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<meta name="DC.Title" content="A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms" />
<meta name="DC.Identifier" content="10.3174/ajnr.A7865" />
<meta name="DC.Date" content="2023-06-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2023 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety and efficacy of the 2 treatments in a randomized trial.

MATERIALS AND METHODS: Clipping or endovascular treatments were randomly allocated to patients with one or more 3- to 25-mm unruptured intracranial aneurysms judged treatable both ways by participating physicians. The study hypothesized that clipping would decrease the incidence of treatment failure from 13% to 4%, a composite primary outcome defined as failure of aneurysm occlusion, intracranial hemorrhage during follow-up, or residual aneurysms at 1 year, as adjudicated by a core lab. Safety outcomes included new neurologic deficits following treatment, hospitalization of &gt;5 days, and overall morbidity and mortality (mRS &gt; 2) at 1 year. There was no blinding.

RESULTS: Two hundred ninety-one patients were enrolled from 2010 to 2020 in 7 centers. The 1-year primary outcome, ascertainable in 290/291 (99%) patients, was reached in 13/142 (9%; 95% CI, 5%–15%) patients allocated to surgery and in 28/148 (19%; 95% CI, 13%–26%) patients allocated to endovascular treatments (relative risk: 2.07; 95% CI, 1.12–3.83; P = .021). Morbidity and mortality (mRS &gt;2) at 1 year occurred in 3/143 and 3/148 (2%; 95% CI, 1%–6%) patients allocated to surgery and endovascular treatments, respectively. Neurologic deficits (32/143, 22%; 95% CI, 16%–30% versus 19/148, 12%; 95% CI, 8%–19%; relative risk: 1.74; 95% CI, 1.04–2.92; P = .04) and hospitalizations beyond 5 days (69/143, 48%; 95% CI, 40%–56% versus 12/148, 8%; 95% CI, 5%–14%; relative risk: 0.18; 95% CI, 0.11–0.31; P  &lt; .001) were more frequent after surgery.

CONCLUSIONS: Surgical clipping is more effective than endovascular treatment of unruptured intracranial aneurysms in terms of the frequency of the primary outcome of treatment failure. Results were mainly driven by angiographic results at 1 year.

