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    Decreased Craniocervical CSF Flow in Patients with Normal Pressure Hydrocephalus: A Pilot Study | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticleAdult Brain

  
      

  
      
Decreased Craniocervical CSF Flow in Patients with Normal Pressure Hydrocephalus: A Pilot Study
  
    	
S.M. Stöcklein, M. Brandlhuber, S.S. Lause, A. Pomschar, K. Jahn, R. Schniepp, N. Alperin and B. Ertl-Wagner

  
    	
American Journal of Neuroradiology February 2022,  43 (2) 230-237; DOI: https://doi.org/10.3174/ajnr.A7385 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵
    1. Adams  RD, 
    2. Fisher  CM, 
    3. Hakim  S, et al
    . Symptomatic occult hydrocephalus with “normal” cerebrospinal-fluid pressure: a treatable syndrome. N Engl J Med 1965;273:117–26 doi:10.1056/NEJM196507152730301 pmid:14303656
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Graff-Radford  NR, 
    2. Godersky  JC, 
    3. Jones  MP
    . Variables predicting surgical outcome in symptomatic hydrocephalus in the elderly. Neurology 1989;39:1601–04 doi:10.1212/wnl.39.12.1601 pmid:2586777
    Abstract/FREE Full Text
  3. 3.↵
    1. Marmarou  A, 
    2. Young  HF, 
    3. Aygok  GA, et al
    . Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients. J Neurosurg 2005;102:987–97 doi:10.3171/jns.2005.102.6.0987 pmid:16028756
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Kitagaki  H, 
    2. Mori  E, 
    3. Ishii  K, et al
    . CSF spaces in idiopathic normal pressure hydrocephalus: morphology and volumetry. AJNR Am J Neuroradiol 1998;19:1277–84 pmid:9726467
    PubMed
  5. 5.↵
    1. Virhammar  J, 
    2. Laurell  K, 
    3. Cesarini  KG, et al
    . The callosal angle measured on MRI as a predictor of outcome in idiopathic normal-pressure hydrocephalus. J Neurosurg 2014;120:178–84 doi:10.3171/2013.8.JNS13575 pmid:24074491
    CrossRefPubMed
  6. 6.↵
    1. Ghosh  S, 
    2. Lippa  C
    . Diagnosis and prognosis in idiopathic normal pressure hydrocephalus. Am J Alzheimers Dis Other Demen 2014;29:583–89 doi:10.1177/1533317514523485 pmid:24550545
    CrossRefPubMed
  7. 7.↵
    1. Iddon  JL, 
    2. Pickard  JD, 
    3. Cross  JJ, et al
    . Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer’s disease: a pilot study. J Neurol Neurosurg Psychiatry 1999;67:723–32 doi:10.1136/jnnp.67.6.723 pmid:10567486
    Abstract/FREE Full Text
  8. 8.↵
    1. Bradley  WG, 
    2. Whittemore  AR, 
    3. Kortman  KE   Jr., et al
    . Marked cerebrospinal fluid void: indicator of successful shunt in patients with suspected normal-pressure hydrocephalus. Radiology 1991;178:459–66 doi:10.1148/radiology.178.2.1987609 pmid:1987609
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Lee  VS, 
    2. Spritzer  CE, 
    3. Carroll  BA, et al
    . Flow quantification using fast cine phase-contrast MR imaging, conventional cine phase-contrast MR imaging, and Doppler sonography: in vitro and in vivo validation. AJR Am J Roentgenol 1997;169:1125–31 doi:10.2214/ajr.169.4.9308476 pmid:9308476
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. El Sankari  S, 
    2. Fichten  A, 
    3. Gondry-Jouet  C, et al
    . Correlation between tap test and CSF aqueductal stroke volume in idiopathic normal pressure hydrocephalus. Acta Neurochir Suppl 2012;113:43–46 doi:10.1007/978-3-7091-0923-6_9 pmid:22116421
    CrossRefPubMed
  11. 11.↵
