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<meta name="DC.Title" content="Brain Abnormalities in Becker Muscular Dystrophy: Evaluation by Voxel-Based DTI and Morphometric Analysis" />
<meta name="DC.Identifier" content="10.3174/ajnr.A8041" />
<meta name="DC.Date" content="2023-12-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Although various neuropsychological problems in Becker muscular dystrophy have attracted attention, there have been few related neuroimaging studies. We investigated brain abnormalities in patients with Becker muscular dystrophy using 3D T1WI and DTI.

MATERIALS AND METHODS: MR images were obtained for 30 male patients and 30 age-matched healthy male controls. We classified patients into Dp140+ and Dp140− subgroups based on their predicted dystrophin Dp140 isoform expression and performed voxel-based comparisons of gray and white matter volumes and DTI metrics among the patients, patient subgroups, and controls. ROI-based DTI analyses were also performed.

RESULTS: Significantly decreased fractional anisotropy was observed in the left planum temporale and right superior parietal lobule compared between the Becker muscular dystrophy and control groups. In the Dp140− subgroup, decreased fractional anisotropy was observed in the left planum temporale, but no significant changes were seen in the Dp140+ subgroup. The ROI-based analysis obtained the same results. No significant differences were evident in the gray or white matter volumes or the DTI metrics other than fractional anisotropy between the groups.

CONCLUSIONS: A DTI metric analysis is useful to detect white-matter microstructural abnormalities in Becker muscular dystrophy that may be affected by the Dp140 isoform expression.

AD
:   axial diffusivity
BMD
:   Becker muscular dystrophy
DARTEL
:   Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra
DMD
:   Duchenne muscular dystrophy
FA
:   fractional anisotropy
IQ
:   intelligence quotient
MD
:   mean diffusivity
RD
:   radial diffusivity
VBM
:   voxel-based morphometry
WAIS
:   Wechsler Adult Intelligence Scale" />
<meta name="DC.Contributor" content="Hiroyuki Maki" />
<meta name="DC.Contributor" content="Madoka Mori-Yoshimura" />
<meta name="DC.Contributor" content="Hiroshi Matsuda" />
<meta name="DC.Contributor" content="Yasumasa Hashimoto" />
<meta name="DC.Contributor" content="Miho Ota" />
<meta name="DC.Contributor" content="Yukio Kimura" />
<meta name="DC.Contributor" content="Yoko Shigemoto" />
<meta name="DC.Contributor" content="Naoko Ishihara" />
<meta name="DC.Contributor" content="Hirohito Kan" />
<meta name="DC.Contributor" content="Emiko Chiba" />
<meta name="DC.Contributor" content="Elly Arizono" />
<meta name="DC.Contributor" content="Sumiko Yoshida" />
<meta name="DC.Contributor" content="Yuji Takahashi" />
<meta name="DC.Contributor" content="Noriko Sato" />
<meta name="article:published_time" content="2023-12-01" />
<meta name="article:section" content="Neurodegenerative Disorder Imaging" />
<meta name="citation_title" content="Brain Abnormalities in Becker Muscular Dystrophy: Evaluation by Voxel-Based DTI and Morphometric Analysis" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Although various neuropsychological problems in Becker muscular dystrophy have attracted attention, there have been few related neuroimaging studies. We investigated brain abnormalities in patients with Becker muscular dystrophy using 3D T1WI and DTI.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;MR images were obtained for 30 male patients and 30 age-matched healthy male controls. We classified patients into Dp140+ and Dp140− subgroups based on their predicted dystrophin Dp140 isoform expression and performed voxel-based comparisons of gray and white matter volumes and DTI metrics among the patients, patient subgroups, and controls. ROI-based DTI analyses were also performed.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Significantly decreased fractional anisotropy was observed in the left planum temporale and right superior parietal lobule compared between the Becker muscular dystrophy and control groups. In the Dp140− subgroup, decreased fractional anisotropy was observed in the left planum temporale, but no significant changes were seen in the Dp140+ subgroup. The ROI-based analysis obtained the same results. No significant differences were evident in the gray or white matter volumes or the DTI metrics other than fractional anisotropy between the groups.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;A DTI metric analysis is useful to detect white-matter microstructural abnormalities in Becker muscular dystrophy that may be affected by the Dp140 isoform expression.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2023/12/01" />
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<meta name="citation_firstpage" content="1405" />
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<meta name="citation_author" content="Hiroyuki Maki" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology (H. Maki, Y.K., Y.S., E.C., E.A., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan" />
<meta name="citation_author_orcid" content="https://orcid.org/0000-0001-6434-4732" />
<meta name="citation_author" content="Madoka Mori-Yoshimura" />
<meta name="citation_author_institution" content="bDepartment of Neurology (M.M.-Y., Y.T.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan" />
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<meta name="citation_author" content="Hiroshi Matsuda" />
<meta name="citation_author_institution" content="cDepartment of Biofunctional Imaging (H. Matsuda), Fukushima Medical University, Fukushima, Japan" />
<meta name="citation_author" content="Yasumasa Hashimoto" />
<meta name="citation_author_institution" content="dDepartment of Neurology (Y.H.), Kansai Medical University, Osaka, Japan" />
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<meta name="citation_author" content="Miho Ota" />
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<meta name="citation_author" content="Yukio Kimura" />
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<meta name="twitter:title" content="Brain Abnormalities in Becker Muscular Dystrophy: Evaluation by Voxel-Based DTI and Morphometric Analysis" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Although various neuropsychological problems in Becker muscular dystrophy have attracted attention, there have been few related neuroimaging studies. We investigated brain abnormalities in patients with Becker muscular dystrophy using 3D T1WI and DTI.

