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    Focal Leptomeningeal Disease with Perivascular Invasion in EGFR-Mutant Non-Small-Cell Lung Cancer | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Research ArticleADULT BRAIN

  
      

  
      
Focal Leptomeningeal Disease with Perivascular Invasion in EGFR-Mutant Non-Small-Cell Lung Cancer
  
    	
A. Dasgupta, F.Y. Moraes, S. Rawal, P. Diamandis and D.B. Shultz

  
    	
American Journal of Neuroradiology July 2020,  DOI: https://doi.org/10.3174/ajnr.A6640 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
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    1. Liao  BC, 
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    . Epidermal growth factor receptor tyrosine kinase inhibitors for non-small-cell lung cancer patients with leptomeningeal carcinomatosis. J Thorac Oncol 2015;10:1754–61 doi:10.1097/JTO.0000000000000669 pmid:26334749
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    . Stereotactic radiosurgery for focal leptomeningeal disease in patients with brain metastases. J Neurooncol 2017;134:139–43 doi:10.1007/s11060-017-2497-6 pmid:28536993
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    . Association of neurosurgical resection with development of pachymeningeal seeding in patients with brain metastases. JAMA Oncol 2019;5:703–09 doi:10.1001/jamaoncol.2018.7204
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    . Brain MRI imaging characteristics predict treatment response and outcome in patients with de novo brain metastasis of EGFR-mutated NSCLC. Medicine (Baltimore) 2019;98:e16766 doi:10.1097/MD.0000000000016766 pmid:31415376
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    . Radiographic appearance of leptomeningeal disease in patients with EGFR-mutated non-small-cell lung carcinoma treated with tyrosine kinase inhibitors: a case series. CNS Oncol 2019;8:CNS4 doi:10.2217/cns-2019-0010 pmid:31777268
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    . Osimertinib in patients with epidermal growth factor receptor mutation-positive non-small-cell lung cancer and leptomeningeal metastases: the BLOOM study. J Clin Oncol 2020;38:538–47 doi:10.1200/JCO.19.00457 pmid:31809241
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    . The imaging and neuropathological effects of bevacizumab (Avastin) in patients with leptomeningeal carcinomatosis. J Neurooncol 2010;96:375–84 doi:10.1007/s11060-009-9969-2 pmid:19609489
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    1. Takei  H, 
    2. Rouah  E, 
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    . Imaging of angiotropism/vascular co-option in a murine model of brain melanoma: implications for melanoma progression along extravascular pathways. Sci Rep 2016;6:23834 doi:10.1038/srep23834 pmid:27048955
    CrossRefPubMed
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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Focal Leptomeningeal Disease with Perivascular Invasion in EGFR-Mutant Non-Small-Cell Lung Cancer
  
    	
A. Dasgupta, F.Y. Moraes, S. Rawal, P. Diamandis, D.B. Shultz

  
    	
American Journal of Neuroradiology Jul 2020, DOI: 10.3174/ajnr.A6640 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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