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<meta name="DC.Title" content="Comparison of CTA- and DSA-Based Collateral Flow Assessment in Patients with Anterior Circulation Stroke" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4878" />
<meta name="DC.Date" content="2016-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2016 by American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Collateral flow is associated with clinical outcome after acute ischemic stroke and may serve as a parameter for patient selection for intra-arterial therapy. In clinical trials, DSA and CTA are 2 imaging modalities commonly used to assess collateral flow. We aimed to determine the agreement between collateral flow assessment on CTA and DSA and their respective associations with clinical outcome.

MATERIALS AND METHODS: Patients randomized in MR CLEAN with middle cerebral artery occlusion and both baseline CTA images and complete DSA runs were included. Collateral flow on CTA and DSA was graded 0 (absent) to 3 (good). Quadratic weighted κ statistics determined agreement between both methods. The association of both modalities with mRS at 90 days was assessed. Also, association between the dichotomized collateral score and mRS 0–2 (functional independence) was ascertained.

RESULTS: Of 45 patients with evaluable imaging data, collateral flow was graded on CTA as 0, 1, 2, 3 for 3, 10, 20, and 12 patients, respectively, and on DSA for 12, 17, 10, and 6 patients, respectively. The κ-value was 0.24 (95% CI, 0.16–0.32). The overall proportion of agreement was 24% (95% CI, 0.12–0.38). The adjusted odds ratio for favorable outcome on mRS was 2.27 and 1.29 for CTA and DSA, respectively. The relationship between the dichotomized collateral score and mRS 0–2 was significant for CTA ( P = .01), but not for DSA ( P = .77).

CONCLUSIONS: Commonly applied collateral flow assessment on CTA and DSA showed large differences, indicating that these techniques are not interchangeable. CTA was significantly associated with mRS at 90 days, whereas DSA was not.

CS
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IAT
:   intra-arterial therapy
MR CLEAN
:   Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands" />
<meta name="DC.Contributor" content="I.G.H. Jansen" />
<meta name="DC.Contributor" content="O.A. Berkhemer" />
<meta name="DC.Contributor" content="A.J. Yoo" />
<meta name="DC.Contributor" content="J.A. Vos" />
<meta name="DC.Contributor" content="G.J. Lycklama à Nijeholt" />
<meta name="DC.Contributor" content="M.E.S. Sprengers" />
<meta name="DC.Contributor" content="W.H. van Zwam" />
<meta name="DC.Contributor" content="W.J. Schonewille" />
<meta name="DC.Contributor" content="J. Boiten" />
<meta name="DC.Contributor" content="M.A.A. van Walderveen" />
<meta name="DC.Contributor" content="R.J. van Oostenbrugge" />
<meta name="DC.Contributor" content="A. van der Lugt" />
<meta name="DC.Contributor" content="H.A. Marquering" />
<meta name="DC.Contributor" content="C.B.L.M. Majoie" />
<meta name="DC.Contributor" content="on behalf of the MR CLEAN investigators (www.mrclean-trial.org)" />
<meta name="article:published_time" content="2016-11-01" />
<meta name="article:section" content="ADULT BRAIN" />
<meta name="citation_title" content="Comparison of CTA- and DSA-Based Collateral Flow Assessment in Patients with Anterior Circulation Stroke" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Collateral flow is associated with clinical outcome after acute ischemic stroke and may serve as a parameter for patient selection for intra-arterial therapy. In clinical trials, DSA and CTA are 2 imaging modalities commonly used to assess collateral flow. We aimed to determine the agreement between collateral flow assessment on CTA and DSA and their respective associations with clinical outcome.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Patients randomized in MR CLEAN with middle cerebral artery occlusion and both baseline CTA images and complete DSA runs were included. Collateral flow on CTA and DSA was graded 0 (absent) to 3 (good). Quadratic weighted κ statistics determined agreement between both methods. The association of both modalities with mRS at 90 days was assessed. Also, association between the dichotomized collateral score and mRS 0–2 (functional independence) was ascertained.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Of 45 patients with evaluable imaging data, collateral flow was graded on CTA as 0, 1, 2, 3 for 3, 10, 20, and 12 patients, respectively, and on DSA for 12, 17, 10, and 6 patients, respectively. The κ-value was 0.24 (95% CI, 0.16–0.32). The overall proportion of agreement was 24% (95% CI, 0.12–0.38). The adjusted odds ratio for favorable outcome on mRS was 2.27 and 1.29 for CTA and DSA, respectively. The relationship between the dichotomized collateral score and mRS 0–2 was significant for CTA (&lt;i&gt;P&lt;/i&gt; = .01), but not for DSA (&lt;i&gt;P&lt;/i&gt; = .77).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Commonly applied collateral flow assessment on CTA and DSA showed large differences, indicating that these techniques are not interchangeable. CTA was significantly associated with mRS at 90 days, whereas DSA was not.&lt;/p&gt;" />
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<meta name="twitter:title" content="Comparison of CTA- and DSA-Based Collateral Flow Assessment in Patients with Anterior Circulation Stroke" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Collateral flow is associated with clinical outcome after acute ischemic stroke and may serve as a parameter for patient selection for intra-arterial therapy. In clinical trials, DSA and CTA are 2 imaging modalities commonly used to assess collateral flow. We aimed to determine the agreement between collateral flow assessment on CTA and DSA and their respective associations with clinical outcome.

