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<meta name="DC.Title" content="Imaging Assessments and Clinical Significance of Brain Frailty in Moyamoya Disease" />
<meta name="DC.Identifier" content="10.3174/ajnr.A8232" />
<meta name="DC.Date" content="2024-07-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2024 by American Journal of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Imaging assessment of brain frailty in ischemic stroke has been extensively studied, while the correlation between brain frailty and Moyamoya disease remains obscure. This study aimed to investigate the imaging characteristics of brain frailty and its clinical applications in Moyamoya disease.

MATERIALS AND METHODS: This study included 60 patients with Moyamoya disease (107 hemispheres). All patients were divided into stroke and nonstroke groups based on clinical symptoms and imaging findings. The modified brain frailty score was adapted to consider 4 imaging signs: white matter hyperintensity, enlargement of perivascular space, old vascular lesions, and cerebral microbleed. The relative CBF of the MCA territory was quantified using pseudocontinuous arterial-spin labeling. Surgical outcome after revascularization surgery was defined by the Matsushima grade.

RESULTS: The relative CBF of the MCA territory decreased as the modified brain frailty score and periventricular white matter hyperintensity grades increased (ρ = −0.22, P  = .02; ρ = −0.27, P  = .005). Clinically, the modified brain frailty score could identify patients with Moyamoya disease with stroke (OR = 2.00, P  = .02). Although the modified brain frailty score showed no predictive value for surgical outcome, basal ganglia enlargement of the perivascular space had a significant correlation with the postoperative Matsushima grade (OR = 1.29, P  = .03).

CONCLUSIONS: The modified brain frailty score could reflect a cerebral perfusion deficit and clinical symptoms of Moyamoya disease, and its component basal ganglia enlargement of perivascular space may be a promising marker to predict surgical outcome and thus aid future clinical decision-making.

CMB
:   cerebral microbleed
EDAS
:   encephaloduroarteriosynangiosis
EPVS
:   enlargement of the perivascular space
MMD
:   Moyamoya disease
PCA
:   posterior cerebral artery
pCASL
:   pseudocontinuous arterial-spin labeling
PVS
:   perivascular space
rCBFmca
:   relative CBF of the MCA
WMH
:   white matter hyperintensity" />
<meta name="DC.Contributor" content="Liuxian Wang" />
<meta name="DC.Contributor" content="Jinhao Lyu" />
<meta name="DC.Contributor" content="Dongshan Han" />
<meta name="DC.Contributor" content="Xiangbing Bian" />
<meta name="DC.Contributor" content="Dekang Zhang" />
<meta name="DC.Contributor" content="Hui Wang" />
<meta name="DC.Contributor" content="Fangbin Hao" />
<meta name="DC.Contributor" content="Lian Duan" />
<meta name="DC.Contributor" content="Lin Ma" />
<meta name="DC.Contributor" content="Xin Lou" />
<meta name="article:published_time" content="2024-07-01" />
<meta name="article:section" content="Neurovascular/Stroke Imaging" />
<meta name="citation_title" content="Imaging Assessments and Clinical Significance of Brain Frailty in Moyamoya Disease" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Imaging assessment of brain frailty in ischemic stroke has been extensively studied, while the correlation between brain frailty and Moyamoya disease remains obscure. This study aimed to investigate the imaging characteristics of brain frailty and its clinical applications in Moyamoya disease.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;This study included 60 patients with Moyamoya disease (107 hemispheres). All patients were divided into stroke and nonstroke groups based on clinical symptoms and imaging findings. The modified brain frailty score was adapted to consider 4 imaging signs: white matter hyperintensity, enlargement of perivascular space, old vascular lesions, and cerebral microbleed. The relative CBF of the MCA territory was quantified using pseudocontinuous arterial-spin labeling. Surgical outcome after revascularization surgery was defined by the Matsushima grade.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The relative CBF of the MCA territory decreased as the modified brain frailty score and periventricular white matter hyperintensity grades increased (ρ = −0.22, &lt;i&gt;P &lt;/i&gt;= .02; ρ = −0.27, &lt;i&gt;P &lt;/i&gt;= .005). Clinically, the modified brain frailty score could identify patients with Moyamoya disease with stroke (OR = 2.00, &lt;i&gt;P &lt;/i&gt;= .02). Although the modified brain frailty score showed no predictive value for surgical outcome, basal ganglia enlargement of the perivascular space had a significant correlation with the postoperative Matsushima grade (OR = 1.29, &lt;i&gt;P &lt;/i&gt;= .03).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The modified brain frailty score could reflect a cerebral perfusion deficit and clinical symptoms of Moyamoya disease, and its component basal ganglia enlargement of perivascular space may be a promising marker to predict surgical outcome and thus aid future clinical decision-making.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2024/07/01" />
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<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
<meta name="citation_doi" content="10.3174/ajnr.A8232" />
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<meta name="citation_volume" content="45" />
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<meta name="citation_article_type" content="Research Article" />
<meta name="citation_section" content="Neurovascular/Stroke Imaging" />
<meta name="citation_firstpage" content="855" />
<meta name="citation_lastpage" content="862" />
<meta name="citation_author" content="Liuxian Wang" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China" />
<meta name="citation_author_orcid" content="https://orcid.org/0000-0002-7655-0397" />
<meta name="citation_author" content="Jinhao Lyu" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China" />
<meta name="citation_author_orcid" content="https://orcid.org/0000-0002-5177-7640" />
<meta name="citation_author" content="Dongshan Han" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China" />
<meta name="citation_author_orcid" content="https://orcid.org/0000-0002-4216-4869" />
<meta name="citation_author" content="Xiangbing Bian" />
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<meta name="citation_author" content="Lian Duan" />
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<meta name="citation_author" content="Lin Ma" />
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<meta name="twitter:title" content="Imaging Assessments and Clinical Significance of Brain Frailty in Moyamoya Disease" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Imaging assessment of brain frailty in ischemic stroke has been extensively studied, while the correlation between brain frailty and Moyamoya disease remains obscure. This study aimed to investigate the imaging characteristics of brain frailty and its clinical applications in Moyamoya disease.

