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<meta name="DC.Title" content="Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord" />
<meta name="DC.Identifier" content="10.3174/ajnr.A7843" />
<meta name="DC.Date" content="2023-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: In MS, it is common to acquire brain and spinal cord MR imaging sequences separately to assess the extent of the disease. The goal of this study was to see how replacing the traditional brain T1-weighted images (brain-T1) with an acquisition that included both the brain and the cervical spinal cord (cns-T1) affected brain- and spinal cord–derived measures.

MATERIALS AND METHODS: Thirty-six healthy controls (HC) and 42 patients with MS were included. Of those, 18 HC and 35 patients with MS had baseline and follow-up at 1 year acquired on a 3T magnet. Two 3D T1-weighted images (brain-T1 and cns-T1) were acquired at each time point. Regional cortical thickness and volumes were determined with FastSurfer, and the percentage brain volume change per year was obtained with SIENA. The spinal cord area was estimated with the Spinal Cord Toolbox. Intraclass correlation coefficients (ICC) were calculated to check for consistency of measures obtained from brain-T1 and cns-T1.

RESULTS: Cortical thickness measures showed an ICC &gt;0.75 in 94% of regions in healthy controls and 80% in patients with MS. Estimated regional volumes had an ICC &gt;0.88, and the percentage brain volume change had an ICC &gt;0.79 for both groups. The spinal cord area measures had an ICC of 0.68 in healthy controls and 0.92 in patients with MS.

CONCLUSIONS: Brain measurements obtained from 3D cns-T1 are highly equivalent to those obtained from a brain-T1, suggesting that it could be feasible to replace the brain-T1 with cns-T1.

cns
:   central nervous system
EDSS
:   Expanded Disability Status Scale
HC
:   healthy control
ICC
:   intraclass correlation coefficient
PBVC
:   percentage brain volume change
SCA
:   spinal cord area
SSIM
:   structural similarity index" />
<meta name="DC.Contributor" content="D. Pareto" />
<meta name="DC.Contributor" content="J.F. Corral" />
<meta name="DC.Contributor" content="A. Garcia-Vidal" />
<meta name="DC.Contributor" content="M. Alberich" />
<meta name="DC.Contributor" content="C. Auger" />
<meta name="DC.Contributor" content="J. Rio" />
<meta name="DC.Contributor" content="N. Mongay" />
<meta name="DC.Contributor" content="J. Sastre-Garriga" />
<meta name="DC.Contributor" content="À. Rovira" />
<meta name="article:published_time" content="2023-05-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;In MS, it is common to acquire brain and spinal cord MR imaging sequences separately to assess the extent of the disease. The goal of this study was to see how replacing the traditional brain T1-weighted images (brain-T1) with an acquisition that included both the brain and the cervical spinal cord (cns-T1) affected brain- and spinal cord–derived measures.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Thirty-six healthy controls (HC) and 42 patients with MS were included. Of those, 18 HC and 35 patients with MS had baseline and follow-up at 1 year acquired on a 3T magnet. Two 3D T1-weighted images (brain-T1 and cns-T1) were acquired at each time point. Regional cortical thickness and volumes were determined with FastSurfer, and the percentage brain volume change per year was obtained with SIENA. The spinal cord area was estimated with the Spinal Cord Toolbox. Intraclass correlation coefficients (ICC) were calculated to check for consistency of measures obtained from brain-T1 and cns-T1.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Cortical thickness measures showed an ICC &amp;gt;0.75 in 94% of regions in healthy controls and 80% in patients with MS. Estimated regional volumes had an ICC &amp;gt;0.88, and the percentage brain volume change had an ICC &amp;gt;0.79 for both groups. The spinal cord area measures had an ICC of 0.68 in healthy controls and 0.92 in patients with MS.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Brain measurements obtained from 3D cns-T1 are highly equivalent to those obtained from a brain-T1, suggesting that it could be feasible to replace the brain-T1 with cns-T1.&lt;/p&gt;" />
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<meta name="twitter:title" content="Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/44/5.cover-source.jpg" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: In MS, it is common to acquire brain and spinal cord MR imaging sequences separately to assess the extent of the disease. The goal of this study was to see how replacing the traditional brain T1-weighted images (brain-T1) with an acquisition that included both the brain and the cervical spinal cord (cns-T1) affected brain- and spinal cord–derived measures.

