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<meta name="DC.Description" content="SUMMARY: GABA serves as a major neurotransmitter of the brain and functions mainly to inhibit neural excitatory activity. Disruption of the GABAergic processes appears to occur in various neurologic and psychiatric conditions, including epilepsy, mood disorders, motor disorders such as focal dystonia and stiff-person syndrome, sleep disorders, neuroplasticity, and drug and alcohol dependence. These concentration differences may be ascertained by using MR spectroscopy to provide information on the concentration of different metabolites. This review briefly discusses advances in MR spectroscopy methods and explores the application of this technique to detect changes in GABA due to disease processes and medication-induced effects.

AED
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GABA
:   γ-aminobutyric acid
GABAAR
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GABABR
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GABA-T
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GAD
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J-PRESS
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SSRI
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&lt;p&gt;GABA serves as a major neurotransmitter of the brain and functions mainly to inhibit neural excitatory activity. Disruption of the GABAergic processes appears to occur in various neurologic and psychiatric conditions, including epilepsy, mood disorders, motor disorders such as focal dystonia and stiff-person syndrome, sleep disorders, neuroplasticity, and drug and alcohol dependence. These concentration differences may be ascertained by using MR spectroscopy to provide information on the concentration of different metabolites. This review briefly discusses advances in MR spectroscopy methods and explores the application of this technique to detect changes in GABA due to disease processes and medication-induced effects.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=JE. Jensen;citation_author=BD. Frederick;citation_author=L. Wang;citation_title=Two-dimensional, J-resolved spectroscopic imaging of GABA at 4 Tesla in the human brain.;citation_pages=783-788;citation_volume=54;citation_year=2005;citation_issue=4;citation_pmid=16155894;citation_doi=10.1002/mrm.20644" />
<meta name="citation_reference" content="citation_journal_title=NMR in biomedicine;citation_journal_abbrev=NMR Biomed;citation_author=JE. Jensen;citation_author=B. Frederick Bde;citation_author=PF. Renshaw;citation_title=Grey and white matter GABA level differences in the human brain using two-dimensional, J-resolved spectroscopic imaging.;citation_pages=570-576;citation_volume=18;citation_year=2005;citation_issue=8;citation_pmid=16273508;citation_doi=10.1002/nbm.994" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=JR. Keltner;citation_author=LL. Wald;citation_author=BD. Frederick;citation_title=In vivo detection of GABA in human brain using a localized double-quantum filter technique.;citation_pages=366-371;citation_volume=37;citation_year=1997;citation_issue=3;citation_pmid=9055226;citation_doi=10.1002/mrm.1910370312" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=C. Choi;citation_author=PP. Bhardwaj;citation_author=S. Kalra;citation_title=Measurement of GABA and contaminants in gray and white matter in human brain in vivo.;citation_pages=27-33;citation_volume=58;citation_year=2007;citation_issue=1;citation_pmid=17659613;citation_doi=10.1002/mrm.21275" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance (San Diego, Calif. :  1997);citation_journal_abbrev=J Magn Reson;citation_author=IY. Choi;citation_author=SP. Lee;citation_author=J. Shen;citation_title=In vivo single-shot three-dimensionally localized multiple quantum spectroscopy of GABA in the human brain with improved spectral selectivity.;citation_pages=9-16;citation_volume=172;citation_year=2005;citation_issue=1;citation_pmid=15589402;citation_doi=10.1016/j.jmr.2004.09.021" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=IY. Choi;citation_author=SP. Lee;citation_author=H. Merkle;citation_title=Single-shot two-echo technique for simultaneous measurement of GABA and creatine in the human brain in vivo.;citation_pages=1115-1121;citation_volume=51;citation_year=2004;citation_issue=6;citation_pmid=15170830;citation_doi=10.1002/mrm.20082" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance (San Diego, Calif. :  1997);citation_journal_abbrev=J Magn Reson;citation_author=J. Snyder;citation_author=CC. Hanstock;citation_author=AH. Wilman;citation_title=Spectral editing of weakly coupled spins using variable flip angles in PRESS constant echo time difference spectroscopy: application to GABA.;citation_pages=245-250;citation_volume=200;citation_year=2009;citation_issue=2;citation_pmid=19648038;citation_doi=10.1016/j.jmr.2009.07.010" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance (San Diego, Calif. :  1997);citation_journal_abbrev=J Magn Reson;citation_author=J. Shen;citation_title=Slice-selective J-coupled