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<meta name="DC.Language" content="en" />
<meta name="DC.Title" content="Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3303" />
<meta name="DC.Date" content="2012-08-23" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2013 American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: MTI is a quantitative MR imaging technique that has recently demonstrated structural integrity differences between controls and patients with HD. Potentially, MTI can be used as a biomarker for monitoring disease progression. To establish the value of MTI as a biomarker, we aimed to examine the change in these measures during the course of HD.

MATERIALS AND METHODS: From the Leiden TRACK-HD study, 25 controls, 21 premanifest gene carriers, and 21 patients with manifest HD participated at baseline and during a 2-year follow-up visit. Brain segmentation of the cortical gray matter, white matter, caudate nucleus, putamen, pallidum, thalamus, amygdala, and hippocampus was performed by using the automated tools FAST and FIRST in FSL. Individual MTR values were calculated from these regions, and MTR histograms were constructed.

RESULTS: In the premanifest HD group stage “far from disease onset,” a significant increase in MTR peak height of the putamen was observed with time. During the manifest HD stage, neither the mean MTR nor the MTR peak height showed a significant change during a 2-year follow-up.

CONCLUSIONS: MTI-derived measures are not suitable for monitoring in Huntington disease during a 2-year period because there was no decrease in structural integrity detected in any of the manifest HD groups longitudinally. The finding of increased putaminal MTR peak height in the premanifest far from disease onset group could relate to a predegenerative process, compensatory mechanisms, or aberrant development but should be interpreted with caution until future studies confirm this finding.

### Abbreviations

HD
:   Huntington disease
HD 1
:   manifest HD stage 1
HD 2
:   manifest HD stage 2
MTI
:   magnetization transfer imaging
MTR
:   magnetization-transfer ratio" />
<meta name="DC.Contributor" content="S.J.A. van den Bogaard" />
<meta name="DC.Contributor" content="E.M. Dumas" />
<meta name="DC.Contributor" content="E.P. Hart" />
<meta name="DC.Contributor" content="J. Milles" />
<meta name="DC.Contributor" content="R. Reilmann" />
<meta name="DC.Contributor" content="J.C. Stout" />
<meta name="DC.Contributor" content="D. Craufurd" />
<meta name="DC.Contributor" content="C.R. Gibbard" />
<meta name="DC.Contributor" content="S.J. Tabrizi" />
<meta name="DC.Contributor" content="M.A. van Buchem" />
<meta name="DC.Contributor" content="J. van der Grond" />
<meta name="DC.Contributor" content="R.A.C. Roos" />
<meta name="article:published_time" content="2012-08-23" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;MTI is a quantitative MR imaging technique that has recently demonstrated structural integrity differences between controls and patients with HD. Potentially, MTI can be used as a biomarker for monitoring disease progression. To establish the value of MTI as a biomarker, we aimed to examine the change in these measures during the course of HD.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;From the Leiden TRACK-HD study, 25 controls, 21 premanifest gene carriers, and 21 patients with manifest HD participated at baseline and during a 2-year follow-up visit. Brain segmentation of the cortical gray matter, white matter, caudate nucleus, putamen, pallidum, thalamus, amygdala, and hippocampus was performed by using the automated tools FAST and FIRST in FSL. Individual MTR values were calculated from these regions, and MTR histograms were constructed.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;In the premanifest HD group stage “far from disease onset,” a significant increase in MTR peak height of the putamen was observed with time. During the manifest HD stage, neither the mean MTR nor the MTR peak height showed a significant change during a 2-year follow-up.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;MTI-derived measures are not suitable for monitoring in Huntington disease during a 2-year period because there was no decrease in structural integrity detected in any of the manifest HD groups longitudinally. The finding of increased putaminal MTR peak height in the premanifest far from disease onset group could relate to a predegenerative process, compensatory mechanisms, or aberrant development but should be interpreted with caution until future studies confirm this finding.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2012/08/23" />
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<meta name="citation_section" content="BRAIN" />
<meta name="citation_author" content="S.J.A. van den Bogaard" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
<meta name="citation_author" content="E.M. Dumas" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
<meta name="citation_author" content="E.P. Hart" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
<meta name="citation_author" content="J. Milles" />
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<meta name="citation_author" content="R. Reilmann" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
<meta name="citation_author" content="J.C. Stout" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
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<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
<meta name="citation_author" content="C.R. Gibbard" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
<meta name="citation_author" content="S.J. Tabrizi" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
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<meta name="citation_author" content="J. van der Grond" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
<meta name="citation_author" content="R.A.C. Roos" />
<meta name="citation_author_institution" content="From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK." />
<meta name="twitter:title" content="Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up" />
<meta name="twitter:card" content="summary" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: MTI is a quantitative MR imaging technique that has recently demonstrated structural integrity differences between controls and patients with HD. Potentially, MTI can be used as a biomarker for monitoring disease progression. To establish the value of MTI as a biomarker, we aimed to examine the change in these measures during the course of HD.

