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<!DOCTYPE html>
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<meta name="DC.Title" content="CT Perfusion Spot Sign Improves Sensitivity for Prediction of Outcome Compared with CTA and Postcontrast CT" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3338" />
<meta name="DC.Date" content="2012-11-08" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2013 American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Recent studies have recommended both early and late imaging to increase spot sign detection. However optimal acquisition timing for spot detection and impact on outcome prediction is uncertain. Our aim was to assess the utility of CTP in spot sign detection and characterization with emphasis on its impact on the prediction of outcome in patients with acute primary ICH.

MATERIALS AND METHODS: A retrospective review of 28 patients presenting within 6 hours of ICH, studied with CTA, CTP, and postcontrast CT, was performed. CTA, CTP, and postcontrast CT spot sign characteristics were recorded according to predefined radiologic criteria. A combined primary outcome of hematoma expansion or poor clinical outcome was used and defined as hematoma expansion ≥6 mL or ≥30%, need for surgical drainage, or in-hospital mortality. Associations with the primary outcome and spot sign presence were examined against baseline clinical, laboratory, and radiographic variables. Predictive ability of CTA, CTP, and postcontrast CT spot characteristics were compared among modalities.

RESULTS: Primary outcome criteria were met in 18 patients (61%). CTP spot sign presence was an independent predictor of hematoma expansion or poor outcome ( P = .040) and demonstrated greater sensitivity (78%) than spots detected on CTA (44%, P = .034) and postcontrast CT (50%, P = .025). Specificity and positive predictive value of the spot sign was high (100%) on all modalities. CTP detected the greatest number of spots (80%) with peak spot attenuation demonstrated at a median (interquartile range) time of 50 seconds (range, 34–63 seconds) after contrast bolus injection. CTP spot appearance was later than CTA-detected spots ( P = .002) and earlier than postcontrast CT spots ( P &lt; .001).

CONCLUSIONS: CTP spot sign detection improves the sensitivity for prediction of outcome compared with CTA or postcontrast CT–detected spots.

### Abbreviations

CI
:   confidence interval
ICH
:   intracerebral hemorrhage
IVH
:   intraventricular hemorrhage
mRS
:   modified Rankin Scale
PCT
:   postcontrast CT" />
<meta name="DC.Contributor" content="A. Koculym" />
<meta name="DC.Contributor" content="T.J. Huynh" />
<meta name="DC.Contributor" content="R. Jakubovic" />
<meta name="DC.Contributor" content="L. Zhang" />
<meta name="DC.Contributor" content="R.I. Aviv" />
<meta name="article:published_time" content="2012-11-08" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="CT Perfusion Spot Sign Improves Sensitivity for Prediction of Outcome Compared with CTA and Postcontrast CT" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Recent studies have recommended both early and late imaging to increase spot sign detection. However optimal acquisition timing for spot detection and impact on outcome prediction is uncertain. Our aim was to assess the utility of CTP in spot sign detection and characterization with emphasis on its impact on the prediction of outcome in patients with acute primary ICH.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;A retrospective review of 28 patients presenting within 6 hours of ICH, studied with CTA, CTP, and postcontrast CT, was performed. CTA, CTP, and postcontrast CT spot sign characteristics were recorded according to predefined radiologic criteria. A combined primary outcome of hematoma expansion or poor clinical outcome was used and defined as hematoma expansion ≥6 mL or ≥30%, need for surgical drainage, or in-hospital mortality. Associations with the primary outcome and spot sign presence were examined against baseline clinical, laboratory, and radiographic variables. Predictive ability of CTA, CTP, and postcontrast CT spot characteristics were compared among modalities.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Primary outcome criteria were met in 18 patients (61%). CTP spot sign presence was an independent predictor of hematoma expansion or poor outcome (&lt;i&gt;P&lt;/i&gt; = .040) and demonstrated greater sensitivity (78%) than spots detected on CTA (44%, &lt;i&gt;P&lt;/i&gt; = .034) and postcontrast CT (50%, &lt;i&gt;P&lt;/i&gt; = .025). Specificity and positive predictive value of the spot sign was high (100%) on all modalities. CTP detected the greatest number of spots (80%) with peak spot attenuation demonstrated at a median (interquartile range) time of 50 seconds (range, 34–63 seconds) after contrast bolus injection. CTP spot appearance was later than CTA-detected spots (&lt;i&gt;P&lt;/i&gt; = .002) and earlier than postcontrast CT spots (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;CTP spot sign detection improves the sensitivity for prediction of outcome compared with CTA or postcontrast CT–detected spots.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2012/11/08" />
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<meta name="citation_author" content="A. Koculym" />
<meta name="citation_author_institution" content="From the Department of Medical Imaging, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada." />
<meta name="citation_author" content="T.J. Huynh" />
<meta name="citation_author_institution" content="From the Department of Medical Imaging, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada." />
<meta name="citation_author" content="R. Jakubovic" />
<meta name="citation_author_institution" content="From the Department of Medical Imaging, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada." />
<meta name="citation_author" content="L. Zhang" />
<meta name="citation_author_institution" content="From the Department of Medical Imaging, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada." />
<meta name="citation_author" content="R.I. Aviv" />
<meta name="citation_author_institution" content="From the Department of Medical Imaging, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada." />
<meta name="twitter:title" content="CT Perfusion Spot Sign Improves Sensitivity for Prediction of Outcome Compared with CTA and Postcontrast CT" />
<meta name="twitter:card" content="summary" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Recent studies have recommended both early and late imaging to increase spot sign detection. However optimal acquisition timing for spot detection and impact on outcome prediction is uncertain. Our aim was to assess the utility of CTP in spot sign detection and characterization with emphasis on its impact on the prediction of outcome in patients with acute primary ICH.