    1. El Sankari  S, 
    2. Gondry-Jouet  C, 
    3. Fichten  A, et al
    . Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer’s disease: a differential diagnosis from idiopathic normal pressure hydrocephalus. Fluids Barriers CNS 2011;8:12 doi:10.1186/2045-8118-8-12 pmid:21349149
    CrossRefPubMed
  12. 12.↵
    1. Shanks  J, 
    2. Markenroth Bloch  K, 
    3. Laurell  K, et al
    . Aqueductal CSF stroke volume is increased in patients with idiopathic normal pressure hydrocephalus and decreases after shunt surgery. AJNR Am J Neuroradiol 2019;40:453–59 doi:10.3174/ajnr.A5972 pmid:30792248
    Abstract/FREE Full Text
  13. 13.↵
    1. Buijs  PC, 
    2. Krabbe-Hartkamp  MJ, 
    3. Bakker  CJ, et al
    . Effect of age on cerebral blood flow: measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults. Radiology 1998;209:667–74 doi:10.1148/radiology.209.3.9844657 pmid:9844657
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Schmid Daners  M, 
    2. Knobloch  V, 
    3. Soellinger  M, et al
    . Age-specific characteristics and coupling of cerebral arterial inflow and cerebrospinal fluid dynamics. PLoS One 2012;7:e37502 doi:10.1371/journal.pone.0037502 pmid:22666360
    CrossRefPubMed
  15. 15.↵
    1. Bradley  WG, 
    2. Whittemore  AR, 
    3. Watanabe  AS   Jr., et al
    . Association of deep white matter infarction with chronic communicating hydrocephalus: implications regarding the possible origin of normal-pressure hydrocephalus. AJNR Am J Neuroradiol 1991;12:31–39 pmid:1899515
    Abstract/FREE Full Text
  16. 16.↵
    1. Ritter  S, 
    2. Dinh  TT
    . Progressive postnatal dilation of brain ventricles in spontaneously hypertensive rats. Brain Res 1986;370:327–32 doi:10.1016/0006-8993(86)90488-9 pmid:3708330
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Boon  AJ, 
    2. Tans  JT, 
    3. Delwel  EJ, et al
    . Dutch Normal-Pressure Hydrocephalus Study: the role of cerebrovascular disease. J Neurosurg 1999;90:221–26 doi:10.3171/jns.1999.90.2.0221 pmid:9950492
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Bradley  WG
    . Normal pressure hydrocephalus: new concepts on etiology and diagnosis. AJNR Am J Neuroradiol 2000;21:1586–90 pmid:11039335
    PubMedWeb of Science
  19. 19.↵
    1. Kuriyama  N, 
    2. Tokuda  T, 
    3. Miyamoto  J, et al
    . Retrograde jugular flow associated with idiopathic normal pressure hydrocephalus. Ann Neurol 2008;64:217–21 doi:10.1002/ana.21410 pmid:18570299
    CrossRefPubMed
  20. 20.↵
    1. Qvarlander  S, 
    2. Lundkvist  B, 
    3. Koskinen  LO, et al
    . Pulsatility in CSF dynamics: pathophysiology of idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry 2013;84:735–41 doi:10.1136/jnnp-2012-302924 pmid:23408066
    Abstract/FREE Full Text
  21. 21.↵
    1. Bateman  GA
    . Vascular compliance in normal pressure hydrocephalus. AJNR Am J Neuroradiol 2000;21:1574–85 pmid:11039334
    PubMed
  22. 22.↵
    1. Owler  BK, 
    2. Pickard  JD
    . Normal pressure hydrocephalus and cerebral blood flow: a review. Acta Neurol Scand 2001;104:325–42 doi:10.1034/j.1600-0404.2001.00092.x pmid:11903086
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Silverberg  GD
    . Normal pressure hydrocephalus (NPH): ischaemia, CSF stagnation or both. Brain 2004;127:947–48 doi:10.1093/brain/awh178 pmid:15111447
    CrossRefPubMed
  24. 24.↵
    1. Shprecher  D, 
    2. Schwalb  J, 