EVT
:   endovascular treatment
RR
:   relative risk
UIA
:   unruptured intracranial aneurysm" />
<meta name="DC.Contributor" content="T.E. Darsaut" />
<meta name="DC.Contributor" content="J.M. Findlay" />
<meta name="DC.Contributor" content="M.W. Bojanowski" />
<meta name="DC.Contributor" content="C. Chalaala" />
<meta name="DC.Contributor" content="D. Iancu" />
<meta name="DC.Contributor" content="D. Roy" />
<meta name="DC.Contributor" content="A. Weill" />
<meta name="DC.Contributor" content="W. Boisseau" />
<meta name="DC.Contributor" content="A. Diouf" />
<meta name="DC.Contributor" content="E. Magro" />
<meta name="DC.Contributor" content="M. Kotowski" />
<meta name="DC.Contributor" content="M.B. Keough" />
<meta name="DC.Contributor" content="L. Estrade" />
<meta name="DC.Contributor" content="N. Bricout" />
<meta name="DC.Contributor" content="J.-P. Lejeune" />
<meta name="DC.Contributor" content="M.M.C. Chow" />
<meta name="DC.Contributor" content="C.J. O’Kelly" />
<meta name="DC.Contributor" content="J.L. Rempel" />
<meta name="DC.Contributor" content="R.A. Ashforth" />
<meta name="DC.Contributor" content="H. Lesiuk" />
<meta name="DC.Contributor" content="J. Sinclair" />
<meta name="DC.Contributor" content="U.-E. Erdenebold" />
<meta name="DC.Contributor" content="J.H. Wong" />
<meta name="DC.Contributor" content="F. Scholtes" />
<meta name="DC.Contributor" content="D. Martin" />
<meta name="DC.Contributor" content="B. Otto" />
<meta name="DC.Contributor" content="A. Bilocq" />
<meta name="DC.Contributor" content="E. Truffer" />
<meta name="DC.Contributor" content="K. Butcher" />
<meta name="DC.Contributor" content="A.J. Fox" />
<meta name="DC.Contributor" content="A.S. Arthur" />
<meta name="DC.Contributor" content="L. Létourneau-Guillon" />
<meta name="DC.Contributor" content="F. Guilbert" />
<meta name="DC.Contributor" content="M. Chagnon" />
<meta name="DC.Contributor" content="J. Zehr" />
<meta name="DC.Contributor" content="B. Farzin" />
<meta name="DC.Contributor" content="G. Gevry" />
<meta name="DC.Contributor" content="J. Raymond" />
<meta name="article:published_time" content="2023-06-01" />
<meta name="article:section" content="Interventional" />
<meta name="citation_title" content="A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety and efficacy of the 2 treatments in a randomized trial.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Clipping or endovascular treatments were randomly allocated to patients with one or more 3- to 25-mm unruptured intracranial aneurysms judged treatable both ways by participating physicians. The study hypothesized that clipping would decrease the incidence of treatment failure from 13% to 4%, a composite primary outcome defined as failure of aneurysm occlusion, intracranial hemorrhage during follow-up, or residual aneurysms at 1 year, as adjudicated by a core lab. Safety outcomes included new neurologic deficits following treatment, hospitalization of &amp;gt;5 days, and overall morbidity and mortality (mRS &amp;gt; 2) at 1 year. There was no blinding.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Two hundred ninety-one patients were enrolled from 2010 to 2020 in 7 centers. The 1-year primary outcome, ascertainable in 290/291 (99%) patients, was reached in 13/142 (9%; 95% CI, 5%–15%) patients allocated to surgery and in 28/148 (19%; 95% CI, 13%–26%) patients allocated to endovascular treatments (relative risk: 2.07; 95% CI, 1.12–3.83; &lt;i&gt;P&lt;/i&gt; = .021). Morbidity and mortality (mRS &amp;gt;2) at 1 year occurred in 3/143 and 3/148 (2%; 95% CI, 1%–6%) patients allocated to surgery and endovascular treatments, respectively. Neurologic deficits (32/143, 22%; 95% CI, 16%–30% versus 19/148, 12%; 95% CI, 8%–19%; relative risk: 1.74; 95% CI, 1.04–2.92; &lt;i&gt;P&lt;/i&gt; = .04) and hospitalizations beyond 5 days (69/143, 48%; 95% CI, 40%–56% versus 12/148, 8%; 95% CI, 5%–14%; relative risk: 0.18; 95% CI, 0.11–0.31; &lt;i&gt;P &lt;/i&gt;&amp;lt; .001) were more frequent after surgery.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Surgical clipping is more effective than endovascular treatment of unruptured intracranial aneurysms in terms of the frequency of the primary outcome of treatment failure. Results were mainly driven by angiographic results at 1 year.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2023/06/01" />
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<meta name="twitter:title" content="A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety and efficacy of the 2 treatments in a randomized trial.

MATERIALS AND METHODS: Clipping or endovascular treatments were randomly allocated to patients with one or more 3- to 25-mm unruptured intracranial aneurysms judged treatable both ways by participating physicians. The study hypothesized that clipping would decrease the incidence of treatment failure from 13% to 4%, a composite primary outcome defined as failure of aneurysm occlusion, intracranial hemorrhage during follow-up, or residual aneurysms at 1 year, as adjudicated by a core lab. Safety outcomes included new neurologic deficits following treatment, hospitalization of &gt;5 days, and overall morbidity and mortality (mRS &gt; 2) at 1 year. There was no blinding.

RESULTS: Two hundred ninety-one patients were enrolled from 2010 to 2020 in 7 centers. The 1-year primary outcome, ascertainable in 290/291 (99%) patients, was reached in 13/142 (9%; 95% CI, 5%–15%) patients allocated to surgery and in 28/148 (19%; 95% CI, 13%–26%) patients allocated to endovascular treatments (relative risk: 2.07; 95% CI, 1.12–3.83; P = .021). Morbidity and mortality (mRS &gt;2) at 1 year occurred in 3/143 and 3/148 (2%; 95% CI, 1%–6%) patients allocated to surgery and endovascular treatments, respectively. Neurologic deficits (32/143, 22%; 95% CI, 16%–30% versus 19/148, 12%; 95% CI, 8%–19%; relative risk: 1.74; 95% CI, 1.04–2.92; P = .04) and hospitalizations beyond 5 days (69/143, 48%; 95% CI, 40%–56% versus 12/148, 8%; 95% CI, 5%–14%; relative risk: 0.18; 95% CI, 0.11–0.31; P  &lt; .001) were more frequent after surgery.

