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<meta name="DC.Title" content="Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center" />
<meta name="DC.Identifier" content="10.3174/ajnr.A7505" />
<meta name="DC.Date" content="2022-06-01" />
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<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia.

MATERIALS AND METHODS: This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected.

RESULTS: Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%–19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6–4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture.

CONCLUSIONS: Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed.

ACVRL1 
:   activin receptor-like kinase 1 or ALK-1 
BVM
:   brain vascular malformation
ENG 
:   endoglin 
HHT
:   hereditary hemorrhagic telangiectasia
IA
:   intracranial aneurysm
IQR
:   25–75 interquartile range
MADH4 
:   mothers against decapentaplegic drosophila homolog 4 
MMP
:   matrix metalloproteinase
TGFβ/BMP
:   Transforming Growth Factorβ/bone morphogenetic protein" />
<meta name="DC.Contributor" content="M.S. Perez Akly" />
<meta name="DC.Contributor" content="C. Vazquez" />
<meta name="DC.Contributor" content="C.H. Besada" />
<meta name="DC.Contributor" content="M.J. Rodriguez" />
<meta name="DC.Contributor" content="M.F. Conde" />
<meta name="DC.Contributor" content="A.R. Cajal" />
<meta name="DC.Contributor" content="V.A. Peuchot" />
<meta name="DC.Contributor" content="D. Dardik" />
<meta name="DC.Contributor" content="M.M. Baccanelli" />
<meta name="DC.Contributor" content="M.M. Serra" />
<meta name="article:published_time" content="2022-06-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%–19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6–4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=Front Genet;citation_author=J. McDonald;citation_author=W. Wooderchak-Donahue;citation_author=C. VanSant Webb;citation_title=Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era;citation_pages=1;citation_volume=6;citation_year=2015;citation_pmid=25674101;citation_doi=10.3389/fgene.2015.00001" />
<meta name="citation_reference" content="citation_journal_title=J Med Genet;citation_author=SA. Abdalla;citation_author=M. Letarte;citation_title=Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease;citation_volume=43;citation_year=2006;citation_pmid=15879500;citation_doi=10.1136/jmg.2005.030833" />
<meta name="citation_reference" content="citation_journal_title=Ann Intern Med;citation_author=ME. Faughnan;citation_author=JJ. Mager;citation_author=SW. Hetts;citation_title=Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia;citation_pages=989-1001;citation_volume=173;citation_year=2020;citation_pmid=32894695;citation_doi=10.7326/M20-1443" />
<meta name="citation_reference" content="citation_journal_title=Orphanet J Rare Dis;citation_author=MM. Serra;citation_author=CH. Besada;citation_author=A. Cabana Cal;citation_title=Central nervous system manganese induced lesions and clinical consequences in patients with hereditary hemorrhagic telangiectasia;citation_pages=92;citation_volume=12;citation_year=2017;citation_pmid=28521822;citation_doi=10.1186/s13023-017-0632-2" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=JM. Klostranec;citation_author=L. Chen;citation_author=S. Mathur;citation_title=A theory for polymicrogyria and brain arteriovenous malformations in HHT;citation_pages=34-42;citation_volume=92;citation_year=2019;citation_issue=1;citation_pmid=30584075;citation_doi=10.1212/WNL.0000000000006686" />
<meta name="citation_reference" content="citation_journal_title=J Med Genet;citation_author=HHT Foundation International Guidelines Working Group;citation_title=International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia;citation_volume=48;citation_year=2011;citation_pmid=19553198;citation_doi=10.1136/jmg.2009.069013" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_author=RK. Fulbright;citation_author=JC. Chaloupka;citation_author=CM. Putman;citation_title=MR of hereditary hemorrhagic telangiectasia: prevalence and spectrum of cerebrovascular malformations;citation_pages=477-484;citation_volume=19;citation_year=1998;citation_issue=3;citation_pmid=9541302" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=RB. Willemse;citation_author=JJ. Mager;citation_author=CJ. Westermann;citation_title=Bleeding risk of cerebrovascular malformations in hereditary hemorrhagic telangiectasia.;citation_pages=779-784;citation_volume=92;citation_year=2000;citation_issue=5;citation_pmid=10794291;citation_doi=10.3171/jns.2000.92.5.0779" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_author=Malformation Consortium HHT Investigator Group;citation_title=Surgical treatment vs nonsurgical treatment for brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia: a retrospective multicenter consortium study;citation_pages=253;citation_volume=82;citation_year=2018;citation_pmid=28973426;citation_doi=10.1093/neuros/nyx16" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_journal_abbrev=Neurosurgery;citation_author=PS. Amenta;citation_author=S. Yadla;citation_author=PG. Campbell;citation_title=Analysis of nonmodifiable risk factors for intracranial aneurysm rupture in a large, retrospective cohort.;citation_pages=693-699;citation_volume=70;citation_year=2012;citation_issue=3;citation_pmid=21904261;citation_doi=10.1227/NEU.0b013e3182354d68" />
<meta name="citation_reference" content="citation_journal_title=Disease-a-month :  DM;citation_journal_abbrev=Dis Mon;citation_author=TJ. Grobelny;citation_title=Brain aneurysms: epidemiology, treatment options, and milestones of endovascular treatment evolution.;citation_pages=647-655;citation_volume=57;citation_year=2011;citation_issue=10;citation_pmid=22036120;citation_doi=10.1016/j.disamonth.2011.08.022" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=RD. Brown;citation_author=DO. Wiebers;citation_author=GS. Forbes;citation_title=Unruptured intracranial aneurysms and arteriovenous malformations: frequency of intracranial hemorrhage and relationship of lesions.;citation_pages=859-863;citation_volume=73;citation_year=1990;citation_issue=6;citation_pmid=2230969;citation_doi=10.3171/jns.1990.73.6.0859" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=SK. Rammos;citation_author=B. Gardenghi;citation_author=C. Bortolotti;citation_title=Aneurysms associated with brain arteriovenous malformations;citation_volume=37;citation_year=2016;citation_pmid=27339951;citation_doi=10.3174/ajnr.A4869" />
<meta name="citation_reference" content="citation_journal_title=Lancet. Neurology;citation_journal_abbrev=Lancet Neurol;citation_author=MH. Vlak;citation_author=A. Algra;citation_author=R. Brandenburg;citation_title=Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis.;citation_pages=626-636;citation_volume=10;citation_year=2011;citation_issue=7;citation_pmid=21641282;citation_doi=10.1016/S1474-4422(11)70109-0" />
<meta name="citation_reference" content="citation_journal_title=J Med Life;citation_author=D. Mohan;citation_author=V. Munteanu;citation_author=T. Coman;citation_title=Genetic factors involves in intracranial aneurysms–actualities;citation_pages=336-41;citation_volume=8;citation_year=2015;citation_pmid=26351537" />
<meta name="citation_reference" content="citation_journal_title=Interv Neuroradiol;citation_author=ST. Kim;citation_author=W. Brinjikji;citation_author=G. Lanzino;citation_title=Neurovascular manifestations of connective-tissue diseases: a review;citation_volume=22;citation_year=2016;citation_pmid=27511817;citation_doi=10.1177/1591019916659262" />
<meta name="citation_reference" content="citation_journal_title=The American journal of surgical pathology;citation_journal_abbrev=Am J Surg Pathol;citation_author=JJ. Maleszewski;citation_author=DV. Miller;citation_author=J. Lu;citation_title=Histopathologic findings in ascending aortas from individuals with Loeys-Dietz syndrome (LDS).;citation_pages=194-201;citation_volume=33;citation_year=2009;citation_issue=2;citation_pmid=18852674;citation_doi=10.1097/PAS.0b013e31817f3661" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=ST. Kim;citation_author=W. Brinjikji;citation_author=DF. Kallmes;citation_title=Prevalence of intracranial aneurysms in patients with connective tissue diseases: a retrospective study;citation_volume=37;citation_year=2016;citation_pmid=26992822;citation_doi=10.3174/ajnr.A4718" />
<meta name="citation_reference" content="citation_journal_title=Int J Cardiol;citation_author=VM. Vorselaars;citation_author=A. Diederik;citation_author=V. Prabhudesai;citation_title=SMAD4 gene mutation increases the risk of aortic dilation in patients with hereditary haemorrhagic telangiectasia;citation_pages=114-18;citation_volume=245;citation_year=2017;citation_pmid=28874282;citation_doi=10.1016/j.ijcard.2017.06.059" />
