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<meta name="DC.Title" content="Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center" />
<meta name="DC.Identifier" content="10.3174/ajnr.A7505" />
<meta name="DC.Date" content="2022-06-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2022 by American Journal of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia.

MATERIALS AND METHODS: This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected.

RESULTS: Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%–19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6–4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture.

CONCLUSIONS: Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed.

ACVRL1 
:   activin receptor-like kinase 1 or ALK-1 
BVM
:   brain vascular malformation
ENG 
:   endoglin 
HHT
:   hereditary hemorrhagic telangiectasia
IA
:   intracranial aneurysm
IQR
:   25–75 interquartile range
MADH4 
:   mothers against decapentaplegic drosophila homolog 4 
MMP
:   matrix metalloproteinase
TGFβ/BMP
:   Transforming Growth Factorβ/bone morphogenetic protein" />
<meta name="DC.Contributor" content="M.S. Perez Akly" />
<meta name="DC.Contributor" content="C. Vazquez" />
<meta name="DC.Contributor" content="C.H. Besada" />
<meta name="DC.Contributor" content="M.J. Rodriguez" />
<meta name="DC.Contributor" content="M.F. Conde" />
<meta name="DC.Contributor" content="A.R. Cajal" />
<meta name="DC.Contributor" content="V.A. Peuchot" />
<meta name="DC.Contributor" content="D. Dardik" />
<meta name="DC.Contributor" content="M.M. Baccanelli" />
<meta name="DC.Contributor" content="M.M. Serra" />
<meta name="article:published_time" content="2022-06-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%–19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6–4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2022/06/01" />
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<meta name="citation_firstpage" content="844" />
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<meta name="citation_author" content="M.S. Perez Akly" />
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<meta name="citation_author_institution" content="cDepartment of Internal Medicine (C.V., M.M.S.), Hospital Italiano, Buenos Aires, Argentina" />
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<meta name="citation_author" content="C.H. Besada" />
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<meta name="citation_author_institution" content="iFrom the Department of Radiology (D.D.), Clínica Instituto de Diagnóstico Sociedad Anónima (INDISA), Santiago, Chile" />
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<meta name="citation_author_institution" content="cDepartment of Internal Medicine (C.V., M.M.S.), Hospital Italiano, Buenos Aires, Argentina" />
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<meta name="citation_reference" content="citation_journal_title=Thorax;citation_journal_abbrev=Thorax;citation_author=CL. Shovlin;citation_author=M. Letarte;citation_title=Rare diseases bullet  4: Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms;citation_pages=714-729;citation_volume=54;citation_year=1999;citation_issue=8;citation_pmid=10413726;citation_doi=10.1136/thx.54.8.714" />
<meta name="citation_reference" content="citation_journal_title=European journal of human genetics :  EJHG;citation_journal_abbrev=Eur J Hum Genet;citation_author=FS. Govani;citation_author=CL. Shovlin;citation_title=Hereditary haemorrhagic telangiectasia: a clinical and scientific review.;citation_pages=860-871;citation_volume=17;citation_year=2009;citation_issue=7;citation_pmid=19337313;citation_doi=10.1038/ejhg.2009.35" />
<meta name="citation_reference" content="citation_journal_title=Blood reviews;citation_journal_abbrev=Blood Rev;citation_author=CL. Shovlin;citation_title=Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment.;citation_pages=203-219;citation_volume=24;citation_year=2010;citation_issue=6;citation_pmid=20870325;citation_doi=10.1016/j.blre.2010.07.001" />
<meta name="citation_reference" content="citation_journal_title=J Clin Med;citation_author=C. Bernabeu;citation_author=P. Bayrak-Toydemir;citation_author=J. McDonald;citation_title=Potential second-hits in hereditary hemorrhagic telangiectasia;citation_pages=3571;citation_volume=9;citation_year=2020;citation_pmid=33167572;citation_doi=10.3390/jcm9113571" />