    3. Kurlan  R
    . Normal pressure hydrocephalus: diagnosis and treatment. Curr Neurol Neurosci Rep 2008;8:371–76 doi:10.1007/s11910-008-0058-2 pmid:18713572
    CrossRefPubMed
  25. 25.↵
    1. Nakajima  M, 
    2. Yamada  S, 
    3. Miyajima  M, et al
    ; research committee of idiopathic normal pressure hydrocephalus. Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): endorsed by the Japanese Society of Normal Pressure Hydrocephalus. Neurol Med Chir (Tokyo) 2021;61:63–97 doi:10.2176/nmc.st.2020-0292 pmid:33455998
    CrossRefPubMed
  26. 26.↵
    1. Williams  MA, 
    2. Relkin  NR
    . Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract 2013;3:375–85 doi:10.1212/CPJ.0b013e3182a78f6b pmid:24175154
    Abstract/FREE Full Text
  27. 27.↵
    1. Tain  RW, 
    2. Ertl-Wagner  B, 
    3. Alperin  N
    . Influence of the compliance of the neck arteries and veins on the measurement of intracranial volume change by phase-contrast MRI. J Magn Reson Imaging 2009;30:878–83 doi:10.1002/jmri.21925 pmid:19787740
    CrossRefPubMed
  28. 28.↵
    1. Alperin  N, 
    2. Mazda  M, 
    3. Lichtor  T, et al
    . From cerebrospinal fluid pulsation to noninvasive intracranial compliance and pressure measured by MRI flow studies. Current Medical Imaging Reviews 2006;2:117–29 doi:10.2174/157340506775541622
    CrossRef
  29. 29.↵
    1. Alperin  N, 
    2. Lee  SH
    . PUBS: Pulsatility-based segmentation of lumens conducting non-steady flow. Magn Reson Med 2003;49:934–44 doi:10.1002/mrm.10455 pmid:12704777
    CrossRefPubMed
  30. 30.↵
    1. Greitz  D, 
    2. Hannerz  J, 
    3. Rahn  T, et al
    . MR imaging of cerebrospinal fluid dynamics in health and disease: on the vascular pathogenesis of communicating hydrocephalus and benign intracranial hypertension. Acta Radiology 1994;35:204–211 pmid:8192953
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Stoquart-ElSankari  S, 
    2. Balédent  O, 
    3. Gondry-Jouet  C, et al
    . Aging effects on cerebral blood and cerebrospinal fluid flows. J Cereb Blood Flow Metab 2007;27:1563–72 doi:10.1038/sj.jcbfm.9600462 pmid:17311079
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Daouk  J, 
    2. Bouzerar  R, 
    3. Baledent  O
    . Heart rate and respiration influence on macroscopic blood and CSF flows. Acta Radiol 2017;58:977–82 doi:10.1177/0284185116676655 pmid:28273732
    CrossRefPubMed
  33. 33.↵
    1. Dreha-Kulaczewski  S, 
    2. Konopka  M, 
    3. Joseph  AA, et al
    . Respiration and the watershed of spinal CSF flow in humans. Sci Rep 2018;8:5594 doi:10.1038/s41598-018-23908-z pmid:29618801
    CrossRefPubMed
  34. 34.↵
    1. Vinje  V, 
    2. Ringstad  G, 
    3. Lindstrøm  EK, et al
    . Respiratory influence on cerebrospinal fluid flow - a computational study based on long-term intracranial pressure measurements. Sci Rep 2019;9:9732 doi:10.1038/s41598-019-46055-5 pmid:31278278
    CrossRefPubMed
  35. 35.↵
    1. Eide  PK, 
    2. Valnes  LM, 
    3. Lindstrom  EK, et al
    . Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases. Fluids Barriers CNS 2021;18:16 doi:10.1186/s12987-021-00251-6 pmid:33794929
    CrossRefPubMed
  36. 36.↵
    1. Lindstrom  EK, 
    2. Ringstad  G, 
    3. Mardal  KA, et al
    . Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus. Neuroimage Clin 2018;20:731–41 doi:10.1016/j.nicl.2018.09.006 pmid:30238917
    CrossRefPubMed
  37. 37.↵