coherence transfer using symmetric linear phase pulses: applications to localized GABA spectroscopy.;citation_pages=73-80;citation_volume=163;citation_year=2003;citation_issue=1;citation_pmid=12852909;citation_doi=10.1016/S1090-7807(03)00112-5" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance imaging;citation_journal_abbrev=Magn Reson Imaging;citation_author=KW. Waddell;citation_author=MJ. Avison;citation_author=JM. Joers;citation_title=A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil.;citation_pages=1032-1038;citation_volume=25;citation_year=2007;citation_issue=7;citation_pmid=17707165;citation_doi=10.1016/j.mri.2006.11.026" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance (San Diego, Calif. :  1997);citation_journal_abbrev=J Magn Reson;citation_author=ME. Henry;citation_author=TL. Lauriat;citation_author=M. Shanahan;citation_title=Accuracy and stability of measuring GABA, glutamate, and glutamine by proton magnetic resonance spectroscopy: a phantom study at 4 Tesla.;citation_pages=210-218;citation_volume=208;citation_year=2011;citation_issue=2;citation_pmid=21130670;citation_doi=10.1016/j.jmr.2010.11.003" />
<meta name="citation_reference" content="citation_journal_title=Psychiatry research;citation_journal_abbrev=Psychiatry Res;citation_author=Y. Ke;citation_author=BM. Cohen;citation_author=JY. Bang;citation_title=Assessment of GABA concentration in human brain using two-dimensional proton magnetic resonance spectroscopy.;citation_pages=169-178;citation_volume=100;citation_year=2000;citation_issue=3;citation_pmid=11120443;citation_doi=10.1016/S0925-4927(00)00075-5" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance. Series B;citation_journal_abbrev=J Magn Reson B;citation_author=LN. Ryner;citation_author=JA. Sorenson;citation_author=MA. Thomas;citation_title=3D localized 2D NMR spectroscopy on an MRI scanner.;citation_pages=126-137;citation_volume=107;citation_year=1995;citation_issue=2;citation_pmid=7599948;citation_doi=10.1006/jmrb.1995.1068" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance imaging;citation_journal_abbrev=Magn Reson Imaging;citation_author=LN. Ryner;citation_author=JA. Sorenson;citation_author=MA. Thomas;citation_title=Localized 2D J-resolved 1H MR spectroscopy: strong coupling effects in vitro and in vivo.;citation_pages=853-869;citation_volume=13;citation_year=1995;citation_issue=6;citation_pmid=8544657;citation_doi=10.1016/0730-725X(95)00031-B" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=RA. Edden;citation_author=PB. Barker;citation_title=Spatial effects in the detection of gamma-aminobutyric acid: improved sensitivity at high fields using inner volume saturation.;citation_pages=1276-1282;citation_volume=58;citation_year=2007;citation_issue=6;citation_pmid=17969062;citation_doi=10.1002/mrm.21383" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=RA. Edden;citation_author=PB. Barker;citation_title=If J doesn't evolve, it won't J-resolve: J-PRESS with bandwidth-limited refocusing pulses.;citation_pages=1509-1514;citation_volume=65;citation_year=2011;citation_issue=6;citation_pmid=21590799;citation_doi=10.1002/mrm.22747" />
<meta name="citation_reference" content="citation_journal_abbrev=NeuroImage;citation_author=MJ. Donahue;citation_author=J. Near;citation_author=JU. Blicher;citation_title=Baseline GABA concentration and fMRI response.;citation_pages=392-398;citation_volume=53;citation_year=2010;citation_issue=2;citation_pmid=20633664;citation_doi=10.1016/j.neuroimage.2010.07.017" />
<meta name="citation_reference" content="citation_journal_title=Nature neuroscience;citation_journal_abbrev=Nat Neurosci;citation_author=G. Northoff;citation_author=M. Walter;citation_author=RF. Schulte;citation_title=GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI.;citation_pages=1515-1517;citation_volume=10;citation_year=2007;citation_issue=12;citation_pmid=17982452;citation_doi=10.1038/nn2001" />
<meta name="citation_reference" content="citation_journal_title=Proc Natl Acad Sci U S A;citation_author=SD. Muthukumaraswamy;citation_author=RA. Edden;citation_author=DK. Jones;citation_title=Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans;citation_volume=106;citation_year=2009;citation_pmid=19416820;citation_doi=10.1073/pnas.0900728106" />
<meta name="citation_reference" content="citation_journal_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_author=LM. Levy;citation_author=U. Ziemann;citation_author=R. Chen;citation_title=Rapid modulation of GABA in sensorimotor cortex induced by acute deafferentation.;citation_pages=755-761;citation_volume=52;citation_year=2002;citation_issue=6;citation_pmid=12447929;citation_doi=10.1002/ana.10372" />