CONCLUSIONS: Surgical clipping is more effective than endovascular treatment of unruptured intracranial aneurysms in terms of the frequency of the primary outcome of treatment failure. Results were mainly driven by angiographic results at 1 year.

EVT
:   endovascular treatment
RR
:   relative risk
UIA
:   unruptured intracranial aneurysm" />
<meta name="og-title" property="og:title" content="A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/44/6/634" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety and efficacy of the 2 treatments in a randomized trial.

MATERIALS AND METHODS: Clipping or endovascular treatments were randomly allocated to patients with one or more 3- to 25-mm unruptured intracranial aneurysms judged treatable both ways by participating physicians. The study hypothesized that clipping would decrease the incidence of treatment failure from 13% to 4%, a composite primary outcome defined as failure of aneurysm occlusion, intracranial hemorrhage during follow-up, or residual aneurysms at 1 year, as adjudicated by a core lab. Safety outcomes included new neurologic deficits following treatment, hospitalization of &gt;5 days, and overall morbidity and mortality (mRS &gt; 2) at 1 year. There was no blinding.

RESULTS: Two hundred ninety-one patients were enrolled from 2010 to 2020 in 7 centers. The 1-year primary outcome, ascertainable in 290/291 (99%) patients, was reached in 13/142 (9%; 95% CI, 5%–15%) patients allocated to surgery and in 28/148 (19%; 95% CI, 13%–26%) patients allocated to endovascular treatments (relative risk: 2.07; 95% CI, 1.12–3.83; P = .021). Morbidity and mortality (mRS &gt;2) at 1 year occurred in 3/143 and 3/148 (2%; 95% CI, 1%–6%) patients allocated to surgery and endovascular treatments, respectively. Neurologic deficits (32/143, 22%; 95% CI, 16%–30% versus 19/148, 12%; 95% CI, 8%–19%; relative risk: 1.74; 95% CI, 1.04–2.92; P = .04) and hospitalizations beyond 5 days (69/143, 48%; 95% CI, 40%–56% versus 12/148, 8%; 95% CI, 5%–14%; relative risk: 0.18; 95% CI, 0.11–0.31; P  &lt; .001) were more frequent after surgery.

CONCLUSIONS: Surgical clipping is more effective than endovascular treatment of unruptured intracranial aneurysms in terms of the frequency of the primary outcome of treatment failure. Results were mainly driven by angiographic results at 1 year.