MATERIALS AND METHODS: Patients randomized in MR CLEAN with middle cerebral artery occlusion and both baseline CTA images and complete DSA runs were included. Collateral flow on CTA and DSA was graded 0 (absent) to 3 (good). Quadratic weighted κ statistics determined agreement between both methods. The association of both modalities with mRS at 90 days was assessed. Also, association between the dichotomized collateral score and mRS 0–2 (functional independence) was ascertained.

RESULTS: Of 45 patients with evaluable imaging data, collateral flow was graded on CTA as 0, 1, 2, 3 for 3, 10, 20, and 12 patients, respectively, and on DSA for 12, 17, 10, and 6 patients, respectively. The κ-value was 0.24 (95% CI, 0.16–0.32). The overall proportion of agreement was 24% (95% CI, 0.12–0.38). The adjusted odds ratio for favorable outcome on mRS was 2.27 and 1.29 for CTA and DSA, respectively. The relationship between the dichotomized collateral score and mRS 0–2 was significant for CTA ( P = .01), but not for DSA ( P = .77).

CONCLUSIONS: Commonly applied collateral flow assessment on CTA and DSA showed large differences, indicating that these techniques are not interchangeable. CTA was significantly associated with mRS at 90 days, whereas DSA was not.

CS
:   collateral score
IAT
:   intra-arterial therapy
MR CLEAN
:   Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands" />
<meta name="og-title" property="og:title" content="Comparison of CTA- and DSA-Based Collateral Flow Assessment in Patients with Anterior Circulation Stroke" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/37/11/2037" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Collateral flow is associated with clinical outcome after acute ischemic stroke and may serve as a parameter for patient selection for intra-arterial therapy. In clinical trials, DSA and CTA are 2 imaging modalities commonly used to assess collateral flow. We aimed to determine the agreement between collateral flow assessment on CTA and DSA and their respective associations with clinical outcome.

MATERIALS AND METHODS: Patients randomized in MR CLEAN with middle cerebral artery occlusion and both baseline CTA images and complete DSA runs were included. Collateral flow on CTA and DSA was graded 0 (absent) to 3 (good). Quadratic weighted κ statistics determined agreement between both methods. The association of both modalities with mRS at 90 days was assessed. Also, association between the dichotomized collateral score and mRS 0–2 (functional independence) was ascertained.

RESULTS: Of 45 patients with evaluable imaging data, collateral flow was graded on CTA as 0, 1, 2, 3 for 3, 10, 20, and 12 patients, respectively, and on DSA for 12, 17, 10, and 6 patients, respectively. The κ-value was 0.24 (95% CI, 0.16–0.32). The overall proportion of agreement was 24% (95% CI, 0.12–0.38). The adjusted odds ratio for favorable outcome on mRS was 2.27 and 1.29 for CTA and DSA, respectively. The relationship between the dichotomized collateral score and mRS 0–2 was significant for CTA ( P = .01), but not for DSA ( P = .77).

