz%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Doz%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BDoz%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9286-4831" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. Doz</a></li></ul></div><div class="author-tooltip-13"><div class="author-tooltip-name">N. Boddaert </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Pediatric Radiology Department (V.D.-R., C.-J.R., N.B.), Assistance Publique–Hôpitaux de Paris, Hôpital Universitaire Necker-Enfants Malades, Paris, France</div><div class='author-affiliation'><span class='nlm-sup'>g</span>Institut Imagine (V.D.-R., N.B.), Université de Paris, Unité Médicale de Recherche (UMR) 1163, Paris, France</div><div class='author-affiliation'><span class='nlm-sup'>k</span>Université de Paris (V.D.-R., K.B., F.D., N.B.), Institut National de la Santé et de la Recherche Médicale, ERL UA10, Paris, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BBoddaert%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Boddaert%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BBoddaert%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0991-7774" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Boddaert</a></li></ul></div><div class="author-tooltip-14"><div class="author-tooltip-name">H.J. Brisse </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging Department (L.C., N.N., H.J.B.)</div><div class='author-affiliation'><span class='nlm-sup'>l</span>Université Paris Saclay (H.J.B.), Institut National de la Santé et de la Recherche Médicale, LITO U1288, Orsay, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.J.%2BBrisse%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Brisse%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.J.%2BBrisse%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2794-5875" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H.J. Brisse</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">L. Cardoen</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">A. Tauziède-Espariat</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">d</a>, </li><li class="contributor" id="contrib-3"><span class="name">V. Dangouloff-Ros</span><a id="xref-aff-6-1" class="xref-aff" href="#aff-6">f</a><span class="xref-sep">,</span><a id="xref-aff-7-1" class="xref-aff" href="#aff-7">g</a><span class="xref-sep">,</span><a id="xref-aff-11-1" class="xref-aff" href="#aff-11">k</a>, </li><li class="contributor" id="contrib-4"><span class="name">S. Moalla</span><a id="xref-aff-8-1" class="xref-aff" href="#aff-8">h</a>, </li><li class="contributor" id="contrib-5"><span class="name">N. Nicolas</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-6"><span class="name">C.-J. Roux</span><a id="xref-aff-6-2" class="xref-aff" href="#aff-6">f</a>, </li><li class="contributor" id="contrib-7"><span class="name">Y. Bouchoucha</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-8"><span class="name">F. Bourdeaut</span><a id="xref-aff-2-2" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-9"><span class="name">K. Beccaria</span><a id="xref-aff-5-1" class="xref-aff" href="#aff-5">e</a><span class="xref-sep">,</span><a id="xref-aff-11-2" class="xref-aff" href="#aff-11">k</a>, </li><li class="contributor" id="contrib-10"><span class="name">S. Bolle</span><a id="xref-aff-9-1" class="xref-aff" href="#aff-9">i</a>, </li><li class="contributor" id="contrib-11"><span class="name">G. Pierron</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-12"><span class="name">C. Dufour</span><a id="xref-aff-10-1" class="xref-aff" href="#aff-10">j</a>, </li><li class="contributor" id="contrib-13"><span class="name">F. Doz</span><a id="xref-aff-2-3" class="xref-aff" href="#aff-2">b</a><span class="xref-sep">,</span><a id="xref-aff-11-3" class="xref-aff" href="#aff-11">k</a>, </li><li class="contributor" id="contrib-14"><span class="name">N. Boddaert</span><a id="xref-aff-6-3" class="xref-aff" href="#aff-6">f</a><span class="xref-sep">,</span><a id="xref-aff-7-2" class="xref-aff" href="#aff-7">g</a><span class="xref-sep">,</span><a id="xref-aff-11-4" class="xref-aff" href="#aff-11">k</a> and </li><li class="last" id="contrib-15"><span class="name">H.J. Brisse</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-12-1" class="xref-aff" href="#aff-12">l</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Imaging Department (L.C., N.N., H.J.B.)</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>SIREDO Oncology Center Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer (Y.B., F.B., F.D.)</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Department of Biopathology and Genetics (G.P.), Institut Curie, Paris, France</address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>d</sup>Department of Neuropathology (A.T.-E.), Centre Hospitalier Sainte Anne, Paris, France</address></li><li class="aff"><a id="aff-5" name="aff-5"></a><address><sup>e</sup>Department of Neurosurgery (K.B.)</address></li><li class="aff"><a id="aff-6" name="aff-6"></a><address><sup>f</sup>Pediatric Radiology Department (V.D.-R., C.-J.R., N.B.), Assistance Publique–Hôpitaux de Paris, Hôpital Universitaire Necker-Enfants Malades, Paris, France</address></li><li class="aff"><a id="aff-7" name="aff-7"></a><address><sup>g</sup>Institut Imagine (V.D.-R., N.B.), Université de Paris, Unité Médicale de Recherche (UMR) 1163, Paris, France</address></li><li class="aff"><a id="aff-8" name="aff-8"></a><address><sup>h</sup>Departments of Radiology (S.M.)</address></li><li class="aff"><a id="aff-9" name="aff-9"></a><address><sup>i</sup>Radiation Oncology (S.B.)</address></li><li class="aff"><a id="aff-10" name="aff-10"></a><address><sup>j</sup>Paediatric and Adolescent Oncology (C.D.), Gustave Roussy, Villejuif, France</address></li><li class="aff"><a id="aff-11" name="aff-11"></a><address><sup>k</sup>Université de Paris (V.D.-R., K.B., F.D., N.B.), Institut National de la Santé et de la Recherche Médicale, ERL UA10, Paris, France</address></li><li class="aff"><a id="aff-12" name="aff-12"></a><address><sup>l</sup>Université Paris Saclay (H.J.B.), Institut National de la Santé et de la Recherche Médicale, LITO U1288, Orsay, France</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Liesbeth Cardoen, MD, <span class="addr-line">Institut Curie, 26, rue d’Ulm, Paris 75248, France</span>; e-mail: <span class="em-link"><span class="em-addr">liesbeth.cardoen{at}curie.fr</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/43/1/151.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-cite-title">Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a <em>BCOR</em> Internal Tandem Duplication</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Cardoen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Tauziède-Espariat</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">V.</span> <span class="nlm-surname">Dangouloff-Ros</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Moalla</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Nicolas</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">C.-J.</span> <span class="nlm-surname">Roux</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Bouchoucha</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Bourdeaut</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Beccaria</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Bolle</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Pierron</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Dufour</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Doz</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Boddaert</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">H.J.</span> <span class="nlm-surname">Brisse</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2022, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">43 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">151-156; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A7367 </span></div>
  
  
  
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      <div class="highwire-cite-title">Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a <em>BCOR</em> Internal Tandem Duplication</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Cardoen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Tauziède-Espariat</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">V.</span> <span class="nlm-surname">Dangouloff-Ros</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Moalla</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Nicolas</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">C.-J.</span> <span class="nlm-surname">Roux</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Bouchoucha</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Bourdeaut</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Beccaria</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Bolle</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Pierron</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Dufour</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Doz</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Boddaert</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">H.J.</span> <span class="nlm-surname">Brisse</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2022, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">43 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">151-156; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A7367 </span></div>
  
  
  
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