EVT
:   endovascular treatment
RR
:   relative risk
UIA
:   unruptured intracranial aneurysm" />
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">June 2023,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">44 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">634-640; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7865 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-102700--6751298482" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">T.E. Darsaut </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.E.%2BDarsaut%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Darsaut%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AT.E.%2BDarsaut%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4662-1550" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for T.E. Darsaut</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J.M. Findlay </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.M.%2BFindlay%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Findlay%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.M.%2BFindlay%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4842-3905" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.M. Findlay</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">M.W. Bojanowski </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Service of Neurosurgery (M.W.B., C.C.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.W.%2BBojanowski%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bojanowski%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.W.%2BBojanowski%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0967-2730" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.W. Bojanowski</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">C. Chalaala </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Service of Neurosurgery (M.W.B., C.C.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BChalaala%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chalaala%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BChalaala%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-6079-1455" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. Chalaala</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">D. Iancu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Surgery, and Service of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BIancu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Iancu%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BIancu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2041-9178" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. 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Roy </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Surgery, and Service of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BRoy%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Roy%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BRoy%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6066-4453" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. 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Weill </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Surgery, and Service of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BWeill%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Weill%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BWeill%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0281-6201" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. 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Diouf </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Surgery, and Service of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BDiouf%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Diouf%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BDiouf%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1778-5057" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. 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Magro </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Service of Neurosurgery (E.M.), Centre Hospitalier Universitaire Cavale Blanche, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1101 LaTIM, Brest, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BMagro%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Magro%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2BMagro%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1319-5292" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. 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Kotowski </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Surgery, and Service of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BKotowski%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kotowski%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BKotowski%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6123-2767" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. 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Estrade </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Interventional Neuroradiology (L.E., N.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.%2BEstrade%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Estrade%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AL.%2BEstrade%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9010-7447" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for L. Estrade</a></li></ul></div><div class="author-tooltip-13"><div class="author-tooltip-name">N. Bricout </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Interventional Neuroradiology (L.E., N.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BBricout%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bricout%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BBricout%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1469-3613" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Bricout</a></li></ul></div><div class="author-tooltip-14"><div class="author-tooltip-name">J.-P. Lejeune </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Service of Neurosurgery (J.-P.L.), Centre Hospitalier Universitaire de Lille, Lille, France</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.-P.%2BLejeune%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lejeune%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.-P.%2BLejeune%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1152-821X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.-P. 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Chow </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.M.C.%2BChow%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chow%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.M.C.%2BChow%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-8074-3511" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.M.C. 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O’Kelly </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.J.%2BO%E2%80%99Kelly%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=O%E2%80%99Kelly%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.J.%2BO%25E2%2580%2599Kelly%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9950-3964" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.J. O’Kelly</a></li></ul></div><div class="author-tooltip-17"><div class="author-tooltip-name">J.L. Rempel </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Surgery, and Department of Radiology and Diagnostic Imaging (J.L.R., R.A.A.), Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, Alberta, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.L.%2BRempel%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rempel%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.L.%2BRempel%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2324-8415" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.L. Rempel</a></li></ul></div><div class="author-tooltip-18"><div class="author-tooltip-name">R.A. Ashforth </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Surgery, and Department of Radiology and Diagnostic Imaging (J.L.R., R.A.A.), Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, Alberta, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.A.%2BAshforth%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ashforth%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.A.%2BAshforth%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7035-5910" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R.A. Ashforth</a></li></ul></div><div class="author-tooltip-19"><div class="author-tooltip-name">H. Lesiuk </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Section of Neurosurgery (H.L., J.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BLesiuk%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lesiuk%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.%2BLesiuk%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2365-7163" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H. Lesiuk</a></li></ul></div><div class="author-tooltip-20"><div class="author-tooltip-name">J. Sinclair </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Section of Neurosurgery (H.L., J.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BSinclair%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sinclair%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BSinclair%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1962-0934" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Sinclair</a></li></ul></div><div class="author-tooltip-21"><div class="author-tooltip-name">U.-E. Erdenebold </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>i</span>Department of Surgery, and Department of Medical Imaging (U.-E.E.), Section of Interventional Neuroradiology, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=U.-E.%2BErdenebold%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Erdenebold%20U&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AU.-E.%2BErdenebold%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2246-4861" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for U.-E. Erdenebold</a></li></ul></div><div class="author-tooltip-22"><div class="author-tooltip-name">J.H. Wong </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>j</span>Division of Neurosurgery (J.H.W.), Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.H.%2BWong%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wong%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.H.%2BWong%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4777-9456" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.H. Wong</a></li></ul></div><div class="author-tooltip-23"><div class="author-tooltip-name">F. Scholtes </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>k</span>Departments of Neurosurgery (F.S., D.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BScholtes%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Scholtes%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BScholtes%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8179-0240" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. Scholtes</a></li></ul></div><div class="author-tooltip-24"><div class="author-tooltip-name">D. Martin </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>k</span>Departments of Neurosurgery (F.S., D.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BMartin%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Martin%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BMartin%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-7325-4958" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. Martin</a></li></ul></div><div class="author-tooltip-25"><div class="author-tooltip-name">B. Otto </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>l</span>Medical Physics (B.O.), Division of Medical Imaging, Centre Hospitalier Universitaire de Liège, Liège, Belgium</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.%2BOtto%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Otto%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AB.%2BOtto%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1766-0481" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for B. Otto</a></li></ul></div><div class="author-tooltip-26"><div class="author-tooltip-name">A. Bilocq </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>m</span>Service of Neurosurgery (A.B., E.T.), Centre Hospitalier Régional de Trois-Rivières, Trois-Rivières, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BBilocq%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bilocq%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BBilocq%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0009-0005-1849-5210" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Bilocq</a></li></ul></div><div class="author-tooltip-27"><div class="author-tooltip-name">E. Truffer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>m</span>Service of Neurosurgery (A.B., E.T.), Centre Hospitalier Régional de Trois-Rivières, Trois-Rivières, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BTruffer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Truffer%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AE.%2BTruffer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0009-0001-9335-7206" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for E. Truffer</a></li></ul></div><div class="author-tooltip-28"><div class="author-tooltip-name">K. Butcher </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>n</span>Clinical Neurosciences (K.B.), Prince of Wales Clinical School, University of New South Wales, Randwick, New South Wales, Australia</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.%2BButcher%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Butcher%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AK.%2BButcher%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0590-7918" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for K. Butcher</a></li></ul></div><div class="author-tooltip-29"><div class="author-tooltip-name">A.J. Fox </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>o</span>Department of Medical Imaging (A.J.F.), University of Toronto, Toronto, Ontario, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.J.%2BFox%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fox%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.J.%2BFox%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5465-5801" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.J. Fox</a></li></ul></div><div class="author-tooltip-30"><div class="author-tooltip-name">A.S. Arthur </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>p</span>Department of Neurosurgery (A.S.A.), University of Tennessee Health Science Center and Semmes-Murphey Clinic, Memphis, Tennessee</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.S.%2BArthur%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Arthur%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.S.%2BArthur%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1536-1613" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.S. Arthur</a></li></ul></div><div class="author-tooltip-31"><div class="author-tooltip-name">L. Létourneau-Guillon </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Surgery, and Service of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.%2BL%C3%A9tourneau-Guillon%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=L%C3%A9tourneau-Guillon%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AL.%2BL%25C3%25A9tourneau-Guillon%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6325-7538" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for L. Létourneau-Guillon</a></li></ul></div><div class="author-tooltip-32"><div class="author-tooltip-name">F. Guilbert </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Surgery, and Service of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BGuilbert%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Guilbert%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BGuilbert%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7866-0493" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. Guilbert</a></li></ul></div><div class="author-tooltip-33"><div class="author-tooltip-name">M. Chagnon </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>q</span>Department of Mathematics and Statistics (M.C., J.Z.), Université de Montréal, Montréal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BChagnon%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chagnon%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BChagnon%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2291-9566" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Chagnon</a></li></ul></div><div class="author-tooltip-34"><div class="author-tooltip-name">J. Zehr </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>q</span>Department of Mathematics and Statistics (M.C., J.Z.), Université de Montréal, Montréal, Québec, Canada</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BZehr%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zehr%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BZehr%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-8295-4590" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Zehr</a></li></ul></div><div class="author-tooltip-35"><div class="author-tooltip-name">B. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 44</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jun 2023 </div></div>
      
