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<meta name="DC.Title" content="Widening the Neuroimaging Features of Adenosine Deaminase 2 Deficiency" />
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<meta name="DC.Description" content="SUMMARY: Adenosine deaminase 2 deficiency (OMIM #615688) is an autosomal recessive disorder characterized by a wide clinical spectrum, including small- and medium-sized vessel vasculopathies, but data focusing on the associated neuroimaging features are still scarce in the literature. Here, we describe the clinical neuroimaging features of 12 patients with genetically proven adenosine deaminase 2 deficiency (6 males; median age at disease onset, 1.3 years; median age at genetic diagnosis, 15.5 years). Our findings expand the neuroimaging phenotype of this condition demonstrating, in addition to multiple, recurrent brain lacunar ischemic and/or hemorrhagic strokes, spinal infarcts, and intracranial aneurysms, also cerebral microbleeds and a peculiar, likely inflammatory, perivascular tissue in the basal and peripontine cisterns. Together with early clinical onset, positive family history, inflammatory flares and systemic abnormalities, these findings should raise the suspicion of adenosine deaminase 2 deficiency, thus prompting genetic evaluation and institution of tumor necrosis factor inhibitors, with a potential great impact on neurologic outcome.

DADA2
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TNF
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PAN
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&lt;p&gt;Adenosine deaminase 2 deficiency (OMIM #615688) is an autosomal recessive disorder characterized by a wide clinical spectrum, including small- and medium-sized vessel vasculopathies, but data focusing on the associated neuroimaging features are still scarce in the literature. Here, we describe the clinical neuroimaging features of 12 patients with genetically proven adenosine deaminase 2 deficiency (6 males; median age at disease onset, 1.3 years; median age at genetic diagnosis, 15.5 years). Our findings expand the neuroimaging phenotype of this condition demonstrating, in addition to multiple, recurrent brain lacunar ischemic and/or hemorrhagic strokes, spinal infarcts, and intracranial aneurysms, also cerebral microbleeds and a peculiar, likely inflammatory, perivascular tissue in the basal and peripontine cisterns. Together with early clinical onset, positive family history, inflammatory flares and systemic abnormalities, these findings should raise the suspicion of adenosine deaminase 2 deficiency, thus prompting genetic evaluation and institution of tumor necrosis factor inhibitors, with a potential great impact on neurologic outcome.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=N Engl J Med;citation_author=Q. Zhou;citation_author=D. Yang;citation_author=AK. Ombrello;citation_title=Early-onset stroke and vasculopathy associated with mutations in ADA2;citation_pages=911-20;citation_volume=370;citation_year=2014;citation_pmid=24552284;citation_doi=10.1056/NEJMoa1307361" />
<meta name="citation_reference" content="citation_journal_title=N Engl J Med;citation_author=J. Bras;citation_author=R. Guerreiro;citation_author=GC. Santo;citation_title=Mutant ADA2 in vasculopathies;citation_pages=478-80;citation_volume=371;citation_year=2014;citation_pmid=25075845;citation_doi=10.1056/NEJMc1405506" />
<meta name="citation_reference" content="citation_journal_title=Rheumatology (Oxford);citation_author=JM. Van Montfrans;citation_author=EAR. Hartman;citation_author=KPJ. Braun;citation_title=Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations;citation_volume=55;citation_year=2016;citation_pmid=26867732;citation_doi=10.1093/rheumatology/kev439" />
<meta name="citation_reference" content="citation_journal_title=J Allergy Clin Immunol;citation_author=PY. Lee;citation_author=ES. Kellner;citation_author=Y. Huang;citation_title=Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2);citation_volume=145;citation_year=2020;citation_pmid=31945408;citation_doi=10.1016/j.jaci.2019.12.908" />
