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<meta name="DC.Title" content="A Fully Automated, Atlas-Based Approach for Superior Cerebellar Peduncle Evaluation in Progressive Supranuclear Palsy Phenotypes" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5048" />
<meta name="DC.Date" content="2016-12-29" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2017 American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: The superior cerebellar peduncle is damaged in progressive supranuclear palsy. However, alterations differ between progressive supranuclear palsy with Richardson syndrome and progressive supranuclear palsy-parkinsonism. In this study, we propose an automated tool for superior cerebellar peduncle integrity assessment and test its performance in patients with progressive supranuclear palsy with Richardson syndrome, progressive supranuclear palsy-parkinsonism, Parkinson disease, and healthy controls.

MATERIALS AND METHODS: Structural and diffusion MRI was performed in 21 patients with progressive supranuclear palsy with Richardson syndrome, 9 with progressive supranuclear palsy-parkinsonism, 20 with Parkinson disease, and 30 healthy subjects. In a fully automated pipeline, the left and right superior cerebellar peduncles were first identified on MR imaging by using a tractography-based atlas of white matter tracts; subsequently, volume, mean diffusivity, and fractional anisotropy were extracted from superior cerebellar peduncles. These measures were compared across groups, and their discriminative power in differentiating patients was evaluated in a linear discriminant analysis.

RESULTS: Compared with those with Parkinson disease and controls, patients with progressive supranuclear palsy with Richardson syndrome showed alterations of all superior cerebellar peduncle metrics (decreased volume and fractional anisotropy, increased mean diffusivity). Patients with progressive supranuclear palsy-parkinsonism had smaller volumes than those with Parkinson disease and controls and lower fractional anisotropy than those with Parkinson disease. Patients with progressive supranuclear palsy with Richardson syndrome had significantly altered fractional anisotropy and mean diffusivity in the left superior cerebellar peduncle compared with those with progressive supranuclear palsy-parkinsonism. Discriminant analysis with the sole use of significant variables separated progressive supranuclear palsy-parkinsonism from progressive supranuclear palsy with Richardson syndrome with 70% accuracy and progressive supranuclear palsy-parkinsonism from Parkinson disease with 74% accuracy.

CONCLUSIONS: We demonstrate the feasibility of an automated approach for extracting multimodal MR imaging metrics from the superior cerebellar peduncle in healthy subjects and patients with parkinsonian. We provide evidence that structural and diffusion measures of the superior cerebellar peduncle might be valuable for computer-aided diagnosis of progressive supranuclear palsy subtypes and for differentiating patients with progressive supranuclear palsy-parkinsonism from with those with Parkinson disease.