<meta name="citation_reference" content="citation_journal_title=Folia psychiatrica et neurologica japonica;citation_journal_abbrev=Folia Psychiatr Neurol Jpn;citation_author=M. Yamamoto;citation_author=S. Takahashi;citation_author=S. Otsuki;citation_title=GABA levels in cerebrospinal fluid of patients with epilepsy.;citation_pages=515-519;citation_volume=39;citation_year=1985;citation_issue=4;citation_pmid=3938765" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=K. McKnight;citation_author=Y. Jiang;citation_author=Y. Hart;citation_title=Serum antibodies in epilepsy and seizure-associated disorders;citation_pages=1730-1736;citation_volume=65;citation_year=2005;citation_issue=11;citation_issn=0028-3878;citation_pmid=16344514;citation_doi=10.1212/01.wnl.0000187129.66353.13" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=J. Peltola;citation_author=P. Kulmala;citation_author=J. Isojarvi;citation_title=Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy;citation_pages=46-50;citation_volume=55;citation_year=2000;citation_issue=1;citation_issn=0028-3878;citation_pmid=10891904;citation_doi=10.1159/000023513" />
<meta name="citation_reference" content="citation_journal_abbrev=Epilepsia;citation_author=CJ. Stagg;citation_author=B. Lang;citation_author=JG. Best;citation_title=Autoantibodies to glutamic acid decarboxylase in patients with epilepsy are associated with low cortical GABA levels.;citation_pages=1898-1901;citation_volume=51;citation_year=2010;citation_issue=9;citation_pmid=20550553;citation_doi=10.1111/j.1528-1167.2010.02644.x" />
<meta name="citation_reference" content="citation_journal_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_author=OA. Petroff;citation_author=DL. Rothman;citation_author=KL. Behar;citation_title=Low brain GABA level is associated with poor seizure control.;citation_pages=908-911;citation_volume=40;citation_year=1996;citation_issue=6;citation_pmid=9007096;citation_doi=10.1002/ana.410400613" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=OA. Petroff;citation_author=F. Hyder;citation_author=DL. Rothman;citation_title=Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures;citation_pages=709-715;citation_volume=56;citation_year=2001;citation_issue=6;citation_issn=0028-3878;citation_pmid=11274303" />
<meta name="citation_reference" content="citation_journal_title=Advances in neurology;citation_journal_abbrev=Adv Neurol;citation_author=OA. Petroff;citation_author=KL. Behar;citation_author=DL. Rothman;citation_title=New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures.;citation_pages=939-945;citation_volume=79;citation_year=1999;citation_pmid=10514877" />
<meta name="citation_reference" content="citation_journal_title=Epilepsy research;citation_journal_abbrev=Epilepsy Res;citation_author=RJ. Simister;citation_author=MA. McLean;citation_author=GJ. Barker;citation_title=Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection.;citation_pages=168-176;citation_volume=83;citation_year=2009;citation_issue=2-3;citation_pmid=19118980;citation_doi=10.1016/j.eplepsyres.2008.11.006" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=RJ. Simister;citation_author=MA. McLean;citation_author=GJ. Barker;citation_title=Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy;citation_pages=897-902;citation_volume=61;citation_year=2003;citation_issue=7;citation_issn=0028-3878;citation_pmid=14557556" />
<meta name="citation_reference" content="citation_journal_title=Epilepsy research;citation_journal_abbrev=Epilepsy Res;citation_author=RJ. Simister;citation_author=MA. McLean;citation_author=GJ. Barker;citation_title=Proton magnetic resonance spectroscopy of malformations of cortical development causing epilepsy.;citation_pages=107-115;citation_volume=74;citation_year=2007;citation_issue=2-3;citation_pmid=17379481;citation_doi=10.1016/j.eplepsyres.2007.02.002" />
<meta name="citation_reference" content="citation_journal_abbrev=NeuroImage;citation_author=MM. Taki;citation_author=M. Harada;citation_author=K. Mori;citation_title=High gamma-aminobutyric acid level in cortical tubers in epileptic infants with tuberous sclerosis complex measured with the MEGA-editing J-difference method and a three-Tesla clinical MRI Instrument.;citation_pages=1207-1214;citation_volume=47;citation_year=2009;citation_issue=4;citation_pmid=19481612;citation_doi=10.1016/j.neuroimage.2009.05.060" />
<meta name="citation_reference" content="citation_journal_title=Epilepsy research;citation_journal_abbrev=Epilepsy Res;citation_author=J. Aasly;citation_author=H. Silfvenius;citation_author=TC. Aas;citation_title=Proton magnetic resonance spectroscopy of brain biopsies from patients with intractable epilepsy.;citation_pages=211-217;citation_volume=35;citation_year=1999;citation_issue=3;citation_pmid=10413316;citation_doi=10.1016/S0920-1211(99)00011-X" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance imaging;citation_journal_abbrev=Magn Reson Imaging;citation_author=OA. Petroff;citation_author=LA. Pleban;citation_author=DD. Spencer;citation_title=Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain.;citation_pages=1197-1211;citation_volume=13;citation_year=1995;citation_issue=8;citation_pmid=8750337;citation_doi=10.1016/0730-725X(95)02033-P" />
<meta name="citation_reference" content="citation_journal_title=Epilepsia;citation_author=OA. Petroff;citation_author=DL. Rothman;citation_author=KL. Behar;citation_title=Initial observations on effect of vigabatrin on in vivo 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate, and glutamine in human brain;citation_pages=457-64;citation_volume=36;citation_year=1995;citation_pmid=7614922;citation_doi=10.1111/j.1528-1157.1995.tb00486.x" />