<meta name="citation_reference" content="citation_journal_title=Int J Cardiol;citation_author=G. Cavalli;citation_title=SMAD4 gene mutation and risk of aortic dilation: lessons from hereditary hemorrhagic telangiectasia;citation_pages=145-46;citation_volume=245;citation_year=2017;citation_pmid=28874286;citation_doi=10.1016/j.ijcard.2017.07.046" />
<meta name="citation_reference" content="citation_journal_title=Neurologia medico-chirurgica;citation_journal_abbrev=Neurol Med Chir (Tokyo);citation_author=D. Ishii;citation_author=A. Takechi;citation_author=G. Seyama;citation_title=Ruptured large basilar artery aneurysm associated with an arteriovenous malformation in hereditary hemorrhagic telangiectasia.;citation_pages=502-505;citation_volume=52;citation_year=2012;citation_issue=7;citation_pmid=22850500;citation_doi=10.2176/nmc.52.502" />
<meta name="citation_reference" content="citation_journal_abbrev=Intern Emerg Med;citation_author=JF. Chick;citation_author=SE. Sheehan;citation_author=NR. Chauhan;citation_title=The many faces of Hereditary Hemorrhagic Telangiectasia: median arcuate ligament syndrome, arteriovenous malformations, and cerebral aneurysms.;citation_pages=385-386;citation_volume=7;citation_year=2012;citation_issue=4;citation_pmid=22782335;citation_doi=10.1007/s11739-012-0810-0" />
<meta name="citation_reference" content="citation_journal_title=Der Nervenarzt;citation_journal_abbrev=Nervenarzt;citation_author=C. Helmchen;citation_author=HC. Nahser;citation_author=T. Yousry;citation_title=[Therapy of cerebral aneurysms and arteriovenous vascular malformations in hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease)];citation_pages=124-128;citation_volume=66;citation_year=1995;citation_issue=2;citation_pmid=7715751" />
<meta name="citation_reference" content="citation_journal_title=Archives françaises de pédiatrie;citation_journal_abbrev=Arch Fr Pediatr;citation_author=C. Roy;citation_author=G. Noseda;citation_author=A. Arzimanoglou;citation_title=[Rendu Osler disease revealed by ruptured cerebral arterial aneurysm in an infant];citation_pages=741-742;citation_volume=47;citation_year=1990;citation_issue=10;citation_pmid=2082850" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_author=D. Sobel;citation_author=D. Norman;citation_title=CNS manifestations of hereditary hemorrhagic telangiectasia.;citation_pages=569-573;citation_volume=5;citation_year=1984;citation_issue=5;citation_pmid=6435422" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_journal_abbrev=Stroke;citation_author=M. Fisher;citation_author=JL. Zito;citation_title=Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia;citation_pages=419-421;citation_volume=14;citation_year=1983;citation_issue=3;citation_pmid=6658911;citation_doi=10.1161/01.str.14.3.419" />
<meta name="citation_reference" content="citation_journal_title=No shinkei geka. Neurological surgery;citation_journal_abbrev=No Shinkei Geka;citation_author=K. Kamiyama;citation_author=H. Okada;citation_author=H. Niizuma;citation_title=[A case report: Osler-Weber-Rendu disease with cerebral aneurysm, cerebral arteriovenous malformation and pulmonary arteriovenous fistula (author's transl)];citation_pages=67-72;citation_volume=9;citation_year=1981;citation_issue=1;citation_pmid=7231629" />
<meta name="citation_reference" content="citation_journal_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_author=G. Román;citation_author=M. Fisher;citation_author=DP. Perl;citation_title=Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature.;citation_pages=130-144;citation_volume=4;citation_year=1978;citation_issue=2;citation_pmid=707984;citation_doi=10.1002/ana.410040207" />
<meta name="citation_reference" content="citation_journal_title=Surgical neurology;citation_journal_abbrev=Surg Neurol;citation_author=J. Grollmus;citation_author=J. Hoff;citation_title=Multiple aneurysms associated with Osler-Weber-Rendu disease.;citation_pages=91-93;citation_volume=1;citation_year=1973;citation_issue=2;citation_pmid=4772800" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=RD. Brown;citation_author=J. Huston;citation_author=R. Hornung;citation_title=Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection.;citation_pages=1132-1138;citation_volume=108;citation_year=2008;citation_issue=6;citation_pmid=18518716;citation_doi=10.3171/JNS/2008/108/6/1132" />
<meta name="citation_reference" content="citation_journal_title=Eur J Radiol;citation_author=F. Caranci;citation_author=F. Briganti;citation_author=L. Cirillo;citation_title=Epidemiology and genetics of intracranial aneurysms;citation_pages=1598-605;citation_volume=82;citation_year=2013;citation_pmid=23399038;citation_doi=10.1016/j.ejrad.2012.12.026" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_journal_abbrev=Stroke;citation_author=CO. Maher;citation_author=DG. Piepgras;citation_author=RD. Brown;citation_title=Cerebrovascular Manifestations in 321 Cases of Hereditary Hemorrhagic Telangiectasia;citation_pages=877-882;citation_volume=32;citation_year=2001;citation_issue=4;citation_pmid=11283386;citation_doi=10.1161/01.STR.32.4.877" />
<meta name="citation_reference" content="citation_journal_title=Neuroradiology;citation_journal_abbrev=Neuroradiology;citation_author=T. Krings;citation_author=A. Ozanne;citation_author=SM. Chng;citation_title=Neurovascular phenotypes in hereditary haemorrhagic telangiectasia patients according to age. Review of 50 consecutive patients aged 1 day-60 years.;citation_pages=711-720;citation_volume=47;citation_year=2005;citation_issue=10;citation_pmid=16136265;citation_doi=10.1007/s00234-005-1390-8" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=W. Brinjikji;citation_author=VN. Iyer;citation_author=V. Yamaki;citation_title=Neurovascular manifestations of hereditary hemorrhagic telangiectasia: a consecutive series of 376 patients during 15 years;citation_volume=37;citation_year=2016;citation_pmid=27012295;citation_doi=10.3174/ajnr.A4762" />
<meta name="citation_reference" content="citation_journal_title=J Neurosurg;citation_author=MN. Woodall;citation_author=M. McGettigan;citation_author=R. Figueroa;citation_title=Cerebral vascular malformations in hereditary hemorrhagic telangiectasia;citation_pages=87-92;citation_volume=120;citation_year=2014;citation_pmid=24236651;citation_doi=10.3171/2013.10.JNS122402" />
<meta name="citation_reference" content="citation_journal_title=J Vasc Interv Radiol;citation_author=NY. Ring;citation_author=MA. Latif;citation_author=N. Hafezi-Nejad;citation_title=Prevalence of and factors associated with arterial aneurysms in patients with hereditary hemorrhagic telangiectasia: 17-year retrospective series of 418 patients;citation_pages=1661-69;citation_volume=32;citation_year=2021;citation_pmid=34478850;citation_doi=10.1016/j.jvir.2021.08.018" />
<meta name="citation_reference" content="citation_journal_title=J Neurosurg;citation_author=W. Brinjikji;citation_author=VN. Iyer;citation_author=CP. Wood;citation_title=Prevalence and characteristics of brain arteriovenous malformations in hereditary hemorrhagic telangiectasia: a systematic review and meta-analysis;citation_volume=127;citation_year=2017;citation_pmid=27767404;citation_doi=10.3171/2016.7.JNS16847" />
<meta name="citation_reference" content="citation_journal_title=Acta Neurochir (Wien);citation_author=F. Cagnazzo;citation_author=W. Brinjikji;citation_author=G. Lanzino;citation_title=Arterial aneurysms associated with arteriovenous malformations of the brain: classification, incidence, risk of hemorrhage, and treatment-a systematic review;citation_pages=2095-104;citation_volume=158;citation_year=2016;citation_pmid=27644700;citation_doi=10.1007/s00701-016-2957-3" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=N. Chalouhi;citation_author=BL. Hoh;citation_author=D. Hasan;citation_title=Review of cerebral aneurysm formation, growth, and rupture;citation_volume=44;citation_year=2013;citation_pmid=24130141;citation_doi=10.1161/STROKEAHA.113.002390" />
<meta name="citation_reference" content="citation_journal_title=Front Genet;citation_author=CK. Dingenouts;citation_author=M-J. Goumans;citation_author=W. Bakker;citation_title=Mononuclear cells and vascular repair in HHT;citation_pages=114;citation_volume=6;citation_year=2015;citation_pmid=25852751;citation_doi=10.3389/fgene.2015.00114" />
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<meta name="twitter:title" content="Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia.