MATERIALS AND METHODS: This study included 60 patients with Moyamoya disease (107 hemispheres). All patients were divided into stroke and nonstroke groups based on clinical symptoms and imaging findings. The modified brain frailty score was adapted to consider 4 imaging signs: white matter hyperintensity, enlargement of perivascular space, old vascular lesions, and cerebral microbleed. The relative CBF of the MCA territory was quantified using pseudocontinuous arterial-spin labeling. Surgical outcome after revascularization surgery was defined by the Matsushima grade.

RESULTS: The relative CBF of the MCA territory decreased as the modified brain frailty score and periventricular white matter hyperintensity grades increased (ρ = −0.22, P  = .02; ρ = −0.27, P  = .005). Clinically, the modified brain frailty score could identify patients with Moyamoya disease with stroke (OR = 2.00, P  = .02). Although the modified brain frailty score showed no predictive value for surgical outcome, basal ganglia enlargement of the perivascular space had a significant correlation with the postoperative Matsushima grade (OR = 1.29, P  = .03).

CONCLUSIONS: The modified brain frailty score could reflect a cerebral perfusion deficit and clinical symptoms of Moyamoya disease, and its component basal ganglia enlargement of perivascular space may be a promising marker to predict surgical outcome and thus aid future clinical decision-making.

CMB
:   cerebral microbleed
EDAS
:   encephaloduroarteriosynangiosis
EPVS
:   enlargement of the perivascular space
MMD
:   Moyamoya disease
PCA
:   posterior cerebral artery
pCASL
:   pseudocontinuous arterial-spin labeling
PVS
:   perivascular space
rCBFmca
:   relative CBF of the MCA
WMH
:   white matter hyperintensity" />
<meta name="og-title" property="og:title" content="Imaging Assessments and Clinical Significance of Brain Frailty in Moyamoya Disease" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/45/7/855" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Imaging assessment of brain frailty in ischemic stroke has been extensively studied, while the correlation between brain frailty and Moyamoya disease remains obscure. This study aimed to investigate the imaging characteristics of brain frailty and its clinical applications in Moyamoya disease.

MATERIALS AND METHODS: This study included 60 patients with Moyamoya disease (107 hemispheres). All patients were divided into stroke and nonstroke groups based on clinical symptoms and imaging findings. The modified brain frailty score was adapted to consider 4 imaging signs: white matter hyperintensity, enlargement of perivascular space, old vascular lesions, and cerebral microbleed. The relative CBF of the MCA territory was quantified using pseudocontinuous arterial-spin labeling. Surgical outcome after revascularization surgery was defined by the Matsushima grade.

RESULTS: The relative CBF of the MCA territory decreased as the modified brain frailty score and periventricular white matter hyperintensity grades increased (ρ = −0.22, P  = .02; ρ = −0.27, P  = .005). Clinically, the modified brain frailty score could identify patients with Moyamoya disease with stroke (OR = 2.00, P  = .02). Although the modified brain frailty score showed no predictive value for surgical outcome, basal ganglia enlargement of the perivascular space had a significant correlation with the postoperative Matsushima grade (OR = 1.29, P  = .03).