    1. Bradley  WG, 
    2. Scalzo  D, 
    3. Queralt  J   Jr., et al
    . Normal-pressure hydrocephalus: evaluation with cerebrospinal fluid flow measurements at MR imaging. Radiology 1996;198:523–29 doi:10.1148/radiology.198.2.8596861 pmid:8596861
    CrossRefPubMedWeb of Science
  38. 38.↵
    1. Sharma  AK, 
    2. Gaikwad  S, 
    3. Gupta  V, et al
    . Measurement of peak CSF flow velocity at cerebral aqueduct, before and after lumbar CSF drainage, by use of phase-contrast MRI: utility in the management of idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg 2008;110:363–68 doi:10.1016/j.clineuro.2007.12.021 pmid:18282655
    CrossRefPubMed
  39. 39.↵
    1. Dixon  GR, 
    2. Friedman  JA, 
    3. Luetmer  PH, et al
    . Use of cerebrospinal fluid flow rates measured by phase-contrast MR to predict outcome of ventriculoperitoneal shunting for idiopathic normal-pressure hydrocephalus. Mayo Clin Proc 2002;77:509–14 doi:10.4065/77.6.509 pmid:12059119
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Blitz  AM, 
    2. Shin  J, 
    3. Balédent  O, et al
    . Does phase-contrast imaging through the cerebral aqueduct predict the outcome of lumbar CSF drainage or shunt surgery in patients with suspected adult hydrocephalus? AJNR Am J Neuroradiol 2018;39:2224–30 doi:10.3174/ajnr.A5857 pmid:30467214
    Abstract/FREE Full Text
  41. 41.↵
    1. Chiang  WW, 
    2. Takoudis  CG, 
    3. Lee  SH, et al
    . Relationship between ventricular morphology and aqueductal cerebrospinal fluid flow in healthy and communicating hydrocephalus. Invest Radiol 2009;44:192–99 doi:10.1097/RLI.0b013e31819a640b pmid:19300098
    CrossRefPubMed
  42. 42.↵
    1. Abdalla  RN, 
    2. Ghani Zghair  MA
    . The role of magnetic resonance imaging cerebrospinal fluid flowmetry in differentiation between normal flow hydrocephalus and involutional brain atrophy. J Pak Med Assoc 2019;69:S78–82 pmid:31603883
    PubMed
  43. 43.↵
    1. Di Palma  C, 
    2. Goulay  R, 
    3. Chagnot  S, et al
    . Cerebrospinal fluid flow increases from newborn to adult stages. Dev Neurobiol 2018;78:851–58 doi:10.1002/dneu.22622 pmid:30027587
    CrossRefPubMed
  44. 44.↵
    1. Lokossou  A, 
    2. Metanbou  S, 
    3. Gondry-Jouet  C, et al
    . Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study. Fluids Barriers CNS 2020;17:1 doi:10.1186/s12987-019-0163-4 pmid:31931818
    CrossRefPubMed
  45. 45.↵
    1. Sartoretti  T, 
    2. Wyss  M, 
    3. Sartoretti  E, et al
    . Sex and age dependencies of aqueductal cerebrospinal fluid dynamics parameters in healthy subjects. Front Aging Neurosci 2019;11:19 doi:10.3389/fnagi.2019.00199 pmid:31427956
    CrossRefPubMed
  46. 46.↵
    1. Moghaddamjou  A, 
    2. Badhiwala  JH, 
    3. Fehlings  MG
    . Degenerative cervical myelopathy: changing frontiers. World Neurosurg 2020;135:377–78 doi:10.1016/j.wneu.2019.12.138 pmid:32143242
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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Decreased Craniocervical CSF Flow in Patients with Normal Pressure Hydrocephalus: A Pilot Study
  
    	
S.M. Stöcklein, M. Brandlhuber, S.S. Lause, A. Pomschar, K. Jahn, R. Schniepp, N. Alperin, B. Ertl-Wagner

  
    	
American Journal of Neuroradiology Feb 2022, 43 (2) 230-237; DOI: 10.3174/ajnr.A7385 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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