MATERIALS AND METHODS: This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected.

RESULTS: Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%–19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6–4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture.

CONCLUSIONS: Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed.

ACVRL1 
:   activin receptor-like kinase 1 or ALK-1 
BVM
:   brain vascular malformation
ENG 
:   endoglin 
HHT
:   hereditary hemorrhagic telangiectasia
IA
:   intracranial aneurysm
IQR
:   25–75 interquartile range
MADH4 
:   mothers against decapentaplegic drosophila homolog 4 
MMP
:   matrix metalloproteinase
TGFβ/BMP
:   Transforming Growth Factorβ/bone morphogenetic protein" />
<meta name="og-title" property="og:title" content="Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/43/6/844" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia.

MATERIALS AND METHODS: This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected.

RESULTS: Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%–19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6–4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture.

CONCLUSIONS: Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed.

ACVRL1 
:   activin receptor-like kinase 1 or ALK-1 
BVM
:   brain vascular malformation
ENG 
:   endoglin 
HHT
:   hereditary hemorrhagic telangiectasia
IA
:   intracranial aneurysm
IQR
:   25–75 interquartile range
MADH4 
:   mothers against decapentaplegic drosophila homolog 4 
MMP
:   matrix metalloproteinase
TGFβ/BMP
:   Transforming Growth Factorβ/bone morphogenetic protein" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node97365--5" data-node-nid="97365" id="top-node-97365--61299976464" data-pisa="ajnr;43/6/844" data-pisa-master="ajnr;ajnr.A7505" data-apath="/ajnr/43/6/844.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Adult Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">M.S. Perez Akly</span>, <span class="highwire-citation-author" data-delta="1">C. Vazquez</span>, <span class="highwire-citation-author" data-delta="2">C.H. Besada</span>, <span class="highwire-citation-author" data-delta="3">M.J. Rodriguez</span>, <span class="highwire-citation-author" data-delta="4">M.F. Conde</span>, <span class="highwire-citation-author" data-delta="5">A.R. Cajal</span>, <span class="highwire-citation-author" data-delta="6">V.A. Peuchot</span>, <span class="highwire-citation-author" data-delta="7">D. Dardik</span>, <span class="highwire-citation-author" data-delta="8">M.M. Baccanelli</span> and <span class="highwire-citation-author" data-delta="9">M.M. Serra</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">June 2022,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">43 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">844-849; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7505 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-97365--61299976464" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M.S. Perez Akly </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.S.%2BPerez%2BAkly%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Perez%20Akly%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.S.%2BPerez%2BAkly%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5144-6462" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.S. Perez Akly</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">C. Vazquez </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Internal Medicine (C.V., M.M.S.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BVazquez%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vazquez%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BVazquez%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2834-9047" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. Vazquez</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">C.H. Besada </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.H.%2BBesada%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Besada%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.H.%2BBesada%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2559-7125" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.H. Besada</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">M.J. Rodriguez </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.J.%2BRodriguez%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rodriguez%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.J.%2BRodriguez%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0476-3649" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.J. Rodriguez</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">M.F. Conde </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.F.%2BConde%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Conde%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.F.%2BConde%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2237-0216" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.F. Conde</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">A.R. Cajal </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Translational Medicine and Biomedical Engineering Institute (A.R.C.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>g</span>University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.R.%2BCajal%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cajal%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.R.%2BCajal%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-8063-8877" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.R. Cajal</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">V.A. Peuchot </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>h</span>Internal Medicine Research Area (V.A.P.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=V.A.%2BPeuchot%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Peuchot%20V&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AV.A.%2BPeuchot%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0658-5516" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for V.A. Peuchot</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">D. Dardik </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>i</span>From the Department of Radiology (D.D.), Clínica Instituto de Diagnóstico Sociedad Anónima (INDISA), Santiago, Chile</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BDardik%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dardik%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BDardik%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5269-9410" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. Dardik</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">M.M. Baccanelli </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neurosurgery (M.M.B.), Hospital Italiano, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>g</span>University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.M.%2BBaccanelli%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Baccanelli%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.M.%2BBaccanelli%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8955-5640" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.M. 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Hospital Italiano, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>g</span>University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.M.%2BSerra%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Serra%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.M.%2BSerra%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9912-9503" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.M. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" xmlns:xhtml="http://www.w3.org/1999/xhtml" class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.1" data-doi="10.1136/thx.54.8.714"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Shovlin</span>  <span class="cit-name-given-names">CL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Letarte</span>  <span class="cit-name-given-names">M</span></span></li></ol><cite>. <span class="cit-article-title">Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms</span>. <abbr class="cit-jnl-abbrev">Thorax</abbr> <span class="cit-pub-date">1999</span>;<span class="cit-vol">54</span>:<span class="cit-fpage">714</span>–<span class="cit-lpage">29</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/thx.54.8.714</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>10413726</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiRlVMTCI7czoxMToiam91cm5hbENvZGUiO3M6OToidGhvcmF4am5sIjtzOjU6InJlc2lkIjtzOjg6IjU0LzgvNzE0IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzQzLzYvODQ0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">2.</span><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2. in text" id="ref-2">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.2" data-doi="10.1038/ejhg.2009.35"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Govani</span>  <span class="cit-name-given-names">FS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shovlin</span>  <span class="cit-name-given-names">CL</span></span></li></ol><cite>. <span class="cit-article-title">Hereditary haemorrhagic telangiectasia: a clinical and scientific review</span>. <abbr class="cit-jnl-abbrev">Eur J Hum Genet</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">17</span>:<span class="cit-fpage">860</span>–<span class="cit-lpage">71</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/ejhg.2009.35</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19337313</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1038/ejhg.2009.35&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19337313&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000267141600003&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">3.</span><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3. in text" id="ref-3">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.3" data-doi="10.1016/j.blre.2010.07.001"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Shovlin</span>  <span class="cit-name-given-names">CL</span></span></li></ol><cite>. <span class="cit-article-title">Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment</span>. <abbr class="cit-jnl-abbrev">Blood Rev</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">24</span>:<span class="cit-fpage">203</span>–<span class="cit-lpage">19</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.blre.2010.07.001</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20870325</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.blre.2010.07.001&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20870325&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000285171400001&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">4.