<meta name="citation_reference" content="citation_journal_title=Front Genet;citation_author=J. McDonald;citation_author=W. Wooderchak-Donahue;citation_author=C. VanSant Webb;citation_title=Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era;citation_pages=1;citation_volume=6;citation_year=2015;citation_pmid=25674101;citation_doi=10.3389/fgene.2015.00001" />
<meta name="citation_reference" content="citation_journal_title=J Med Genet;citation_author=SA. Abdalla;citation_author=M. Letarte;citation_title=Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease;citation_volume=43;citation_year=2006;citation_pmid=15879500;citation_doi=10.1136/jmg.2005.030833" />
<meta name="citation_reference" content="citation_journal_title=Ann Intern Med;citation_author=ME. Faughnan;citation_author=JJ. Mager;citation_author=SW. Hetts;citation_title=Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia;citation_pages=989-1001;citation_volume=173;citation_year=2020;citation_pmid=32894695;citation_doi=10.7326/M20-1443" />
<meta name="citation_reference" content="citation_journal_title=Orphanet J Rare Dis;citation_author=MM. Serra;citation_author=CH. Besada;citation_author=A. Cabana Cal;citation_title=Central nervous system manganese induced lesions and clinical consequences in patients with hereditary hemorrhagic telangiectasia;citation_pages=92;citation_volume=12;citation_year=2017;citation_pmid=28521822;citation_doi=10.1186/s13023-017-0632-2" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=JM. Klostranec;citation_author=L. Chen;citation_author=S. Mathur;citation_title=A theory for polymicrogyria and brain arteriovenous malformations in HHT;citation_pages=34-42;citation_volume=92;citation_year=2019;citation_issue=1;citation_pmid=30584075;citation_doi=10.1212/WNL.0000000000006686" />
<meta name="citation_reference" content="citation_journal_title=J Med Genet;citation_author=HHT Foundation International Guidelines Working Group;citation_title=International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia;citation_volume=48;citation_year=2011;citation_pmid=19553198;citation_doi=10.1136/jmg.2009.069013" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_author=RK. Fulbright;citation_author=JC. Chaloupka;citation_author=CM. Putman;citation_title=MR of hereditary hemorrhagic telangiectasia: prevalence and spectrum of cerebrovascular malformations;citation_pages=477-484;citation_volume=19;citation_year=1998;citation_issue=3;citation_pmid=9541302" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=RB. Willemse;citation_author=JJ. Mager;citation_author=CJ. Westermann;citation_title=Bleeding risk of cerebrovascular malformations in hereditary hemorrhagic telangiectasia.;citation_pages=779-784;citation_volume=92;citation_year=2000;citation_issue=5;citation_pmid=10794291;citation_doi=10.3171/jns.2000.92.5.0779" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_author=Malformation Consortium HHT Investigator Group;citation_title=Surgical treatment vs nonsurgical treatment for brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia: a retrospective multicenter consortium study;citation_pages=253;citation_volume=82;citation_year=2018;citation_pmid=28973426;citation_doi=10.1093/neuros/nyx16" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_journal_abbrev=Neurosurgery;citation_author=PS. Amenta;citation_author=S. Yadla;citation_author=PG. Campbell;citation_title=Analysis of nonmodifiable risk factors for intracranial aneurysm rupture in a large, retrospective cohort.;citation_pages=693-699;citation_volume=70;citation_year=2012;citation_issue=3;citation_pmid=21904261;citation_doi=10.1227/NEU.0b013e3182354d68" />
<meta name="citation_reference" content="citation_journal_title=Disease-a-month :  DM;citation_journal_abbrev=Dis Mon;citation_author=TJ. Grobelny;citation_title=Brain aneurysms: epidemiology, treatment options, and milestones of endovascular treatment evolution.;citation_pages=647-655;citation_volume=57;citation_year=2011;citation_issue=10;citation_pmid=22036120;citation_doi=10.1016/j.disamonth.2011.08.022" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=RD. Brown;citation_author=DO. Wiebers;citation_author=GS. Forbes;citation_title=Unruptured intracranial aneurysms and arteriovenous malformations: frequency of intracranial hemorrhage and relationship of lesions.;citation_pages=859-863;citation_volume=73;citation_year=1990;citation_issue=6;citation_pmid=2230969;citation_doi=10.3171/jns.1990.73.6.0859" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=SK. Rammos;citation_author=B. Gardenghi;citation_author=C. Bortolotti;citation_title=Aneurysms associated with brain arteriovenous malformations;citation_volume=37;citation_year=2016;citation_pmid=27339951;citation_doi=10.3174/ajnr.A4869" />