MATERIALS AND METHODS: MR images were obtained for 30 male patients and 30 age-matched healthy male controls. We classified patients into Dp140+ and Dp140− subgroups based on their predicted dystrophin Dp140 isoform expression and performed voxel-based comparisons of gray and white matter volumes and DTI metrics among the patients, patient subgroups, and controls. ROI-based DTI analyses were also performed.

RESULTS: Significantly decreased fractional anisotropy was observed in the left planum temporale and right superior parietal lobule compared between the Becker muscular dystrophy and control groups. In the Dp140− subgroup, decreased fractional anisotropy was observed in the left planum temporale, but no significant changes were seen in the Dp140+ subgroup. The ROI-based analysis obtained the same results. No significant differences were evident in the gray or white matter volumes or the DTI metrics other than fractional anisotropy between the groups.

CONCLUSIONS: A DTI metric analysis is useful to detect white-matter microstructural abnormalities in Becker muscular dystrophy that may be affected by the Dp140 isoform expression.

AD
:   axial diffusivity
BMD
:   Becker muscular dystrophy
DARTEL
:   Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra
DMD
:   Duchenne muscular dystrophy
FA
:   fractional anisotropy
IQ
:   intelligence quotient
MD
:   mean diffusivity
RD
:   radial diffusivity
VBM
:   voxel-based morphometry
WAIS
:   Wechsler Adult Intelligence Scale" />
<meta name="og-title" property="og:title" content="Brain Abnormalities in Becker Muscular Dystrophy: Evaluation by Voxel-Based DTI and Morphometric Analysis" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/44/12/1405" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Although various neuropsychological problems in Becker muscular dystrophy have attracted attention, there have been few related neuroimaging studies. We investigated brain abnormalities in patients with Becker muscular dystrophy using 3D T1WI and DTI.

MATERIALS AND METHODS: MR images were obtained for 30 male patients and 30 age-matched healthy male controls. We classified patients into Dp140+ and Dp140− subgroups based on their predicted dystrophin Dp140 isoform expression and performed voxel-based comparisons of gray and white matter volumes and DTI metrics among the patients, patient subgroups, and controls. ROI-based DTI analyses were also performed.

RESULTS: Significantly decreased fractional anisotropy was observed in the left planum temporale and right superior parietal lobule compared between the Becker muscular dystrophy and control groups. In the Dp140− subgroup, decreased fractional anisotropy was observed in the left planum temporale, but no significant changes were seen in the Dp140+ subgroup. The ROI-based analysis obtained the same results. No significant differences were evident in the gray or white matter volumes or the DTI metrics other than fractional anisotropy between the groups.

CONCLUSIONS: A DTI metric analysis is useful to detect white-matter microstructural abnormalities in Becker muscular dystrophy that may be affected by the Dp140 isoform expression.