</span><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4. in text" id="ref-4">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.4" data-doi="10.3390/jcm9113571"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Bernabeu</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bayrak-Toydemir</span>  <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">McDonald</span>  <span class="cit-name-given-names">J</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Potential second-hits in hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">J Clin Med</abbr> <span class="cit-pub-date">2020</span>;<span class="cit-vol">9</span>:<span class="cit-fpage">3571</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3390/jcm9113571</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>33167572</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3390/jcm9113571&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=33167572&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">5.</span><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5. in text" id="ref-5">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.5" data-doi="10.3389/fgene.2015.00001"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">McDonald</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wooderchak-Donahue</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">VanSant Webb</span>  <span class="cit-name-given-names">C</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era</span>. <abbr class="cit-jnl-abbrev">Front Genet</abbr> <span class="cit-pub-date">2015</span>;<span class="cit-vol">6</span>:<span class="cit-fpage">1</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3389/fgene.2015.00001</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25674101</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3389/fgene.2015.00001&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25674101&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">6.</span><a class="rev-xref-ref" href="#xref-ref-6-1" title="View reference 6. in text" id="ref-6">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.6" data-doi="10.1136/jmg.2005.030833"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Abdalla</span>  <span class="cit-name-given-names">SA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Letarte</span>  <span class="cit-name-given-names">M</span></span></li></ol><cite>. <span class="cit-article-title">Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease</span>. <abbr class="cit-jnl-abbrev">J Med Genet</abbr> <span class="cit-pub-date">2006</span>;<span class="cit-vol">43</span>:<span class="cit-fpage">97</span>–<span class="cit-lpage">110</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/jmg.2005.030833</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>15879500</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToiam1lZGdlbmV0IjtzOjU6InJlc2lkIjtzOjc6IjQzLzIvOTciO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvNDMvNi84NDQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">7.</span><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7. in text" id="ref-7">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.7" data-doi="10.7326/M20-1443"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Faughnan</span>  <span class="cit-name-given-names">ME</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mager</span>  <span class="cit-name-given-names">JJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hetts</span>  <span class="cit-name-given-names">SW</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia</span>. <abbr class="cit-jnl-abbrev">Ann Intern Med</abbr> <span class="cit-pub-date">2020</span>;<span class="cit-vol">173</span>:<span class="cit-fpage">989</span>–<span class="cit-lpage">1001</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.7326/M20-1443</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32894695</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.7326/M20-1443&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32894695&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">8.</span><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8. in text" id="ref-8">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.8" data-doi="10.1186/s13023-017-0632-2"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Serra</span>  <span class="cit-name-given-names">MM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Besada</span>  <span class="cit-name-given-names">CH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cabana Cal</span>  <span class="cit-name-given-names">A</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Central nervous system manganese induced lesions and clinical consequences in patients with hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">Orphanet J Rare Dis</abbr> <span class="cit-pub-date">2017</span>;<span class="cit-vol">12</span>:<span class="cit-fpage">92</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1186/s13023-017-0632-2</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28521822</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1186/s13023-017-0632-2&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28521822&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">9.</span><a class="rev-xref-ref" href="#xref-ref-9-1" title="View reference 9. in text" id="ref-9">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.9" data-doi="10.1212/WNL.0000000000006686"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Klostranec</span>  <span class="cit-name-given-names">JM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chen</span>  <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mathur</span>  <span class="cit-name-given-names">S</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A theory for polymicrogyria and brain arteriovenous malformations in HHT</span>. <abbr class="cit-jnl-abbrev">Neurology</abbr> <span class="cit-pub-date">2019</span>;<span class="cit-vol">92</span>:<span class="cit-fpage">34</span>–<span class="cit-lpage">42</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1212/WNL.0000000000006686</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30584075</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjc6IjkyLzEvMzQiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvNDMvNi84NDQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">10.</span><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10. in text" id="ref-10">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.10" data-doi="10.1136/jmg.2009.069013"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Faughnan</span>  <span class="cit-name-given-names">ME</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Palda</span>  <span class="cit-name-given-names">VA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Garcia-Tsao</span>  <span class="cit-name-given-names">G</span></span>, <span class="cit-etal">et al</span></li></ol><cite>; <span class="cit-auth cit-collab">HHT Foundation International Guidelines Working Group</span>. <span class="cit-article-title">International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">J Med Genet</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">48</span>:<span class="cit-fpage">73</span>–<span class="cit-lpage">87</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/jmg.2009.069013</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19553198</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToiam1lZGdlbmV0IjtzOjU6InJlc2lkIjtzOjc6IjQ4LzIvNzMiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvNDMvNi84NDQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">11.</span><a class="rev-xref-ref" href="#xref-ref-11-1" title="View reference 11. in text" id="ref-11">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.11"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Fulbright</span>  <span class="cit-name-given-names">RK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chaloupka</span>  <span class="cit-name-given-names">JC</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Putman</span>  <span class="cit-name-given-names">CM</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">MR of hereditary hemorrhagic telangiectasia: prevalence and spectrum of cerebrovascular malformations</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">1998</span>;<span class="cit-vol">19</span>:<span class="cit-fpage">477</span>–<span class="cit-lpage">84</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9541302</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=9541302&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000072548100014&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">12.</span><a class="rev-xref-ref" href="#xref-ref-12-1" title="View reference 12. in text" id="ref-12">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.12" data-doi="10.3171/jns.2000.92.5.0779"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Willemse</span>  <span class="cit-name-given-names">RB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mager</span>  <span class="cit-name-given-names">JJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Westermann</span>  <span class="cit-name-given-names">CJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Bleeding risk of cerebrovascular malformations in hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">J Neurosurg</abbr> <span class="cit-pub-date">2000</span>;<span class="cit-vol">92</span>:<span class="cit-fpage">779</span>–<span class="cit-lpage">84</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3171/jns.2000.92.5.0779</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>10794291</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3171/jns.2000.92.5.0779&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10794291&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000086675600005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">13.