More articles from Brain
- SWI or T2*: Which MRI Sequence to Use in the Detection of Cerebral Microbleeds? The Karolinska Imaging Dementia Study
The prevalence of cerebral microbleeds was evaluated in 246 patients using T2* and SWI. Microbleeds were detected in 21% by SWI vs. 17% by T2* imaging. SWI performed well with both thin and thick sections. Thus, SWI is better than T2* for this purpose and robust enough to permit comparison across studies.
- Statin Therapy Does Not Affect the Radiographic and Clinical Profile of Patients with TIA and Minor Stroke
Imaging and clinical outcomes of high-risk patients with TIA and stroke who underwent acute statin treatment were assessed. These patients tended to be older, male, hypertensive, and have more atherosclerotic disease than those who did not receive statins. Early statin therapy was not associated with a reduction of DWI-positive lesions, infarct volume, or functional outcome at 3 months.
- Increased Number of White Matter Lesions in Patients with Familial Cerebral Cavernous Malformations
Because endothelial cell abnormalities are found in white matter hyperintensities and cavernous malformations, the authors set out to determine if an increased number of white matter lesions was present in 191 patients with familial cerebral cavernous malformations all carrying the same gene defect. Results were compared with those obtained via logistic regression analysis in healthy controls and patients with sporadic cavernous malformations. White matter lesions were found in 15% of patients with the familial disease, 2% of healthy controls, and 2.5% of those with sporadic malformations. In patients with the familial disease, only age was associated with white matter lesions.
- Diffusion and Perfusion MRI to Differentiate Treatment-Related Changes Including Pseudoprogression from Recurrent Tumors in High-Grade Gliomas with Histopathologic Evidence
Sixty-eight patients with treated high-grade gliomas who developed increasing enhancing masses of indeterminate nature underwent DWI and DSC as part of their studies. Pseudoprogression was found in 15% who showed higher ADC as well as lower relative cerebral blood volume when compared with those with recurrent tumors.