<meta name="citation_reference" content="citation_journal_title=Lancet. Neurology;citation_journal_abbrev=Lancet Neurol;citation_author=MH. Vlak;citation_author=A. Algra;citation_author=R. Brandenburg;citation_title=Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis.;citation_pages=626-636;citation_volume=10;citation_year=2011;citation_issue=7;citation_pmid=21641282;citation_doi=10.1016/S1474-4422(11)70109-0" />
<meta name="citation_reference" content="citation_journal_title=J Med Life;citation_author=D. Mohan;citation_author=V. Munteanu;citation_author=T. Coman;citation_title=Genetic factors involves in intracranial aneurysms–actualities;citation_pages=336-41;citation_volume=8;citation_year=2015;citation_pmid=26351537" />
<meta name="citation_reference" content="citation_journal_title=Interv Neuroradiol;citation_author=ST. Kim;citation_author=W. Brinjikji;citation_author=G. Lanzino;citation_title=Neurovascular manifestations of connective-tissue diseases: a review;citation_volume=22;citation_year=2016;citation_pmid=27511817;citation_doi=10.1177/1591019916659262" />
<meta name="citation_reference" content="citation_journal_title=The American journal of surgical pathology;citation_journal_abbrev=Am J Surg Pathol;citation_author=JJ. Maleszewski;citation_author=DV. Miller;citation_author=J. Lu;citation_title=Histopathologic findings in ascending aortas from individuals with Loeys-Dietz syndrome (LDS).;citation_pages=194-201;citation_volume=33;citation_year=2009;citation_issue=2;citation_pmid=18852674;citation_doi=10.1097/PAS.0b013e31817f3661" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=ST. Kim;citation_author=W. Brinjikji;citation_author=DF. Kallmes;citation_title=Prevalence of intracranial aneurysms in patients with connective tissue diseases: a retrospective study;citation_volume=37;citation_year=2016;citation_pmid=26992822;citation_doi=10.3174/ajnr.A4718" />
<meta name="citation_reference" content="citation_journal_title=Int J Cardiol;citation_author=VM. Vorselaars;citation_author=A. Diederik;citation_author=V. Prabhudesai;citation_title=SMAD4 gene mutation increases the risk of aortic dilation in patients with hereditary haemorrhagic telangiectasia;citation_pages=114-18;citation_volume=245;citation_year=2017;citation_pmid=28874282;citation_doi=10.1016/j.ijcard.2017.06.059" />
<meta name="citation_reference" content="citation_journal_title=Int J Cardiol;citation_author=G. Cavalli;citation_title=SMAD4 gene mutation and risk of aortic dilation: lessons from hereditary hemorrhagic telangiectasia;citation_pages=145-46;citation_volume=245;citation_year=2017;citation_pmid=28874286;citation_doi=10.1016/j.ijcard.2017.07.046" />
<meta name="citation_reference" content="citation_journal_title=Neurologia medico-chirurgica;citation_journal_abbrev=Neurol Med Chir (Tokyo);citation_author=D. Ishii;citation_author=A. Takechi;citation_author=G. Seyama;citation_title=Ruptured large basilar artery aneurysm associated with an arteriovenous malformation in hereditary hemorrhagic telangiectasia.;citation_pages=502-505;citation_volume=52;citation_year=2012;citation_issue=7;citation_pmid=22850500;citation_doi=10.2176/nmc.52.502" />
<meta name="citation_reference" content="citation_journal_abbrev=Intern Emerg Med;citation_author=JF. Chick;citation_author=SE. Sheehan;citation_author=NR. Chauhan;citation_title=The many faces of Hereditary Hemorrhagic Telangiectasia: median arcuate ligament syndrome, arteriovenous malformations, and cerebral aneurysms.;citation_pages=385-386;citation_volume=7;citation_year=2012;citation_issue=4;citation_pmid=22782335;citation_doi=10.1007/s11739-012-0810-0" />
