1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => Controlled
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)
1naresh
Array
(
    [urn:ac.highwire.org:guest:identity] => Array
        (
            [runtime-id] => urn:ac.highwire.org:guest:identity
            [type] => guest
            [service-id] => ajnr-ac.highwire.org
            [access-type] => OpenAccess
            [privilege] => Array
                (
                    [urn:ac.highwire.org:guest:privilege] => Array
                        (
                            [runtime-id] => urn:ac.highwire.org:guest:privilege
                            [type] => privilege-set
                            [privilege-set] => GUEST
                        )

                )

            [credentials] => Array
                (
                    [method] => guest
                )

        )

)


  
    






























































































































    Central Nervous System Involvement in Adults with Epidemic Hemolytic Uremic Syndrome | American Journal of Neuroradiology  
    



















    































    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



    

  


  


  


  
  
  
  
  
  

  	      



          


    
      

    
  
    
        
    

  

    
                        

  

                
    

      

	  

		
		

			

			  

  
      
  
  

    

  
  
      
Research ArticleBrain

  
      
Open Access

  
      
Central Nervous System Involvement in Adults with Epidemic Hemolytic Uremic Syndrome
  
    	
M. Wengenroth, J. Hoeltje, J. Repenthin, T.N. Meyer, F. Bonk, H. Becker, S. Faiss, O. Stammel, P.P. Urban and R. Bruening

  
    	
American Journal of Neuroradiology May 2013,  34 (5) 1016-1021; DOI: https://doi.org/10.3174/ajnr.A3336 

  
  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    
References
  1. 1.↵


    1. Griffin  PM, 
    2. Ostroff  SM, 
    3. Tauxe  RV, 
    4. et al
    . Illnesses associated with Escherichia coli O157:H7 infections: a broad clinical spectrum. Ann Intern Med 1988;109:705–12
    CrossRefPubMedWeb of Science
  2. 2.↵


    1. Toldo  I, 
    2. Manara  R, 
    3. Cogo  P, 
    4. et al
    . Diffusion-weighted imaging findings in hemolytic uremic syndrome with central nervous system involvement. J Child Neurol 2009;24:247–50
    Abstract/FREE Full Text
  3. 3.↵


    1. Sherwood  JW, 
    2. Wagle  WA
    . Hemolytic uremic syndrome: MR findings of CNS complications. AJNR Am J Neuroradiol 1991;12:703–04
    FREE Full Text
  4. 4.↵


    1. Jeong  YK, 
    2. Kim  IO, 
    3. Kim  WS, 
    4. et al
    . Hemolytic uremic syndrome: MR findings of CNS complications. Pediatr Radiol 1994;24:585–86
    CrossRefPubMed
  5. 5.↵


    1. Ogura  H, 
    2. Takaoka  M, 
    3. Kishi  M, 
    4. et al
    . Reversible MR findings of hemolytic uremic syndrome with mild encephalopathy. AJNR Am J Neuroradiol 1998;19:1144–45
    Abstract
  6. 6.↵


    1. Hager  A, 
    2. Staudt  M, 
    3. Klare  B, 
    4. et al
    . Hemolytic-uremic syndrome with involvement of basal ganglia and cerebellum. Neuropediatrics 1999;30:210–13
    CrossRefPubMed
  7. 7.↵


    1. Yasuhara  A, 
    2. Araki  A, 
    3. Ochi  A, 
    4. et al
    . Magnetic resonance imaging of brain lesions of a patient with hemolytic uremic syndrome following Escherichia coli O157 infection. Pediatr Int 2000;42:302–05
    CrossRefPubMed
  8. 8.↵


    1. Signorini  E, 
    2. Lucchi  S, 
    3. Mastrangelo  M, 
    4. et al
    . Central nervous system involvement in a child with hemolytic uremic syndrome. Pediatr Nephrol 2000;14:990–92
    CrossRefPubMedWeb of Science
  9. 9.↵


