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<meta name="DC.Title" content="Quantitative Measurement of Regional Cerebral Blood Flow with Flow-Sensitive Alternating Inversion Recovery Imaging: Comparison with [Iodine 123]-Iodoamphetamin Single Photon Emission CT" />
<meta name="DC.Date" content="2002-03-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Flow-sensitive alternating inversion recovery (FAIR) MR imaging is a technique for depicting cerebral perfusion without contrast enhancement. Our purpose was to determine whether quantification at FAIR imaging can be used to assess regional cerebral blood flow (rCBF) in a manner similar to [iodine 123]-iodoamphetamin (123I-IMP) single photon emission CT (SPECT).

METHODS: Nine patients with internal carotid or major cerebral arterial stenosis underwent 123I-IMP SPECT and FAIR imaging (single section, different TIs, 1.5 T) at rest and after acetazolamide (Diamox) stress. FAIR and 123I-IMP rCBF values were compared and correlated. Receiver operating characteristic analysis was conducted to detect hypoperfused segments on FAIR images.

RESULTS: rCBF values of normally perfused segments were 41.53 and 51.91 mL/100 g/min for pre- and post-acetazolamide 123I-IMP studies, respectively. Corresponding values for pre- and post-acetazolamide FAIR images, respectively, were 46.64 and 59.60 mL/100 g/min with a TI of 1200 milliseconds and 53.23 and 68.17 mL/100 g/min with a TI of 1400 milliseconds. 123I-IMP and FAIR resultswere significantly correlated, with both pre- and post-acetazolamide images. Sensitivity (86%) in detecting hypoperfused segments was significantly higher with post-acetazolamide images (TI, 1400 milliseconds), and specificity (82–85%) and accuracy (80–82%) were higher with all pre- and post-acetazolamide images (all TIs).

CONCLUSIONS: The significant correlation, high specificity and accuracy in detecting hypoperfused segments, similar increases in flow on both post-acetazolamide images, and absence of the need for contrast enhancement suggest that FAIR imaging, like nuclear medicine study, is complementary to routine MR imaging in the assessment of cerebral perfusion." />
<meta name="DC.Contributor" content="Ali Syed Arbab" />
<meta name="DC.Contributor" content="Shigeki Aoki" />
<meta name="DC.Contributor" content="Keiji Toyama" />
<meta name="DC.Contributor" content="Nobuhiko Miyazawa" />
<meta name="DC.Contributor" content="Hiroshi Kumagai" />
<meta name="DC.Contributor" content="Takako Umeda" />
<meta name="DC.Contributor" content="Takao Arai" />
<meta name="DC.Contributor" content="Tsutomu Araki" />
<meta name="DC.Contributor" content="Hiroyuki Kabasawa" />
<meta name="DC.Contributor" content="Yoshiyuki Takahashi" />
<meta name="article:published_time" content="2002-03-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Quantitative Measurement of Regional Cerebral Blood Flow with Flow-Sensitive Alternating Inversion Recovery Imaging: Comparison with [Iodine 123]-Iodoamphetamin Single Photon Emission CT" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Flow-sensitive alternating inversion recovery (FAIR) MR imaging is a technique for depicting cerebral perfusion without contrast enhancement. Our purpose was to determine whether quantification at FAIR imaging can be used to assess regional cerebral blood flow (rCBF) in a manner similar to [iodine 123]-iodoamphetamin (&lt;sup&gt;123&lt;/sup&gt;I-IMP) single photon emission CT (SPECT).&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Nine patients with internal carotid or major cerebral arterial stenosis underwent &lt;sup&gt;123&lt;/sup&gt;I-IMP SPECT and FAIR imaging (single section, different TIs, 1.5 T) at rest and after acetazolamide (Diamox) stress. FAIR and &lt;sup&gt;123&lt;/sup&gt;I-IMP rCBF values were compared and correlated. Receiver operating characteristic analysis was conducted to detect hypoperfused segments on FAIR images.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; rCBF values of normally perfused segments were 41.53 and 51.91 mL/100 g/min for pre- and post-acetazolamide &lt;sup&gt;123&lt;/sup&gt;I-IMP studies, respectively. Corresponding values for pre- and post-acetazolamide FAIR images, respectively, were 46.64 and 59.60 mL/100 g/min with a TI of 1200 milliseconds and 53.23 and 68.17 mL/100 g/min with a TI of 1400 milliseconds. &lt;sup&gt;123&lt;/sup&gt;I-IMP and FAIR resultswere significantly correlated, with both pre- and post-acetazolamide images. Sensitivity (86%) in detecting hypoperfused segments was significantly higher with post-acetazolamide images (TI, 1400 milliseconds), and specificity (82–85%) and accuracy (80–82%) were higher with all pre- and post-acetazolamide images (all TIs).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSIONS:&lt;/i&gt; The significant correlation, high specificity and accuracy in detecting hypoperfused segments, similar increases in flow on both post-acetazolamide images, and absence of the need for contrast enhancement suggest that FAIR imaging, like nuclear medicine study, is complementary to routine MR imaging in the assessment of cerebral perfusion.&lt;/p&gt;" />
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<meta name="citation_mjid" content="ajnr;23/3/381" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Flow-sensitive alternating inversion recovery (FAIR) MR imaging is a technique for depicting cerebral perfusion without contrast enhancement. Our purpose was to determine whether quantification at FAIR imaging can be used to assess regional cerebral blood flow (rCBF) in a manner similar to [iodine 123]-iodoamphetamin (123I-IMP) single photon emission CT (SPECT).

