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<meta name="DC.Title" content="Impact of Retrievable Stents on Acute Ischemic Stroke Treatment" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.

MATERIALS AND METHODS: Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.

RESULTS: Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; P = .018) but were not significantly different at day 1 (14 versus 10; P = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; P = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; P = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; P = .001). Recanalization rate was higher in group A than group B (94% versus 78%; P = .17).

CONCLUSIONS: Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate." />
<meta name="DC.Contributor" content="C. Brekenfeld" />
<meta name="DC.Contributor" content="G. Schroth" />
<meta name="DC.Contributor" content="P. Mordasini" />
<meta name="DC.Contributor" content="U. Fischer" />
<meta name="DC.Contributor" content="M.-L. Mono" />
<meta name="DC.Contributor" content="A. Weck" />
<meta name="DC.Contributor" content="M. Arnold" />
<meta name="DC.Contributor" content="M. El-Koussy" />
<meta name="DC.Contributor" content="J. Gralla" />
<meta name="article:published_time" content="2011-05-11" />
<meta name="article:section" content="INTERVENTIONAL" />
<meta name="citation_title" content="Impact of Retrievable Stents on Acute Ischemic Stroke Treatment" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; &lt;i&gt;P&lt;/i&gt; = .018) but were not significantly different at day 1 (14 versus 10; &lt;i&gt;P&lt;/i&gt; = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; &lt;i&gt;P&lt;/i&gt; = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; &lt;i&gt;P&lt;/i&gt; = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; &lt;i&gt;P&lt;/i&gt; = .001). Recanalization rate was higher in group A than group B (94% versus 78%; &lt;i&gt;P&lt;/i&gt; = .17).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_article_type" content="Research Article" />
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<meta name="citation_author" content="C. Brekenfeld" />
<meta name="citation_author" content="G. Schroth" />
<meta name="citation_author" content="P. Mordasini" />
<meta name="citation_author" content="U. Fischer" />
<meta name="citation_author" content="M.-L. Mono" />
<meta name="citation_author" content="A. Weck" />
<meta name="citation_author" content="M. Arnold" />
<meta name="citation_author" content="M. El-Koussy" />
<meta name="citation_author" content="J. Gralla" />
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<meta name="twitter:title" content="Impact of Retrievable Stents on Acute Ischemic Stroke Treatment" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.

MATERIALS AND METHODS: Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.

RESULTS: Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; P = .018) but were not significantly different at day 1 (14 versus 10; P = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; P = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; P = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; P = .001). Recanalization rate was higher in group A than group B (94% versus 78%; P = .17).

CONCLUSIONS: Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate." />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.

MATERIALS AND METHODS: Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.

RESULTS: Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; P = .018) but were not significantly different at day 1 (14 versus 10; P = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; P = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; P = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; P = .001). Recanalization rate was higher in group A than group B (94% versus 78%; P = .17).

CONCLUSIONS: Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate." />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node49072--7" data-node-nid="49072" id="top-node-49072--81306857220" data-pisa="ajnr;ajnr.A2494v1" data-pisa-master="ajnr;ajnr.A2494" data-apath="/ajnr/early/2011/05/12/ajnr.A2494.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">INTERVENTIONAL</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Impact of Retrievable Stents on Acute Ischemic Stroke Treatment</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">C. Brekenfeld</span>, <span class="highwire-citation-author" data-delta="1">G. Schroth</span>, <span class="highwire-citation-author" data-delta="2">P. Mordasini</span>, <span class="highwire-citation-author" data-delta="3">U. Fischer</span>, <span class="highwire-citation-author" data-delta="4">M.-L. Mono</span>, <span class="highwire-citation-author" data-delta="5">A. Weck</span>, <span class="highwire-citation-author" data-delta="6">M. Arnold</span>, <span class="highwire-citation-author" data-delta="7">M. El-Koussy</span> and <span class="highwire-citation-author" data-delta="8">J. Gralla</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2011,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2494 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-49072--81306857220" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">C. Brekenfeld </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BBrekenfeld%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Brekenfeld%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.%2BBrekenfeld%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">G. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">C. Brekenfeld</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1"></a>, </li><li class="contributor" id="contrib-2"><span class="name">G. Schroth</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1"></a>, </li><li class="contributor" id="contrib-3"><span class="name">P. Mordasini</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1"></a>, </li><li class="contributor" id="contrib-4"><span class="name">U. Fischer</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1"></a>, </li><li class="contributor" id="contrib-5"><span class="name">M.-L. Mono</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1"></a>, </li><li class="contributor" id="contrib-6"><span class="name">A. Weck</span><a id="xref-aff-1-6" class="xref-aff" href="#aff-1"></a>, </li><li class="contributor" id="contrib-7"><span class="name">M. Arnold</span><a id="xref-aff-1-7" class="xref-aff" href="#aff-1"></a>, </li><li class="contributor" id="contrib-8"><span class="name">M. El-Koussy</span><a id="xref-aff-1-8" class="xref-aff" href="#aff-1"></a> and </li><li class="last" id="contrib-9"><span class="name">J. Gralla</span><a id="xref-aff-1-9" class="xref-aff" href="#aff-1"></a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address>From the University Institute of Diagnostic and Interventional Neuroradiology (C.B., G.S., P.M., M.E.-K., J.G.), Inselspital, Bern, Switzerland; and Department of Neurology (U.F., M.-L.M., A.W., M.A.), Inselspital, Bern, Switzerland</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Please address correspondence to Caspar Brekenfeld, MD, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Freiburgstr 4, CH-3010 Bern, Switzerland; e-mail, <span class="em-link"><span class="em-addr">caspar.brekenfeld{at}insel.ch</span></span></li></ol></div></div></div>  </div>

  
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