    1. Schmidt  S, 
    2. Gudinchet  F, 
    3. Meagher-Villemure  K, 
    4. et al
    . Brain involvement in haemolytic-uraemic syndrome: MRI features of coagulative necrosis. Neuroradiology 2001;43:581–85
    CrossRefPubMedWeb of Science
  10. 10.↵


    1. Bennett  B, 
    2. Booth  T, 
    3. Quan  A
    . Late onset seizures, hemiparesis and blindness in hemolytic uremic syndrome. Clin Nephrol 2003;59:196–200
    PubMed
  11. 11.↵


    1. Vergouwen  MD, 
    2. Adriani  KS, 
    3. Roos  YB, 
    4. et al
    . Proximal cerebral artery stenosis in a patient with hemolytic uremic syndrome. AJNR Am J Neuroradiol 2008;29:e34
    FREE Full Text
  12. 12.↵


    1. Koehl  B, 
    2. Boyer  O, 
    3. Biebuyck-Gouge  N, 
    4. et al
    . Neurological involvement in a child with atypical hemolytic uremic syndrome. Pediatr Nephrol 2010;25:2539–42
    CrossRefPubMed
  13. 13.↵


    1. Theobald  I, 
    2. Kuwertz-Broking  E, 
    3. Schiborr  M, 
    4. et al
    . Central nervous system involvement in hemolytic uremic syndrome (HUS): a retrospective analysis of cerebral CT and MRI studies. Clin Nephrol 2001;56:S3–8
    PubMed
  14. 14.↵


    1. Steinborn  M, 
    2. Leiz  S, 
    3. Rudisser  K, 
    4. et al
    . CT and MRI in haemolytic uraemic syndrome with central nervous system involvement: distribution of lesions and prognostic value of imaging findings. Pediatr Radiol 2004;34:805–10
    PubMedWeb of Science
  15. 15.↵


    1. Nathanson  S, 
    2. Kwon  T, 
    3. Elmaleh  M, 
    4. et al
    . Acute neurological involvement in diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol 2010;5:1218–28
    Abstract/FREE Full Text
  16. 16.↵


    1. Lapeyraque  AL, 
    2. Malina  M, 
    3. Fremeaux-Bacchi  V, 
    4. et al
    . Eculizumab in severe Shiga-toxin-associated HUS. N Engl J Med 2011;364:2561–63
    CrossRefPubMedWeb of Science
  17. 17.↵


    1. Nakamura  H, 
    2. Takaba  H, 
    3. Inoue  T, 
    4. et al
    . MRI findings of hemolytic uremic syndrome with encephalopathy: widespread symmetrical distribution. J Neuroimaging 2003;13:75–78
    PubMed
  18. 18.↵


    1. Taylor  MB, 
    2. Jackson  A, 
    3. Weller  JM
    . Dynamic susceptibility contrast enhanced MRI in reversible posterior leukoencephalopathy syndrome associated with haemolytic uraemic syndrome. Br J Radiol 2000;73:438–42
    Abstract
  19. 19.↵


    1. Frank  C, 
    2. Werber  D, 
    3. Cramer  JP, 
    4. et al
    . Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med 2011;365:1771–80
    CrossRefPubMedWeb of Science
  20. 20.↵


    1. Bielaszewska  M, 
    2. Mellmann  A, 
    3. Zhang  W, 
    4. et al
    . Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study. Lancet Infect Dis 2011;11:671–76
    CrossRefPubMedWeb of Science
  21. 21.↵


    1. Buchholz  U, 
    2. Bernard  H, 
    3. Werber  D, 
    4. et al
    . German outbreak of Escherichia coli O104:H4 associated with sprouts. N Engl J Med 2011;365:1763–70
    CrossRefPubMedWeb of Science
  22. 22.↵


    1. Dücker  C, 
    2. Dautel  P, 
    3. Wagner  K, 
    4. et al
    . Clinical symptoms, treatment and outcome of EHEC and EHEC-HUS patients treated as in-patients [in German]. Dtsch Med Wochenschr 2011;136:1770–76
    CrossRefPubMed
  23. 23.↵