METHODS: Nine patients with internal carotid or major cerebral arterial stenosis underwent 123I-IMP SPECT and FAIR imaging (single section, different TIs, 1.5 T) at rest and after acetazolamide (Diamox) stress. FAIR and 123I-IMP rCBF values were compared and correlated. Receiver operating characteristic analysis was conducted to detect hypoperfused segments on FAIR images.

RESULTS: rCBF values of normally perfused segments were 41.53 and 51.91 mL/100 g/min for pre- and post-acetazolamide 123I-IMP studies, respectively. Corresponding values for pre- and post-acetazolamide FAIR images, respectively, were 46.64 and 59.60 mL/100 g/min with a TI of 1200 milliseconds and 53.23 and 68.17 mL/100 g/min with a TI of 1400 milliseconds. 123I-IMP and FAIR resultswere significantly correlated, with both pre- and post-acetazolamide images. Sensitivity (86%) in detecting hypoperfused segments was significantly higher with post-acetazolamide images (TI, 1400 milliseconds), and specificity (82–85%) and accuracy (80–82%) were higher with all pre- and post-acetazolamide images (all TIs).

CONCLUSIONS: The significant correlation, high specificity and accuracy in detecting hypoperfused segments, similar increases in flow on both post-acetazolamide images, and absence of the need for contrast enhancement suggest that FAIR imaging, like nuclear medicine study, is complementary to routine MR imaging in the assessment of cerebral perfusion." />
<meta name="og-title" property="og:title" content="Quantitative Measurement of Regional Cerebral Blood Flow with Flow-Sensitive Alternating Inversion Recovery Imaging: Comparison with [Iodine 123]-Iodoamphetamin Single Photon Emission CT" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Flow-sensitive alternating inversion recovery (FAIR) MR imaging is a technique for depicting cerebral perfusion without contrast enhancement. Our purpose was to determine whether quantification at FAIR imaging can be used to assess regional cerebral blood flow (rCBF) in a manner similar to [iodine 123]-iodoamphetamin (123I-IMP) single photon emission CT (SPECT).

METHODS: Nine patients with internal carotid or major cerebral arterial stenosis underwent 123I-IMP SPECT and FAIR imaging (single section, different TIs, 1.5 T) at rest and after acetazolamide (Diamox) stress. FAIR and 123I-IMP rCBF values were compared and correlated. Receiver operating characteristic analysis was conducted to detect hypoperfused segments on FAIR images.

RESULTS: rCBF values of normally perfused segments were 41.53 and 51.91 mL/100 g/min for pre- and post-acetazolamide 123I-IMP studies, respectively. Corresponding values for pre- and post-acetazolamide FAIR images, respectively, were 46.64 and 59.60 mL/100 g/min with a TI of 1200 milliseconds and 53.23 and 68.17 mL/100 g/min with a TI of 1400 milliseconds. 123I-IMP and FAIR resultswere significantly correlated, with both pre- and post-acetazolamide images. Sensitivity (86%) in detecting hypoperfused segments was significantly higher with post-acetazolamide images (TI, 1400 milliseconds), and specificity (82–85%) and accuracy (80–82%) were higher with all pre- and post-acetazolamide images (all TIs).