<meta name="citation_reference" content="citation_journal_title=Archives of Neurology;citation_journal_abbrev=Arch Neurol;citation_author=LM. Levy;citation_author=I. Levy-Reis;citation_author=M. Fujii;citation_title=Brain {gamma}-Aminobutyric Acid Changes in Stiff-Person Syndrome;citation_pages=970-974;citation_volume=62;citation_year=2005;citation_issue=6;citation_issn=0003-9942;citation_pmid=15956168;citation_doi=10.1001/archneur.62.6.970" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=MC. Dalakas;citation_author=M. Fujii;citation_author=M. Li;citation_title=The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome;citation_pages=1531-1535;citation_volume=55;citation_year=2000;citation_issue=10;citation_issn=0028-3878;citation_pmid=11094109;citation_doi=10.1212/WNL.55.10.1531" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=MC. Dalakas;citation_author=M. Li;citation_author=M. Fujii;citation_title=Stiff person syndrome: Quantification, specificity, and intrathecal synthesis of GAD65 antibodies;citation_pages=780-784;citation_volume=57;citation_year=2001;citation_issue=5;citation_issn=0028-3878;citation_pmid=11552003;citation_doi=10.1212/WNL.57.5.780" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=BB. Murinson;citation_author=M. Butler;citation_author=K. Marfurt;citation_title=Markedly elevated GAD antibodies in SPS: Effects of age and illness duration;citation_pages=2146-2148;citation_volume=63;citation_year=2004;citation_issue=11;citation_issn=0028-3878;citation_pmid=15596766;citation_doi=10.1212/01.WNL.0000145661.01675.A8" />
<meta name="citation_reference" content="citation_journal_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_author=LM. Levy;citation_author=M. Hallett;citation_title=Impaired brain GABA in focal dystonia.;citation_pages=93-101;citation_volume=51;citation_year=2002;citation_issue=1;citation_pmid=11782988;citation_doi=10.1002/ana.10073" />
<meta name="citation_reference" content="citation_journal_title=Trends in neurosciences;citation_journal_abbrev=Trends Neurosci;citation_author=A. Quartarone;citation_author=HR. Siebner;citation_author=JC. Rothwell;citation_title=Task-specific hand dystonia: can too much plasticity be bad for you?;citation_pages=192-199;citation_volume=29;citation_year=2006;citation_issue=4;citation_pmid=16519953;citation_doi=10.1016/j.tins.2006.02.007" />
<meta name="citation_reference" content="citation_journal_title=Psychological medicine;citation_journal_abbrev=Psychol Med;citation_author=M. Taylor;citation_author=Z. Bhagwagar;citation_author=PJ. Cowen;citation_title=GABA and mood disorders.;citation_pages=387-393;citation_volume=33;citation_year=2003;citation_issue=3;citation_pmid=12701660;citation_doi=10.1017/S0033291702006876" />
<meta name="citation_reference" content="citation_journal_title=Archives of General Psychiatry;citation_journal_abbrev=Arch Gen Psychiatry;citation_author=G. Hasler;citation_author=JW. van der Veen;citation_author=T. Tumonis;citation_title=Reduced Prefrontal Glutamate/Glutamine and {gamma}-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy;citation_pages=193-200;citation_volume=64;citation_year=2007;citation_issue=2;citation_issn=0003-990X;citation_pmid=17283286;citation_doi=10.1001/archpsyc.64.2.193" />
<meta name="citation_reference" content="citation_journal_title=Archives of General Psychiatry;citation_journal_abbrev=Arch Gen Psychiatry;citation_author=G. Sanacora;citation_author=GF. Mason;citation_author=DL. Rothman;citation_title=Reduced Cortical {gamma}-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy;citation_pages=1043-1047;citation_volume=56;citation_year=1999;citation_issue=11;citation_issn=0003-990X;citation_pmid=10565505;citation_doi=10.1001/archpsyc.56.11.1043" />
<meta name="citation_reference" content="citation_journal_title=Int J Neuropsychopharmacol;citation_author=Z. Bhagwagar;citation_author=M. Wylezinska;citation_author=P. Jezzard;citation_title=Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients;citation_volume=11;citation_year=2008;citation_pmid=17625025;citation_doi=10.1017/S1461145707007924" />
<meta name="citation_reference" content="citation_journal_title=Biological psychiatry;citation_journal_abbrev=Biol Psychiatry;citation_author=D. Cotter;citation_author=S. Landau;citation_author=C. Beasley;citation_title=The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia.;citation_pages=377-386;citation_volume=51;citation_year=2002;citation_issue=5;citation_pmid=11904132;citation_doi=10.1016/S0006-3223(01)01243-4" />
<meta name="citation_reference" content="citation_journal_title=Biological psychiatry;citation_journal_abbrev=Biol Psychiatry;citation_author=WH. Berrettini;citation_author=JI. Nurnberger;citation_author=TA. Hare;citation_title=Reduced plasma and CSF gamma-aminobutyric acid in affective illness: effect of lithium carbonate.;citation_pages=185-194;citation_volume=18;citation_year=1983;citation_issue=2;citation_pmid=6403063" />
