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    The Role of Amyloid-β, tau, and Apolipoprotein E ε4 in Alzheimer Disease: How Is the Team Playing? | American Journal of Neuroradiology  
    

















    





























    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Article CommentaryBrain

  
      

  
      
The Role of Amyloid-β, tau, and Apolipoprotein E ε4 in Alzheimer Disease: How Is the Team Playing?
  
    	
M. Filippi, E. Canu and F. Agosta

  
    	
American Journal of Neuroradiology March 2013,  34 (3) 511-512; DOI: https://doi.org/10.3174/ajnr.A3295 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
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    1. Jack  CR  Jr., 
    2. Knopman  DS, 
    3. Jagust  WJ, 
    4. et al
    . Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010;9:119–28
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    1. Desikan  RS, 
    2. McEvoy  LK, 
    3. Thompson  WK, 
    4. et al
    . Amyloid-beta associated volume loss occurs only in the presence of phospho-tau. Ann Neurol 2011;70:657–61
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    1. Bendlin  BB, 
    2. Carlsson  CM, 
    3. Johnson  SC, 
    4. et al
    . CSF T-tau/Abeta(42) predicts white matter microstructure in healthy adults at risk for Alzheimer's disease. PLoS One 2012;7:e37720
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    1. Agosta  F, 
    2. Pievani  M, 
    3. Sala  S, 
    4. et al
    . White matter damage in Alzheimer disease and its relationship to gray matter atrophy. Radiology 2011;258:853–63
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    1. Canu  E, 
    2. Frisoni  GB, 
    3. Agosta  F, 
    4. et al
    . Early and late onset Alzheimer's disease patients have distinct patterns of white matter damage. Neurobiol Aging 2012;33:1023–33
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  6. 6.↵


    1. Vemuri  P, 
    2. Wiste  HJ, 
    3. Weigand  SD, 
    4. et al
    . Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease. Ann Neurol 2010;67:308–16
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  7. 7.↵


    1. Agosta  F, 
    2. Vossel  KA, 
    3. Miller  BL, 
    4. et al
    . Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia. Proc Natl Acad Sci U S A 2009;106:2018–22
    Abstract/FREE Full Text
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

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The Role of Amyloid-β, tau, and Apolipoprotein E ε4 in Alzheimer Disease: How Is the Team Playing?
  
    	
M. Filippi, E. Canu, F. Agosta

  
    	
American Journal of Neuroradiology Mar 2013, 34 (3) 511-512; DOI: 10.3174/ajnr.A3295 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
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