</span><a class="rev-xref-ref" href="#xref-ref-13-1" title="View reference 13. in text" id="ref-13">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.13" data-doi="10.1093/neuros/nyx16"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Meybodi</span>  <span class="cit-name-given-names">AT</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kim</span>  <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Nelson</span>  <span class="cit-name-given-names">J</span></span>, <span class="cit-etal">et al</span></li></ol><cite>; <span class="cit-auth cit-collab">Malformation Consortium HHT Investigator Group</span>. <span class="cit-article-title">Surgical treatment vs nonsurgical treatment for brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia: a retrospective multicenter consortium study</span>. <abbr class="cit-jnl-abbrev">Neurosurgery</abbr> <span class="cit-pub-date">2018</span>;<span class="cit-vol">82</span>:<span class="cit-fpage">253</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1093/neuros/nyx16</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28973426</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1093/neuros/nyx16&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28973426&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">14.</span><a class="rev-xref-ref" href="#xref-ref-14-1" title="View reference 14. in text" id="ref-14">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.14" data-doi="10.1227/NEU.0b013e3182354d68"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Amenta</span>  <span class="cit-name-given-names">PS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yadla</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Campbell</span>  <span class="cit-name-given-names">PG</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Analysis of nonmodifiable risk factors for intracranial aneurysm rupture in a large, retrospective cohort</span>. <abbr class="cit-jnl-abbrev">Neurosurgery</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">70</span>:<span class="cit-fpage">693</span>–<span class="cit-lpage">701</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1227/NEU.0b013e3182354d68</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21904261</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1227/NEU.0b013e3182354d68&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21904261&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">15.</span><a class="rev-xref-ref" href="#xref-ref-15-1" title="View reference 15. in text" id="ref-15">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.15" data-doi="10.1016/j.disamonth.2011.08.022"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Grobelny</span>  <span class="cit-name-given-names">TJ</span></span></li></ol><cite>. <span class="cit-article-title">Brain aneurysms: epidemiology, treatment options, and milestones of endovascular treatment evolution</span>. <abbr class="cit-jnl-abbrev">Dis Mon</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">57</span>:<span class="cit-fpage">647</span>–<span class="cit-lpage">55</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.disamonth.2011.08.022</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22036120</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.disamonth.2011.08.022&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22036120&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">16.</span><a class="rev-xref-ref" href="#xref-ref-16-1" title="View reference 16. in text" id="ref-16">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.16" data-doi="10.3171/jns.1990.73.6.0859"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Brown</span>  <span class="cit-name-given-names">RD</span>   <span class="cit-name-suffix">Jr</span>.</span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wiebers</span>  <span class="cit-name-given-names">DO</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Forbes</span>  <span class="cit-name-given-names">GS</span></span></li></ol><cite>. <span class="cit-article-title">Unruptured intracranial aneurysms and arteriovenous malformations: frequency of intracranial hemorrhage and relationship of lesions</span>. <abbr class="cit-jnl-abbrev">J Neurosurg</abbr> <span class="cit-pub-date">1990</span>;<span class="cit-vol">73</span>:<span class="cit-fpage">859</span>–<span class="cit-lpage">63</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3171/jns.1990.73.6.0859</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>2230969</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3171/jns.1990.73.6.0859&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=2230969&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1990EK58300005&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">17.</span><a class="rev-xref-ref" href="#xref-ref-17-1" title="View reference 17. in text" id="ref-17">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.17" data-doi="10.3174/ajnr.A4869"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Rammos</span>  <span class="cit-name-given-names">SK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Gardenghi</span>  <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bortolotti</span>  <span class="cit-name-given-names">C</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Aneurysms associated with brain arteriovenous malformations</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">37</span>:<span class="cit-fpage">1966</span>–<span class="cit-lpage">71</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3174/ajnr.A4869</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27339951</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czoxMDoiMzcvMTEvMTk2NiI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci80My82Lzg0NC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">18.</span><a class="rev-xref-ref" href="#xref-ref-18-1" title="View reference 18. in text" id="ref-18">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.18" data-doi="10.1016/S1474-4422(11)70109-0"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Vlak</span>  <span class="cit-name-given-names">MH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Algra</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brandenburg</span>  <span class="cit-name-given-names">R</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis</span>. <abbr class="cit-jnl-abbrev">Lancet Neurol</abbr> <span class="cit-pub-date">2011</span>;<span class="cit-vol">10</span>:<span class="cit-fpage">626</span>–<span class="cit-lpage">36</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S1474-4422(11)70109-0</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21641282</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S1474-4422(11)70109-0&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21641282&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000292487400009&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">19.</span><a class="rev-xref-ref" href="#xref-ref-19-1" title="View reference 19. in text" id="ref-19">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.19"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Mohan</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Munteanu</span>  <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Coman</span>  <span class="cit-name-given-names">T</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Genetic factors involves in intracranial aneurysms–actualities</span>. <abbr class="cit-jnl-abbrev">J Med Life</abbr> <span class="cit-pub-date">2015</span>;<span class="cit-vol">8</span>:<span class="cit-fpage">336</span>–<span class="cit-lpage">41</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26351537</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=26351537&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">20.</span><a class="rev-xref-ref" href="#xref-ref-20-1" title="View reference 20. in text" id="ref-20">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.20" data-doi="10.1177/1591019916659262"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Kim</span>  <span class="cit-name-given-names">ST</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brinjikji</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lanzino</span>  <span class="cit-name-given-names">G</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Neurovascular manifestations of connective-tissue diseases: a review</span>. <abbr class="cit-jnl-abbrev">Interv Neuroradiol</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">22</span>:<span class="cit-fpage">624</span>–<span class="cit-lpage">37</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1177/1591019916659262</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27511817</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1177/1591019916659262&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=27511817&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">21.</span><a class="rev-xref-ref" href="#xref-ref-21-1" title="View reference 21. in text" id="ref-21">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.21" data-doi="10.1097/PAS.0b013e31817f3661"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Maleszewski</span>  <span class="cit-name-given-names">JJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Miller</span>  <span class="cit-name-given-names">DV</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lu</span>  <span class="cit-name-given-names">J</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Histopathologic findings in ascending aortas from individuals with Loeys-Dietz syndrome (LDS)</span>. <abbr class="cit-jnl-abbrev">Am J Surg Pathol</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">33</span>:<span class="cit-fpage">194</span>–<span class="cit-lpage">201</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1097/PAS.0b013e31817f3661</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18852674</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/PAS.0b013e31817f3661&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18852674&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">22.