### Abbreviations

FA
:   fractional anisotropy
MD
:   mean diffusivity
PD
:   Parkinson disease
PSP
:   progressive supranuclear palsy
PSP-P
:   progressive supranuclear palsy-parkinsonism
PSP-RS
:   progressive supranuclear palsy with Richardson syndrome
SCP
:   superior cerebellar peduncle" />
<meta name="DC.Contributor" content="G. Nicoletti" />
<meta name="DC.Contributor" content="M.E. Caligiuri" />
<meta name="DC.Contributor" content="A. Cherubini" />
<meta name="DC.Contributor" content="M. Morelli" />
<meta name="DC.Contributor" content="F. Novellino" />
<meta name="DC.Contributor" content="G. Arabia" />
<meta name="DC.Contributor" content="M. Salsone" />
<meta name="DC.Contributor" content="A. Quattrone" />
<meta name="article:published_time" content="2016-12-29" />
<meta name="article:section" content="ADULT BRAIN" />
<meta name="citation_title" content="A Fully Automated, Atlas-Based Approach for Superior Cerebellar Peduncle Evaluation in Progressive Supranuclear Palsy Phenotypes" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;The superior cerebellar peduncle is damaged in progressive supranuclear palsy. However, alterations differ between progressive supranuclear palsy with Richardson syndrome and progressive supranuclear palsy-parkinsonism. In this study, we propose an automated tool for superior cerebellar peduncle integrity assessment and test its performance in patients with progressive supranuclear palsy with Richardson syndrome, progressive supranuclear palsy-parkinsonism, Parkinson disease, and healthy controls.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Structural and diffusion MRI was performed in 21 patients with progressive supranuclear palsy with Richardson syndrome, 9 with progressive supranuclear palsy-parkinsonism, 20 with Parkinson disease, and 30 healthy subjects. In a fully automated pipeline, the left and right superior cerebellar peduncles were first identified on MR imaging by using a tractography-based atlas of white matter tracts; subsequently, volume, mean diffusivity, and fractional anisotropy were extracted from superior cerebellar peduncles. These measures were compared across groups, and their discriminative power in differentiating patients was evaluated in a linear discriminant analysis.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Compared with those with Parkinson disease and controls, patients with progressive supranuclear palsy with Richardson syndrome showed alterations of all superior cerebellar peduncle metrics (decreased volume and fractional anisotropy, increased mean diffusivity). Patients with progressive supranuclear palsy-parkinsonism had smaller volumes than those with Parkinson disease and controls and lower fractional anisotropy than those with Parkinson disease. Patients with progressive supranuclear palsy with Richardson syndrome had significantly altered fractional anisotropy and mean diffusivity in the left superior cerebellar peduncle compared with those with progressive supranuclear palsy-parkinsonism. Discriminant analysis with the sole use of significant variables separated progressive supranuclear palsy-parkinsonism from progressive supranuclear palsy with Richardson syndrome with 70% accuracy and progressive supranuclear palsy-parkinsonism from Parkinson disease with 74% accuracy.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;We demonstrate the feasibility of an automated approach for extracting multimodal MR imaging metrics from the superior cerebellar peduncle in healthy subjects and patients with parkinsonian. We provide evidence that structural and diffusion measures of the superior cerebellar peduncle might be valuable for computer-aided diagnosis of progressive supranuclear palsy subtypes and for differentiating patients with progressive supranuclear palsy-parkinsonism from with those with Parkinson disease.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2016/12/29" />
<meta name="citation_mjid" content="ajnr;ajnr.A5048v1" />
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<meta name="citation_section" content="ADULT BRAIN" />
<meta name="citation_author" content="G. Nicoletti" />
<meta name="citation_author_institution" content="From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0002-0761-6188" />
<meta name="citation_author" content="M.E. Caligiuri" />
<meta name="citation_author_institution" content="From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0002-2030-5552" />
<meta name="citation_author" content="A. Cherubini" />
<meta name="citation_author_institution" content="From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0002-5946-4390" />
<meta name="citation_author" content="M. Morelli" />
<meta name="citation_author_institution" content="From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0002-7263-1229" />
<meta name="citation_author" content="F. Novellino" />
<meta name="citation_author_institution" content="From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0002-5898-938X" />
<meta name="citation_author" content="G. Arabia" />
<meta name="citation_author_institution" content="From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0002-8775-4061" />
<meta name="citation_author" content="M. Salsone" />
<meta name="citation_author_institution" content="From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0001-5375-3733" />
<meta name="citation_author" content="A. Quattrone" />
<meta name="citation_author_institution" content="From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0003-2001-957X" />
<meta name="twitter:title" content="A Fully Automated, Atlas-Based Approach for Superior Cerebellar Peduncle Evaluation in Progressive Supranuclear Palsy Phenotypes" />
<meta name="twitter:card" content="summary" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: The superior cerebellar peduncle is damaged in progressive supranuclear palsy. However, alterations differ between progressive supranuclear palsy with Richardson syndrome and progressive supranuclear palsy-parkinsonism. In this study, we propose an automated tool for superior cerebellar peduncle integrity assessment and test its performance in patients with progressive supranuclear palsy with Richardson syndrome, progressive supranuclear palsy-parkinsonism, Parkinson disease, and healthy controls.