<meta name="citation_reference" content="citation_journal_title=Archives of General Psychiatry;citation_journal_abbrev=Arch Gen Psychiatry;citation_author=AW. Goddard;citation_author=GF. Mason;citation_author=A. Almai;citation_title=Reductions in Occipital Cortex GABA Levels in Panic Disorder Detected With 1H-Magnetic Resonance Spectroscopy;citation_pages=556-561;citation_volume=58;citation_year=2001;citation_issue=6;citation_issn=0003-990X;citation_pmid=11386984;citation_doi=10.1001/archpsyc.58.6.556" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Psychiatry;citation_journal_abbrev=Am. J. Psychiatry;citation_author=AW. Goddard;citation_author=GF. Mason;citation_author=M. Appel;citation_title=Impaired GABA Neuronal Response to Acute Benzodiazepine Administration in Panic Disorder;citation_pages=2186-2193;citation_volume=161;citation_year=2004;citation_issue=12;citation_issn=0002-953X;citation_pmid=15569888;citation_doi=10.1176/appi.ajp.161.12.2186" />
<meta name="citation_reference" content="citation_journal_title=Progress in neuro-psychopharmacology &amp; biological psychiatry;citation_journal_abbrev=Prog Neuropsychopharmacol Biol Psychiatry;citation_author=MH. Pollack;citation_author=JE. Jensen;citation_author=NM. Simon;citation_title=High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam.;citation_pages=739-743;citation_volume=32;citation_year=2008;citation_issue=3;citation_pmid=18206286;citation_doi=10.1016/j.pnpbp.2007.11.023" />
<meta name="citation_reference" content="citation_journal_title=Am J Psychiatry;citation_author=G. Hasler;citation_author=JW. van der Veen;citation_author=C. Grillon;citation_title=Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy;citation_volume=167;citation_year=2010;citation_pmid=20634372;citation_doi=10.1176/appi.ajp.2010.09070994" />
<meta name="citation_reference" content="citation_journal_title=Am J Psychiatry;citation_author=T. Hashimoto;citation_author=HH. Bazmi;citation_author=K. Mirnics;citation_title=Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia;citation_volume=165;citation_year=2008;citation_pmid=18281411;citation_doi=10.1176/appi.ajp.2007.07081223" />
<meta name="citation_reference" content="citation_journal_title=Journal of Neuroscience;citation_journal_abbrev=J. Neurosci.;citation_author=JH. Yoon;citation_author=RJ. Maddock;citation_author=A. Rokem;citation_title=GABA Concentration Is Reduced in Visual Cortex in Schizophrenia and Correlates with Orientation-Specific Surround Suppression;citation_pages=3777-3781;citation_volume=30;citation_year=2010;citation_issue=10;citation_issn=0270-6474;citation_pmid=20220012;citation_doi=10.1523/JNEUROSCI.6158-09.2010" />
<meta name="citation_reference" content="citation_journal_title=Schizophrenia research;citation_journal_abbrev=Schizophr Res;citation_author=S. Tayoshi;citation_author=M. Nakataki;citation_author=S. Sumitani;citation_title=GABA concentration in schizophrenia patients and the effects of antipsychotic medication: a proton magnetic resonance spectroscopy study.;citation_pages=83-91;citation_volume=117;citation_year=2010;citation_issue=1;citation_pmid=20022731;citation_doi=10.1016/j.schres.2009.11.011" />
<meta name="citation_reference" content="citation_journal_title=Archives of General Psychiatry;citation_journal_abbrev=Arch Gen Psychiatry;citation_author=JH. Krystal;citation_author=J. Staley;citation_author=G. Mason;citation_title={gamma}-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment.;citation_pages=957-968;citation_volume=63;citation_year=2006;citation_issue=9;citation_issn=0003-990X;citation_pmid=16952998;citation_doi=10.1001/archpsyc.63.9.957" />
<meta name="citation_reference" content="citation_journal_title=Alcohol and Alcoholism;citation_journal_abbrev=Alcohol Alcohol;citation_author=G. Addolorato;citation_author=F. Caputo;citation_author=E. Capristo;citation_title=BACLOFEN EFFICACY IN REDUCING ALCOHOL CRAVING AND INTAKE: A PRELIMINARY DOUBLE-BLIND RANDOMIZED CONTROLLED STUDY;citation_pages=504-508;citation_volume=37;citation_year=2002;citation_issue=5;citation_issn=0735-0414;citation_pmid=12217947;citation_doi=10.1093/alcalc/37.5.504" />
<meta name="citation_reference" content="citation_journal_title=Annals of medicine;citation_journal_abbrev=Ann Med;citation_author=MK. Ticku;citation_title=Alcohol and GABA-benzodiazepine receptor function.;citation_pages=241-246;citation_volume=22;citation_year=1990;citation_issue=4;citation_pmid=1701092" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Psychiatry;citation_journal_abbrev=Am. J. Psychiatry;citation_author=KL. Behar;citation_author=DL. Rothman;citation_author=KF. Petersen;citation_title=Preliminary Evidence of Low Cortical GABA Levels in Localized 1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients;citation_pages=952-954;citation_volume=156;citation_year=1999;citation_issue=6;citation_issn=0002-953X;citation_pmid=10360140" />