</span><a class="rev-xref-ref" href="#xref-ref-22-1" title="View reference 22. in text" id="ref-22">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.22" data-doi="10.3174/ajnr.A4718"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Kim</span>  <span class="cit-name-given-names">ST</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brinjikji</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kallmes</span>  <span class="cit-name-given-names">DF</span></span></li></ol><cite>. <span class="cit-article-title">Prevalence of intracranial aneurysms in patients with connective tissue diseases: a retrospective study</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">37</span>:<span class="cit-fpage">1422</span>–<span class="cit-lpage">26</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3174/ajnr.A4718</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26992822</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo5OiIzNy84LzE0MjIiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvNDMvNi84NDQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">23.</span><a class="rev-xref-ref" href="#xref-ref-23-1" title="View reference 23. in text" id="ref-23">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.23" data-doi="10.1016/j.ijcard.2017.06.059"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Vorselaars</span>  <span class="cit-name-given-names">VM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Diederik</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Prabhudesai</span>  <span class="cit-name-given-names">V</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">SMAD4 gene mutation increases the risk of aortic dilation in patients with hereditary haemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">Int J Cardiol</abbr> <span class="cit-pub-date">2017</span>;<span class="cit-vol">245</span>:<span class="cit-fpage">114</span>–<span class="cit-lpage">18</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.ijcard.2017.06.059</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28874282</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.ijcard.2017.06.059&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28874282&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">24.</span><a class="rev-xref-ref" href="#xref-ref-24-1" title="View reference 24. in text" id="ref-24">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.24" data-doi="10.1016/j.ijcard.2017.07.046"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Cavalli</span>  <span class="cit-name-given-names">G</span></span></li></ol><cite>. <span class="cit-article-title">SMAD4 gene mutation and risk of aortic dilation: lessons from hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">Int J Cardiol</abbr> <span class="cit-pub-date">2017</span>;<span class="cit-vol">245</span>:<span class="cit-fpage">145</span>–<span class="cit-lpage">46</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.ijcard.2017.07.046</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28874286</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.ijcard.2017.07.046&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28874286&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">25.</span><a class="rev-xref-ref" href="#xref-ref-25-1" title="View reference 25. in text" id="ref-25">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.25" data-doi="10.2176/nmc.52.502"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Ishii</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Takechi</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Seyama</span>  <span class="cit-name-given-names">G</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Ruptured large basilar artery aneurysm associated with an arteriovenous malformation in hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">Neurol Med Chir (Tokyo)</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">52</span>:<span class="cit-fpage">502</span>–<span class="cit-lpage">05</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.2176/nmc.52.502</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22850500</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.2176/nmc.52.502&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22850500&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">26.</span><a class="rev-xref-ref" href="#xref-ref-26-1" title="View reference 26. in text" id="ref-26">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.26" data-doi="10.1007/s11739-012-0810-0"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Chick</span>  <span class="cit-name-given-names">JF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sheehan</span>  <span class="cit-name-given-names">SE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chauhan</span>  <span class="cit-name-given-names">NR</span></span></li></ol><cite>. <span class="cit-article-title">The many faces of hereditary hemorrhagic telangiectasia: median arcuate ligament syndrome, arteriovenous malformations, and cerebral aneurysms</span>. <abbr class="cit-jnl-abbrev">Intern Emerg Med</abbr> <span class="cit-pub-date">2012</span>;<span class="cit-vol">7</span>:<span class="cit-fpage">385</span>–<span class="cit-lpage">86</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s11739-012-0810-0</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22782335</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s11739-012-0810-0&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22782335&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">27.</span><a class="rev-xref-ref" href="#xref-ref-27-1" title="View reference 27. in text" id="ref-27">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.27"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Helmchen</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Nahser</span>  <span class="cit-name-given-names">HC</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yousry</span>  <span class="cit-name-given-names">T</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Therapy of cerebral aneurysms and arteriovenous vascular malformations in hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease)</span> <span class="cit-comment">(in German)</span>. <abbr class="cit-jnl-abbrev">Nervenarzt</abbr> <span class="cit-pub-date">1995</span>;<span class="cit-vol">66</span>:<span class="cit-fpage">124</span>–<span class="cit-lpage">28</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>7715751</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=7715751&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">28.</span><a class="rev-xref-ref" href="#xref-ref-28-1" title="View reference 28. in text" id="ref-28">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.28"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Roy</span>  <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Noseda</span>  <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Arzimanoglou</span>  <span class="cit-name-given-names">A</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Rendu Osler disease revealed by ruptured cerebral arterial aneurysm in an infant</span>. <abbr class="cit-jnl-abbrev">Arch Fr Pediatr</abbr> <span class="cit-pub-date">1990</span>;<span class="cit-vol">47</span>:<span class="cit-fpage">741</span>–<span class="cit-lpage">42</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>2082850</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=2082850&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1990EV96100011&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">29.</span><a class="rev-xref-ref" href="#xref-ref-29-1" title="View reference 29. in text" id="ref-29">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.29"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Sobel</span>  <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Norman</span>  <span class="cit-name-given-names">D</span></span></li></ol><cite>. <span class="cit-article-title">CNS manifestations of hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">1984</span>;<span class="cit-vol">5</span>:<span class="cit-fpage">569</span>–<span class="cit-lpage">73</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>6435422</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo3OiI1LzUvNTY5IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzQzLzYvODQ0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">30.</span><a class="rev-xref-ref" href="#xref-ref-30-1" title="View reference 30. in text" id="ref-30">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.30" data-doi="10.1161/01.str.14.3.419"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Fisher</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Zito</span>  <span class="cit-name-given-names">JL</span></span></li></ol><cite>. <span class="cit-article-title">Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">1983</span>;<span class="cit-vol">14</span>:<span class="cit-fpage">419</span>–<span class="cit-lpage">21</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1161/01.str.14.3.419</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>6658911</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjg6IjE0LzMvNDE5IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzQzLzYvODQ0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">31.</span><a class="rev-xref-ref" href="#xref-ref-31-1" title="View reference 31. in text" id="ref-31">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.31"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Kamiyama</span>  <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Okada</span>  <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Niizuma</span>  <span class="cit-name-given-names">H</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A case report: Osler-Weber-Rendu disease with cerebral aneurysm, cerebral arteriovenous malformation and pulmonary arteriovenous fistula</span> <span class="cit-comment">(author's transl)</span>. <abbr class="cit-jnl-abbrev">No Shinkei Geka</abbr> <span class="cit-pub-date">1981</span>;<span class="cit-vol">9</span>:<span class="cit-fpage">67</span>–<span class="cit-lpage">72</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>7231629</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=7231629&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">32.</span><a class="rev-xref-ref" href="#xref-ref-32-1" title="View reference 32. in text" id="ref-32">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.32" data-doi="10.1002/ana.410040207"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Román</span>  <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fisher</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Perl</span>  <span class="cit-name-given-names">DP</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature</span>. <abbr class="cit-jnl-abbrev">Ann Neurol</abbr> <span class="cit-pub-date">1978</span>;<span class="cit-vol">4</span>:<span class="cit-fpage">130</span>–<span class="cit-lpage">44</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/ana.410040207</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>707984</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/ana.410040207&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=707984&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1978FM28600006&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">33.