MATERIALS AND METHODS: Structural and diffusion MRI was performed in 21 patients with progressive supranuclear palsy with Richardson syndrome, 9 with progressive supranuclear palsy-parkinsonism, 20 with Parkinson disease, and 30 healthy subjects. In a fully automated pipeline, the left and right superior cerebellar peduncles were first identified on MR imaging by using a tractography-based atlas of white matter tracts; subsequently, volume, mean diffusivity, and fractional anisotropy were extracted from superior cerebellar peduncles. These measures were compared across groups, and their discriminative power in differentiating patients was evaluated in a linear discriminant analysis.

RESULTS: Compared with those with Parkinson disease and controls, patients with progressive supranuclear palsy with Richardson syndrome showed alterations of all superior cerebellar peduncle metrics (decreased volume and fractional anisotropy, increased mean diffusivity). Patients with progressive supranuclear palsy-parkinsonism had smaller volumes than those with Parkinson disease and controls and lower fractional anisotropy than those with Parkinson disease. Patients with progressive supranuclear palsy with Richardson syndrome had significantly altered fractional anisotropy and mean diffusivity in the left superior cerebellar peduncle compared with those with progressive supranuclear palsy-parkinsonism. Discriminant analysis with the sole use of significant variables separated progressive supranuclear palsy-parkinsonism from progressive supranuclear palsy with Richardson syndrome with 70% accuracy and progressive supranuclear palsy-parkinsonism from Parkinson disease with 74% accuracy.

CONCLUSIONS: We demonstrate the feasibility of an automated approach for extracting multimodal MR imaging metrics from the superior cerebellar peduncle in healthy subjects and patients with parkinsonian. We provide evidence that structural and diffusion measures of the superior cerebellar peduncle might be valuable for computer-aided diagnosis of progressive supranuclear palsy subtypes and for differentiating patients with progressive supranuclear palsy-parkinsonism from with those with Parkinson disease.

### Abbreviations

FA
:   fractional anisotropy
MD
:   mean diffusivity
PD
:   Parkinson disease
PSP
:   progressive supranuclear palsy
PSP-P
:   progressive supranuclear palsy-parkinsonism
PSP-RS
:   progressive supranuclear palsy with Richardson syndrome
SCP
:   superior cerebellar peduncle" />
<meta name="og-title" property="og:title" content="A Fully Automated, Atlas-Based Approach for Superior Cerebellar Peduncle Evaluation in Progressive Supranuclear Palsy Phenotypes" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/early/2016/12/29/ajnr.A5048" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: The superior cerebellar peduncle is damaged in progressive supranuclear palsy. However, alterations differ between progressive supranuclear palsy with Richardson syndrome and progressive supranuclear palsy-parkinsonism. In this study, we propose an automated tool for superior cerebellar peduncle integrity assessment and test its performance in patients with progressive supranuclear palsy with Richardson syndrome, progressive supranuclear palsy-parkinsonism, Parkinson disease, and healthy controls.

MATERIALS AND METHODS: Structural and diffusion MRI was performed in 21 patients with progressive supranuclear palsy with Richardson syndrome, 9 with progressive supranuclear palsy-parkinsonism, 20 with Parkinson disease, and 30 healthy subjects. In a fully automated pipeline, the left and right superior cerebellar peduncles were first identified on MR imaging by using a tractography-based atlas of white matter tracts; subsequently, volume, mean diffusivity, and fractional anisotropy were extracted from superior cerebellar peduncles. These measures were compared across groups, and their discriminative power in differentiating patients was evaluated in a linear discriminant analysis.

