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<meta name="citation_funding_source" content="citation_grant_number=Basic Science Research Program 2017R1D1A1B03034388;citation_grant_number=2020R1C1C1005724;" />
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<meta name="HW.identifier" content="/ajnr/early/2021/05/13/ajnr.A7155.atom" />
<meta name="HW.pisa" content="ajnr;ajnr.A7155v1" />
<meta name="DC.Format" content="text/html" />
<meta name="DC.Language" content="en" />
<meta name="DC.Title" content="MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment" />
<meta name="DC.Identifier" content="10.3174/ajnr.A7155" />
<meta name="DC.Date" content="2021-05-13" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2021 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: The association of perivascular spaces in the centrum semiovale with amyloid accumulation among patients with Alzheimer disease–related cognitive impairment is unknown. We evaluated this association in patients with Alzheimer disease–related cognitive impairment and β-amyloid deposition, assessed with [18F] florbetaben PET/CT.

MATERIALS AND METHODS: MR imaging and [18F] florbetaben PET/CT images of 144 patients with Alzheimer disease–related cognitive impairment were retrospectively evaluated. MR imaging–visible perivascular spaces were rated on a 4-point visual scale: a score of ≥3 or &lt;3 indicated a high or low degree of MR imaging–visible perivascular spaces, respectively. Amyloid deposition was evaluated using the brain β-amyloid plaque load scoring system.

RESULTS: Compared with patients negative for β-amyloid, those positive for it were older and more likely to have lower cognitive function, a diagnosis of Alzheimer disease, white matter hyperintensity, the Apolipoprotein E ε4 allele, and a high degree of MR imaging–visible perivascular spaces in the centrum semiovale. Multivariable analysis, adjusted for age and Apolipoprotein E status, revealed that a high degree of MR imaging–visible perivascular spaces in the centrum semiovale was independently associated with β-amyloid positivity (odds ratio, 2.307; 95% CI, 1.036–5.136; P = .041).

CONCLUSIONS: A high degree of MR imaging–visible perivascular spaces in the centrum semiovale independently predicted β-amyloid positivity in patients with Alzheimer disease–related cognitive impairment. Thus, MR imaging–visible perivascular spaces in the centrum semiovale are associated with amyloid pathology of the brain and could be an indirect imaging marker of amyloid burden in patients with Alzheimer disease–related cognitive impairment.

AD
:   Alzheimer disease
ADCI
:   AD-related cognitive impairment
APOE 
:   Apolipoprotein E 
BAPL
:   β-amyloid plaque load
[18F] FBB
:   [18F] florbetaben
MMSE
:   Mini-Mental State Examination
PVS
:   perivascular spaces
PVS-CS
:   perivascular spaces in the centrum semiovale
SUVr
:   standardized uptake value ratios
WMH
:   white matter hyperintensity" />
<meta name="DC.Contributor" content="H.J. Kim" />
<meta name="DC.Contributor" content="H. Cho" />
<meta name="DC.Contributor" content="M. Park" />
<meta name="DC.Contributor" content="J.W. Kim" />
<meta name="DC.Contributor" content="S.J. Ahn" />
<meta name="DC.Contributor" content="C.H. Lyoo" />
<meta name="DC.Contributor" content="S.H. Suh" />
<meta name="DC.Contributor" content="Y.H. Ryu" />
<meta name="article:published_time" content="2021-05-13" />
<meta name="article:section" content="ADULT BRAIN" />
<meta name="citation_title" content="MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;The association of perivascular spaces in the centrum semiovale with amyloid accumulation among patients with Alzheimer disease–related cognitive impairment is unknown. We evaluated this association in patients with Alzheimer disease–related cognitive impairment and β-amyloid deposition, assessed with [&lt;sup&gt;18&lt;/sup&gt;F] florbetaben PET/CT.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;MR imaging and [&lt;sup&gt;18&lt;/sup&gt;F] florbetaben PET/CT images of 144 patients with Alzheimer disease–related cognitive impairment were retrospectively evaluated. MR imaging–visible perivascular spaces were rated on a 4-point visual scale: a score of ≥3 or &amp;lt;3 indicated a high or low degree of MR imaging–visible perivascular spaces, respectively. Amyloid deposition was evaluated using the brain β-amyloid plaque load scoring system.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Compared with patients negative for β-amyloid, those positive for it were older and more likely to have lower cognitive function, a diagnosis of Alzheimer disease, white matter hyperintensity, the &lt;i&gt;Apolipoprotein E&lt;/i&gt; ε4 allele, and a high degree of MR imaging–visible perivascular spaces in the centrum semiovale. Multivariable analysis, adjusted for age and &lt;i&gt;Apolipoprotein E&lt;/i&gt; status, revealed that a high degree of MR imaging–visible perivascular spaces in the centrum semiovale was independently associated with β-amyloid positivity (odds ratio, 2.307; 95% CI, 1.036–5.136; &lt;i&gt;P&lt;/i&gt; = .041).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;A high degree of MR imaging–visible perivascular spaces in the centrum semiovale independently predicted β-amyloid positivity in patients with Alzheimer disease–related cognitive impairment. Thus, MR imaging–visible perivascular spaces in the centrum semiovale are associated with amyloid pathology of the brain and could be an indirect imaging marker of amyloid burden in patients with Alzheimer disease–related cognitive impairment.&lt;/p&gt;" />
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<meta name="twitter:title" content="MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment" />
<meta name="twitter:card" content="summary" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: The association of perivascular spaces in the centrum semiovale with amyloid accumulation among patients with Alzheimer disease–related cognitive impairment is unknown. We evaluated this association in patients with Alzheimer disease–related cognitive impairment and β-amyloid deposition, assessed with [18F] florbetaben PET/CT.