<meta name="citation_reference" content="citation_journal_title=Rev Med Interne;citation_author=A. Fayand;citation_author=G. Sarrabay;citation_author=A. Belot;citation_title=Multiple facets of ADA2 deficiency: vasculitis, auto-inflammatory disease and im-munodeficiency: a literature review of 135 cases from literature;citation_pages=297-306;citation_volume=39;citation_year=2018;citation_pmid=29273180;citation_doi=10.1016/j.revmed.2017.11.006" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_author=WF. Westendorp;citation_author=PJ. Nederkoorn;citation_author=I. Aksentijevich;citation_title=Unexplained early-onset lacunar stroke and inflammatory skin lesions: consider ADA2 deficiency;citation_volume=84;citation_year=2015;citation_pmid=25888558;citation_doi=10.1212/WNL.0000000000001581" />
<meta name="citation_reference" content="citation_journal_title=Arthritis Rheumatol;citation_author=S. Nanthapisal;citation_author=C. Murphy;citation_author=E. Omoyinmi;citation_title=Deficiency of adenosine deaminase type 2: a description of phenotype and genotype in fifteen cases;citation_pages=2314-22;citation_volume=68;citation_year=2016;citation_pmid=27059682;citation_doi=10.1002/art.39699" />
<meta name="citation_reference" content="citation_journal_title=Neuropediatrics;citation_author=M. Elbracht;citation_author=M. Mull;citation_author=N. Wagner;citation_title=Stroke as initial manifestation of adenosine deaminase 2 deficiency;citation_pages=111-14;citation_volume=48;citation_year=2017;citation_pmid=28024309;citation_doi=10.1055/s-0036-1597611" />
<meta name="citation_reference" content="citation_journal_title=Ann Rheum Dis;citation_author=R. Caorsi;citation_author=F. Penco;citation_author=A. Grossi;citation_title=ADA2 deficiency (DADA2) as an unrecognised cause of early onset polyarteritis nodosa and stroke: a multicentre national study;citation_volume=76;citation_year=2017;citation_pmid=28522451;citation_doi=10.1136/annrheumdis-2016-210802" />
<meta name="citation_reference" content="citation_journal_title=J Rheumatol;citation_author=S. Özen;citation_author=ED. Batu;citation_author=EZ. Taşkiran;citation_title=A monogenic disease with a variety of phenotypes: deficiency of adenosine deaminase 2;citation_volume=47;citation_year=2020;citation_pmid=31043544;citation_doi=10.3899/jrheum.181384" />
<meta name="citation_reference" content="citation_journal_title=Rheumatol Int;citation_author=S. Sahin;citation_author=A. Adrovic;citation_author=K. Barut;citation_title=Clinical, imaging and genotypical features of three deceased and five surviving cases with ADA2 deficiency;citation_pages=129-36;citation_volume=38;citation_year=2018;citation_pmid=28516235;citation_doi=10.1007/s00296-017-3740-3" />
<meta name="citation_reference" content="citation_journal_title=Ped Rheumatol;citation_author=R. Caorsi;citation_author=A. Omenetti;citation_author=A. Morreale;citation_title=Rapid and sustained effect of anti-TNF treatment in patients with ADA2 deficiency;citation_volume=13;citation_year=2015;citation_doi=10.1186/1546-0096-13-S1-O80" />
<meta name="citation_reference" content="citation_journal_title=J Neuroradiol;citation_author=E. Bulut;citation_author=A. Erden;citation_author=O. Karadag;citation_title=Deficiency of adenosine deaminase 2; special focus on central nervous system imaging;citation_pages=193-98;citation_volume=46;citation_year=2019;citation_pmid=29913178;citation_doi=10.1016/j.neurad.2018.05.002" />
<meta name="citation_reference" content="citation_journal_title=Clin Rheumatol;citation_author=S. Ganhão;citation_author=GB. Loureiro;citation_author=DR. Oliveira;citation_title=Two cases of ADA2 deficiency presenting as childhood polyarteritis nodosa: novel ADA2 variant, atypical CNS manifestations, and literature review;citation_pages=3853-60;citation_volume=39;citation_year=2020;citation_pmid=32535845;citation_doi=10.1007/s10067-020-05210-4" />
<meta name="citation_reference" content="citation_journal_title=Neurol Med Chir (Tokyo);citation_author=K. Toyoda;citation_author=K. Tsutsumi;citation_author=T. Hirao;citation_title=Ruptured intracranial aneurysms in pediatric polyarteritis nodosa;citation_pages=928-932;citation_volume=52;citation_year=2012;citation_pmid=23269053;citation_doi=10.2176/nmc.52.928" />