</span><a class="rev-xref-ref" href="#xref-ref-33-1" title="View reference 33. in text" id="ref-33">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.33"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Grollmus</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hoff</span>  <span class="cit-name-given-names">J</span></span></li></ol><cite>. <span class="cit-article-title">Multiple aneurysms associated with Osler-Weber-Rendu disease</span>. <abbr class="cit-jnl-abbrev">Surg Neurol</abbr> <span class="cit-pub-date">1973</span>;<span class="cit-vol">1</span>:<span class="cit-fpage">91</span>–<span class="cit-lpage">93</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>4772800</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=4772800&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">34.</span><a class="rev-xref-ref" href="#xref-ref-34-1" title="View reference 34. in text" id="ref-34">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.34" data-doi="10.3171/JNS/2008/108/6/1132"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Brown</span>  <span class="cit-name-given-names">RD</span>   <span class="cit-name-suffix">Jr</span>.</span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Huston</span>  <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hornung</span>  <span class="cit-name-given-names">R</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection</span>. <abbr class="cit-jnl-abbrev">J Neurosurg</abbr> <span class="cit-pub-date">2008</span>;<span class="cit-vol">108</span>:<span class="cit-fpage">1132</span>–<span class="cit-lpage">38</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3171/JNS/2008/108/6/1132</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18518716</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3171/JNS/2008/108/6/1132&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18518716&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">35.</span><a class="rev-xref-ref" href="#xref-ref-35-1" title="View reference 35. in text" id="ref-35">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.35" data-doi="10.1016/j.ejrad.2012.12.026"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Caranci</span>  <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Briganti</span>  <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cirillo</span>  <span class="cit-name-given-names">L</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Epidemiology and genetics of intracranial aneurysms</span>. <abbr class="cit-jnl-abbrev">Eur J Radiol</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">82</span>:<span class="cit-fpage">1598</span>–<span class="cit-lpage">605</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.ejrad.2012.12.026</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23399038</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.ejrad.2012.12.026&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23399038&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">36.</span><a class="rev-xref-ref" href="#xref-ref-36-1" title="View reference 36. in text" id="ref-36">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.36" data-doi="10.1161/01.STR.32.4.877"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Maher</span>  <span class="cit-name-given-names">CO</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Piepgras</span>  <span class="cit-name-given-names">DG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brown</span>  <span class="cit-name-given-names">RD</span>   <span class="cit-name-suffix">Jr</span>.</span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebrovascular manifestations in 321 cases of hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">2001</span>;<span class="cit-vol">32</span>:<span class="cit-fpage">877</span>–<span class="cit-lpage">82</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1161/01.str.32.4.877</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>11283386</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjg6IjMyLzQvODc3IjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzQzLzYvODQ0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">37.</span><a class="rev-xref-ref" href="#xref-ref-37-1" title="View reference 37. in text" id="ref-37">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.37" data-doi="10.1007/s00234-005-1390-8"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Krings</span>  <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ozanne</span>  <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chng</span>  <span class="cit-name-given-names">SM</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Neurovascular phenotypes in hereditary haemorrhagic telangiectasia patients according to age: review of 50 consecutive patients aged 1 day-60 years</span>. <abbr class="cit-jnl-abbrev">Neuroradiology</abbr> <span class="cit-pub-date">2005</span>;<span class="cit-vol">47</span>:<span class="cit-fpage">711</span>–<span class="cit-lpage">20</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s00234-005-1390-8</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>16136265</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s00234-005-1390-8&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=16136265&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000232531000001&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">38.</span><a class="rev-xref-ref" href="#xref-ref-38-1" title="View reference 38. in text" id="ref-38">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.38" data-doi="10.3174/ajnr.A4762"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Brinjikji</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Iyer</span>  <span class="cit-name-given-names">VN</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yamaki</span>  <span class="cit-name-given-names">V</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Neurovascular manifestations of hereditary hemorrhagic telangiectasia: a consecutive series of 376 patients during 15 years</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">37</span>:<span class="cit-fpage">1479</span>–<span class="cit-lpage">86</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3174/ajnr.A4762</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27012295</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo5OiIzNy84LzE0NzkiO3M6NDoiYXRvbSI7czoxOToiL2FqbnIvNDMvNi84NDQuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">39.</span><a class="rev-xref-ref" href="#xref-ref-39-1" title="View reference 39. in text" id="ref-39">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.39" data-doi="10.3171/2013.10.JNS122402"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Woodall</span>  <span class="cit-name-given-names">MN</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">McGettigan</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Figueroa</span>  <span class="cit-name-given-names">R</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Cerebral vascular malformations in hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">J Neurosurg</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">120</span>:<span class="cit-fpage">87</span>–<span class="cit-lpage">92</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3171/2013.10.JNS122402</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24236651</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3171/2013.10.JNS122402&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24236651&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">40.</span><a class="rev-xref-ref" href="#xref-ref-40-1" title="View reference 40. in text" id="ref-40">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.40" data-doi="10.1016/j.jvir.2021.08.018"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Ring</span>  <span class="cit-name-given-names">NY</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Latif</span>  <span class="cit-name-given-names">MA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hafezi-Nejad</span>  <span class="cit-name-given-names">N</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Prevalence of and factors associated with arterial aneurysms in patients with hereditary hemorrhagic telangiectasia: 17-year retrospective series of 418 patients</span>. <abbr class="cit-jnl-abbrev">J Vasc Interv Radiol</abbr> <span class="cit-pub-date">2021</span>;<span class="cit-vol">32</span>:<span class="cit-fpage">1661</span>–<span class="cit-lpage">69</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jvir.2021.08.018</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34478850</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.jvir.2021.08.018&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34478850&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">41.</span><a class="rev-xref-ref" href="#xref-ref-41-1" title="View reference 41. in text" id="ref-41">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.41" data-doi="10.3171/2016.7.JNS16847"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Brinjikji</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Iyer</span>  <span class="cit-name-given-names">VN</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wood</span>  <span class="cit-name-given-names">CP</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Prevalence and characteristics of brain arteriovenous malformations in hereditary hemorrhagic telangiectasia: a systematic review and meta-analysis</span>. <abbr class="cit-jnl-abbrev">J Neurosurg</abbr> <span class="cit-pub-date">2017</span>;<span class="cit-vol">127</span>:<span class="cit-fpage">302</span>–<span class="cit-lpage">10</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3171/2016.7.JNS16847</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27767404</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3171/2016.7.JNS16847&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=27767404&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">42.