MATERIALS AND METHODS: Thirty-six healthy controls (HC) and 42 patients with MS were included. Of those, 18 HC and 35 patients with MS had baseline and follow-up at 1 year acquired on a 3T magnet. Two 3D T1-weighted images (brain-T1 and cns-T1) were acquired at each time point. Regional cortical thickness and volumes were determined with FastSurfer, and the percentage brain volume change per year was obtained with SIENA. The spinal cord area was estimated with the Spinal Cord Toolbox. Intraclass correlation coefficients (ICC) were calculated to check for consistency of measures obtained from brain-T1 and cns-T1.

RESULTS: Cortical thickness measures showed an ICC &gt;0.75 in 94% of regions in healthy controls and 80% in patients with MS. Estimated regional volumes had an ICC &gt;0.88, and the percentage brain volume change had an ICC &gt;0.79 for both groups. The spinal cord area measures had an ICC of 0.68 in healthy controls and 0.92 in patients with MS.

CONCLUSIONS: Brain measurements obtained from 3D cns-T1 are highly equivalent to those obtained from a brain-T1, suggesting that it could be feasible to replace the brain-T1 with cns-T1.

cns
:   central nervous system
EDSS
:   Expanded Disability Status Scale
HC
:   healthy control
ICC
:   intraclass correlation coefficient
PBVC
:   percentage brain volume change
SCA
:   spinal cord area
SSIM
:   structural similarity index" />
<meta name="og-title" property="og:title" content="Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: In MS, it is common to acquire brain and spinal cord MR imaging sequences separately to assess the extent of the disease. The goal of this study was to see how replacing the traditional brain T1-weighted images (brain-T1) with an acquisition that included both the brain and the cervical spinal cord (cns-T1) affected brain- and spinal cord–derived measures.

MATERIALS AND METHODS: Thirty-six healthy controls (HC) and 42 patients with MS were included. Of those, 18 HC and 35 patients with MS had baseline and follow-up at 1 year acquired on a 3T magnet. Two 3D T1-weighted images (brain-T1 and cns-T1) were acquired at each time point. Regional cortical thickness and volumes were determined with FastSurfer, and the percentage brain volume change per year was obtained with SIENA. The spinal cord area was estimated with the Spinal Cord Toolbox. Intraclass correlation coefficients (ICC) were calculated to check for consistency of measures obtained from brain-T1 and cns-T1.

RESULTS: Cortical thickness measures showed an ICC &gt;0.75 in 94% of regions in healthy controls and 80% in patients with MS. Estimated regional volumes had an ICC &gt;0.88, and the percentage brain volume change had an ICC &gt;0.79 for both groups. The spinal cord area measures had an ICC of 0.68 in healthy controls and 0.92 in patients with MS.

CONCLUSIONS: Brain measurements obtained from 3D cns-T1 are highly equivalent to those obtained from a brain-T1, suggesting that it could be feasible to replace the brain-T1 with cns-T1.