<meta name="citation_reference" content="citation_journal_title=Der Nervenarzt;citation_journal_abbrev=Nervenarzt;citation_author=C. Helmchen;citation_author=HC. Nahser;citation_author=T. Yousry;citation_title=[Therapy of cerebral aneurysms and arteriovenous vascular malformations in hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease)];citation_pages=124-128;citation_volume=66;citation_year=1995;citation_issue=2;citation_pmid=7715751" />
<meta name="citation_reference" content="citation_journal_title=Archives françaises de pédiatrie;citation_journal_abbrev=Arch Fr Pediatr;citation_author=C. Roy;citation_author=G. Noseda;citation_author=A. Arzimanoglou;citation_title=[Rendu Osler disease revealed by ruptured cerebral arterial aneurysm in an infant];citation_pages=741-742;citation_volume=47;citation_year=1990;citation_issue=10;citation_pmid=2082850" />
<meta name="citation_reference" content="citation_journal_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_author=D. Sobel;citation_author=D. Norman;citation_title=CNS manifestations of hereditary hemorrhagic telangiectasia.;citation_pages=569-573;citation_volume=5;citation_year=1984;citation_issue=5;citation_pmid=6435422" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_journal_abbrev=Stroke;citation_author=M. Fisher;citation_author=JL. Zito;citation_title=Focal cerebral ischemia distal to a cerebral aneurysm in hereditary hemorrhagic telangiectasia;citation_pages=419-421;citation_volume=14;citation_year=1983;citation_issue=3;citation_pmid=6658911;citation_doi=10.1161/01.str.14.3.419" />
<meta name="citation_reference" content="citation_journal_title=No shinkei geka. Neurological surgery;citation_journal_abbrev=No Shinkei Geka;citation_author=K. Kamiyama;citation_author=H. Okada;citation_author=H. Niizuma;citation_title=[A case report: Osler-Weber-Rendu disease with cerebral aneurysm, cerebral arteriovenous malformation and pulmonary arteriovenous fistula (author's transl)];citation_pages=67-72;citation_volume=9;citation_year=1981;citation_issue=1;citation_pmid=7231629" />
<meta name="citation_reference" content="citation_journal_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_author=G. Román;citation_author=M. Fisher;citation_author=DP. Perl;citation_title=Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature.;citation_pages=130-144;citation_volume=4;citation_year=1978;citation_issue=2;citation_pmid=707984;citation_doi=10.1002/ana.410040207" />
<meta name="citation_reference" content="citation_journal_title=Surgical neurology;citation_journal_abbrev=Surg Neurol;citation_author=J. Grollmus;citation_author=J. Hoff;citation_title=Multiple aneurysms associated with Osler-Weber-Rendu disease.;citation_pages=91-93;citation_volume=1;citation_year=1973;citation_issue=2;citation_pmid=4772800" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=RD. Brown;citation_author=J. Huston;citation_author=R. Hornung;citation_title=Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection.;citation_pages=1132-1138;citation_volume=108;citation_year=2008;citation_issue=6;citation_pmid=18518716;citation_doi=10.3171/JNS/2008/108/6/1132" />
<meta name="citation_reference" content="citation_journal_title=Eur J Radiol;citation_author=F. Caranci;citation_author=F. Briganti;citation_author=L. Cirillo;citation_title=Epidemiology and genetics of intracranial aneurysms;citation_pages=1598-605;citation_volume=82;citation_year=2013;citation_pmid=23399038;citation_doi=10.1016/j.ejrad.2012.12.026" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_journal_abbrev=Stroke;citation_author=CO. Maher;citation_author=DG. Piepgras;citation_author=RD. Brown;citation_title=Cerebrovascular Manifestations in 321 Cases of Hereditary Hemorrhagic Telangiectasia;citation_pages=877-882;citation_volume=32;citation_year=2001;citation_issue=4;citation_pmid=11283386;citation_doi=10.1161/01.STR.32.4.877" />
<meta name="citation_reference" content="citation_journal_title=Neuroradiology;citation_journal_abbrev=Neuroradiology;citation_author=T. Krings;citation_author=A. Ozanne;citation_author=SM. Chng;citation_title=Neurovascular phenotypes in hereditary haemorrhagic telangiectasia patients according to age. Review of 50 consecutive patients aged 1 day-60 years.;citation_pages=711-720;citation_volume=47;citation_year=2005;citation_issue=10;citation_pmid=16136265;citation_doi=10.1007/s00234-005-1390-8" />