MATERIALS AND METHODS: MR imaging and [18F] florbetaben PET/CT images of 144 patients with Alzheimer disease–related cognitive impairment were retrospectively evaluated. MR imaging–visible perivascular spaces were rated on a 4-point visual scale: a score of ≥3 or &lt;3 indicated a high or low degree of MR imaging–visible perivascular spaces, respectively. Amyloid deposition was evaluated using the brain β-amyloid plaque load scoring system.

RESULTS: Compared with patients negative for β-amyloid, those positive for it were older and more likely to have lower cognitive function, a diagnosis of Alzheimer disease, white matter hyperintensity, the Apolipoprotein E ε4 allele, and a high degree of MR imaging–visible perivascular spaces in the centrum semiovale. Multivariable analysis, adjusted for age and Apolipoprotein E status, revealed that a high degree of MR imaging–visible perivascular spaces in the centrum semiovale was independently associated with β-amyloid positivity (odds ratio, 2.307; 95% CI, 1.036–5.136; P = .041).

CONCLUSIONS: A high degree of MR imaging–visible perivascular spaces in the centrum semiovale independently predicted β-amyloid positivity in patients with Alzheimer disease–related cognitive impairment. Thus, MR imaging–visible perivascular spaces in the centrum semiovale are associated with amyloid pathology of the brain and could be an indirect imaging marker of amyloid burden in patients with Alzheimer disease–related cognitive impairment.

AD
:   Alzheimer disease
ADCI
:   AD-related cognitive impairment
APOE 
:   Apolipoprotein E 
BAPL
:   β-amyloid plaque load
[18F] FBB
:   [18F] florbetaben
MMSE
:   Mini-Mental State Examination
PVS
:   perivascular spaces
PVS-CS
:   perivascular spaces in the centrum semiovale
SUVr
:   standardized uptake value ratios
WMH
:   white matter hyperintensity" />
<meta name="og-title" property="og:title" content="MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/early/2021/05/13/ajnr.A7155" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: The association of perivascular spaces in the centrum semiovale with amyloid accumulation among patients with Alzheimer disease–related cognitive impairment is unknown. We evaluated this association in patients with Alzheimer disease–related cognitive impairment and β-amyloid deposition, assessed with [18F] florbetaben PET/CT.

MATERIALS AND METHODS: MR imaging and [18F] florbetaben PET/CT images of 144 patients with Alzheimer disease–related cognitive impairment were retrospectively evaluated. MR imaging–visible perivascular spaces were rated on a 4-point visual scale: a score of ≥3 or &lt;3 indicated a high or low degree of MR imaging–visible perivascular spaces, respectively. Amyloid deposition was evaluated using the brain β-amyloid plaque load scoring system.

RESULTS: Compared with patients negative for β-amyloid, those positive for it were older and more likely to have lower cognitive function, a diagnosis of Alzheimer disease, white matter hyperintensity, the Apolipoprotein E ε4 allele, and a high degree of MR imaging–visible perivascular spaces in the centrum semiovale. Multivariable analysis, adjusted for age and Apolipoprotein E status, revealed that a high degree of MR imaging–visible perivascular spaces in the centrum semiovale was independently associated with β-amyloid positivity (odds ratio, 2.307; 95% CI, 1.036–5.136; P = .041).

CONCLUSIONS: A high degree of MR imaging–visible perivascular spaces in the centrum semiovale independently predicted β-amyloid positivity in patients with Alzheimer disease–related cognitive impairment. Thus, MR imaging–visible perivascular spaces in the centrum semiovale are associated with amyloid pathology of the brain and could be an indirect imaging marker of amyloid burden in patients with Alzheimer disease–related cognitive impairment.

AD
:   Alzheimer disease
ADCI
:   AD-related cognitive impairment
APOE 
:   Apolipoprotein E 
BAPL
:   β-amyloid plaque load
[18F] FBB
:   [18F] florbetaben
MMSE
:   Mini-Mental State Examination
PVS
:   perivascular spaces
PVS-CS
:   perivascular spaces in the centrum semiovale
SUVr
:   standardized uptake value ratios
WMH
:   white matter hyperintensity" />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">ADULT BRAIN</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H.J. Kim</span>, <span class="highwire-citation-author" data-delta="1">H. Cho</span>, <span class="highwire-citation-author" data-delta="2">M. Park</span>, <span class="highwire-citation-author" data-delta="3">J.W. Kim</span>, <span class="highwire-citation-author" data-delta="4">S.J. Ahn</span>, <span class="highwire-citation-author" data-delta="5">C.H. Lyoo</span>, <span class="highwire-citation-author" data-delta="6">S.H. Suh</span> and <span class="highwire-citation-author" data-delta="7">Y.H. Ryu</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2021,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7155 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-91156--6998646448" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">H.J. Kim </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Nuclear Medicine (H.J.K., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Nuclear Medicine (H.J.K.), Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, South Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.J.%2BKim%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kim%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.J.%2BKim%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3116-8848" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H.J. Kim</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">H. Cho </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurology (H.C., C.H.L.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BCho%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cho%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.%2BCho%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5936-1546" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H. Cho</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">M. Park </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Radiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BPark%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Park%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BPark%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2005-7560" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Park</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J.W. Kim </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Radiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.W.%2BKim%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kim%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.W.%2BKim%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3155-0569" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.W. 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Ahn </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Radiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.J.%2BAhn%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ahn%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.J.%2BAhn%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0075-2432" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S.J. Ahn</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">C.H. 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