      
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data-delta="6"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Weill</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Boisseau</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Diouf</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Magro</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Kotowski</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">M.B.</span> <span class="nlm-surname">Keough</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Estrade</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Bricout</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">J.-P.</span> <span class="nlm-surname">Lejeune</span></span>, <span class="highwire-citation-author" data-delta="15"><span class="nlm-given-names">M.M.C.</span> <span class="nlm-surname">Chow</span></span>, <span class="highwire-citation-author" data-delta="16"><span class="nlm-given-names">C.J.</span> <span class="nlm-surname">O’Kelly</span></span>, <span class="highwire-citation-author" data-delta="17"><span class="nlm-given-names">J.L.</span> <span class="nlm-surname">Rempel</span></span>, <span class="highwire-citation-author" data-delta="18"><span class="nlm-given-names">R.A.</span> <span class="nlm-surname">Ashforth</span></span>, <span class="highwire-citation-author" data-delta="19"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Lesiuk</span></span>, <span class="highwire-citation-author" data-delta="20"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Sinclair</span></span>, <span class="highwire-citation-author" data-delta="21"><span class="nlm-given-names">U.-E.</span> <span class="nlm-surname">Erdenebold</span></span>, <span class="highwire-citation-author" data-delta="22"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Wong</span></span>, <span class="highwire-citation-author" data-delta="23"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Scholtes</span></span>, <span class="highwire-citation-author" data-delta="24"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Martin</span></span>, <span class="highwire-citation-author" data-delta="25"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Otto</span></span>, <span class="highwire-citation-author" data-delta="26"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Bilocq</span></span>, <span class="highwire-citation-author" data-delta="27"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Truffer</span></span>, <span class="highwire-citation-author" data-delta="28"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Butcher</span></span>, <span class="highwire-citation-author" data-delta="29"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Fox</span></span>, <span class="highwire-citation-author" data-delta="30"><span class="nlm-given-names">A.S.</span> <span class="nlm-surname">Arthur</span></span>, <span class="highwire-citation-author" data-delta="31"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Létourneau-Guillon</span></span>, <span class="highwire-citation-author" data-delta="32"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Guilbert</span></span>, <span class="highwire-citation-author" data-delta="33"><span 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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2023, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">44 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">634-640; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A7865 </span></div>
  
