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<meta name="DC.Title" content="Vertebral Endplate Changes Are Not Associated with Chronic Low Back Pain among Southern European Subjects: A Case Control Study" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3087" />
<meta name="DC.Date" content="2012-04-12" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Data on the association between vertebral endplate changes and low back pain are contradictory. This study was designed to assess whether this association exists among Southern European subjects.

MATERIALS AND METHODS: Patients in this study serving as cases were 35–50 years of age with low back pain lasting &gt;90 days, for whom a lumbar MR imaging had been prescribed. Controls were subjects 35–50 years of age, having a cranial MR imaging for headache with normal findings, and no history of clinically relevant LBP. Two hundred forty cases and 64 controls were recruited consecutively in the radiology services across 6 cities in Spain. Imaging findings and subject characteristics were gathered through previously validated instruments. Radiologists who interpreted MRI were blinded to the subject characteristics. A multivariate logistic regression model was developed to assess the association of vertebral endplate changes with LBP, adjusting for sex, age, body mass index, lifetime exposure to smoking, physical activity, disk degeneration, and the interaction between disk degeneration and vertebral endplate changes.

RESULTS: Vertebral endplate changes were found in 80.4% of the cases and in 87.5% of the controls. In the regression model, disk degeneration was the only variable showing a confounding effect. Results showed that after adjusting for disk degeneration, the presence of vertebral endplate changes is associated with the absence of chronic LBP (OR for LBP: 0.31; 95% CI, 0.10–0.95).

CONCLUSIONS: In Southern European subjects, vertebral endplate changes are not associated with chronic LBP.

### Abbreviations

BMI
:   body mass index
CI
:   confidence interval
LBP
:   low back pain
OR
:   odds ratio
RMQ
:   Roland-Morris Questionnaire
VAS
:   visual analog scale" />
<meta name="DC.Contributor" content="F.M. Kovacs" />
<meta name="DC.Contributor" content="E. Arana" />
<meta name="DC.Contributor" content="A. Royuela" />
<meta name="DC.Contributor" content="A. Estremera" />
<meta name="DC.Contributor" content="G. Amengual" />
<meta name="DC.Contributor" content="B. Asenjo" />
<meta name="DC.Contributor" content="H. Sarasíbar" />
<meta name="DC.Contributor" content="I. Galarraga" />
<meta name="DC.Contributor" content="A. Alonso" />
<meta name="DC.Contributor" content="C. Casillas" />
<meta name="DC.Contributor" content="A. Muriel" />
<meta name="DC.Contributor" content="C. Martínez" />
<meta name="DC.Contributor" content="V. Abraira" />
<meta name="DC.Contributor" content="for the Spanish Back Pain Research Network" />
<meta name="article:published_time" content="2012-04-12" />
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<meta name="citation_title" content="Vertebral Endplate Changes Are Not Associated with Chronic Low Back Pain among Southern European Subjects: A Case Control Study" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Data on the association between vertebral endplate changes and low back pain are contradictory. This study was designed to assess whether this association exists among Southern European subjects.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Patients in this study serving as cases were 35–50 years of age with low back pain lasting &amp;gt;90 days, for whom a lumbar MR imaging had been prescribed. Controls were subjects 35–50 years of age, having a cranial MR imaging for headache with normal findings, and no history of clinically relevant LBP. Two hundred forty cases and 64 controls were recruited consecutively in the radiology services across 6 cities in Spain. Imaging findings and subject characteristics were gathered through previously validated instruments. Radiologists who interpreted MRI were blinded to the subject characteristics. A multivariate logistic regression model was developed to assess the association of vertebral endplate changes with LBP, adjusting for sex, age, body mass index, lifetime exposure to smoking, physical activity, disk degeneration, and the interaction between disk degeneration and vertebral endplate changes.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Vertebral endplate changes were found in 80.4% of the cases and in 87.5% of the controls. In the regression model, disk degeneration was the only variable showing a confounding effect. Results showed that after adjusting for disk degeneration, the presence of vertebral endplate changes is associated with the absence of chronic LBP (OR for LBP: 0.31; 95% CI, 0.10–0.95).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;In Southern European subjects, vertebral endplate changes are not associated with chronic LBP.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_author" content="F.M. Kovacs" />
<meta name="citation_author" content="E. Arana" />
<meta name="citation_author" content="A. Royuela" />
<meta name="citation_author" content="A. Estremera" />
<meta name="citation_author" content="G. Amengual" />
<meta name="citation_author" content="B. Asenjo" />
<meta name="citation_author" content="H. Sarasíbar" />
<meta name="citation_author" content="I. Galarraga" />
<meta name="citation_author" content="A. Alonso" />
<meta name="citation_author" content="C. Casillas" />
<meta name="citation_author" content="A. Muriel" />
<meta name="citation_author" content="C. Martínez" />
<meta name="citation_author" content="V. Abraira" />
<meta name="citation_author" content="for the Spanish Back Pain Research Network" />
<meta name="twitter:title" content="Vertebral Endplate Changes Are Not Associated with Chronic Low Back Pain among Southern European Subjects: A Case Control Study" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Data on the association between vertebral endplate changes and low back pain are contradictory. This study was designed to assess whether this association exists among Southern European subjects.