MATERIALS AND METHODS: From the Leiden TRACK-HD study, 25 controls, 21 premanifest gene carriers, and 21 patients with manifest HD participated at baseline and during a 2-year follow-up visit. Brain segmentation of the cortical gray matter, white matter, caudate nucleus, putamen, pallidum, thalamus, amygdala, and hippocampus was performed by using the automated tools FAST and FIRST in FSL. Individual MTR values were calculated from these regions, and MTR histograms were constructed.

RESULTS: In the premanifest HD group stage “far from disease onset,” a significant increase in MTR peak height of the putamen was observed with time. During the manifest HD stage, neither the mean MTR nor the MTR peak height showed a significant change during a 2-year follow-up.

CONCLUSIONS: MTI-derived measures are not suitable for monitoring in Huntington disease during a 2-year period because there was no decrease in structural integrity detected in any of the manifest HD groups longitudinally. The finding of increased putaminal MTR peak height in the premanifest far from disease onset group could relate to a predegenerative process, compensatory mechanisms, or aberrant development but should be interpreted with caution until future studies confirm this finding.

### Abbreviations

HD
:   Huntington disease
HD 1
:   manifest HD stage 1
HD 2
:   manifest HD stage 2
MTI
:   magnetization transfer imaging
MTR
:   magnetization-transfer ratio" />
<meta name="og-title" property="og:title" content="Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/early/2012/08/23/ajnr.A3303" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: MTI is a quantitative MR imaging technique that has recently demonstrated structural integrity differences between controls and patients with HD. Potentially, MTI can be used as a biomarker for monitoring disease progression. To establish the value of MTI as a biomarker, we aimed to examine the change in these measures during the course of HD.

MATERIALS AND METHODS: From the Leiden TRACK-HD study, 25 controls, 21 premanifest gene carriers, and 21 patients with manifest HD participated at baseline and during a 2-year follow-up visit. Brain segmentation of the cortical gray matter, white matter, caudate nucleus, putamen, pallidum, thalamus, amygdala, and hippocampus was performed by using the automated tools FAST and FIRST in FSL. Individual MTR values were calculated from these regions, and MTR histograms were constructed.

RESULTS: In the premanifest HD group stage “far from disease onset,” a significant increase in MTR peak height of the putamen was observed with time. During the manifest HD stage, neither the mean MTR nor the MTR peak height showed a significant change during a 2-year follow-up.

CONCLUSIONS: MTI-derived measures are not suitable for monitoring in Huntington disease during a 2-year period because there was no decrease in structural integrity detected in any of the manifest HD groups longitudinally. The finding of increased putaminal MTR peak height in the premanifest far from disease onset group could relate to a predegenerative process, compensatory mechanisms, or aberrant development but should be interpreted with caution until future studies confirm this finding.