<meta name="citation_reference" content="citation_journal_title=Biological psychiatry;citation_journal_abbrev=Biol Psychiatry;citation_author=GF. Mason;citation_author=IL. Petrakis;citation_author=RA. de Graaf;citation_title=Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking.;citation_pages=85-93;citation_volume=59;citation_year=2006;citation_issue=1;citation_pmid=16289397;citation_doi=10.1016/j.biopsych.2005.06.009" />
<meta name="citation_reference" content="citation_journal_title=Alcohol Clin Exp Res;citation_title=Brain GABA falls by 1 month of detoxification and remains low;citation_author=G. Mason;citation_author=M. Appel;citation_author=R. de Graaf;citation_pages=56A;citation_year=2003;citation_issue=27" />
<meta name="citation_reference" content="citation_journal_title=Psychiatry research;citation_journal_abbrev=Psychiatry Res;citation_author=Y. Ke;citation_author=CC. Streeter;citation_author=LE. Nassar;citation_title=Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study.;citation_pages=283-293;citation_volume=130;citation_year=2004;citation_issue=3;citation_pmid=15135161;citation_doi=10.1016/j.psychres.2004.05.002" />
<meta name="citation_reference" content="citation_title=A J-resolved, two dimensional MRS study of brain GABA and NAA levels in cocaine dependent subjects-before and after treatment;citation_author=Y. Ke;citation_author=CC. Streeter;citation_author=DA. Yurgelun-Todd" />
<meta name="citation_reference" content="citation_journal_title=Sleep;citation_author=JW. Winkelman;citation_author=OM. Buxton;citation_author=JE. Jensen;citation_title=Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS);citation_pages=1499-506;citation_volume=31;citation_year=2008;citation_pmid=19014069" />
<meta name="citation_reference" content="citation_journal_title=Psychiatry research;citation_journal_abbrev=Psychiatry Res;citation_author=S. Kakeda;citation_author=Y. Korogi;citation_author=J. Moriya;citation_title=Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA): evaluation with proton magnetic resonance spectroscopy at 3T.;citation_pages=55-59;citation_volume=192;citation_year=2011;citation_issue=1;citation_pmid=21377845;citation_doi=10.1016/j.pscychresns.2010.10.011" />
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<meta name="citation_reference" content="citation_journal_title=Journal of autism and developmental disorders;citation_journal_abbrev=J Autism Dev Disord;citation_author=SH. Fatemi;citation_author=TJ. Reutiman;citation_author=TD. Folsom;citation_title=GABA(A) receptor downregulation in brains of subjects with autism.;citation_pages=223-230;citation_volume=39;citation_year=2009;citation_issue=2;citation_pmid=18821008;citation_doi=10.1007/s10803-008-0646-7" />
<meta name="citation_reference" content="citation_journal_title=Journal of autism and developmental disorders;citation_journal_abbrev=J Autism Dev Disord;citation_author=M. Harada;citation_author=MM. Taki;citation_author=A. Nose;citation_title=Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument.;citation_pages=447-454;citation_volume=41;citation_year=2011;citation_issue=4;citation_pmid=20652388;citation_doi=10.1007/s10803-010-1065-0" />
<meta name="citation_reference" content="citation_journal_title=Journal of computer assisted tomography;citation_journal_abbrev=J Comput Assist Tomogr;citation_author=RI. Henkin;citation_author=LM. Levy;citation_author=CS. Lin;citation_title=Taste and smell phantoms revealed by brain functional MRI (fMRI).;citation_pages=106-123;citation_volume=24;citation_year=2000;citation_issue=1;citation_pmid=10667670;citation_doi=10.1097/00004728-200001000-00022" />
<meta name="citation_reference" content="citation_journal_title=Journal of computer assisted tomography;citation_journal_abbrev=J Comput Assist Tomogr;citation_author=LM. Levy;citation_author=RI. Henkin;citation_title=Brain gamma-aminobutyric acid levels are decreased in patients with phantageusia and phantosmia demonstrated by magnetic resonance spectroscopy.;citation_pages=721-727;citation_volume=28;citation_year=2004;citation_issue=6;citation_pmid=15538143;citation_doi=10.1097/00004728-200411000-00001" />
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<meta name="citation_reference" content="citation_journal_title=Acta neurologica Scandinavica.  Supplementum;citation_journal_abbrev=Acta Neurol Scand Suppl;citation_author=RH. Mattson;citation_author=OA. Petroff;citation_author=D. Rothman;citation_title=Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy.;citation_pages=27-30;citation_volume=162;citation_year=1995;citation_pmid=7495186" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=OA. Petroff;citation_author=DL. Rothman;citation_author=KL. Behar;citation_title=Human brain GABA levels rise rapidly after initiation of vigabatrin therapy;citation_pages=1567-1571;citation_volume=47;citation_year=1996;citation_issue=6;citation_issn=0028-3878;citation_pmid=8960747" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance imaging;citation_journal_abbrev=Magn Reson Imaging;citation_author=OM. Weber;citation_author=A. Verhagen;citation_author=CO. Duc;citation_title=Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission tomography.;citation_pages=417-425;citation_volume=17;citation_year=1999;citation_issue=3;citation_pmid=10195585;citation_doi=10.1016/S0730-725X(98)00184-2" />