CONCLUSIONS: The significant correlation, high specificity and accuracy in detecting hypoperfused segments, similar increases in flow on both post-acetazolamide images, and absence of the need for contrast enhancement suggest that FAIR imaging, like nuclear medicine study, is complementary to routine MR imaging in the assessment of cerebral perfusion." />
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    <title>Quantitative Measurement of Regional Cerebral Blood Flow with Flow-Sensitive Alternating Inversion Recovery Imaging: Comparison with [Iodine 123]-Iodoamphetamin Single Photon Emission CT | American Journal of Neuroradiology</title>  
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      <h1 class="highwire-cite-title" id="page-title">Quantitative Measurement of Regional Cerebral Blood Flow with Flow-Sensitive Alternating Inversion Recovery Imaging: Comparison with [Iodine 123]-Iodoamphetamin Single Photon Emission CT</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Ali Syed Arbab</span>, <span class="highwire-citation-author" data-delta="1">Shigeki Aoki</span>, <span class="highwire-citation-author" data-delta="2">Keiji Toyama</span>, <span class="highwire-citation-author" data-delta="3">Nobuhiko Miyazawa</span>, <span class="highwire-citation-author" data-delta="4">Hiroshi Kumagai</span>, <span class="highwire-citation-author" data-delta="5">Takako Umeda</span>, <span class="highwire-citation-author" data-delta="6">Takao Arai</span>, <span class="highwire-citation-author" data-delta="7">Tsutomu Araki</span>, <span class="highwire-citation-author" data-delta="8">Hiroyuki Kabasawa</span> and <span class="highwire-citation-author" data-delta="9">Yoshiyuki Takahashi</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2002,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">23 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">381-388; </span></div>
  
  
  
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    <div class="field field-name-field-highwire-publication-history field-type-text field-label-inline clearfix"><div class="field-label">History&nbsp;</div><div class="field-items"><div class="field-item even"><ul class="publication-history"><li>Received  February 16, 2001</li><li>Accepted after revision  September 6, 2001</li><li class="published"><span class="published-label">Published online</span> March 1, 2002.</li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Ali Syed Arbab</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">Shigeki Aoki</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-3"><span class="name">Keiji Toyama</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-4"><span class="name">Nobuhiko Miyazawa</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">b</a>, </li><li class="contributor" id="contrib-5"><span class="name">Hiroshi Kumagai</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-6"><span class="name">Takako Umeda</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-7"><span class="name">Takao Arai</span><a id="xref-aff-1-6" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-8"><span class="name">Tsutomu Araki</span><a id="xref-aff-1-7" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-9"><span class="name">Hiroyuki Kabasawa</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">c</a> and </li><li class="last" id="contrib-10"><span class="name">Yoshiyuki Takahashi</span><a id="xref-aff-3-2" class="xref-aff" href="#aff-3">c</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>Department of Radiology Yamanashi Medical University, Yamanashi</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>b</sup>Department of Neurosurgery Yamanashi Medical University, Yamanashi</address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>c</sup>Department of GE-YMS Tokyo, Japan</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Address reprint requests to Ali Syed Arbab, MBBS, PhD, Radiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan</li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/23/3/381.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ali Syed</span> <span class="nlm-surname">Arbab</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Shigeki</span> <span class="nlm-surname">Aoki</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Keiji</span> <span class="nlm-surname">Toyama</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Nobuhiko</span> <span class="nlm-surname">Miyazawa</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Hiroshi</span> <span class="nlm-surname">Kumagai</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Takako</span> <span class="nlm-surname">Umeda</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Takao</span> <span class="nlm-surname">Arai</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Tsutomu</span> <span class="nlm-surname">Araki</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Hiroyuki</span> <span class="nlm-surname">Kabasawa</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Yoshiyuki</span> <span class="nlm-surname">Takahashi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2002, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">23 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">381-388; </span></div>
  
  
  
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      <div class="highwire-cite-title">Quantitative Measurement of Regional Cerebral Blood Flow with Flow-Sensitive Alternating Inversion Recovery Imaging: Comparison with [Iodine 123]-Iodoamphetamin Single Photon Emission CT</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ali Syed</span> <span class="nlm-surname">Arbab</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Shigeki</span> <span class="nlm-surname">Aoki</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Keiji</span> <span class="nlm-surname">Toyama</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Nobuhiko</span> <span class="nlm-surname">Miyazawa</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Hiroshi</span> <span class="nlm-surname">Kumagai</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Takako</span> <span class="nlm-surname">Umeda</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Takao</span> <span class="nlm-surname">Arai</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Tsutomu</span> <span class="nlm-surname">Araki</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Hiroyuki</span> <span class="nlm-surname">Kabasawa</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Yoshiyuki</span> <span class="nlm-surname">Takahashi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2002, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">23 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">381-388; </span></div>
  
  
  
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