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Hippocampal and Deep Gray Matter Nuclei Atrophy Is Relevant for Explaining Cognitive Impairment in MS: A Multicenter Study
D. Damjanovic, P. Valsasina, M.A. Rocca, M.L. Stromillo, A. Gallo, C. Enzinger, H.E. Hulst, A. Rovira, N. Muhlert, N. De Stefano, A. Bisecco, F. Fazekas, M.J. Arévalo, T.A. Yousry and M. Filippi
American Journal of Neuroradiology September 2016, DOI: https://doi.org/10.3174/ajnr.A4952
D. Damjanovic
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
P. Valsasina
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
M.A. Rocca
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
M.L. Stromillo
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
A. Gallo
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
C. Enzinger
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
H.E. Hulst
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
A. Rovira
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
N. Muhlert
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
N. De Stefano
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
A. Bisecco
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
F. Fazekas
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
M.J. Arévalo
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
T.A. Yousry
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
M. Filippi
From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.

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- Published online September 29, 2016.
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Author Information
- D. Damjanovic,
- P. Valsasina,
- M.A. Rocca,
- M.L. Stromillo,
- A. Gallo,
- C. Enzinger,
- H.E. Hulst,
- A. Rovira,
- N. Muhlert,
- N. De Stefano,
- A. Bisecco,
- F. Fazekas,
- M.J. Arévalo,
- T.A. Yousry and
- M. Filippi
- From the Neuroimaging Research Unit (D.D., P.V., M.A.R., M.F.) and Department of Neurology (M.A.R., M.F.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Center for Radiology and MRI of Clinical Center of Serbia (D.D.), Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Neurological and Behavioural Sciences (M.L.S., N.D.S.), University of Siena, Siena, Italy; MRI Center “SUN-FISM” (A.G., A.B.), Second University of Naples and Institute of Diagnosis and Care “Hermitage-Capodimonte,” Naples, Italy; I Division of Neurology (A.G., A.B.), Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Department of Neurology (C.E., F.F.) and Division of Neuroradiology (C.E.), Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria; Department of Radiology and Nuclear Medicine (H.E.H.), MS Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Magnetic Resonance Unit (A.R., M.J.A.), Department of Radiology and MS Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; and NMR Research Unit (N.M., T.A.Y.), Queen Square MS Centre, University College London Institute of Neurology, London, UK.
- Please address correspondence to Massimo Filippi, MD, Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy; e-mail: filippi.massimo{at}hsr.it
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Hippocampal and Deep Gray Matter Nuclei Atrophy Is Relevant for Explaining Cognitive Impairment in MS: A Multicenter Study
D. Damjanovic, P. Valsasina, M.A. Rocca, M.L. Stromillo, A. Gallo, C. Enzinger, H.E. Hulst, A. Rovira, N. Muhlert, N. De Stefano, A. Bisecco, F. Fazekas, M.J. Arévalo, T.A. Yousry, M. Filippi
American Journal of Neuroradiology Sep 2016, DOI: 10.3174/ajnr.A4952
Hippocampal and Deep Gray Matter Nuclei Atrophy Is Relevant for Explaining Cognitive Impairment in MS: A Multicenter Study
D. Damjanovic, P. Valsasina, M.A. Rocca, M.L. Stromillo, A. Gallo, C. Enzinger, H.E. Hulst, A. Rovira, N. Muhlert, N. De Stefano, A. Bisecco, F. Fazekas, M.J. Arévalo, T.A. Yousry, M. Filippi
American Journal of Neuroradiology Sep 2016, DOI: 10.3174/ajnr.A4952
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