    1. Gultekin  SH, 
    2. Rosenfeld  MR, 
    3. Voltz  R, 
    4. et al
    . Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain 2000;123(pt 7):1481–94
    Abstract/FREE Full Text
  24. 24.↵


    1. Vincent  A, 
    2. Bien  CG, 
    3. Irani  SR, 
    4. et al
    . Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011;10:759–72
    CrossRefPubMedWeb of Science
  25. 25.↵


    1. Flanagan  EP, 
    2. Caselli  RJ
    . Autoimmune encephalopathy. Semin Neurol 2011;31:144–57
    CrossRefPubMed
  26. 26.↵


    1. Boccoli  J, 
    2. Loidl  CF, 
    3. Lopez-Costa  JJ, 
    4. et al
    . Intracerebroventricular administration of Shiga toxin type 2 altered the expression levels of neuronal nitric oxide synthase and glial fibrillary acidic protein in rat brains. Brain Res 2008;1230:320–33
    CrossRefPubMedWeb of Science
  27. 27.↵


    1. Fujii  J, 
    2. Kinoshita  Y, 
    3. Matsukawa  A, 
    4. et al
    . Successful steroid pulse therapy for brain lesion caused by Shiga toxin 2 in rabbits. Microb Pathog 2009;46:179–84
    CrossRefPubMed
  28. 28.↵


    1. Fujii  K, 
    2. Matsuo  K, 
    3. Takatani  T, 
    4. et al
    . Multiple cavitations in posterior reversible leukoencephalopathy syndrome associated with hemolytic-uremic syndrome. Brain Dev 2012;34:318–21
    CrossRefPubMed
  29. 29.↵


    1. Magnus  T, 
    2. Röther  J, 
    3. Simova  O, 
    4. et al
    . The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak. Brain 2012;135:1850–59
    Abstract/FREE Full Text
  30. 30.↵


    1. Miura  S, 
    2. Kurita  T, 
    3. Noda  K, 
    4. et al
    . Symmetrical brainstem encephalitis caused by herpes simplex virus. J Clin Neurosci 2009;16:589–90
    CrossRefPubMed
  31. 31.↵


    1. Kim  E, 
    2. Na  DG, 
    3. Kim  EY, 
    4. et al
    . MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings. AJNR Am J Neuroradiol 2007;28:1652–58
    Abstract/FREE Full Text
  


  
  



  




  


  
  



  
      
  
  

    
  


  
  



  
      
  
  

     Back to top  


  
  



			

		

		
		

			

			  

  
        
In this issue

    
  
  

    
  


  
  



  
      
  
  

    

  

    

  
      
  
  

    


Advertisement



  



  


  
  



  



  


  
  



  
      
  
  

    

	  
  

		

          

            

  
      
  
  

     Print  


  
  



  
      
  
  

     Download PDF  


  
  



  
      
  
  

    
 Email Article
  


  
  



  
      
  
  

    
 Citation Tools
  


  
  



          

        

        
        

          

            



  
      
  
  

    

  

    

  
      
  
  

    

  
  
  
  
      
Central Nervous System Involvement in Adults with Epidemic Hemolytic Uremic Syndrome
  
    	
M. Wengenroth, J. Hoeltje, J. Repenthin, T.N. Meyer, F. Bonk, H. Becker, S. Faiss, O. Stammel, P.P. Urban, R. Bruening

  
    	
 American Journal of Neuroradiology May 2013, 34 (5) 1016-1021; DOI: 10.3174/ajnr.A3336 

  
  
  



  


  
  



  
      
  
  

    

  
    
  
  
    
  
  
    
  


  


  
  



  
      
  
  

    
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  


  
  



  



  


  
  



  
      
  
  

    
  


  
  



          

        

	
 	
	
	


  


  
  



  
      
  
  

    
              Purchase  


  
  



  
        
Jump to section

    
  
  

    
  


  
  



  
      
  
  

    
  


  
  



			

		

	
	
 	
	
	


    

  



  

                
    

      

  

    

  
      
  
  

    


Advertisement