cns
:   central nervous system
EDSS
:   Expanded Disability Status Scale
HC
:   healthy control
ICC
:   intraclass correlation coefficient
PBVC
:   percentage brain volume change
SCA
:   spinal cord area
SSIM
:   structural similarity index" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node102272--7" data-node-nid="102272" id="top-node-102272--8526214165" data-pisa="ajnr;44/5/569" data-pisa-master="ajnr;ajnr.A7843" data-apath="/ajnr/44/5/569.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Adult Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">D. Pareto</span>, <span class="highwire-citation-author" data-delta="1">J.F. Corral</span>, <span class="highwire-citation-author" data-delta="2">A. Garcia-Vidal</span>, <span class="highwire-citation-author" data-delta="3">M. Alberich</span>, <span class="highwire-citation-author" data-delta="4">C. Auger</span>, <span class="highwire-citation-author" data-delta="5">J. Rio</span>, <span class="highwire-citation-author" data-delta="6">N. Mongay</span>, <span class="highwire-citation-author" data-delta="7">J. Sastre-Garriga</span> and <span class="highwire-citation-author" data-delta="8">À. Rovira</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2023,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">44 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">569-573; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7843 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-102272--8526214165" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">D. Pareto </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Neuroradiology Group (D.P., J.F.C., A.G.-V., C.A., À.R.), Vall d’Hebron Research Institute, Barcelona, Spain</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Section of Neuroradiology (D.P., J.F.C., M.A., À.R.), Radiology Department, Vall d’Hebron University Hospital, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BPareto%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Pareto%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BPareto%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-7356-3769" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. Pareto</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J.F. Corral </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Neuroradiology Group (D.P., J.F.C., A.G.-V., C.A., À.R.), Vall d’Hebron Research Institute, Barcelona, Spain</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Section of Neuroradiology (D.P., J.F.C., M.A., À.R.), Radiology Department, Vall d’Hebron University Hospital, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.F.%2BCorral%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Corral%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.F.%2BCorral%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A. Garcia-Vidal </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Neuroradiology Group (D.P., J.F.C., A.G.-V., C.A., À.R.), Vall d’Hebron Research Institute, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BGarcia-Vidal%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Garcia-Vidal%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BGarcia-Vidal%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1739-8636" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Garcia-Vidal</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">M. Alberich </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Section of Neuroradiology (D.P., J.F.C., M.A., À.R.), Radiology Department, Vall d’Hebron University Hospital, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BAlberich%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Alberich%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BAlberich%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4132-0620" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Alberich</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">C. Auger </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Neuroradiology Group (D.P., J.F.C., A.G.-V., C.A., À.R.), Vall d’Hebron Research Institute, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BAuger%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Auger%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BAuger%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9846-4767" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. Auger</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">J. Rio </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurology and Neuroimmunology (J.R., N.M., J.S.-G.), Multiple Sclerosis Centre of Catalonia, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BRio%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rio%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BRio%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4546-7627" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Rio</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">N. Mongay </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurology and Neuroimmunology (J.R., N.M., J.S.-G.), Multiple Sclerosis Centre of Catalonia, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BMongay%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Mongay%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BMongay%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0338-4797" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Mongay</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">J. Sastre-Garriga </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurology and Neuroimmunology (J.R., N.M., J.S.-G.), Multiple Sclerosis Centre of Catalonia, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BSastre-Garriga%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sastre-Garriga%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BSastre-Garriga%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1589-2254" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Sastre-Garriga</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">À. Rovira </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Neuroradiology Group (D.P., J.F.C., A.G.-V., C.A., À.R.), Vall d’Hebron Research Institute, Barcelona, Spain</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Section of Neuroradiology (D.P., J.F.C., M.A., À.R.), Radiology Department, Vall d’Hebron University Hospital, Barcelona, Spain</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=%C3%80.%2BRovira%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rovira%20%C3%80&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3A%25C3%2580.%2BRovira%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2132-6750" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for À. Rovira</a></li></ul></div></div></div>  </div>

  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">vol. 44 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">no. 5 </span><span  class="highwire-cite-metadata-page-string highwire-cite-metadata">569-573 </span></div>
  
  
  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">D. Pareto</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-2"><span class="name">J.F. Corral</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-2" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-3"><span class="name">A. Garcia-Vidal</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-4"><span class="name">M. Alberich</span><a id="xref-aff-2-3" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-5"><span class="name">C. Auger</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-6"><span class="name">J. Rio</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-7"><span class="name">N. Mongay</span><a id="xref-aff-3-2" class="xref-aff" href="#aff-3">c</a>, </li><li class="contributor" id="contrib-8"><span class="name">J. Sastre-Garriga</span><a id="xref-aff-3-3" class="xref-aff" href="#aff-3">c</a> and </li><li class="last" id="contrib-9"><span class="name">À. Rovira</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">a</a><span class="xref-sep">,</span><a id="xref-aff-2-4" class="xref-aff" href="#aff-2">b</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Neuroradiology Group (D.P., J.F.C., A.G.-V., C.A., À.R.), Vall d’Hebron Research Institute, Barcelona, Spain</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Section of Neuroradiology (D.P., J.F.C., M.A., À.R.), Radiology Department, Vall d’Hebron University Hospital, Barcelona, Spain</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Department of Neurology and Neuroimmunology (J.R., N.M., J.S.-G.), Multiple Sclerosis Centre of Catalonia, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Deborah Pareto, PhD, <span class="addr-line">Section of Neuroradiology, Vall d’Hebron University Hospital Psg, Vall Hebron 119-129, 08035 Barcelona, Spain</span>; e-mail: <span class="em-link"><span class="em-addr">deborah.pareto.idi{at}gencat.cat</span></span></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/44/5/569.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Pareto</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.F.</span> <span class="nlm-surname">Corral</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Garcia-Vidal</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Alberich</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Auger</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Rio</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Mongay</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Sastre-Garriga</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">À.</span> <span class="nlm-surname">Rovira</span></span></span></div>
  
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