### Abbreviations

HD
:   Huntington disease
HD 1
:   manifest HD stage 1
HD 2
:   manifest HD stage 2
MTI
:   magnetization transfer imaging
MTR
:   magnetization-transfer ratio" />
<meta name="og-type" property="og:type" content="article" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node50009--5" data-node-nid="50009" id="top-node-50009--6923378027" data-pisa="ajnr;ajnr.A3303v1" data-pisa-master="ajnr;ajnr.A3303" data-apath="/ajnr/early/2012/08/23/ajnr.A3303.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">BRAIN</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="ajnr;ajnr.A3303" data-atom-uri="/ajnr/early/2012/08/23/ajnr.A3303.atom" data-request-view="full"></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S.J.A. van den Bogaard</span>, <span class="highwire-citation-author" data-delta="1">E.M. Dumas</span>, <span class="highwire-citation-author" data-delta="2">E.P. Hart</span>, <span class="highwire-citation-author" data-delta="3">J. Milles</span>, <span class="highwire-citation-author" data-delta="4">R. Reilmann</span>, <span class="highwire-citation-author" data-delta="5">J.C. Stout</span>, <span class="highwire-citation-author" data-delta="6">D. Craufurd</span>, <span class="highwire-citation-author" data-delta="7">C.R. Gibbard</span>, <span class="highwire-citation-author" data-delta="8">S.J. Tabrizi</span>, <span class="highwire-citation-author" data-delta="9">M.A. van Buchem</span>, <span class="highwire-citation-author" data-delta="10">J. van der Grond</span> and <span class="highwire-citation-author" data-delta="11">R.A.C. Roos</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2012,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3303 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-50009--6923378027" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S.J.A. van den Bogaard </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.J.A.%2Bvan%2Bden%2BBogaard%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20den%20Bogaard%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.J.A.%2Bvan%2Bden%2BBogaard%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">E.M. Dumas </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.M.%2BDumas%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dumas%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.M.%2BDumas%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">E.P. Hart </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.P.%2BHart%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hart%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.P.%2BHart%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J. Milles </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BMilles%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Milles%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.%2BMilles%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">R. Reilmann </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BReilmann%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Reilmann%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.%2BReilmann%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">J.C. Stout </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.C.%2BStout%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Stout%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.C.%2BStout%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">D. Craufurd </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BCraufurd%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Craufurd%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.%2BCraufurd%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">C.R. Gibbard </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.R.%2BGibbard%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gibbard%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.R.%2BGibbard%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">S.J. Tabrizi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.J.%2BTabrizi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tabrizi%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.J.%2BTabrizi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">M.A. van Buchem </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.A.%2Bvan%2BBuchem%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20Buchem%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.A.%2Bvan%2BBuchem%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">J. van der Grond </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2Bvan%2Bder%2BGrond%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20der%20Grond%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.%2Bvan%2Bder%2BGrond%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">R.A.C. Roos </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Department of Neurology (S.J.A.v.d.B., E.M.D., E.P.H., R.A.C.R.), Division of Image Processing, Department of Radiology (J.M.), and Department of Radiology (M.A.v.B., J.v.d.G.), Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology (R.R.), University of Munster, Munster, Germany; School of Psychology and Psychiatry (J.C.S.), Monash University, Victoria, Australia; Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust (D.C.), University of Manchester, Manchester, UK; and Department of Neurology (C.R.G., S.J.T.), Institute of Neurology, University College London, London, UK.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.A.C.%2BRoos%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Roos%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.A.C.%2BRoos%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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            <h2>Supplemental Online Materials</h2>
            <p><strong>Files in this Data Supplement:</strong></p>
            <ul><li><a href="/highwire/filestream/52399/field_highwire_adjunct_files/0/3303_materials.pdf" class="rewritten" data-icon-position="" data-hide-link-title="0">Online Appendix and Tables (PDF)</a> -
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                  <em>Online Appendix:</em> see file
                  <br/><br/>
                  <em>Online Table 1:</em> MTI-derived values in 14 different regions on both baseline and follow-up visit for the premanifest HD A and premanifest
                  HD B group
                  <br/><br/>
                  <em>Online Table 2:</em> MTI-derived values in 14 different regions on both baseline and follow-up visit for the manifest HD 1 and manifest HD 2 group
                  <br/><br/>
                  <em>Online Table 3:</em> Volumetric analysis of 14 brain regions in premanifest HD
                  <br/><br/>
                  <em>Online Table 4:</em> Volumetric analysis of 14 brain regions in manifest HD
                  <br/><br/>
                  <em>Online Table 5:</em> Control values of MTR parameters
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