CONCLUSIONS: The modified brain frailty score could reflect a cerebral perfusion deficit and clinical symptoms of Moyamoya disease, and its component basal ganglia enlargement of perivascular space may be a promising marker to predict surgical outcome and thus aid future clinical decision-making.

CMB
:   cerebral microbleed
EDAS
:   encephaloduroarteriosynangiosis
EPVS
:   enlargement of the perivascular space
MMD
:   Moyamoya disease
PCA
:   posterior cerebral artery
pCASL
:   pseudocontinuous arterial-spin labeling
PVS
:   perivascular space
rCBFmca
:   relative CBF of the MCA
WMH
:   white matter hyperintensity" />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Neurovascular/Stroke Imaging</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Imaging Assessments and Clinical Significance of Brain Frailty in Moyamoya Disease</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Liuxian Wang</span>, <span class="highwire-citation-author" data-delta="1">Jinhao Lyu</span>, <span class="highwire-citation-author" data-delta="2">Dongshan Han</span>, <span class="highwire-citation-author" data-delta="3">Xiangbing Bian</span>, <span class="highwire-citation-author" data-delta="4">Dekang Zhang</span>, <span class="highwire-citation-author" data-delta="5">Hui Wang</span>, <span class="highwire-citation-author" data-delta="6">Fangbin Hao</span>, <span class="highwire-citation-author" data-delta="7">Lian Duan</span>, <span class="highwire-citation-author" data-delta="8">Lin Ma</span> and <span class="highwire-citation-author" data-delta="9">Xin Lou</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">July 2024,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">45 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">855-862; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A8232 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-108552--6655323124" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Liuxian Wang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Liuxian%2BWang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wang%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on 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href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Jinhao%2BLyu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lyu%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJinhao%2BLyu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5177-7640" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Jinhao Lyu</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Dongshan Han </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Dongshan%2BHan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Han%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3ADongshan%2BHan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4216-4869" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Dongshan Han</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Xiangbing Bian </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Xiangbing%2BBian%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bian%20X&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AXiangbing%2BBian%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-7016-6503" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Xiangbing Bian</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Dekang Zhang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Dekang%2BZhang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhang%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3ADekang%2BZhang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9711-6733" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Dekang Zhang</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">Hui Wang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Hui%2BWang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wang%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AHui%2BWang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1152-5860" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Hui Wang</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">Fangbin Hao </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurosurgery (F.B.H., L.D.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Fangbin%2BHao%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hao%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AFangbin%2BHao%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5607-6926" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Fangbin Hao</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">Lian Duan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurosurgery (F.B.H., L.D.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Lian%2BDuan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Duan%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3ALian%2BDuan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-7210-056X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Lian Duan</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">Lin Ma </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Lin%2BMa%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ma%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3ALin%2BMa%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2911-3653" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Lin Ma</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">Xin Lou </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (L.X.W., J.H.L., D.S.H., X.B.B., D.K.Z., H.W., L.M., X.L.), Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Xin%2BLou%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lou%20X&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AXin%2BLou%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2980-5171" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Xin Lou</a></li></ul></div></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 45</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 7 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jul 2024 </div></div>
      
      
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      <div class="highwire-cite-title">Imaging Assessments and Clinical Significance of Brain Frailty in Moyamoya Disease</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Liuxian</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Jinhao</span> <span class="nlm-surname">Lyu</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Dongshan</span> <span class="nlm-surname">Han</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Xiangbing</span> <span class="nlm-surname">Bian</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Dekang</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Hui</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Fangbin</span> <span class="nlm-surname">Hao</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Lian</span> <span class="nlm-surname">Duan</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Lin</span> <span class="nlm-surname">Ma</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Xin</span> <span class="nlm-surname">Lou</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jul 2024, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">45 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">855-862; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A8232 </span></div>
  
  
  
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      <div class="highwire-cite-title">Imaging Assessments and Clinical Significance of Brain Frailty in Moyamoya Disease</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Liuxian</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Jinhao</span> <span class="nlm-surname">Lyu</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Dongshan</span> <span class="nlm-surname">Han</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Xiangbing</span> <span class="nlm-surname">Bian</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Dekang</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Hui</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Fangbin</span> <span class="nlm-surname">Hao</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Lian</span> <span class="nlm-surname">Duan</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Lin</span> <span class="nlm-surname">Ma</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Xin</span> <span class="nlm-surname">Lou</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jul 2024, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">45 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">855-862; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A8232 </span></div>
  
  
  
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