<meta name="citation_reference" content="citation_journal_title=J Stroke Cerebrovasc Dis;citation_author=M. Boukobza;citation_author=A. Dossier;citation_author=JP. Laissy;citation_title=Thrombosed aneurysm of the posterior inferior cerebellar artery and lateral medullary ischemia as the initial presentation of polyarteritis nodosa: case report and literature review;citation_pages=e168-71;citation_volume=27;citation_year=2018;citation_pmid=29602618;citation_doi=10.1016/j.jstrokecerebrovasdis.2018.02.061" />
<meta name="citation_reference" content="citation_journal_title=Clin Imaging;citation_author=G. Smith;citation_author=BL. Hoh;citation_author=MS. Albayram;citation_title=Anterior spinal artery aneurysm presenting with spinal subarachnoid hemorrhage in a case of polyarteritis nodosa;citation_pages=108-13;citation_volume=56;citation_year=2019;citation_pmid=31029009;citation_doi=10.1016/j.clinimag.2019.04.008" />
<meta name="citation_reference" content="citation_journal_title=Lancet Neurol;citation_author=JM. Wardlaw;citation_author=C. Smith;citation_author=M. Dichgans;citation_title=Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging;citation_pages=483-97;citation_volume=12;citation_year=2013;citation_pmid=23602162;citation_doi=10.1016/S1474-4422(13)70060-7" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=DM. Mandell;citation_author=M. Mossa-Basha;citation_author=Y. Qiao;citation_title=Intracranial vessel wall MRI: principles and expert consensus recommendations of the American Society of Neuroradiology;citation_volume=38;citation_year=2017;citation_pmid=27469212;citation_doi=10.3174/ajnr.A4893" />
<meta name="citation_reference" content="citation_journal_title=Eur J Pediatr;citation_author=N. Garg;citation_author=O. Kasapcopur;citation_author=J. Foster;citation_title=Novel adenosine deaminase 2 mutations in a child with a fatal vasculopathy;citation_pages=827-30;citation_volume=173;citation_year=2014;citation_pmid=24737293;citation_doi=10.1007/s00431-014-2320-8" />
<meta name="citation_reference" content="citation_journal_title=BMC Res Notes;citation_author=MR. Navinan;citation_author=CJ. Subasinghe;citation_author=T. Kandeepan;citation_title=Polyarteritis nodosa complicated by posterior reversible encephalopathy syndrome: a case report;citation_pages=89;citation_volume=7;citation_year=2014;citation_pmid=24529495;citation_doi=10.1186/1756-0500-7-89" />
<meta name="citation_reference" content="citation_journal_title=Lancet Neurol;citation_author=JE. Fugate;citation_author=AA. Rabinstein;citation_title=Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions;citation_pages=914-25;citation_volume=14;citation_year=2015;citation_pmid=26184985;citation_doi=10.1016/S1474-4422(15)00111-8" />
<meta name="twitter:title" content="Widening the Neuroimaging Features of Adenosine Deaminase 2 Deficiency" />
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<meta name="twitter:description" content="SUMMARY: Adenosine deaminase 2 deficiency (OMIM #615688) is an autosomal recessive disorder characterized by a wide clinical spectrum, including small- and medium-sized vessel vasculopathies, but data focusing on the associated neuroimaging features are still scarce in the literature. Here, we describe the clinical neuroimaging features of 12 patients with genetically proven adenosine deaminase 2 deficiency (6 males; median age at disease onset, 1.3 years; median age at genetic diagnosis, 15.5 years). Our findings expand the neuroimaging phenotype of this condition demonstrating, in addition to multiple, recurrent brain lacunar ischemic and/or hemorrhagic strokes, spinal infarcts, and intracranial aneurysms, also cerebral microbleeds and a peculiar, likely inflammatory, perivascular tissue in the basal and peripontine cisterns. Together with early clinical onset, positive family history, inflammatory flares and systemic abnormalities, these findings should raise the suspicion of adenosine deaminase 2 deficiency, thus prompting genetic evaluation and institution of tumor necrosis factor inhibitors, with a potential great impact on neurologic outcome.