<meta name="citation_reference" content="citation_journal_title=AJNR Am J Neuroradiol;citation_author=W. Brinjikji;citation_author=VN. Iyer;citation_author=V. Yamaki;citation_title=Neurovascular manifestations of hereditary hemorrhagic telangiectasia: a consecutive series of 376 patients during 15 years;citation_volume=37;citation_year=2016;citation_pmid=27012295;citation_doi=10.3174/ajnr.A4762" />
<meta name="citation_reference" content="citation_journal_title=J Neurosurg;citation_author=MN. Woodall;citation_author=M. McGettigan;citation_author=R. Figueroa;citation_title=Cerebral vascular malformations in hereditary hemorrhagic telangiectasia;citation_pages=87-92;citation_volume=120;citation_year=2014;citation_pmid=24236651;citation_doi=10.3171/2013.10.JNS122402" />
<meta name="citation_reference" content="citation_journal_title=J Vasc Interv Radiol;citation_author=NY. Ring;citation_author=MA. Latif;citation_author=N. Hafezi-Nejad;citation_title=Prevalence of and factors associated with arterial aneurysms in patients with hereditary hemorrhagic telangiectasia: 17-year retrospective series of 418 patients;citation_pages=1661-69;citation_volume=32;citation_year=2021;citation_pmid=34478850;citation_doi=10.1016/j.jvir.2021.08.018" />
<meta name="citation_reference" content="citation_journal_title=J Neurosurg;citation_author=W. Brinjikji;citation_author=VN. Iyer;citation_author=CP. Wood;citation_title=Prevalence and characteristics of brain arteriovenous malformations in hereditary hemorrhagic telangiectasia: a systematic review and meta-analysis;citation_volume=127;citation_year=2017;citation_pmid=27767404;citation_doi=10.3171/2016.7.JNS16847" />
<meta name="citation_reference" content="citation_journal_title=Acta Neurochir (Wien);citation_author=F. Cagnazzo;citation_author=W. Brinjikji;citation_author=G. Lanzino;citation_title=Arterial aneurysms associated with arteriovenous malformations of the brain: classification, incidence, risk of hemorrhage, and treatment-a systematic review;citation_pages=2095-104;citation_volume=158;citation_year=2016;citation_pmid=27644700;citation_doi=10.1007/s00701-016-2957-3" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=N. Chalouhi;citation_author=BL. Hoh;citation_author=D. Hasan;citation_title=Review of cerebral aneurysm formation, growth, and rupture;citation_volume=44;citation_year=2013;citation_pmid=24130141;citation_doi=10.1161/STROKEAHA.113.002390" />
<meta name="citation_reference" content="citation_journal_title=Front Genet;citation_author=CK. Dingenouts;citation_author=M-J. Goumans;citation_author=W. Bakker;citation_title=Mononuclear cells and vascular repair in HHT;citation_pages=114;citation_volume=6;citation_year=2015;citation_pmid=25852751;citation_doi=10.3389/fgene.2015.00114" />
<meta name="citation_reference" content="citation_journal_title=Int J Mol Sci;citation_author=M. Aristorena;citation_author=E. Gallardo-Vara;citation_author=M. Vicen;citation_title=MMP-12, secreted by pro-inflammatory macrophages, targets endoglin in human macrophages and endothelial cells;citation_pages=3107;citation_volume=20;citation_year=2019;citation_pmid=31242676;citation_doi=10.3390/ijms20123107" />
<meta name="citation_reference" content="citation_journal_title=Nature medicine;citation_journal_abbrev=Nat Med;citation_author=F. Lebrin;citation_author=S. Srun;citation_author=K. Raymond;citation_title=Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia.;citation_pages=420-428;citation_volume=16;citation_year=2010;citation_issue=4;citation_pmid=20364125;citation_doi=10.1038/nm.2131" />
<meta name="citation_reference" content="citation_journal_title=Laryngoscope Investig Otolaryngol;citation_author=V. Wu;citation_author=JM. Lee;citation_author=NT. Vozoris;citation_title=Weekly epistaxis duration as an indicator of epistaxis severity in hereditary hemorrhagic telangiectasia: preliminary results from a randomized controlled trial;citation_pages=370-75;citation_volume=6;citation_year=2021;citation_pmid=34195356;citation_doi=10.1002/lio2.561" />
<meta name="citation_reference" content="citation_journal_title=Lancet Neurol;citation_author=JP. Greving;citation_author=MJH. Wermer;citation_author=RD. Brown;citation_title=Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies;citation_pages=59-66;citation_volume=13;citation_year=2014;citation_pmid=24290159;citation_doi=10.1016/S1474-4422(13)70263-1" />
<meta name="twitter:title" content="Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia.