  
  
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      <div class="highwire-cite-title">A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">T.E.</span> <span class="nlm-surname">Darsaut</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.M.</span> <span class="nlm-surname">Findlay</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">M.W.</span> <span class="nlm-surname">Bojanowski</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Chalaala</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Iancu</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Roy</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Weill</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Boisseau</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Diouf</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Magro</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Kotowski</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">M.B.</span> <span class="nlm-surname">Keough</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Estrade</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Bricout</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">J.-P.</span> <span class="nlm-surname">Lejeune</span></span>, <span class="highwire-citation-author" data-delta="15"><span class="nlm-given-names">M.M.C.</span> <span class="nlm-surname">Chow</span></span>, <span class="highwire-citation-author" data-delta="16"><span class="nlm-given-names">C.J.</span> <span class="nlm-surname">O’Kelly</span></span>, <span class="highwire-citation-author" data-delta="17"><span class="nlm-given-names">J.L.</span> <span class="nlm-surname">Rempel</span></span>, <span class="highwire-citation-author" data-delta="18"><span class="nlm-given-names">R.A.</span> <span class="nlm-surname">Ashforth</span></span>, <span class="highwire-citation-author" data-delta="19"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Lesiuk</span></span>, <span class="highwire-citation-author" data-delta="20"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Sinclair</span></span>, <span class="highwire-citation-author" data-delta="21"><span class="nlm-given-names">U.-E.</span> <span class="nlm-surname">Erdenebold</span></span>, <span class="highwire-citation-author" data-delta="22"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Wong</span></span>, <span class="highwire-citation-author" data-delta="23"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Scholtes</span></span>, <span class="highwire-citation-author" data-delta="24"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Martin</span></span>, <span class="highwire-citation-author" data-delta="25"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Otto</span></span>, <span class="highwire-citation-author" data-delta="26"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Bilocq</span></span>, <span class="highwire-citation-author" data-delta="27"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Truffer</span></span>, <span class="highwire-citation-author" data-delta="28"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Butcher</span></span>, <span class="highwire-citation-author" data-delta="29"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Fox</span></span>, <span class="highwire-citation-author" data-delta="30"><span class="nlm-given-names">A.S.</span> <span class="nlm-surname">Arthur</span></span>, <span class="highwire-citation-author" data-delta="31"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Létourneau-Guillon</span></span>, <span class="highwire-citation-author" data-delta="32"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Guilbert</span></span>, <span class="highwire-citation-author" data-delta="33"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Chagnon</span></span>, <span class="highwire-citation-author" data-delta="34"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Zehr</span></span>, <span class="highwire-citation-author" data-delta="35"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Farzin</span></span>, <span class="highwire-citation-author" data-delta="36"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Gevry</span></span>, <span class="highwire-citation-author" data-delta="37"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Raymond</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2023, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">44 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">634-640; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A7865 </span></div>
  
  
  
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