MATERIALS AND METHODS: A retrospective review of 28 patients presenting within 6 hours of ICH, studied with CTA, CTP, and postcontrast CT, was performed. CTA, CTP, and postcontrast CT spot sign characteristics were recorded according to predefined radiologic criteria. A combined primary outcome of hematoma expansion or poor clinical outcome was used and defined as hematoma expansion ≥6 mL or ≥30%, need for surgical drainage, or in-hospital mortality. Associations with the primary outcome and spot sign presence were examined against baseline clinical, laboratory, and radiographic variables. Predictive ability of CTA, CTP, and postcontrast CT spot characteristics were compared among modalities.

RESULTS: Primary outcome criteria were met in 18 patients (61%). CTP spot sign presence was an independent predictor of hematoma expansion or poor outcome ( P = .040) and demonstrated greater sensitivity (78%) than spots detected on CTA (44%, P = .034) and postcontrast CT (50%, P = .025). Specificity and positive predictive value of the spot sign was high (100%) on all modalities. CTP detected the greatest number of spots (80%) with peak spot attenuation demonstrated at a median (interquartile range) time of 50 seconds (range, 34–63 seconds) after contrast bolus injection. CTP spot appearance was later than CTA-detected spots ( P = .002) and earlier than postcontrast CT spots ( P &lt; .001).

CONCLUSIONS: CTP spot sign detection improves the sensitivity for prediction of outcome compared with CTA or postcontrast CT–detected spots.

### Abbreviations

CI
:   confidence interval
ICH
:   intracerebral hemorrhage
IVH
:   intraventricular hemorrhage
mRS
:   modified Rankin Scale
PCT
:   postcontrast CT" />
<meta name="og-title" property="og:title" content="CT Perfusion Spot Sign Improves Sensitivity for Prediction of Outcome Compared with CTA and Postcontrast CT" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/early/2012/11/08/ajnr.A3338" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Recent studies have recommended both early and late imaging to increase spot sign detection. However optimal acquisition timing for spot detection and impact on outcome prediction is uncertain. Our aim was to assess the utility of CTP in spot sign detection and characterization with emphasis on its impact on the prediction of outcome in patients with acute primary ICH.

MATERIALS AND METHODS: A retrospective review of 28 patients presenting within 6 hours of ICH, studied with CTA, CTP, and postcontrast CT, was performed. CTA, CTP, and postcontrast CT spot sign characteristics were recorded according to predefined radiologic criteria. A combined primary outcome of hematoma expansion or poor clinical outcome was used and defined as hematoma expansion ≥6 mL or ≥30%, need for surgical drainage, or in-hospital mortality. Associations with the primary outcome and spot sign presence were examined against baseline clinical, laboratory, and radiographic variables. Predictive ability of CTA, CTP, and postcontrast CT spot characteristics were compared among modalities.

RESULTS: Primary outcome criteria were met in 18 patients (61%). CTP spot sign presence was an independent predictor of hematoma expansion or poor outcome ( P = .040) and demonstrated greater sensitivity (78%) than spots detected on CTA (44%, P = .034) and postcontrast CT (50%, P = .025). Specificity and positive predictive value of the spot sign was high (100%) on all modalities. CTP detected the greatest number of spots (80%) with peak spot attenuation demonstrated at a median (interquartile range) time of 50 seconds (range, 34–63 seconds) after contrast bolus injection. CTP spot appearance was later than CTA-detected spots ( P = .002) and earlier than postcontrast CT spots ( P &lt; .001).

CONCLUSIONS: CTP spot sign detection improves the sensitivity for prediction of outcome compared with CTA or postcontrast CT–detected spots.

### Abbreviations

CI
:   confidence interval
ICH
:   intracerebral hemorrhage
IVH
:   intraventricular hemorrhage
mRS
:   modified Rankin Scale
PCT
:   postcontrast CT" />
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      <h1 class="highwire-cite-title" id="page-title">CT Perfusion Spot Sign Improves Sensitivity for Prediction of Outcome Compared with CTA and Postcontrast CT</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">A. Koculym</span>, <span class="highwire-citation-author" data-delta="1">T.J. Huynh</span>, <span class="highwire-citation-author" data-delta="2">R. Jakubovic</span>, <span class="highwire-citation-author" data-delta="3">L. Zhang</span> and <span class="highwire-citation-author" data-delta="4">R.I. Aviv</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2012,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3338 </span></div>
  
  
  
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      <div class="highwire-cite-title">CT Perfusion Spot Sign Improves Sensitivity for Prediction of Outcome Compared with CTA and Postcontrast CT</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Koculym</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">T.J.</span> <span class="nlm-surname">Huynh</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Jakubovic</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.I.</span> <span class="nlm-surname">Aviv</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2012, </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3338 </span></div>
  
  
  
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      <div class="highwire-cite-title">CT Perfusion Spot Sign Improves Sensitivity for Prediction of Outcome Compared with CTA and Postcontrast CT</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Koculym</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">T.J.</span> <span class="nlm-surname">Huynh</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Jakubovic</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.I.</span> <span class="nlm-surname">Aviv</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2012, </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3338 </span></div>
  
  
  
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