CONCLUSIONS: Commonly applied collateral flow assessment on CTA and DSA showed large differences, indicating that these techniques are not interchangeable. CTA was significantly associated with mRS at 90 days, whereas DSA was not.

CS
:   collateral score
IAT
:   intra-arterial therapy
MR CLEAN
:   Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node85--5" data-node-nid="85" id="top-node-85--6136827737" data-pisa="ajnr;37/11/2037" data-pisa-master="ajnr;ajnr.A4878" data-apath="/ajnr/37/11/2037.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">ADULT BRAIN</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Comparison of CTA- and DSA-Based Collateral Flow Assessment in Patients with Anterior Circulation Stroke</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">I.G.H. Jansen</span>, <span class="highwire-citation-author" data-delta="1">O.A. Berkhemer</span>, <span class="highwire-citation-author" data-delta="2">A.J. Yoo</span>, <span class="highwire-citation-author" data-delta="3">J.A. Vos</span>, <span class="highwire-citation-author" data-delta="4">G.J. Lycklama à Nijeholt</span>, <span class="highwire-citation-author" data-delta="5">M.E.S. Sprengers</span>, <span class="highwire-citation-author" data-delta="6">W.H. van Zwam</span>, <span class="highwire-citation-author" data-delta="7">W.J. Schonewille</span>, <span class="highwire-citation-author" data-delta="8">J. Boiten</span>, <span class="highwire-citation-author" data-delta="9">M.A.A. van Walderveen</span>, <span class="highwire-citation-author" data-delta="10">R.J. van Oostenbrugge</span>, <span class="highwire-citation-author" data-delta="11">A. van der Lugt</span>, <span class="highwire-citation-author" data-delta="12">H.A. Marquering</span> and <span class="highwire-citation-author" data-delta="13">C.B.L.M. Majoie</span> <span  class="highwire-citation-author last"><span class="nlm-on-behalf-of">on behalf of the MR CLEAN investigators (www.mrclean-trial.org)</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2016,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2037-2042; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4878 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-85--6136827737" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">I.G.H. Jansen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (I.G.H.J., O.A.B., M.E.S.S., C.B.L.M.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.G.H.%2BJansen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jansen%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AI.G.H.%2BJansen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-8862-1877" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for I.G.H. Jansen</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">O.A. Berkhemer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (I.G.H.J., O.A.B., M.E.S.S., C.B.L.M.M.)</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Departments of Neurology (O.A.B.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=O.A.%2BBerkhemer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Berkhemer%20O&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AO.A.%2BBerkhemer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-2212-6128" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for O.A. Berkhemer</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A.J. Yoo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Texas Stroke Institute (A.J.Y.), Plano, Texas</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.J.%2BYoo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Yoo%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.J.%2BYoo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-7657-142X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.J. Yoo</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J.A. Vos </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Departments of Radiology (J.A.V.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.A.%2BVos%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vos%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.A.%2BVos%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-3614-9168" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J.A. Vos</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">G.J. Lycklama à Nijeholt </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Departments of Radiology (G.J.L.N.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.J.%2BLycklama%2B%C3%A0%2BNijeholt%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lycklama%20%C3%A0%20Nijeholt%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.J.%2BLycklama%2B%25C3%25A0%2BNijeholt%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-6575-9868" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G.J. Lycklama à Nijeholt</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">M.E.S. Sprengers </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (I.G.H.J., O.A.B., M.E.S.S., C.B.L.M.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.E.S.%2BSprengers%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sprengers%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.E.S.%2BSprengers%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-6895-1353" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.E.S. Sprengers</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">W.H. van Zwam </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>j</span>Departments of Radiology (W.H.v.Z.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.H.%2Bvan%2BZwam%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20Zwam%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.H.%2Bvan%2BZwam%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-1631-7056" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W.H. van Zwam</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">W.J. Schonewille </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Neurology (W.J.S.), St. Antonius Hospital, Nieuwegein, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.J.%2BSchonewille%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Schonewille%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AW.J.%2BSchonewille%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-4070-9730" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for W.J. Schonewille</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">J. Boiten </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>i</span>Neurology (J.B.), Haaglanden Medical Center, The Haag, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BBoiten%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Boiten%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BBoiten%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-8850-8225" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Boiten</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">M.A.A. van Walderveen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>l</span>Department of Radiology (M.A.A.v.W.), Leiden University Medical Center, Leiden, the Netherlands.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.A.A.%2Bvan%2BWalderveen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20Walderveen%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.A.A.%2Bvan%2BWalderveen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-4895-229X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.A.A. van Walderveen</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">R.J. van Oostenbrugge </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>k</span>Neurology (R.J.v.O.), Cardiovascular Research Institute, Maastricht, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.J.%2Bvan%2BOostenbrugge%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20Oostenbrugge%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.J.%2Bvan%2BOostenbrugge%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0003-1032-9099" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R.J. van Oostenbrugge</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">A. van der Lugt </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Radiology (A.v.d.L.), Erasmus MC University Medical Center, Rotterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2Bvan%2Bder%2BLugt%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=van%20der%20Lugt%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2Bvan%2Bder%2BLugt%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-6159-2228" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. van der Lugt</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">H.A. Marquering </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Biomedical Engineering and Physics (H.A.M.), Academic Medical Center, Amsterdam, the Netherlands</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.A.%2BMarquering%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Marquering%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.A.%2BMarquering%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-1414-6313" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H.A. 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Majoie </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (I.G.H.J., O.A.B., M.E.S.S., C.B.L.M.M.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.B.L.M.%2BMajoie%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Majoie%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.B.L.M.%2BMajoie%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-7600-9568" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.B.L.M. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-37.11.2037.1" data-doi="10.1056/NEJMoa1411587"><div class="cit-metadata"><ol class="cit-auth-list"><li>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 37</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 11 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Nov 2016 </div></div>
      