AD
:   axial diffusivity
BMD
:   Becker muscular dystrophy
DARTEL
:   Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra
DMD
:   Duchenne muscular dystrophy
FA
:   fractional anisotropy
IQ
:   intelligence quotient
MD
:   mean diffusivity
RD
:   radial diffusivity
VBM
:   voxel-based morphometry
WAIS
:   Wechsler Adult Intelligence Scale" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node105022--5" data-node-nid="105022" id="top-node-105022--6608231681" data-pisa="ajnr;44/12/1405" data-pisa-master="ajnr;ajnr.A8041" data-apath="/ajnr/44/12/1405.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Neurodegenerative Disorder Imaging</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Brain Abnormalities in Becker Muscular Dystrophy: Evaluation by Voxel-Based DTI and Morphometric Analysis</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Hiroyuki Maki</span>, <span class="highwire-citation-author" data-delta="1">Madoka Mori-Yoshimura</span>, <span class="highwire-citation-author" data-delta="2">Hiroshi Matsuda</span>, <span class="highwire-citation-author" data-delta="3">Yasumasa Hashimoto</span>, <span class="highwire-citation-author" data-delta="4">Miho Ota</span>, <span class="highwire-citation-author" data-delta="5">Yukio Kimura</span>, <span class="highwire-citation-author" data-delta="6">Yoko Shigemoto</span>, <span class="highwire-citation-author" data-delta="7">Naoko Ishihara</span>, <span class="highwire-citation-author" data-delta="8">Hirohito Kan</span>, <span class="highwire-citation-author" data-delta="9">Emiko Chiba</span>, <span class="highwire-citation-author" data-delta="10">Elly Arizono</span>, <span class="highwire-citation-author" data-delta="11">Sumiko Yoshida</span>, <span class="highwire-citation-author" data-delta="12">Yuji Takahashi</span> and <span class="highwire-citation-author" data-delta="13">Noriko Sato</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">December 2023,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">44 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1405-1410; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A8041 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-105022--6608231681" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Hiroyuki Maki </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (H. Maki, Y.K., Y.S., E.C., E.A., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Hiroyuki%2BMaki%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Maki%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AHiroyuki%2BMaki%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6434-4732" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Hiroyuki Maki</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Madoka Mori-Yoshimura </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology (M.M.-Y., Y.T.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Madoka%2BMori-Yoshimura%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Mori-Yoshimura%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AMadoka%2BMori-Yoshimura%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4312-9114" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Madoka Mori-Yoshimura</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Hiroshi Matsuda </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Biofunctional Imaging (H. Matsuda), Fukushima Medical University, Fukushima, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Hiroshi%2BMatsuda%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Matsuda%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AHiroshi%2BMatsuda%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Yasumasa Hashimoto </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neurology (Y.H.), Kansai Medical University, Osaka, Japan</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Molecular Therapy (Y.H.), National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Yasumasa%2BHashimoto%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hashimoto%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AYasumasa%2BHashimoto%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Miho Ota </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Neuropsychiatry (M.O.), University of Tsukuba, Ibaraki, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Miho%2BOta%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ota%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AMiho%2BOta%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8873-0822" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Miho Ota</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">Yukio Kimura </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (H. Maki, Y.K., Y.S., E.C., E.A., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Yukio%2BKimura%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kimura%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AYukio%2BKimura%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7979-0863" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Yukio Kimura</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">Yoko Shigemoto </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (H. Maki, Y.K., Y.S., E.C., E.A., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Yoko%2BShigemoto%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Shigemoto%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AYoko%2BShigemoto%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2524-2498" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Yoko Shigemoto</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">Naoko Ishihara </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Medical Genome Center (N.I., S.Y.), National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Naoko%2BIshihara%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ishihara%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ANaoko%2BIshihara%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">Hirohito Kan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Department of Integrated Health Sciences (H.K.), Nagoya University Graduate School of Medicine, Aichi, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Hirohito%2BKan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kan%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AHirohito%2BKan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5688-2685" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Hirohito Kan</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">Emiko Chiba </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (H. Maki, Y.K., Y.S., E.C., E.A., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Emiko%2BChiba%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chiba%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AEmiko%2BChiba%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3170-5217" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Emiko Chiba</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">Elly Arizono </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (H. Maki, Y.K., Y.S., E.C., E.A., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Elly%2BArizono%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Arizono%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AElly%2BArizono%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3442-8489" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Elly Arizono</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">Sumiko Yoshida </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Medical Genome Center (N.I., S.Y.), National Center of Neurology and Psychiatry, Tokyo, Japan</div><div class='author-affiliation'><span class='nlm-sup'>i</span>Department of Psychiatric Rehabilitation (S.Y.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Sumiko%2BYoshida%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Yoshida%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ASumiko%2BYoshida%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">Yuji Takahashi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology (M.M.-Y., Y.T.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Yuji%2BTakahashi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Takahashi%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AYuji%2BTakahashi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5335-7757" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Yuji Takahashi</a></li></ul></div><div class="author-tooltip-13"><div class="author-tooltip-name">Noriko Sato </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (H. Maki, Y.K., Y.S., E.C., E.A., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Noriko%2BSato%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sato%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3ANoriko%2BSato%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9305-7131" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Noriko Sato</a></li></ul></div></div></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Hiroyuki</span> <span class="nlm-surname">Maki</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Madoka</span> <span class="nlm-surname">Mori-Yoshimura</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Hiroshi</span> <span class="nlm-surname">Matsuda</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Yasumasa</span> <span class="nlm-surname">Hashimoto</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Miho</span> <span class="nlm-surname">Ota</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Yukio</span> <span class="nlm-surname">Kimura</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Yoko</span> <span class="nlm-surname">Shigemoto</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Naoko</span> <span class="nlm-surname">Ishihara</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Hirohito</span> <span class="nlm-surname">Kan</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Emiko</span> <span class="nlm-surname">Chiba</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">Elly</span> <span class="nlm-surname">Arizono</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">Sumiko</span> <span class="nlm-surname">Yoshida</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">Yuji</span> <span class="nlm-surname">Takahashi</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">Noriko</span> <span class="nlm-surname">Sato</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Dec 2023, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">44 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1405-1410; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A8041 </span></div>
  
  
  
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