DADA2
:   adenosine deaminase 2 deficiency
TNF
:   tumor necrosis factor
PAN
:   polyarteritis nodosa
PRES
:   posterior reversible encephalopathy syndrome" />
<meta name="og-title" property="og:title" content="Widening the Neuroimaging Features of Adenosine Deaminase 2 Deficiency" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="SUMMARY: Adenosine deaminase 2 deficiency (OMIM #615688) is an autosomal recessive disorder characterized by a wide clinical spectrum, including small- and medium-sized vessel vasculopathies, but data focusing on the associated neuroimaging features are still scarce in the literature. Here, we describe the clinical neuroimaging features of 12 patients with genetically proven adenosine deaminase 2 deficiency (6 males; median age at disease onset, 1.3 years; median age at genetic diagnosis, 15.5 years). Our findings expand the neuroimaging phenotype of this condition demonstrating, in addition to multiple, recurrent brain lacunar ischemic and/or hemorrhagic strokes, spinal infarcts, and intracranial aneurysms, also cerebral microbleeds and a peculiar, likely inflammatory, perivascular tissue in the basal and peripontine cisterns. Together with early clinical onset, positive family history, inflammatory flares and systemic abnormalities, these findings should raise the suspicion of adenosine deaminase 2 deficiency, thus prompting genetic evaluation and institution of tumor necrosis factor inhibitors, with a potential great impact on neurologic outcome.

DADA2
:   adenosine deaminase 2 deficiency
TNF
:   tumor necrosis factor
PAN
:   polyarteritis nodosa
PRES
:   posterior reversible encephalopathy syndrome" />
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      <h1 class="highwire-cite-title" id="page-title">Widening the Neuroimaging Features of Adenosine Deaminase 2 Deficiency</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">A.F. Geraldo</span>, <span class="highwire-citation-author" data-delta="1">R. Caorsi</span>, <span class="highwire-citation-author" data-delta="2">D. Tortora</span>, <span class="highwire-citation-author" data-delta="3">C. Gandolfo</span>, <span class="highwire-citation-author" data-delta="4">R. Ammendola</span>, <span class="highwire-citation-author" data-delta="5">M. Alessio</span>, <span class="highwire-citation-author" data-delta="6">G. Conti</span>, <span class="highwire-citation-author" data-delta="7">A. Insalaco</span>, <span class="highwire-citation-author" data-delta="8">S. Pastore</span>, <span class="highwire-citation-author" data-delta="9">S. Martino</span>, <span class="highwire-citation-author" data-delta="10">I. Ceccherini</span>, <span class="highwire-citation-author" data-delta="11">S. Signa</span>, <span class="highwire-citation-author" data-delta="12">M. Gattorno</span>, <span class="highwire-citation-author" data-delta="13">A. Rossi</span> and <span class="highwire-citation-author" data-delta="14">M. Severino</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2021,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">42 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">975-979; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7019 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-90915--6854681201" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">A.F. Geraldo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Neuroradiology Unit (A.F.G., D.T., R.A., A.R., M.S.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Diagnostic Neuroradiology Unit, Imaging Department (A.F.G.), Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.F.%2BGeraldo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Geraldo%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.F.%2BGeraldo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9663-4387" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.F. Geraldo</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">R. Caorsi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Center for Autoinflammatory Diseases and Immunodeficiencies (R.C., S.S., M.G.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BCaorsi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Caorsi%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.%2BCaorsi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0131-7846" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R. Caorsi</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">D. Tortora </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Neuroradiology Unit (A.F.G., D.T., R.A., A.R., M.S.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BTortora%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tortora%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BTortora%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5621-4046" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. Tortora</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">C. Gandolfo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Interventional Unit (C.G.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BGandolfo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gandolfo%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BGandolfo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1703-9107" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. Gandolfo</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">R. Ammendola </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Neuroradiology Unit (A.F.G., D.T., R.A., A.R., M.S.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BAmmendola%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ammendola%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.%2BAmmendola%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1018-8206" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R. Ammendola</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">M. Alessio </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Translational Medical Sciences (M.A.), Federico II University of Naples, Naples, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BAlessio%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Alessio%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BAlessio%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4568-3135" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Alessio</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">G. Conti </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Pediatric Nephrology and Rheumatology Unit (G.C.), AOU G Martino, Messina, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BConti%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Conti%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AG.