      
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      <div class="highwire-cite-title">Comparison of CTA- and DSA-Based Collateral Flow Assessment in Patients with Anterior Circulation Stroke</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">I.G.H.</span> <span class="nlm-surname">Jansen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">O.A.</span> <span class="nlm-surname">Berkhemer</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Yoo</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Vos</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">G.J.</span> <span class="nlm-surname">Lycklama à Nijeholt</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.E.S.</span> <span class="nlm-surname">Sprengers</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">W.H.</span> <span class="nlm-surname">van Zwam</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">W.J.</span> <span class="nlm-surname">Schonewille</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Boiten</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">M.A.A.</span> <span class="nlm-surname">van Walderveen</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">R.J.</span> <span class="nlm-surname">van Oostenbrugge</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">A.</span> <span class="nlm-surname">van der Lugt</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">H.A.</span> <span class="nlm-surname">Marquering</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">C.B.L.M.</span> <span class="nlm-surname">Majoie</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2037-2042; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4878 </span></div>
  
  
  
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      <div class="highwire-cite-title">Comparison of CTA- and DSA-Based Collateral Flow Assessment in Patients with Anterior Circulation Stroke</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">I.G.H.</span> <span class="nlm-surname">Jansen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">O.A.</span> <span class="nlm-surname">Berkhemer</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Yoo</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Vos</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">G.J.</span> <span class="nlm-surname">Lycklama à Nijeholt</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.E.S.</span> <span class="nlm-surname">Sprengers</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">W.H.</span> <span class="nlm-surname">van Zwam</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">W.J.</span> <span class="nlm-surname">Schonewille</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Boiten</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">M.A.A.</span> <span class="nlm-surname">van Walderveen</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">R.J.</span> <span class="nlm-surname">van Oostenbrugge</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">A.</span> <span class="nlm-surname">van der Lugt</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">H.A.</span> <span class="nlm-surname">Marquering</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">C.B.L.M.</span> <span class="nlm-surname">Majoie</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2016, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">37 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2037-2042; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4878 </span></div>
  
  
  
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