</span><a class="rev-xref-ref" href="#xref-ref-42-1" title="View reference 42. in text" id="ref-42">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.42" data-doi="10.1007/s00701-016-2957-3"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Cagnazzo</span>  <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brinjikji</span>  <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lanzino</span>  <span class="cit-name-given-names">G</span></span></li></ol><cite>. <span class="cit-article-title">Arterial aneurysms associated with arteriovenous malformations of the brain: classification, incidence, risk of hemorrhage, and treatment-a systematic review</span>. <abbr class="cit-jnl-abbrev">Acta Neurochir (Wien)</abbr> <span class="cit-pub-date">2016</span>;<span class="cit-vol">158</span>:<span class="cit-fpage">2095</span>–<span class="cit-lpage">104</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s00701-016-2957-3</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27644700</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1007/s00701-016-2957-3&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=27644700&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">43.</span><a class="rev-xref-ref" href="#xref-ref-43-1" title="View reference 43. in text" id="ref-43">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.43" data-doi="10.1161/STROKEAHA.113.002390"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Chalouhi</span>  <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hoh</span>  <span class="cit-name-given-names">BL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hasan</span>  <span class="cit-name-given-names">D</span></span></li></ol><cite>. <span class="cit-article-title">Review of cerebral aneurysm formation, growth, and rupture</span>. <abbr class="cit-jnl-abbrev">Stroke</abbr> <span class="cit-pub-date">2013</span>;<span class="cit-vol">44</span>:<span class="cit-fpage">3613</span>–<span class="cit-lpage">22</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1161/STROKEAHA.113.002390</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24130141</span></cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiRlVMTCI7czoxMToiam91cm5hbENvZGUiO3M6OToic3Ryb2tlYWhhIjtzOjU6InJlc2lkIjtzOjEwOiI0NC8xMi8zNjEzIjtzOjQ6ImF0b20iO3M6MTk6Ii9ham5yLzQzLzYvODQ0LmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><span class="ref-label">44.</span><a class="rev-xref-ref" href="#xref-ref-44-1" title="View reference 44. in text" id="ref-44">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.44" data-doi="10.3389/fgene.2015.00114"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Dingenouts</span>  <span class="cit-name-given-names">CK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Goumans</span>  <span class="cit-name-given-names">M-J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bakker</span>  <span class="cit-name-given-names">W</span></span></li></ol><cite>. <span class="cit-article-title">Mononuclear cells and vascular repair in HHT</span>. <abbr class="cit-jnl-abbrev">Front Genet</abbr> <span class="cit-pub-date">2015</span>;<span class="cit-vol">6</span>:<span class="cit-fpage">114</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3389/fgene.2015.00114</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25852751</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3389/fgene.2015.00114&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25852751&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">45.</span><a class="rev-xref-ref" href="#xref-ref-45-1" title="View reference 45. in text" id="ref-45">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.45" data-doi="10.3390/ijms20123107"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Aristorena</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Gallardo-Vara</span>  <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Vicen</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">MMP-12, secreted by pro-inflammatory macrophages, targets endoglin in human macrophages and endothelial cells</span>. <abbr class="cit-jnl-abbrev">Int J Mol Sci</abbr> <span class="cit-pub-date">2019</span>;<span class="cit-vol">20</span>:<span class="cit-fpage">3107</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3390/ijms20123107</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31242676</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.3390/ijms20123107&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31242676&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">46.</span><a class="rev-xref-ref" href="#xref-ref-46-1" title="View reference 46. in text" id="ref-46">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.46" data-doi="10.1038/nm.2131"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Lebrin</span>  <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Srun</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Raymond</span>  <span class="cit-name-given-names">K</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia</span>. <abbr class="cit-jnl-abbrev">Nat Med</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">16</span>:<span class="cit-fpage">420</span>–<span class="cit-lpage">48</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/nm.2131</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20364125</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1038/nm.2131&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20364125&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000276446800046&amp;link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><span class="ref-label">47.</span><a class="rev-xref-ref" href="#xref-ref-47-1" title="View reference 47. in text" id="ref-47">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.47" data-doi="10.1002/lio2.561"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Wu</span>  <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lee</span>  <span class="cit-name-given-names">JM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Vozoris</span>  <span class="cit-name-given-names">NT</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Weekly epistaxis duration as an indicator of epistaxis severity in hereditary hemorrhagic telangiectasia: preliminary results from a randomized controlled trial</span>. <abbr class="cit-jnl-abbrev">Laryngoscope Investig Otolaryngol</abbr> <span class="cit-pub-date">2021</span>;<span class="cit-vol">6</span>:<span class="cit-fpage">370</span>–<span class="cit-lpage">75</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/lio2.561</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34195356</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1002/lio2.561&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34195356&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">48.</span><a class="rev-xref-ref" href="#xref-ref-48-1" title="View reference 48. in text" id="ref-48">↵</a><div class="cit ref-cit ref-journal" id="cit-43.6.844.48" data-doi="10.1016/S1474-4422(13)70263-1"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Greving</span>  <span class="cit-name-given-names">JP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wermer</span>  <span class="cit-name-given-names">MJH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brown</span>  <span class="cit-name-given-names">RD</span>   <span class="cit-name-suffix">Jr</span>.</span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies</span>. <abbr class="cit-jnl-abbrev">Lancet Neurol</abbr> <span class="cit-pub-date">2014</span>;<span class="cit-vol">13</span>:<span class="cit-fpage">59</span>–<span class="cit-lpage">66</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S1474-4422(13)70263-1</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24290159</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/S1474-4422(13)70263-1&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24290159&amp;link_type=MED&amp;atom=%2Fajnr%2F43%2F6%2F844.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li></ol></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 43</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jun 2022 </div></div>
      
      
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      <div class="highwire-cite-title">Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.S.</span> <span class="nlm-surname">Perez Akly</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Vazquez</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">C.H.</span> <span class="nlm-surname">Besada</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.J.</span> <span class="nlm-surname">Rodriguez</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.F.</span> <span class="nlm-surname">Conde</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">A.R.</span> <span class="nlm-surname">Cajal</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">V.A.</span> <span class="nlm-surname">Peuchot</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Dardik</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Baccanelli</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Serra</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2022, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">43 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">844-849; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A7505 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.S.</span> <span class="nlm-surname">Perez Akly</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Vazquez</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">C.H.</span> <span class="nlm-surname">Besada</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.J.</span> <span class="nlm-surname">Rodriguez</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.F.</span> <span class="nlm-surname">Conde</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">A.R.</span> <span class="nlm-surname">Cajal</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">V.A.</span> <span class="nlm-surname">Peuchot</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Dardik</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Baccanelli</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Serra</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2022, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">43 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">844-849; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A7505 </span></div>
  
  
  
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