%2BConti%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-0617-500X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for G. Conti</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">A. Insalaco </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Division of Rheumatology (A.I.), IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BInsalaco%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Insalaco%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BInsalaco%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-1443-1840" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Insalaco</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">S. Pastore </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>h</span>Department of Pediatrics (S.P.), Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Trieste, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BPastore%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Pastore%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BPastore%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4697-0777" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Pastore</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">S. Martino </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>i</span>Division of Pediatric Immunology and Rheumatology, Department of Public Health and Pediatrics (S.M.), Regina Margherita Children Hospital, University of Turin, Turin, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BMartino%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Martino%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BMartino%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6861-8566" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Martino</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">I. Ceccherini </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>j</span>UOSD Genetics and Genomics of Rare Diseases (I.C.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.%2BCeccherini%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ceccherini%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AI.%2BCeccherini%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8732-1955" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for I. Ceccherini</a></li></ul></div><div class="author-tooltip-11"><div class="author-tooltip-name">S. Signa </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Center for Autoinflammatory Diseases and Immunodeficiencies (R.C., S.S., M.G.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BSigna%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Signa%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BSigna%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9083-1726" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Signa</a></li></ul></div><div class="author-tooltip-12"><div class="author-tooltip-name">M. Gattorno </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Center for Autoinflammatory Diseases and Immunodeficiencies (R.C., S.S., M.G.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BGattorno%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gattorno%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BGattorno%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0704-1916" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Gattorno</a></li></ul></div><div class="author-tooltip-13"><div class="author-tooltip-name">A. Rossi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Neuroradiology Unit (A.F.G., D.T., R.A., A.R., M.S.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div><div class='author-affiliation'><span class='nlm-sup'>k</span>Department of Health Sciences (DISSAL) (A.R.), University of Genoa, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BRossi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rossi%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.%2BRossi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8575-700X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A. Rossi</a></li></ul></div><div class="author-tooltip-14"><div class="author-tooltip-name">M. Severino </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Neuroradiology Unit (A.F.G., D.T., R.A., A.R., M.S.), IRCCS Istituto Giannina Gaslini, Genoa, Italy</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BSeverino%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Severino%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BSeverino%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-4730-5322" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. Severino</a></li></ul></div></div></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.F.</span> <span class="nlm-surname">Geraldo</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Caorsi</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Tortora</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Gandolfo</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Ammendola</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Alessio</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Conti</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Insalaco</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Pastore</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Martino</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Ceccherini</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Signa</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Gattorno</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Rossi</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Severino</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2021, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">42 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">975-979; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A7019 </span></div>
  
  
  
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      <div class="highwire-cite-title">Widening the Neuroimaging Features of Adenosine Deaminase 2 Deficiency</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.F.</span> <span class="nlm-surname">Geraldo</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Caorsi</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Tortora</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Gandolfo</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Ammendola</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Alessio</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Conti</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Insalaco</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Pastore</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Martino</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Ceccherini</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Signa</span></span>, <span class="highwire-citation-author" data-delta="12"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Gattorno</span></span>, <span class="highwire-citation-author" data-delta="13"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Rossi</span></span>, <span class="highwire-citation-author" data-delta="14"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Severino</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2021, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">42 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">975-979; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A7019 </span></div>
  
  
  
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