RESULTS: Compared with those with Parkinson disease and controls, patients with progressive supranuclear palsy with Richardson syndrome showed alterations of all superior cerebellar peduncle metrics (decreased volume and fractional anisotropy, increased mean diffusivity). Patients with progressive supranuclear palsy-parkinsonism had smaller volumes than those with Parkinson disease and controls and lower fractional anisotropy than those with Parkinson disease. Patients with progressive supranuclear palsy with Richardson syndrome had significantly altered fractional anisotropy and mean diffusivity in the left superior cerebellar peduncle compared with those with progressive supranuclear palsy-parkinsonism. Discriminant analysis with the sole use of significant variables separated progressive supranuclear palsy-parkinsonism from progressive supranuclear palsy with Richardson syndrome with 70% accuracy and progressive supranuclear palsy-parkinsonism from Parkinson disease with 74% accuracy.

CONCLUSIONS: We demonstrate the feasibility of an automated approach for extracting multimodal MR imaging metrics from the superior cerebellar peduncle in healthy subjects and patients with parkinsonian. We provide evidence that structural and diffusion measures of the superior cerebellar peduncle might be valuable for computer-aided diagnosis of progressive supranuclear palsy subtypes and for differentiating patients with progressive supranuclear palsy-parkinsonism from with those with Parkinson disease.

### Abbreviations

FA
:   fractional anisotropy
MD
:   mean diffusivity
PD
:   Parkinson disease
PSP
:   progressive supranuclear palsy
PSP-P
:   progressive supranuclear palsy-parkinsonism
PSP-RS
:   progressive supranuclear palsy with Richardson syndrome
SCP
:   superior cerebellar peduncle" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node800--5" data-node-nid="800" id="top-node-800--6847002289" data-pisa="ajnr;ajnr.A5048v1" data-pisa-master="ajnr;ajnr.A5048" data-apath="/ajnr/early/2016/12/29/ajnr.A5048.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">A Fully Automated, Atlas-Based Approach for Superior Cerebellar Peduncle Evaluation in Progressive Supranuclear Palsy Phenotypes</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">G. Nicoletti</span>, <span class="highwire-citation-author" data-delta="1">M.E. Caligiuri</span>, <span class="highwire-citation-author" data-delta="2">A. Cherubini</span>, <span class="highwire-citation-author" data-delta="3">M. Morelli</span>, <span class="highwire-citation-author" data-delta="4">F. Novellino</span>, <span class="highwire-citation-author" data-delta="5">G. Arabia</span>, <span class="highwire-citation-author" data-delta="6">M. Salsone</span> and <span class="highwire-citation-author" data-delta="7">A. Quattrone</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">December 2016,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5048 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-800--6847002289" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">G. Nicoletti </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BNicoletti%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nicoletti%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BNicoletti%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-0761-6188" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. Nicoletti</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">M.E. Caligiuri </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.E.%2BCaligiuri%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Caligiuri%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.E.%2BCaligiuri%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-2030-5552" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.E. Caligiuri</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A. Cherubini </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BCherubini%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cherubini%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BCherubini%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-5946-4390" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Cherubini</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">M. Morelli </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BMorelli%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Morelli%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BMorelli%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-7263-1229" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Morelli</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">F. Novellino </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BNovellino%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Novellino%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AF.%2BNovellino%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-5898-938X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for F. Novellino</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">G. Arabia </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BArabia%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Arabia%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BArabia%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-8775-4061" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. Arabia</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">M. Salsone </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BSalsone%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Salsone%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BSalsone%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-5375-3733" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. 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Quattrone </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Neuroimaging Research Unit (G.N., M.E.C., A.C., F.N., M.S., A.Q.), Institute of Bioimaging and Molecular Physiology - National Research Council, Catanzaro, Italy; and Neuroimaging Research Unit, (M.M., G.A., A.Q.), Institute of Neurology University, “Magna Graecia” of Catanzaro, Catanzaro, Italy.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BQuattrone%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Quattrone%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BQuattrone%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-2001-957X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. 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