<meta name="citation_reference" content="citation_journal_title=Epilepsia;citation_author=NP. Verhoeff;citation_author=OA. Petroff;citation_author=F. Hyder;citation_title=Effects of vigabatrin on the GABAergic system as determined by [123I]iomazenil SPECT and GABA MRS;citation_pages=1433-38;citation_volume=40;citation_year=1999;citation_pmid=10528940;citation_doi=10.1111/j.1528-1157.1999.tb02016.x" />
<meta name="citation_reference" content="citation_journal_title=Molecular neurobiology;citation_journal_abbrev=Mol Neurobiol;citation_author=OA. Petroff;citation_author=DL. Rothman;citation_title=Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin.;citation_pages=97-121;citation_volume=16;citation_year=1998;citation_issue=1;citation_pmid=9554704" />
<meta name="citation_reference" content="citation_journal_title=Epilepsia;citation_author=SG. Mueller;citation_author=OM. Weber;citation_author=CO. Duc;citation_title=Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics;citation_pages=29-40;citation_volume=42;citation_year=2001" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=R. Kuzniecky;citation_author=H. Hetherington;citation_author=S. Ho;citation_title=Topiramate increases cerebral GABA in healthy humans;citation_pages=627-629;citation_volume=51;citation_year=1998;citation_issue=2;citation_issn=0028-3878;citation_pmid=9710056" />
<meta name="citation_reference" content="citation_journal_title=Psychopharmacologia;citation_journal_abbrev=Psychopharmacologia;citation_author=CM. Moore;citation_author=M. Wardrop;citation_author=B. deB Frederick;citation_title=Topiramate raises anterior cingulate cortex glutamine levels in healthy men; a 4.0 T magnetic resonance spectroscopy study.;citation_pages=236-243;citation_volume=188;citation_year=2006;citation_issue=2;citation_pmid=16944105;citation_doi=10.1007/s00213-006-0451-y" />
<meta name="citation_reference" content="citation_journal_title=Epilepsia;citation_author=OA. Petroff;citation_author=F. Hyder;citation_author=DL. Rothman;citation_title=Topiramate rapidly raises brain GABA in epilepsy patients;citation_pages=543-48;citation_volume=42;citation_year=2001;citation_pmid=11440351;citation_doi=10.1046/j.1528-1157.2001.18800.x" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=OA. Petroff;citation_author=F. Hyder;citation_author=RH. Mattson;citation_title=Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy;citation_pages=473-473;citation_volume=52;citation_year=1999;citation_issue=3;citation_issn=0028-3878;citation_pmid=10025774;citation_doi=10.1212/WNL.52.3.473" />
<meta name="citation_reference" content="citation_journal_title=Progress in neuro-psychopharmacology &amp; biological psychiatry;citation_journal_abbrev=Prog Neuropsychopharmacol Biol Psychiatry;citation_author=IS. Shiah;citation_author=LN. Yatham;citation_author=YC. Gau;citation_title=Effect of lamotrigine on plasma GABA levels in healthy humans.;citation_pages=419-423;citation_volume=27;citation_year=2003;citation_issue=3;citation_pmid=12691776;citation_doi=10.1016/S0278-5846(03)00028-9" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=R. Kuzniecky;citation_author=S. Ho;citation_author=J. Pan;citation_title=Modulation of cerebral GABA by topiramate, lamotrigine, and gabapentin in healthy adults;citation_pages=368-372;citation_volume=58;citation_year=2002;citation_issue=3;citation_issn=0028-3878;citation_pmid=11839834;citation_doi=10.1212/WNL.58.3.368" />
<meta name="citation_reference" content="citation_journal_title=Epilepsia;citation_author=OA. Petroff;citation_author=F. Hyder;citation_author=DL. Rothman;citation_title=Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients;citation_pages=675-80;citation_volume=41;citation_year=2000;citation_pmid=10840398;citation_doi=10.1111/j.1528-1157.2000.tb00227.x" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Psychiatry;citation_journal_abbrev=Am. J. Psychiatry;citation_author=G. Sanacora;citation_author=GF. Mason;citation_author=DL. Rothman;citation_title=Increased Occipital Cortex GABA Concentrations in Depressed Patients After Therapy With Selective Serotonin Reuptake Inhibitors;citation_pages=663-665;citation_volume=159;citation_year=2002;citation_issue=4;citation_issn=0002-953X;citation_pmid=11925309;citation_doi=10.1176/appi.ajp.159.4.663" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Psychiatry;citation_journal_abbrev=Am. J. Psychiatry;citation_author=Z. Bhagwagar;citation_author=M. Wylezinska;citation_author=M. Taylor;citation_title=Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor;citation_pages=368-370;citation_volume=161;citation_year=2004;citation_issue=2;citation_issn=0002-953X;citation_pmid=14754790;citation_doi=10.1176/appi.ajp.161.2.368" />