MATERIALS AND METHODS: This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected.

RESULTS: Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%–19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6–4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture.

CONCLUSIONS: Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed.

ACVRL1 
:   activin receptor-like kinase 1 or ALK-1 
BVM
:   brain vascular malformation
ENG 
:   endoglin 
HHT
:   hereditary hemorrhagic telangiectasia
IA
:   intracranial aneurysm
IQR
:   25–75 interquartile range
MADH4 
:   mothers against decapentaplegic drosophila homolog 4 
MMP
:   matrix metalloproteinase
TGFβ/BMP
:   Transforming Growth Factorβ/bone morphogenetic protein" />
<meta name="og-title" property="og:title" content="Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/43/6/844" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia.

MATERIALS AND METHODS: This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected.

RESULTS: Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%–19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6–4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture.

CONCLUSIONS: Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed.

ACVRL1 
:   activin receptor-like kinase 1 or ALK-1 
BVM
:   brain vascular malformation
ENG 
:   endoglin 
HHT
:   hereditary hemorrhagic telangiectasia
IA
:   intracranial aneurysm
IQR
:   25–75 interquartile range
MADH4 
:   mothers against decapentaplegic drosophila homolog 4 
MMP
:   matrix metalloproteinase
TGFβ/BMP
:   Transforming Growth Factorβ/bone morphogenetic protein" />
<meta name="og-type" property="og:type" content="article" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node97365" data-node-nid="97365" id="top-node-97365--21683236203" data-pisa="ajnr;43/6/844" data-pisa-master="ajnr;ajnr.A7505" data-apath="/ajnr/43/6/844.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Adult Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">M.S. Perez Akly</span>, <span class="highwire-citation-author" data-delta="1">C. Vazquez</span>, <span class="highwire-citation-author" data-delta="2">C.H. Besada</span>, <span class="highwire-citation-author" data-delta="3">M.J. Rodriguez</span>, <span class="highwire-citation-author" data-delta="4">M.F. Conde</span>, <span class="highwire-citation-author" data-delta="5">A.R. Cajal</span>, <span class="highwire-citation-author" data-delta="6">V.A. Peuchot</span>, <span class="highwire-citation-author" data-delta="7">D. Dardik</span>, <span class="highwire-citation-author" data-delta="8">M.M. Baccanelli</span> and <span class="highwire-citation-author" data-delta="9">M.M. Serra</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">June 2022,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">43 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">844-849; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A7505 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-97365--21683236203" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M.S. Perez Akly </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.S.%2BPerez%2BAkly%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Perez%20Akly%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.S.%2BPerez%2BAkly%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5144-6462" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.S. Perez Akly</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">C. Vazquez </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Internal Medicine (C.V., M.M.S.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BVazquez%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Vazquez%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.%2BVazquez%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2834-9047" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C. Vazquez</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">C.H. Besada </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.H.%2BBesada%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Besada%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AC.H.%2BBesada%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2559-7125" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for C.H. Besada</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">M.J. Rodriguez </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.J.%2BRodriguez%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rodriguez%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.J.%2BRodriguez%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0476-3649" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.J. Rodriguez</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">M.F. Conde </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.F.%2BConde%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Conde%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.F.%2BConde%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2237-0216" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.F. Conde</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">A.R. Cajal </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Translational Medicine and Biomedical Engineering Institute (A.R.C.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>g</span>University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.R.%2BCajal%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cajal%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AA.R.%2BCajal%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-8063-8877" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for A.R. 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Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>h</span>Internal Medicine Research Area (V.A.P.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=V.A.%2BPeuchot%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Peuchot%20V&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AV.A.%2BPeuchot%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0658-5516" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for V.A. 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Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>i</span>From the Department of Radiology (D.D.), Clínica Instituto de Diagnóstico Sociedad Anónima (INDISA), Santiago, Chile</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BDardik%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dardik%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AD.%2BDardik%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5269-9410" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for D. 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Hospital Italiano, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>g</span>University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.M.%2BBaccanelli%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Baccanelli%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.M.%2BBaccanelli%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8955-5640" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.M. 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Hospital Italiano, Buenos Aires, Argentina</div><div class='author-affiliation'><span class='nlm-sup'>g</span>University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.M.%2BSerra%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Serra%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.M.%2BSerra%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9912-9503" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M.M. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 43</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jun 2022 </div></div>
      
      
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