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      <h1 class="highwire-cite-title" id="page-title">MR Imaging of White Matter Disease in Children</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Martha A. Nowell</span>, <span class="highwire-citation-author" data-delta="1">Robert I. Grossman</span>, <span class="highwire-citation-author" data-delta="2">David B. Hackney</span>, <span class="highwire-citation-author" data-delta="3">Robert A. Zimmerman</span>, <span class="highwire-citation-author" data-delta="4">Herbert I. Goldberg</span> and <span class="highwire-citation-author" data-delta="5">Larissa T. Bilaniuk</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 1988,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">9 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">503-509; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-13122--61805653858" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Martha A. Nowell </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104. Address reprint requests to R. I. 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<p id="p-1">Twenty-three pediatric patients with white matter abnormalities on MR images were evaluated retrospectively to assess the contribution of MR compared with CT in diagnosing these conditions. In addition, the MR findings in major categories of white matter diseases were analyzed for sensitivity in detecting the presence of an abnormality. White matter disease categories included demyelinating disease (five cases), dysmyelinating disease (eight cases), developmental white matter abnormalities (four cases), and white matter abnormalities of unknown origin (idiopathic) (six cases), as seen on long TR images. We found that MR is not more sensitive than CT in detecting disease in the demyelinating or dysmyelinating categories, although it is more sensitive than CT in detecting the degree of disease present. In cases of developmental delay, MR is distinctly more useful than CT in demonstrating abnormalities of myelination. And in the idiopathic group, MR detected the presence of focal white matter abnormalities on long TR images in children with neurologic complaints and normal CT.</p>
<p id="p-2">MR may serve to redefine and broaden the spectrum of reported imaging abnormalities in pediatric patients.</p>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 9</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 3 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 May 1988 </div></div>
      
      
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      <div class="highwire-cite-title">MR Imaging of White Matter Disease in Children</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Martha A.</span> <span class="nlm-surname">Nowell</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Robert I.</span> <span class="nlm-surname">Grossman</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">David B.</span> <span class="nlm-surname">Hackney</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Robert A.</span> <span class="nlm-surname">Zimmerman</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Herbert I.</span> <span class="nlm-surname">Goldberg</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Larissa T.</span> <span class="nlm-surname">Bilaniuk</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 1988, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">9 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">503-509; </span></div>
  
  
  
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