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<meta name="citation_reference" content="citation_journal_title=Archives of General Psychiatry;citation_journal_abbrev=Arch Gen Psychiatry;citation_author=G. Sanacora;citation_author=R. Gueorguieva;citation_author=CN. Epperson;citation_title=Subtype-Specific Alterations of {gamma}-Aminobutyric Acid and Glutamate in Patients With Major Depression;citation_pages=705-713;citation_volume=61;citation_year=2004;citation_issue=7;citation_issn=0003-990X;citation_pmid=15237082;citation_doi=10.1001/archpsyc.61.7.705" />
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<meta name="citation_reference" content="citation_journal_title=Topics in magnetic resonance imaging :  TMRI;citation_journal_abbrev=Top Magn Reson Imaging;citation_author=SR. Dager;citation_author=NM. Corrigan;citation_author=TL. Richards;citation_title=Research applications of magnetic resonance spectroscopy to investigate psychiatric disorders.;citation_pages=81-96;citation_volume=19;citation_year=2008;citation_issue=2;citation_pmid=19363431;citation_doi=10.1097/RMR.0b013e318181e0be" />
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<meta name="twitter:title" content="GABA-Based Evaluation of Neurologic Conditions: MR Spectroscopy" />
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<meta name="twitter:description" content="SUMMARY: GABA serves as a major neurotransmitter of the brain and functions mainly to inhibit neural excitatory activity. Disruption of the GABAergic processes appears to occur in various neurologic and psychiatric conditions, including epilepsy, mood disorders, motor disorders such as focal dystonia and stiff-person syndrome, sleep disorders, neuroplasticity, and drug and alcohol dependence. These concentration differences may be ascertained by using MR spectroscopy to provide information on the concentration of different metabolites. This review briefly discusses advances in MR spectroscopy methods and explores the application of this technique to detect changes in GABA due to disease processes and medication-induced effects.

AED
:   antiepileptic drug
GABA
:   γ-aminobutyric acid
GABAAR
:   γ-amino butyric acid A receptor
GABABR
:   γ-amino butyric acid B receptor
GABA-T
:   GABA transaminase
GAD
:   glutamic acid decarboxylase
J-PRESS
:   a combined 2D point-resolved spectroscopy sequence
SSRI
:   selective serotonin reuptake inhibitor" />
<meta name="og-title" property="og:title" content="GABA-Based Evaluation of Neurologic Conditions: MR Spectroscopy" />
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<meta name="og-description" property="og:description" content="SUMMARY: GABA serves as a major neurotransmitter of the brain and functions mainly to inhibit neural excitatory activity. Disruption of the GABAergic processes appears to occur in various neurologic and psychiatric conditions, including epilepsy, mood disorders, motor disorders such as focal dystonia and stiff-person syndrome, sleep disorders, neuroplasticity, and drug and alcohol dependence. These concentration differences may be ascertained by using MR spectroscopy to provide information on the concentration of different metabolites. This review briefly discusses advances in MR spectroscopy methods and explores the application of this technique to detect changes in GABA due to disease processes and medication-induced effects.

AED
:   antiepileptic drug
GABA
:   γ-aminobutyric acid
GABAAR
:   γ-amino butyric acid A receptor
GABABR
:   γ-amino butyric acid B receptor
GABA-T
:   GABA transaminase
GAD
:   glutamic acid decarboxylase
J-PRESS
:   a combined 2D point-resolved spectroscopy sequence
SSRI
:   selective serotonin reuptake inhibitor" />
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      <h1 class="highwire-cite-title" id="page-title">GABA-Based Evaluation of Neurologic Conditions: MR Spectroscopy</h1>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2013,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">259-265; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2902 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12256--6871940665" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">L.M. Levy </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, George Washington University Medical Center, Washington, DC.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.M.%2BLevy%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Levy%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AL.M.%2BLevy%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A.J. Degnan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, George Washington University Medical Center, Washington, DC.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.J.%2BDegnan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Degnan%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.J.%2BDegnan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">L.M.</span> <span class="nlm-surname">Levy</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Degnan</span></span></span></div>
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">L.M.</span> <span class="nlm-surname">Levy</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Degnan</span></span></span></div>
  
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