MATERIALS AND METHODS: Patients in this study serving as cases were 35–50 years of age with low back pain lasting &gt;90 days, for whom a lumbar MR imaging had been prescribed. Controls were subjects 35–50 years of age, having a cranial MR imaging for headache with normal findings, and no history of clinically relevant LBP. Two hundred forty cases and 64 controls were recruited consecutively in the radiology services across 6 cities in Spain. Imaging findings and subject characteristics were gathered through previously validated instruments. Radiologists who interpreted MRI were blinded to the subject characteristics. A multivariate logistic regression model was developed to assess the association of vertebral endplate changes with LBP, adjusting for sex, age, body mass index, lifetime exposure to smoking, physical activity, disk degeneration, and the interaction between disk degeneration and vertebral endplate changes.

RESULTS: Vertebral endplate changes were found in 80.4% of the cases and in 87.5% of the controls. In the regression model, disk degeneration was the only variable showing a confounding effect. Results showed that after adjusting for disk degeneration, the presence of vertebral endplate changes is associated with the absence of chronic LBP (OR for LBP: 0.31; 95% CI, 0.10–0.95).

CONCLUSIONS: In Southern European subjects, vertebral endplate changes are not associated with chronic LBP.

### Abbreviations

BMI
:   body mass index
CI
:   confidence interval
LBP
:   low back pain
OR
:   odds ratio
RMQ
:   Roland-Morris Questionnaire
VAS
:   visual analog scale" />
<meta name="og-title" property="og:title" content="Vertebral Endplate Changes Are Not Associated with Chronic Low Back Pain among Southern European Subjects: A Case Control Study" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Data on the association between vertebral endplate changes and low back pain are contradictory. This study was designed to assess whether this association exists among Southern European subjects.

MATERIALS AND METHODS: Patients in this study serving as cases were 35–50 years of age with low back pain lasting &gt;90 days, for whom a lumbar MR imaging had been prescribed. Controls were subjects 35–50 years of age, having a cranial MR imaging for headache with normal findings, and no history of clinically relevant LBP. Two hundred forty cases and 64 controls were recruited consecutively in the radiology services across 6 cities in Spain. Imaging findings and subject characteristics were gathered through previously validated instruments. Radiologists who interpreted MRI were blinded to the subject characteristics. A multivariate logistic regression model was developed to assess the association of vertebral endplate changes with LBP, adjusting for sex, age, body mass index, lifetime exposure to smoking, physical activity, disk degeneration, and the interaction between disk degeneration and vertebral endplate changes.

RESULTS: Vertebral endplate changes were found in 80.4% of the cases and in 87.5% of the controls. In the regression model, disk degeneration was the only variable showing a confounding effect. Results showed that after adjusting for disk degeneration, the presence of vertebral endplate changes is associated with the absence of chronic LBP (OR for LBP: 0.31; 95% CI, 0.10–0.95).

CONCLUSIONS: In Southern European subjects, vertebral endplate changes are not associated with chronic LBP.

### Abbreviations

BMI
:   body mass index
CI
:   confidence interval
LBP
:   low back pain
OR
:   odds ratio
RMQ
:   Roland-Morris Questionnaire
VAS
:   visual analog scale" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node49680--7" data-node-nid="49680" id="top-node-49680--81953678290" data-pisa="ajnr;ajnr.A3087v1" data-pisa-master="ajnr;ajnr.A3087" data-apath="/ajnr/early/2012/04/12/ajnr.A3087.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">Vertebral Endplate Changes Are Not Associated with Chronic Low Back Pain among Southern European Subjects: A Case Control Study</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">F.M. Kovacs</span>, <span class="highwire-citation-author" data-delta="1">E. Arana</span>, <span class="highwire-citation-author" data-delta="2">A. Royuela</span>, <span class="highwire-citation-author" data-delta="3">A. Estremera</span>, <span class="highwire-citation-author" data-delta="4">G. Amengual</span>, <span class="highwire-citation-author" data-delta="5">B. Asenjo</span>, <span class="highwire-citation-author" data-delta="6">H. Sarasíbar</span>, <span class="highwire-citation-author" data-delta="7">I. Galarraga</span>, <span class="highwire-citation-author" data-delta="8">A. Alonso</span>, <span class="highwire-citation-author" data-delta="9">C. Casillas</span>, <span class="highwire-citation-author" data-delta="10">A. Muriel</span>, <span class="highwire-citation-author" data-delta="11">C. Martínez</span>, <span class="highwire-citation-author" data-delta="12">V. Abraira</span> and <span class="highwire-citation-author" data-delta="13"><span class="nlm-collab" data-xlink-type="simple" data-hwp-id="collab-1">for the Spanish Back Pain Research Network</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2012,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3087 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-49680--81953678290" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">F.M. Kovacs </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.M.%2BKovacs%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kovacs%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.M.%2BKovacs%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">E. 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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">F.M.</span> <span class="nlm-surname">Kovacs</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Arana</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Royuela</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Estremera</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Amengual</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Asenjo</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Sarasíbar</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Galarraga</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Alonso</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Casillas</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Muriel</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Martínez</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">V.</span> <span class="nlm-surname">Abraira</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-collab" data-xlink-type="simple" data-hwp-id="collab-1">for the Spanish Back Pain Research Network</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2012, </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3087 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">F.M.</span> <span class="nlm-surname">Kovacs</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Arana</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Royuela</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Estremera</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Amengual</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Asenjo</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Sarasíbar</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Galarraga</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Alonso</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Casillas</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Muriel</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Martínez</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">V.</span> <span class="nlm-surname">Abraira</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-collab" data-xlink-type="simple" data-hwp-id="collab-1">for the Spanish Back Pain Research Network</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2012, </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3087 </span></div>
  
  
  
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