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<meta name="DC.Title" content="Cerebral MR in ophthalmoplegia plus." />
<meta name="DC.Date" content="1994-04-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="PURPOSE To evaluate MR patterns in ophthalmoplegia plus and correlate them with clinical symptoms.

METHODS MR was performed on a 1.5-T whole-body scanner with T2-weighted gradient-echo and spin-echo images. The retrospective analysis included 19 patients with clinically established diagnoses of ophthalmoplegia plus.

RESULTS Two types of cerebral MR abnormalities were found in ophthalmoplegia plus: brain atrophy and hyperintensities restricted to the white matter and basal ganglia, which appeared as either focal or diffuse areas of high signal intensity and were of strictly supratentorial location. No specific distribution was found. These findings differ markedly from infarction-like lesions found in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.

CONCLUSIONS MR is sensitive for the detection of central nervous system involvement in ophthalmoplegia plus, but findings are nonspecific. However, cerebral MR in ophthalmoplegia plus is different from other mitochondrial encephalomyopathies and underlines the clinical differentiation of mitochondrial encephalomyopathies." />
<meta name="DC.Contributor" content="C Leutner" />
<meta name="DC.Contributor" content="G Layer" />
<meta name="DC.Contributor" content="S Zierz" />
<meta name="DC.Contributor" content="L Solymosi" />
<meta name="DC.Contributor" content="W Dewes" />
<meta name="DC.Contributor" content="M Reiser" />
<meta name="article:published_time" content="1994-04-01" />
<meta name="citation_title" content="Cerebral MR in ophthalmoplegia plus." />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;PURPOSE&lt;/h3&gt;
&lt;p&gt;To evaluate MR patterns in ophthalmoplegia plus and correlate them with clinical symptoms.&lt;/p&gt;&lt;h3&gt;METHODS&lt;/h3&gt;
&lt;p&gt;MR was performed on a 1.5-T whole-body scanner with T2-weighted gradient-echo and spin-echo images. The retrospective analysis included 19 patients with clinically established diagnoses of ophthalmoplegia plus.&lt;/p&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;
&lt;p&gt;Two types of cerebral MR abnormalities were found in ophthalmoplegia plus: brain atrophy and hyperintensities restricted to the white matter and basal ganglia, which appeared as either focal or diffuse areas of high signal intensity and were of strictly supratentorial location. No specific distribution was found. These findings differ markedly from infarction-like lesions found in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS&lt;/h3&gt;
&lt;p&gt;MR is sensitive for the detection of central nervous system involvement in ophthalmoplegia plus, but findings are nonspecific. However, cerebral MR in ophthalmoplegia plus is different from other mitochondrial encephalomyopathies and underlines the clinical differentiation of mitochondrial encephalomyopathies.&lt;/p&gt;" />
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<meta name="citation_author" content="C Leutner" />
<meta name="citation_author_institution" content="Department of Radiology, University of Bonn, Germany." />
<meta name="citation_author" content="G Layer" />
<meta name="citation_author_institution" content="Department of Radiology, University of Bonn, Germany." />
<meta name="citation_author" content="S Zierz" />
<meta name="citation_author_institution" content="Department of Radiology, University of Bonn, Germany." />
<meta name="citation_author" content="L Solymosi" />
<meta name="citation_author_institution" content="Department of Radiology, University of Bonn, Germany." />
<meta name="citation_author" content="W Dewes" />
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<meta name="twitter:title" content="Cerebral MR in ophthalmoplegia plus." />
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<meta name="twitter:description" content="PURPOSE To evaluate MR patterns in ophthalmoplegia plus and correlate them with clinical symptoms.

METHODS MR was performed on a 1.5-T whole-body scanner with T2-weighted gradient-echo and spin-echo images. The retrospective analysis included 19 patients with clinically established diagnoses of ophthalmoplegia plus.

RESULTS Two types of cerebral MR abnormalities were found in ophthalmoplegia plus: brain atrophy and hyperintensities restricted to the white matter and basal ganglia, which appeared as either focal or diffuse areas of high signal intensity and were of strictly supratentorial location. No specific distribution was found. These findings differ markedly from infarction-like lesions found in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.

CONCLUSIONS MR is sensitive for the detection of central nervous system involvement in ophthalmoplegia plus, but findings are nonspecific. However, cerebral MR in ophthalmoplegia plus is different from other mitochondrial encephalomyopathies and underlines the clinical differentiation of mitochondrial encephalomyopathies." />
<meta name="og-title" property="og:title" content="Cerebral MR in ophthalmoplegia plus." />
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<meta name="og-description" property="og:description" content="PURPOSE To evaluate MR patterns in ophthalmoplegia plus and correlate them with clinical symptoms.

METHODS MR was performed on a 1.5-T whole-body scanner with T2-weighted gradient-echo and spin-echo images. The retrospective analysis included 19 patients with clinically established diagnoses of ophthalmoplegia plus.

RESULTS Two types of cerebral MR abnormalities were found in ophthalmoplegia plus: brain atrophy and hyperintensities restricted to the white matter and basal ganglia, which appeared as either focal or diffuse areas of high signal intensity and were of strictly supratentorial location. No specific distribution was found. These findings differ markedly from infarction-like lesions found in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.

CONCLUSIONS MR is sensitive for the detection of central nervous system involvement in ophthalmoplegia plus, but findings are nonspecific. However, cerebral MR in ophthalmoplegia plus is different from other mitochondrial encephalomyopathies and underlines the clinical differentiation of mitochondrial encephalomyopathies." />
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      <h1 class="highwire-cite-title" id="page-title">Cerebral MR in ophthalmoplegia plus.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">C Leutner</span>, <span class="highwire-citation-author" data-delta="1">G Layer</span>, <span class="highwire-citation-author" data-delta="2">S Zierz</span>, <span class="highwire-citation-author" data-delta="3">L Solymosi</span>, <span class="highwire-citation-author" data-delta="4">W Dewes</span> and <span class="highwire-citation-author" data-delta="5">M Reiser</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 1994,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">15 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">681-687; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-6009--61976914312" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">C Leutner </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Department of Radiology, University of Bonn, Germany.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C%2BLeutner%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Leutner%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC%2BLeutner%2B" rel="nofollow" class="" data-icon-position="" 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          <p id="p-1"><strong>PURPOSE</strong> To evaluate MR patterns in ophthalmoplegia plus and correlate them with clinical symptoms.</p>
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          <p id="p-2"><strong>METHODS</strong> MR was performed on a 1.5-T whole-body scanner with T2-weighted gradient-echo and spin-echo images. The retrospective analysis included 19 patients with clinically established diagnoses of ophthalmoplegia plus.</p>
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          <p id="p-3"><strong>RESULTS</strong> Two types of cerebral MR abnormalities were found in ophthalmoplegia plus: brain atrophy and hyperintensities restricted to the white matter and basal ganglia, which appeared as either focal or diffuse areas of high signal intensity and were of strictly supratentorial location. No specific distribution was found. These findings differ markedly from infarction-like lesions found in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.</p>
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          <p id="p-4"><strong>CONCLUSIONS</strong> MR is sensitive for the detection of central nervous system involvement in ophthalmoplegia plus, but findings are nonspecific. However, cerebral MR in ophthalmoplegia plus is different from other mitochondrial encephalomyopathies and underlines the clinical differentiation of mitochondrial encephalomyopathies.</p>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 15</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 4 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Apr 1994 </div></div>
      
      
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